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EA200601558A1 - Производные изохинолинов и способы их использования - Google Patents

Производные изохинолинов и способы их использования

Info

Publication number
EA200601558A1
EA200601558A1 EA200601558A EA200601558A EA200601558A1 EA 200601558 A1 EA200601558 A1 EA 200601558A1 EA 200601558 A EA200601558 A EA 200601558A EA 200601558 A EA200601558 A EA 200601558A EA 200601558 A1 EA200601558 A1 EA 200601558A1
Authority
EA
Eurasian Patent Office
Prior art keywords
disease
methods
isoquinoline
derivatives
effective amount
Prior art date
Application number
EA200601558A
Other languages
English (en)
Inventor
Пракаш Джагтап
Эркан Балоглу
Джон Х. Ван Дюзер
Чаба Сабо
Эндрю Л. Салзман
Алока Рой
Уилльям Уилльямс
Александр Ниворожкин
Original Assignee
Инотек Фармасьютикалз Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Инотек Фармасьютикалз Корпорейшн filed Critical Инотек Фармасьютикалз Корпорейшн
Publication of EA200601558A1 publication Critical patent/EA200601558A1/ru

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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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  • Child & Adolescent Psychology (AREA)

Abstract

Настоящее изобретение относится к производным изохинолина, композициям, содержащим эффективное количество производного изохинолина, и к способам лечения или профилактики воспалительного заболевания, реперфузионного повреждения, ишемического состояния, почечной недостаточности, диабета, осложнения при диабете, сосудистого заболевания, иного, чем сердечно-сосудистое заболевание, сердечно-сосудистого заболевания, реоксигенационного повреждения, возникающего в результате трансплантации органов, болезни Паркинсона или рака, включающим введение животному, нуждающемуся в этом, эффективного количества производного изохинолина.
EA200601558A 2004-02-26 2005-02-25 Производные изохинолинов и способы их использования EA200601558A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54789904P 2004-02-26 2004-02-26
PCT/US2005/006243 WO2005082368A1 (en) 2004-02-26 2005-02-25 Isoquinoline derivatives and methods of use thereof

Publications (1)

Publication Number Publication Date
EA200601558A1 true EA200601558A1 (ru) 2007-08-31

Family

ID=34910959

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200601558A EA200601558A1 (ru) 2004-02-26 2005-02-25 Производные изохинолинов и способы их использования

Country Status (14)

Country Link
US (1) US20050228007A1 (ru)
EP (2) EP1722797A4 (ru)
JP (1) JP2007527872A (ru)
KR (1) KR20060125909A (ru)
CN (1) CN1964716A (ru)
AU (1) AU2005216978A1 (ru)
BR (1) BRPI0508233A (ru)
CA (1) CA2557547A1 (ru)
EA (1) EA200601558A1 (ru)
IL (1) IL177650A0 (ru)
MX (1) MXPA06009701A (ru)
NO (1) NO20064328L (ru)
WO (1) WO2005082368A1 (ru)
ZA (1) ZA200607913B (ru)

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US6956035B2 (en) * 2001-08-31 2005-10-18 Inotek Pharmaceuticals Corporation Isoquinoline derivatives and methods of use thereof
US20030096833A1 (en) * 2001-08-31 2003-05-22 Jagtap Prakash G. Substituted ideno[1,2-c]isoquinoline derivatives and methods of use thereof
US7217709B2 (en) * 2003-02-28 2007-05-15 Inotek Pharmaceuticals Corporation Tetracyclic benzamide derivatives and methods of use thereof
CA2556738A1 (en) * 2004-02-26 2005-09-09 Inotek Pharmaceuticals Corporation Tetracyclic lactam derivatives and uses thereof
EP1784186A4 (en) * 2004-06-16 2008-05-14 Inotek Pharmaceuticals Corp METHODS OF TREATING OR PREVENTING ERECTILE DYSFUNCTION OR URINARY INCONTINENCE
KR20070116011A (ko) * 2005-02-25 2007-12-06 이노텍 파마슈티컬스 코포레이션 테트라사이클릭 아미노 및 카복사미도 화합물 및 이의 이용방법
KR20070116016A (ko) * 2005-02-25 2007-12-06 이노텍 파마슈티컬스 코포레이션 이소퀴놀린 화합물 및 그의 이용 방법
JP2008531563A (ja) * 2005-02-25 2008-08-14 イノテック ファーマシューティカルズ コーポレイション 四環スルホンアミド化合物およびこれらの使用法
CN101316592A (zh) * 2005-08-24 2008-12-03 伊诺泰克制药公司 茚并异喹啉酮类似物及其用法
WO2007138355A1 (en) 2006-05-31 2007-12-06 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa Pyrrolo[1,2-a]pyrazin-1(2h)-one and pyrrolo[1,2-d][1,2,4]triazin-1(2h)-one derivatives as inhibitors of poly(adp-ribose)polymerase(parp)
CA2674436C (en) 2007-01-10 2012-07-17 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Amide substituted indazoles as poly(adp-ribose)polymerase (parp) inhibitors
CN101674832A (zh) * 2007-02-28 2010-03-17 伊诺泰克制药公司 茚并异喹啉酮类似物及其使用方法
GB0716532D0 (en) 2007-08-24 2007-10-03 Angeletti P Ist Richerche Bio Therapeutic compounds
MX2010005070A (es) 2007-11-15 2010-05-24 Angeletti P Ist Richerche Bio Derivados de piridazinona como inhibidores de parp.
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