EA200600480A1 - Имидазопиридинзамещённые тропановые производные, обладающие активностью антагониста ccr5 рецептора, для лечения вируса иммунодефицита человека (вич) и воспаления - Google Patents
Имидазопиридинзамещённые тропановые производные, обладающие активностью антагониста ccr5 рецептора, для лечения вируса иммунодефицита человека (вич) и воспаленияInfo
- Publication number
- EA200600480A1 EA200600480A1 EA200600480A EA200600480A EA200600480A1 EA 200600480 A1 EA200600480 A1 EA 200600480A1 EA 200600480 A EA200600480 A EA 200600480A EA 200600480 A EA200600480 A EA 200600480A EA 200600480 A1 EA200600480 A1 EA 200600480A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- treatment
- ccr5 receptor
- hiv
- imidazopiridin
- antagonist
- Prior art date
Links
- 102000004274 CCR5 Receptors Human genes 0.000 title abstract 3
- 108010017088 CCR5 Receptors Proteins 0.000 title abstract 3
- 239000005557 antagonist Substances 0.000 title abstract 2
- 230000000694 effects Effects 0.000 title abstract 2
- 241000725303 Human immunodeficiency virus Species 0.000 title 2
- 206010061218 Inflammation Diseases 0.000 title 1
- 230000004054 inflammatory process Effects 0.000 title 1
- 150000003813 tropane derivatives Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 102000019034 Chemokines Human genes 0.000 abstract 1
- 108010012236 Chemokines Proteins 0.000 abstract 1
- 208000031886 HIV Infections Diseases 0.000 abstract 1
- 208000037357 HIV infectious disease Diseases 0.000 abstract 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 241001430294 unidentified retrovirus Species 0.000 abstract 1
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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Abstract
В настоящем изобретении предложены соединения формулы (I), где Rи Rявляются такими, как определено в описании. Соединения по настоящему изобретению представляют собой модуляторы, в частности антагонисты, активности хемокиновых CCR5 рецепторов. Модуляторы CCR5 рецептора могут быть полезны в лечении различных воспалительных заболеваний и состояний, а также в лечении ВИЧ-инфекции и инфекции, вызываемой генетически родственными ретровирусами.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0323236.0A GB0323236D0 (en) | 2003-10-03 | 2003-10-03 | Chemical compounds |
| GB0325020A GB0325020D0 (en) | 2003-10-27 | 2003-10-27 | Chemical compounds |
| GB0418566A GB0418566D0 (en) | 2004-08-19 | 2004-08-19 | Tropane derivatives |
| PCT/IB2004/003153 WO2005033107A1 (en) | 2003-10-03 | 2004-09-28 | Imidazopyridine substituted tropane derivatives with ccr5 receptor antagonist activity for the treatment of hiv and inflammation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200600480A1 true EA200600480A1 (ru) | 2006-08-25 |
| EA009941B1 EA009941B1 (ru) | 2008-04-28 |
Family
ID=34426592
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200600480A EA009941B1 (ru) | 2003-10-03 | 2004-09-28 | Имидазопиридинзамещённые тропановые производные, обладающие активностью антагониста ccr5 рецептора, для лечения вируса иммунодефицита человека (вич) и воспаления |
Country Status (35)
| Country | Link |
|---|---|
| US (2) | US7309790B2 (ru) |
| EP (1) | EP1682545B1 (ru) |
| JP (1) | JP4874107B2 (ru) |
| KR (1) | KR100777885B1 (ru) |
| AP (1) | AP2174A (ru) |
| AR (1) | AR045856A1 (ru) |
| AT (1) | ATE380813T1 (ru) |
| AU (1) | AU2004278158B2 (ru) |
| BR (1) | BRPI0414862A (ru) |
| CA (1) | CA2540834C (ru) |
| CY (1) | CY1107281T1 (ru) |
| DE (1) | DE602004010708T2 (ru) |
| DK (1) | DK1682545T3 (ru) |
| EA (1) | EA009941B1 (ru) |
| EC (1) | ECSP066475A (ru) |
| ES (1) | ES2295924T3 (ru) |
| GE (1) | GEP20084417B (ru) |
| HN (1) | HN2004000383A (ru) |
| HR (1) | HRP20080052T3 (ru) |
| IL (1) | IL174208A0 (ru) |
| MA (1) | MA28080A1 (ru) |
| MX (1) | MXPA06003749A (ru) |
| MY (1) | MY137609A (ru) |
| NO (1) | NO20061978L (ru) |
| NZ (1) | NZ545837A (ru) |
| OA (1) | OA13266A (ru) |
| PA (1) | PA8614301A1 (ru) |
| PE (1) | PE20050961A1 (ru) |
| PL (1) | PL1682545T3 (ru) |
| PT (1) | PT1682545E (ru) |
| RS (1) | RS20060198A (ru) |
| SI (1) | SI1682545T1 (ru) |
| TW (1) | TWI280244B (ru) |
| UY (1) | UY28546A1 (ru) |
| WO (1) | WO2005033107A1 (ru) |
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| PE20030762A1 (es) | 2001-12-18 | 2003-09-05 | Schering Corp | Compuestos heterociclicos como antagonistas nk1 |
| TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| EP1656372B1 (en) | 2003-07-30 | 2013-04-10 | Rigel Pharmaceuticals, Inc. | 2,4-pyrimidinediamine compounds for use in the treatment or prevention of autoimmune diseases |
| US7491732B2 (en) | 2005-06-08 | 2009-02-17 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the JAK pathway |
| US20070203161A1 (en) | 2006-02-24 | 2007-08-30 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
| CA2642229C (en) | 2006-02-24 | 2015-05-12 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
| JP5155998B2 (ja) * | 2006-04-05 | 2013-03-06 | オプコ ヘルス， インコーポレイテッド | 薬学的処方物：８−［｛１−（３，５−ビス−（トリフルオロメチル）フェニル）−エトキシ｝−メチル］−８−フェニル−１，７−ジアザ−スピロ［４．５］デカン−２−オンの塩およびそれを使用した処置方法 |
| WO2008030853A2 (en) * | 2006-09-06 | 2008-03-13 | Incyte Corporation | Combination therapy for human immunodeficiency virus infection |
| CA2673125C (en) | 2006-10-19 | 2015-04-21 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
| WO2008085302A1 (en) * | 2006-12-20 | 2008-07-17 | Merck & Co., Inc. | Imidazopyridine analogs as cb2 receptor modulators, useful in the treatment of pain, respiratory and non-respiratory diseases |
| AR065802A1 (es) * | 2007-03-22 | 2009-07-01 | Schering Corp | Formulaciones de comprimidos que contienen sales de 8- [( 1- ( 3,5- bis- (trifluorometil) fenil) -etoxi ) - metil) -8- fenil -1, 7- diaza- spiro [ 4,5] decan -2- ona y comprimidos elaborados a partir de estas |
| AU2008317262B2 (en) * | 2007-10-25 | 2013-12-19 | Exelixis, Inc. | Tropane compounds |
| EP2265607B1 (en) | 2008-02-15 | 2016-12-14 | Rigel Pharmaceuticals, Inc. | Pyrimidine-2-amine compounds and their use as inhibitors of jak kinases |
| ES2546502T3 (es) | 2008-04-16 | 2015-09-24 | Portola Pharmaceuticals, Inc. | 2,6-Diamino-pirimidin-5-il-carboxamidas como inhibidores de syk o JAK quinasas |
| US8138339B2 (en) | 2008-04-16 | 2012-03-20 | Portola Pharmaceuticals, Inc. | Inhibitors of protein kinases |
| CN103224497A (zh) | 2008-04-22 | 2013-07-31 | 波托拉医药品公司 | 蛋白激酶抑制剂 |
| SG157299A1 (en) | 2008-05-09 | 2009-12-29 | Agency Science Tech & Res | Diagnosis and treatment of kawasaki disease |
| SG10201407538WA (en) | 2009-08-14 | 2015-01-29 | Opko Health Inc | Intravenous formulations of neurokinin-1 antagonists |
| BR112012024522A2 (pt) | 2010-04-02 | 2017-08-08 | Phivco 1 Llc | combinação, uso de uma combinação, composição farmacêutica, forma de dosagem única , kit, e, método para tratar um distúrbio |
| US9102625B2 (en) | 2010-11-01 | 2015-08-11 | Portola Pharmaceuticals, Inc. | Nicotinamides as JAK kinase modulators |
| US20140271680A1 (en) | 2011-08-12 | 2014-09-18 | Universite Paris-Est Creteil Val De Marne | Methods and pharmaceutical compositions for treatment of pulmonary hypertension |
| KR102019530B1 (ko) | 2011-11-23 | 2019-09-06 | 포톨라 파마슈티컬스, 인코포레이티드 | 피라진 키나아제 저해제 |
| US9676756B2 (en) | 2012-10-08 | 2017-06-13 | Portola Pharmaceuticals, Inc. | Substituted pyrimidinyl kinase inhibitors |
| JP6224256B2 (ja) * | 2013-09-25 | 2017-11-01 | マリンクロッド エルエルシー | 放射ヨウ素標識された３−フルオロプロピル−ＮＯＲ−β−ＣＩＴの調製 |
| GB201321748D0 (en) * | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
| US11629196B2 (en) | 2020-04-27 | 2023-04-18 | Incelldx, Inc. | Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions |
| US20250205220A1 (en) * | 2022-03-31 | 2025-06-26 | Bruce K. Patterson | Methods of Treating a Subject for Post-Treatment Lyme Disease (PTLD) and Compositions for Use in the Same |
| WO2023192361A1 (en) * | 2022-03-31 | 2023-10-05 | Incelldx, Inc. | Methods of treating a subject for fibromyalgia and compositions for use in the same |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
| KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
| PL183025B1 (pl) | 1994-04-19 | 2002-05-31 | Neurosearch As | Pochodne tropanu, sposób ich otrzymywania i zawierające je kompozycje |
| GB9518953D0 (en) * | 1995-09-15 | 1995-11-15 | Pfizer Ltd | Pharmaceutical formulations |
| PL185132B1 (pl) | 1996-02-22 | 2003-02-28 | Neurosearch As | Pochodne tropanowe, ich wytwarzanie i zastosowanie, oraz zawierająca je kompozycja farmaceutyczna |
| WO2000035298A1 (en) | 1996-11-27 | 2000-06-22 | Wm. Wrigley Jr. Company | Chewing gum containing medicament active agents |
| GB9711643D0 (en) | 1997-06-05 | 1997-07-30 | Janssen Pharmaceutica Nv | Glass thermoplastic systems |
| PE20001420A1 (es) * | 1998-12-23 | 2000-12-18 | Pfizer | Moduladores de ccr5 |
| EA007580B1 (ru) * | 2000-05-26 | 2006-12-29 | Пфайзер Инк. | Комбинация, содержащая производные тропана, полезные в терапии |
| US6855724B2 (en) * | 2002-04-08 | 2005-02-15 | Agouron Pharmaceuticals, Inc. | Tropane derivatives useful in therapy |
| DK1492789T3 (da) * | 2002-04-08 | 2006-09-11 | Pfizer | Tropanderivater som CCR5-modulatorer |
-
2004
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