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EA200501462A1 - Альфа-замещенные карбоновые кислоты в качестве модуляторов ppar - Google Patents

Альфа-замещенные карбоновые кислоты в качестве модуляторов ppar

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Publication number
EA200501462A1
EA200501462A1 EA200501462A EA200501462A EA200501462A1 EA 200501462 A1 EA200501462 A1 EA 200501462A1 EA 200501462 A EA200501462 A EA 200501462A EA 200501462 A EA200501462 A EA 200501462A EA 200501462 A1 EA200501462 A1 EA 200501462A1
Authority
EA
Eurasian Patent Office
Prior art keywords
formula
alpha
carbonic acids
ppar modulators
ppar
Prior art date
Application number
EA200501462A
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English (en)
Inventor
Саймон Бейли
Пол Стюарт Хэмфриз
Дональд Джеймс Скалитцки
Вей-Гуо Су
Люк Рэймонд Зендер
Original Assignee
Пфайзер Инк.
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Publication date
Application filed by Пфайзер Инк. filed Critical Пфайзер Инк.
Publication of EA200501462A1 publication Critical patent/EA200501462A1/ru

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C07D213/66—One oxygen atom attached in position 3 or 5 having in position 3 an oxygen atom and in each of the positions 4 and 5 a carbon atom bound to an oxygen, sulphur, or nitrogen atom, e.g. pyridoxal
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    • C07C271/14—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by halogen atoms or by nitro or nitroso groups
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    • C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
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    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
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    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
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    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
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    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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Abstract

Альфа-замещенные карбоновые кислоты формулы (I), где Rи Rтакие, как определено в описании, и Rозначает A) формулу II; B) формулу (III); C) формулу (IV); D) формулу (V), где Y, Art, Are, AP, R, R, R, R, R, R, R, R, R, R, R, кольцо A и p такие, как определено в описании; фармацевтические композиции, содержащие эффективные количества указанных соединений или их солей, полезны для лечения расстройств, связанных с PPAR, конкретно с PPAR α/γ, таких как диабет, дислипидемия, ожирение и воспалительные заболевания.
EA200501462A 2003-04-15 2004-04-01 Альфа-замещенные карбоновые кислоты в качестве модуляторов ppar EA200501462A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46321303P 2003-04-15 2003-04-15
PCT/IB2004/001159 WO2004092145A1 (en) 2003-04-15 2004-04-01 Alpha substituted carboxylic acid as ppar modulators

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EA200501462A1 true EA200501462A1 (ru) 2006-04-28

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EP (1) EP1615899A1 (ru)
JP (1) JP2006523671A (ru)
KR (1) KR20060009846A (ru)
CN (1) CN1805943A (ru)
AP (1) AP2005003418A0 (ru)
AR (1) AR044514A1 (ru)
AU (1) AU2004230316A1 (ru)
BR (1) BRPI0409429A (ru)
CA (1) CA2521915A1 (ru)
CL (1) CL2004000800A1 (ru)
EA (1) EA200501462A1 (ru)
EC (1) ECSP056105A (ru)
IS (1) IS8033A (ru)
MA (1) MA27764A1 (ru)
MX (1) MXPA05010967A (ru)
NL (1) NL1025946C2 (ru)
NO (1) NO20055370L (ru)
OA (1) OA13157A (ru)
PA (1) PA8600201A1 (ru)
PE (1) PE20050415A1 (ru)
TN (1) TNSN05262A1 (ru)
TW (1) TW200510353A (ru)
UY (1) UY28266A1 (ru)
WO (1) WO2004092145A1 (ru)
ZA (1) ZA200508362B (ru)

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BR0207227A (pt) * 2001-02-15 2004-02-10 Pfizer Prod Inc Compostos receptores ativados proliferadores ppar

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OA13157A (en) 2006-12-13
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AU2004230316A1 (en) 2004-10-28
IS8033A (is) 2005-09-15
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NO20055370L (no) 2006-01-12
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WO2004092145A8 (en) 2005-05-12
CA2521915A1 (en) 2004-10-28
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WO2004092145A1 (en) 2004-10-28
TNSN05262A1 (fr) 2007-07-10
PA8600201A1 (es) 2005-02-04
PE20050415A1 (es) 2005-06-13
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AP2005003418A0 (en) 2005-12-31
TW200510353A (en) 2005-03-16
MA27764A1 (fr) 2006-02-01
CL2004000800A1 (es) 2005-03-04
AR044514A1 (es) 2005-09-14
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EP1615899A1 (en) 2006-01-18
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