[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

EA200101046A1 - Производные индигоидных бис-индолов - Google Patents

Производные индигоидных бис-индолов

Info

Publication number
EA200101046A1
EA200101046A1 EA200101046A EA200101046A EA200101046A1 EA 200101046 A1 EA200101046 A1 EA 200101046A1 EA 200101046 A EA200101046 A EA 200101046A EA 200101046 A EA200101046 A EA 200101046A EA 200101046 A1 EA200101046 A1 EA 200101046A1
Authority
EA
Eurasian Patent Office
Prior art keywords
bis
indol derivatives
individual bis
individual
derivatives
Prior art date
Application number
EA200101046A
Other languages
English (en)
Inventor
Герхард Айзенбранд
Original Assignee
Герхард Айзенбранд
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Герхард Айзенбранд filed Critical Герхард Айзенбранд
Publication of EA200101046A1 publication Critical patent/EA200101046A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/36—Oxygen atoms in position 3, e.g. adrenochrome
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Настоящее изобретение относится к новым производным индигоидных бис-индолов, которые могут быть использованы для изготовления медикамента для лечения плотных злокачественных опухолей.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200101046A 1999-04-12 2000-04-12 Производные индигоидных бис-индолов EA200101046A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99106207 1999-04-12
EP99107429 1999-04-27
PCT/EP2000/003285 WO2000061555A1 (en) 1999-04-12 2000-04-12 Indigoid bisindole derivatives

Publications (1)

Publication Number Publication Date
EA200101046A1 true EA200101046A1 (ru) 2002-04-25

Family

ID=26152940

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200101046A EA200101046A1 (ru) 1999-04-12 2000-04-12 Производные индигоидных бис-индолов

Country Status (21)

Country Link
US (1) US6987092B1 (ru)
EP (1) EP1169305A1 (ru)
JP (1) JP2002541244A (ru)
KR (1) KR20010112424A (ru)
CN (1) CN1355789A (ru)
AU (1) AU4117800A (ru)
BG (1) BG105974A (ru)
BR (1) BR0009770A (ru)
CA (1) CA2369670A1 (ru)
CZ (1) CZ20013555A3 (ru)
EA (1) EA200101046A1 (ru)
HK (1) HK1041256A1 (ru)
HR (1) HRP20010735A2 (ru)
HU (1) HUP0200724A3 (ru)
IL (1) IL145743A0 (ru)
MX (1) MXPA01010214A (ru)
NO (1) NO20014948D0 (ru)
NZ (1) NZ514663A (ru)
PL (1) PL351261A1 (ru)
SK (1) SK14272001A3 (ru)
WO (1) WO2000061555A1 (ru)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60041974D1 (de) * 1999-04-12 2009-05-20 Heinz Herbert Fiebig 5-methylindirubin zur verwendung in der behandlung von menschlichen festen tumoren
DE10053474A1 (de) * 2000-10-24 2002-05-02 Schering Ag Schwefelhaltige Indirubinderivate, deren Herstellung und Verwendung
DE10061162A1 (de) * 2000-11-30 2002-07-11 Schering Ag Aryl-substituierte Indirubinderivate, deren Herstellung und Verwendung
DE10114138C2 (de) * 2001-03-16 2003-03-27 Schering Ag Cdk-inhibitorische Indirubinderivate mit erhöhter Löslichkeit
DE10125763A1 (de) * 2001-05-17 2002-11-28 Schering Ag Verwendung selektiver Indirubinderivate als VEGF-R Inhibitoren
DE10129028A1 (de) * 2001-06-11 2003-01-02 Schering Ag Lösliche Cdk-inhibitorische Indirubinderivate
US20050154046A1 (en) 2004-01-12 2005-07-14 Longgui Wang Methods of treating an inflammatory-related disease
US8563525B2 (en) 2004-01-12 2013-10-22 Natrogen Therapeutics International, Inc. Methods of treating an inflammatory-related disease
EP1458734B1 (en) * 2001-12-13 2010-10-13 Natrogen Therapeutics, Inc. Derivatives of isoindigo, indigo and indirubin and use in treating cancer
US6566341B1 (en) * 2001-12-13 2003-05-20 Natrogen Therapeutics, Inc. Derivative of isoindigo, indigo and indirubin for the treatment of cancer
US7582670B2 (en) 2001-12-13 2009-09-01 Natrogen Therapeutics, Inc. Methods of treating an inflammatory-related disease
EP1340745A1 (en) * 2002-02-20 2003-09-03 Gerhard Prof. Dr. Eisenbrand Indirubin derivatives and their use for the treatment of cancer
CN1199946C (zh) * 2002-10-29 2005-05-04 无锡杰西医药科技有限公司 一种特异性吲哚类化合物及制备方法与其在治疗和预防癌症等疾病中的应用
US20120070518A1 (en) * 2004-01-12 2012-03-22 Natrogen Therapeutics International, Inc. Methods and compositions for treating psoriasis
KR100588803B1 (ko) * 2004-01-27 2006-06-12 학교법인조선대학교 암세포주에 항암활성을 지닌 인디루빈 유도체
AU2005239814B2 (en) * 2004-05-12 2010-06-17 Bayer Cropscience Ag Plant growth regulation
JP5448455B2 (ja) * 2005-12-23 2014-03-19 サーントゥル ナシオナル ドゥ ラ ルシェルシュ シャーンティフィク （セ エン エール エス） 新規３’−，７−置換インジルビンおよびそれらの適用
US8518903B2 (en) 2007-04-19 2013-08-27 University of Pittsburgh—of the Commonwealth System of Higher Education Use of toll-like receptor-9 agonists
CN101074229B (zh) * 2007-06-08 2010-09-01 无锡杰西医药科技有限公司 7-氮杂靛玉红和7-氮杂异靛蓝衍生物制备及其药学用途
ATE529402T1 (de) 2008-08-01 2011-11-15 Centre Nat Rech Scient 3',6-substituierte indirubine und ihre biologischen anwendungen
EP2199292A1 (en) 2008-12-22 2010-06-23 Technische Universität Kaiserlautern 7-azaindirubins, 7'-azaindirubins, 7-7'-diazaindirubin and the corresponding 3'-oxime ether derivates: production thereof, their production and use as a medicament
EP2379549B1 (en) 2008-12-22 2016-09-21 Eisenbrand, Gerhard 7-azaindirubins, 7'-azaindirubins, 7-7'-diazaindirubin and the corresponding 3'-oxime ether derivates: production thereof, their production and use as a medicament
WO2012040719A2 (en) * 2010-09-24 2012-03-29 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Novel tlr4 inhibitors for the treatment of human infectious and inflammatory disorders
US10668092B2 (en) 2010-09-24 2020-06-02 The John Hopkins University Compositions and methods for treatment of inflammatory disorders
US9072760B2 (en) 2010-09-24 2015-07-07 University of Pittsburgh—of the Commonwealth System of Higher Education TLR4 inhibitors for the treatment of human infectious and inflammatory disorders
WO2012088425A2 (en) 2010-12-22 2012-06-28 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Gap junction-enhancing agents for treatment of necrotizing enterocolitis and inflammatory bowel disease
WO2013011841A1 (ja) * 2011-07-15 2013-01-24 学校法人日本大学 悪性腫瘍に対する高選択的細胞毒性を有するインディルビン誘導体
US8524121B2 (en) * 2012-01-27 2013-09-03 Xerox Corporation Bi-indoline-dithione polymers
CA2868302A1 (en) 2012-03-23 2013-09-26 Dennis M. Brown Compositions and methods to improve the therapeutic benefit of indirubin and analogs thereof, including meisoindigo
US9562066B2 (en) 2012-09-25 2017-02-07 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Oral therapy of necrotizing enterocolitis
CN103333161B (zh) * 2013-05-28 2015-09-30 滁州市洛达生物科技有限公司 1’-氧代靛玉红的制备和用途
KR101855423B1 (ko) * 2017-04-18 2018-05-09 주식회사 씨케이바이오텍 인디루빈 유도체를 유효성분으로 포함하는 약학 조성물
MX2020004374A (es) * 2017-10-31 2020-11-11 Pelemed Co Ltd Composición farmacéutica para prevenir o tratar la leucemia mieloide aguda o el cáncer de mama metastásico.
KR102326617B1 (ko) 2019-06-20 2021-11-15 서울대학교산학협력단 인돌렌인온의 제조 방법 및 인돌렌인온 합성을 통한 인디루빈 유도체의 제조 방법
CN110590640B (zh) * 2019-06-28 2020-12-15 贵州医科大学 一种靛玉红衍生物及其作为cdk/hdac双靶标抑制剂的应用
WO2021090172A1 (en) * 2019-11-04 2021-05-14 Ck Biotechnology Co. Compositions and methods for suppressing and/or treating neurodegenerative diseases and/or a clinical condition thereof
WO2021112626A1 (ko) * 2019-12-06 2021-06-10 주식회사 펠레메드 신규한 인디루빈 유도체 및 이의 용도
US20240228467A1 (en) * 2021-04-29 2024-07-11 Jawaharlal Nehru Centre For Advanced Scientific Research Indirubin compounds and methods thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS609022B2 (ja) * 1981-06-19 1985-03-07 イスクラ産業株式会社 インジルビン誘導体およびそれを含有する抗腫瘍剤
JPS609023B2 (ja) * 1981-06-19 1985-03-07 イスクラ産業株式会社 インジルビン誘導体およびそれを含有する抗腫瘍剤
JPS617254A (ja) * 1984-06-20 1986-01-13 Isukura Sangyo Kk ビスインドリノンおよびそれを主成分とする制癌剤
HU198946B (en) 1985-06-12 1989-12-28 Richter Gedeon Vegyeszet Process for producing new bisindole derivatives with antitumour action and pharmaceutical compositions comprising same
JPH03223363A (ja) * 1989-12-06 1991-10-02 Mitsui Toatsu Chem Inc ロープ染色用染料および染料組成物、これらを用いる染色法、ならびに染色物
KR20010078722A (ko) 1998-05-29 2001-08-21 아이젠 브란트 게르하르트 고리 의존형 키나제 억제용 약물의 제조를 위한인디고이드 비스인돌 유도체의 용도
EP0966963A1 (en) * 1998-05-29 1999-12-29 Gerhard Prof. Dr. Eisenbrand Use of indigoid bisindole derivatives as CDK1 inhibitors

Also Published As

Publication number Publication date
NZ514663A (en) 2002-09-27
IL145743A0 (en) 2002-07-25
NO20014948L (no) 2001-10-11
PL351261A1 (en) 2003-04-07
HUP0200724A2 (hu) 2002-07-29
EP1169305A1 (en) 2002-01-09
BG105974A (bg) 2002-06-28
US6987092B1 (en) 2006-01-17
AU4117800A (en) 2000-11-14
CN1355789A (zh) 2002-06-26
JP2002541244A (ja) 2002-12-03
MXPA01010214A (es) 2002-03-27
BR0009770A (pt) 2002-01-08
SK14272001A3 (sk) 2002-05-09
WO2000061555A1 (en) 2000-10-19
KR20010112424A (ko) 2001-12-20
CA2369670A1 (en) 2000-10-19
NO20014948D0 (no) 2001-10-11
HUP0200724A3 (en) 2002-10-28
CZ20013555A3 (cs) 2002-05-15
HK1041256A1 (zh) 2002-07-05
HRP20010735A2 (en) 2002-12-31

Similar Documents

Publication Publication Date Title
EA200101046A1 (ru) Производные индигоидных бис-индолов
PT1109812E (pt) Pirrolobenzodiazepinas
CY1105387T1 (el) Υποκατεστημενα παραγωγα 2-διαλκυλαμινοαλκυλοδιφαινθλιου
EA200300528A1 (ru) 1-арил-или 1-алкилсульфонилгетероциклилбензазолы в качестве лигандов 5-гидрокситриптамина-6
ES2207298T3 (es) Nuevos esteres derivados de compuestos fenil-ciclohexil substituidos.
DE50310516D1 (de) Fredericamycin-derivate
HN1999000125A (es) Nuevos derivados sustituidos del pirazol
EA200300717A1 (ru) Гетероциклилиндазольные и -азаиндазольные соединения в качестве 5-гидрокситриптамин-6-лигандов
DE60030741D1 (de) Chinazoline verbindungen als heilmittel
NO20013444D0 (no) Triazolforbindelser med dopamin-D3-reseptor-affinet
SE0002320D0 (sv) Malignant tumors
EA200300829A1 (ru) Производные 1-арил- или 1-алкилсульфонилбензазола в качестве лигандов 5-гидрокситриптамина-6
EA200301142A1 (ru) Производные гетероциклилокси-, -тиокси- и -аминобензазола в качестве лигандов 5-гидрокситриптамина-6
HK1052940A1 (en) Synthetic methods for aplidine and new antitumoralderivatives, methods of making and using them
EA200300716A1 (ru) Гетероциклилалкилиндольные или -азаиндольные соединения в качестве лиганд 5-гидрокситриптамина-6
CY1105039T1 (el) ΥΠΟΚΑΤΕΣΤΗΜΕΝΕΣ ΕΝΩΣΕΙΣ ΒΕΝΖΟ[b]ΑΖΕΠΙΝ-2-ΟΝΗΣ
EA200200545A1 (ru) Онколитические комбинации для лечения рака
EA200200742A1 (ru) 1,2-диарилбензимидазолы для лечения заболеваний, связанных с активацией микроглии
SE9901077D0 (sv) Novel use
ES2160410T3 (es) Preparados de complejos de protrombina inmunotolerantes.
DE60112960D1 (de) Kondensierte pyridoindolderivate
CY1105317T1 (el) Χρηση υποκατεστημενων ενωσεων 6-διμεθυλαμινομεθυλο-1-φαινυλο-κυκλοεξανιου για τη θepαπεια της ακρατειας ουρων
IT1318667B1 (it) Medicamento antinfiammatorio.
EE200300129A (et) Distamütsiini alfa-halogenoakrüloüülderivaadi kasutamine
EA200300727A1 (ru) Производные 2h-1-бензопирана, способы их получения и их фармацевтические композиции