[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

EA200200574A1 - НОВЫЕ ЦИКЛИЧЕСКИЕ α-АМИНО-γ-ГИДРОКСИАМИДНЫЕ СОЕДИНЕНИЯ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ, ИХ СОДЕРЖАЩИЕ - Google Patents

НОВЫЕ ЦИКЛИЧЕСКИЕ α-АМИНО-γ-ГИДРОКСИАМИДНЫЕ СОЕДИНЕНИЯ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ, ИХ СОДЕРЖАЩИЕ

Info

Publication number
EA200200574A1
EA200200574A1 EA200200574A EA200200574A EA200200574A1 EA 200200574 A1 EA200200574 A1 EA 200200574A1 EA 200200574 A EA200200574 A EA 200200574A EA 200200574 A EA200200574 A EA 200200574A EA 200200574 A1 EA200200574 A1 EA 200200574A1
Authority
EA
Eurasian Patent Office
Prior art keywords
amino
pharmaceutical compositions
recovery method
different
hydrogen atom
Prior art date
Application number
EA200200574A
Other languages
English (en)
Other versions
EA004955B1 (ru
Inventor
Мишель Вержбицкий
Жан-Мари Фуркез
Нижель Левен
Бернадетта Юссон-Робер
Оливье Ножан
Мишель Буланже
Original Assignee
Ле Лаборатуар Сервье
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ле Лаборатуар Сервье filed Critical Ле Лаборатуар Сервье
Publication of EA200200574A1 publication Critical patent/EA200200574A1/ru
Publication of EA004955B1 publication Critical patent/EA004955B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/14—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated and containing rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Соединение формулы (I)в которойпредставляет собой необязательно замещенное насыщенное углеродное кольцо, имеющее от 4 до 8 членов кольца,Rи R, которые могут быть одинаковыми или различными, каждый представляет собой атом водорода или ацильную группу,Rи R, которые могут быть одинаковыми или различными, каждый представляет собой атом водорода или алкильную группу,Rи R, которые могут быть одинаковыми или различными, каждый представляет собой атом водорода или алкильную группу,или Rи Rсовместно с атомом азота, их несущим, образуют необязательно замещенный азотсодержащий гетероцикл,его стереоизомеры, а также его аддитивные соли с фармацевтически приемлемой кислотой.Лекарственный препараты.
EA200200574A 2001-06-18 2002-06-17 НОВЫЕ ЦИКЛИЧЕСКИЕ α-АМИНО-γ-ГИДРОКСИАМИДНЫЕ СОЕДИНЕНИЯ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ, ИХ СОДЕРЖАЩИЕ EA004955B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0107934A FR2826003B1 (fr) 2001-06-18 2001-06-18 Nouveaux derives cycliques d'alpha-amino-gamma-hydroxy- amides, leur procede de preparation et les compositions pharmaceutiques que les contiennent

Publications (2)

Publication Number Publication Date
EA200200574A1 true EA200200574A1 (ru) 2002-12-26
EA004955B1 EA004955B1 (ru) 2004-10-28

Family

ID=8864417

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200200574A EA004955B1 (ru) 2001-06-18 2002-06-17 НОВЫЕ ЦИКЛИЧЕСКИЕ α-АМИНО-γ-ГИДРОКСИАМИДНЫЕ СОЕДИНЕНИЯ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ, ИХ СОДЕРЖАЩИЕ

Country Status (25)

Country Link
US (1) US6593312B2 (ru)
EP (1) EP1270562B1 (ru)
JP (1) JP2003012642A (ru)
CN (1) CN1178901C (ru)
AR (1) AR034516A1 (ru)
AT (1) ATE277027T1 (ru)
AU (1) AU781822B2 (ru)
BR (1) BR0202313A (ru)
CA (1) CA2389858C (ru)
CZ (1) CZ20022119A3 (ru)
DE (1) DE60201296T2 (ru)
DK (1) DK1270562T3 (ru)
EA (1) EA004955B1 (ru)
ES (1) ES2229063T3 (ru)
FR (1) FR2826003B1 (ru)
HK (1) HK1050186A1 (ru)
HU (1) HUP0202011A3 (ru)
MX (1) MXPA02005997A (ru)
NO (1) NO322155B1 (ru)
NZ (1) NZ519610A (ru)
PL (1) PL354565A1 (ru)
PT (1) PT1270562E (ru)
SI (1) SI1270562T1 (ru)
SK (1) SK285989B6 (ru)
ZA (1) ZA200204865B (ru)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1385508B1 (en) * 2001-03-27 2008-05-21 Merck & Co., Inc. Dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE122010000020I1 (de) * 1996-04-25 2010-07-08 Prosidion Ltd Verfahren zur Senkung des Blutglukosespiegels in Säugern

Also Published As

Publication number Publication date
CN1178901C (zh) 2004-12-08
NO322155B1 (no) 2006-08-21
US20030004138A1 (en) 2003-01-02
HUP0202011A3 (en) 2005-07-28
BR0202313A (pt) 2003-04-29
SI1270562T1 (en) 2004-12-31
EP1270562B1 (fr) 2004-09-22
AU4882202A (en) 2002-12-19
MXPA02005997A (es) 2005-02-17
FR2826003A1 (fr) 2002-12-20
SK8772002A3 (en) 2003-01-09
DE60201296D1 (de) 2004-10-28
NO20022891L (no) 2002-12-19
DK1270562T3 (da) 2005-01-24
PL354565A1 (en) 2002-12-30
NO20022891D0 (no) 2002-06-17
CZ20022119A3 (cs) 2003-02-12
CA2389858C (fr) 2007-08-28
EP1270562A2 (fr) 2003-01-02
NZ519610A (en) 2003-05-30
ATE277027T1 (de) 2004-10-15
EP1270562A3 (fr) 2003-05-07
HUP0202011A2 (hu) 2003-01-28
FR2826003B1 (fr) 2003-08-15
HU0202011D0 (ru) 2002-08-28
PT1270562E (pt) 2004-11-30
CN1392137A (zh) 2003-01-22
HK1050186A1 (en) 2003-06-13
US6593312B2 (en) 2003-07-15
CA2389858A1 (fr) 2002-12-18
SK285989B6 (sk) 2008-01-07
EA004955B1 (ru) 2004-10-28
ES2229063T3 (es) 2005-04-16
AU781822B2 (en) 2005-06-16
ZA200204865B (en) 2003-02-20
JP2003012642A (ja) 2003-01-15
DE60201296T2 (de) 2006-02-23
AR034516A1 (es) 2004-02-25

Similar Documents

Publication Publication Date Title
EA200300792A1 (ru) Хиназолины в качестве ингибиторов ммр-13
EA200100970A1 (ru) Аминопроизводные как ингибиторы протеазы
EA200200299A1 (ru) НОВЫЕ α-АМИНОКИСЛОТНЫЕ СУЛЬФОНИЛЬНЫЕ СОЕДИНЕНИЯ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ ИХ СОДЕРЖАЩИЕ
DK1325910T3 (da) Aliphatiske nitrogenholdige femleddede ringforbindelser
EA200100983A1 (ru) Производные 13-метилэритромицина
SE8104781L (sv) Heterocykliska foreningar
BR0010324A (pt) Composto, composição farmacêutica, e, método de preparação de um composto
EA200000614A1 (ru) 2,3-замещенные соединения индола в качестве ингибиторов сох-2
EA200000792A2 (ru) Новые пиридиновые соединения, способ их получения и содержащие их фармацевтические композиции
TNSN07357A1 (en) Indanyl-piperazine derivatives, method for preparing same and pharmaceutical compositions containing same
EA200500717A1 (ru) Новые соединения имидазопиридина, способ их получения и фармацевтические композиции, которые их содержат
DE60105610D1 (en) Pyrazinonderivate
EA200300044A1 (ru) Новые замещенные фталиды, способ их получения и содержащие их фармацевтические композиции
BR1101136A (pt) Derivado da pristinamicina iib, (dietilamino-2 metil-1 etil) sulfinil-26 pristinamicina iib, (dietilamino-2 propil) sulfonil-26 pristinamicina iib, (diisopropilamino-2 etil) sulfonil-26 pristinamicina iib, processo de preparação de novo derivado da pristinamicina iib e composição farmacêutica
NO941365L (no) Azabicyklo-arylacetylen- og -arylenyn-oksimer som cholinerge midler og fremgangsmåte for behandling
HUP0203275A2 (hu) 1-(Gyűrűs amino)-alkilciklohexán-származékok, ezeket tartalmazó görcsoldó hatású gyógyszerkészítmények, valamint ezek alkalmazása
EA200001165A1 (ru) Производные тетрагидрохинолина в качестве антагонистов глицина
KR930012698A (ko) β-옥소-β-벤젠프로판티오아미드 유도체
ES2173182T3 (es) Derivado de 4,6-dl-butil-2,3-dihidrobenzotiofenos como antioxidantes de ldl.
EA200200041A1 (ru) Новые четвертичные соединения аммония, способ их получения и фармацевтическое применение
EA200200574A1 (ru) НОВЫЕ ЦИКЛИЧЕСКИЕ α-АМИНО-γ-ГИДРОКСИАМИДНЫЕ СОЕДИНЕНИЯ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ, ИХ СОДЕРЖАЩИЕ
SE8004868L (sv) Nya oximetrar, framstellning derav och farmaceutiska beredningar innehallande sadana etrar
DK160486C (da) N-(4-amino-2,2-diphenyl-butyl)- eller n-(3-amino-2,2-diphenyl-propyl) urinstofforbindelser, fremgangsmaade til fremstilling af disse, samt en farmaceutisk komposition
EA200501232A1 (ru) Новые трициклические соединения азепина, способ их получения и содержащие их фармацевтические композиции
SE8303913D0 (sv) Heterocykliska foreningar

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU