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EA200100939A1 - Продолжительно действующие инсулинотропные пептиды - Google Patents

Продолжительно действующие инсулинотропные пептиды

Info

Publication number
EA200100939A1
EA200100939A1 EA200100939A EA200100939A EA200100939A1 EA 200100939 A1 EA200100939 A1 EA 200100939A1 EA 200100939 A EA200100939 A EA 200100939A EA 200100939 A EA200100939 A EA 200100939A EA 200100939 A1 EA200100939 A1 EA 200100939A1
Authority
EA
Eurasian Patent Office
Prior art keywords
peptides
insulinotropic
insulinotropic peptides
modified
prolonged operating
Prior art date
Application number
EA200100939A
Other languages
English (en)
Other versions
EA003922B1 (ru
Inventor
Доминик П. Бридон
Бенуа Л'Аршевек
Алан М. Эзрин
Даррен Л. Холмс
Анук Леблан
Серж Ст.Пьерр
Original Assignee
Конджачем, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Конджачем, Инк. filed Critical Конджачем, Инк.
Publication of EA200100939A1 publication Critical patent/EA200100939A1/ru
Publication of EA003922B1 publication Critical patent/EA003922B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Virology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychology (AREA)
  • Surgery (AREA)
  • Anesthesiology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Заявляются инсулинотропные пептиды. Модифицированные инсулинотропные пептиды способны образовывать стабилизированный по отношению к пептидазе инсулинотропный белок. Модифицированные инсулинотропные пептиды способны образовывать ковалентные связи с одним или более компонентами крови, давая конъюгат. Конъюгаты могут образовываться in vivo и ex vivo. Модифицированные пептиды вводят для лечения людей, больных диабетом и другими родственными заболеваниями.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200100939A 1999-05-17 2000-05-17 Продолжительно действующие инсулинотропные пептиды EA003922B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13440699P 1999-05-17 1999-05-17
US15978399P 1999-10-15 1999-10-15
PCT/US2000/013563 WO2000069911A1 (en) 1999-05-17 2000-05-17 Long lasting insulinotropic peptides

Publications (2)

Publication Number Publication Date
EA200100939A1 true EA200100939A1 (ru) 2002-04-25
EA003922B1 EA003922B1 (ru) 2003-10-30

Family

ID=26832298

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200100939A EA003922B1 (ru) 1999-05-17 2000-05-17 Продолжительно действующие инсулинотропные пептиды

Country Status (16)

Country Link
US (4) US6329336B1 (ru)
EP (1) EP1180121B9 (ru)
JP (5) JP4115671B2 (ru)
CN (1) CN1191273C (ru)
AT (1) ATE252601T1 (ru)
AU (1) AU754770B2 (ru)
BR (1) BR0010750A (ru)
CA (2) CA2363712C (ru)
DE (1) DE60006100T2 (ru)
DK (1) DK1180121T3 (ru)
EA (1) EA003922B1 (ru)
ES (1) ES2209885T3 (ru)
NO (1) NO20015584L (ru)
PT (1) PT1180121E (ru)
SI (1) SI1180121T1 (ru)
WO (1) WO2000069911A1 (ru)

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US6593295B2 (en) 2003-07-15
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NO20015584D0 (no) 2001-11-15
JP2009001583A (ja) 2009-01-08
US6329336B1 (en) 2001-12-11
BR0010750A (pt) 2002-02-26
CA2363712A1 (en) 2000-11-23
JP2009007371A (ja) 2009-01-15
EP1180121A1 (en) 2002-02-20
AU754770B2 (en) 2002-11-21
EP1180121B1 (en) 2003-10-22
JP2005255689A (ja) 2005-09-22
JP2003527312A (ja) 2003-09-16
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US20060135428A1 (en) 2006-06-22
PT1180121E (pt) 2004-03-31
CA2501421A1 (en) 2000-11-23
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US7741286B2 (en) 2010-06-22
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AU4855500A (en) 2000-12-05
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