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EA200100639A1 - TIOMOCHEVIN DERIVATIVES CONTAINING HETEROCYCLIC CARBOXAMIDE AND PROTECTIVE PHENYLETHYLENAMINE GROUP, AS HERPES VIRUS INHIBITORS - Google Patents

TIOMOCHEVIN DERIVATIVES CONTAINING HETEROCYCLIC CARBOXAMIDE AND PROTECTIVE PHENYLETHYLENAMINE GROUP, AS HERPES VIRUS INHIBITORS

Info

Publication number
EA200100639A1
EA200100639A1 EA200100639A EA200100639A EA200100639A1 EA 200100639 A1 EA200100639 A1 EA 200100639A1 EA 200100639 A EA200100639 A EA 200100639A EA 200100639 A EA200100639 A EA 200100639A EA 200100639 A1 EA200100639 A1 EA 200100639A1
Authority
EA
Eurasian Patent Office
Prior art keywords
carbon atoms
tiomochevin
phenylethylenamine
protective
group
Prior art date
Application number
EA200100639A
Other languages
Russian (ru)
Inventor
Джонатан Дэвид Блум
Кевин Джозеф Каррэн
Мартин Джозеф Дигранди
Расселл Джордж Дашин
Томас Ричард Джоунс
Стэнли Альберт Лэнг
Эдма Антониа Росс
Юджин Энтони Терефенко
Брайан Марк О'Хара
Original Assignee
Американ Хоум Продактс Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Американ Хоум Продактс Корпорейшн filed Critical Американ Хоум Продактс Корпорейшн
Publication of EA200100639A1 publication Critical patent/EA200100639A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/20—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/22—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/06—1,2,3-Thiadiazoles; Hydrogenated 1,2,3-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

Соединения формулы (I), в которой R-Rнезависимо выбирают из водорода или заместителей, R-Rнезависимо представляют собой водород или заместители при условии, что, по меньшей мере, один из R-Rне является водородом; G представляет собой моноциклический гетероарил; Х означает связь, -NH, алкил с 1-6 атомами углерода, алкенил с 2-6 атомами углерода, алкокси с 1-6 атомами углерода или тиоалкил с 1-6 атомами углерода, алкиламино с 1-6 атомами углерода или (CH)J; J представляет собой алкил с 1-6 атомами углерода, циклоалкил с 3-7 атомами углерода, фенил или бензил, используют для лечения заболеваний, связанных с вирусами герпеса, включая цитомегаловирус человека, вирусы простого герпеса, вирус Эпштейна-Барра, вирус ветряной оспы, герпесвирусы 6 и 7 человека и герпесвирус Капоши.Отчет о международном поиске был опубликован 2002.01.31.The compounds of formula (I) in which R-R is independently selected from hydrogen or substituents, R-R independently are hydrogen or substituents, provided that at least one of R-R is not hydrogen; G is monocyclic heteroaryl; X means a bond, -NH, alkyl with 1-6 carbon atoms, alkenyl with 2-6 carbon atoms, alkoxy with 1-6 carbon atoms or thioalkyl with 1-6 carbon atoms, alkylamino with 1-6 carbon atoms or (CH) J; J is alkyl with 1-6 carbon atoms, cycloalkyl with 3-7 carbon atoms, phenyl or benzyl, used to treat diseases associated with herpes viruses, including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, herpes viruses 6 and 7 people and herpes virus Kaposi. The international search report was published 2002.01.31.

EA200100639A 1998-12-09 1999-12-06 TIOMOCHEVIN DERIVATIVES CONTAINING HETEROCYCLIC CARBOXAMIDE AND PROTECTIVE PHENYLETHYLENAMINE GROUP, AS HERPES VIRUS INHIBITORS EA200100639A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20816498A 1998-12-09 1998-12-09
PCT/US1999/028916 WO2000034261A2 (en) 1998-12-09 1999-12-06 Heterocyclic carboxamide-containing thiourea inhibitors of herpes viruses containing a substituted phenylenediamine group

Publications (1)

Publication Number Publication Date
EA200100639A1 true EA200100639A1 (en) 2002-06-27

Family

ID=22773466

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200100639A EA200100639A1 (en) 1998-12-09 1999-12-06 TIOMOCHEVIN DERIVATIVES CONTAINING HETEROCYCLIC CARBOXAMIDE AND PROTECTIVE PHENYLETHYLENAMINE GROUP, AS HERPES VIRUS INHIBITORS

Country Status (14)

Country Link
EP (1) EP1144399A3 (en)
JP (1) JP2002533301A (en)
KR (1) KR20010086091A (en)
CN (1) CN1367785A (en)
AU (1) AU2353900A (en)
BR (1) BR9916043A (en)
CA (1) CA2351690A1 (en)
CZ (1) CZ20012063A3 (en)
EA (1) EA200100639A1 (en)
HU (1) HUP0203405A2 (en)
IL (1) IL143263A0 (en)
NO (1) NO20012835L (en)
WO (1) WO2000034261A2 (en)
ZA (1) ZA200104322B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6844367B1 (en) 1999-09-17 2005-01-18 Millennium Pharmaceuticals, Inc. Benzamides and related inhibitors of factor Xa
WO2001064642A2 (en) 2000-02-29 2001-09-07 Cor Therapeutics, Inc. Benzamides and related inhibitors of factor xa
EA010017B1 (en) * 2003-07-10 2008-06-30 Ачиллион Фармасьютикалз, Инк. Substituted arylthiourea derivatives useful as inhibitors of viral replication
DE102004015007A1 (en) * 2004-03-26 2005-10-13 Bayer Healthcare Ag Substituted imidazoles
TW200600492A (en) 2004-05-18 2006-01-01 Achillion Pharmaceuticals Inc Substituted aryl acylthioureas and related compounds; inhibitors of viral replication
DE102005008183A1 (en) 2005-02-23 2006-08-31 Bayer Healthcare Ag New heterocyclylamide-substituted imidazole compounds useful to treat or prevent viral infections
PT2077995E (en) 2006-11-02 2012-05-10 Millennium Pharm Inc Methods of synthesizing pharmaceutical salts of a factor xa inhibitor
JP6482466B2 (en) 2012-11-03 2019-03-13 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Cytomegalovirus inhibitors
US9334249B2 (en) 2012-11-03 2016-05-10 Boehringer Ingelheim International Gmbh Inhibitors of cytomegalovirus
CN112807294B (en) * 2019-11-18 2023-09-05 武汉大学 Application of an acylthiourea compound in the preparation of medicines for treating or preventing herpes simplex virus type I infection

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE231839T1 (en) * 1997-04-10 2003-02-15 Upjohn Co POLYAROMATIC ANTIVIRAL COMPOSITIONS

Also Published As

Publication number Publication date
JP2002533301A (en) 2002-10-08
KR20010086091A (en) 2001-09-07
WO2000034261A2 (en) 2000-06-15
BR9916043A (en) 2001-12-04
NO20012835L (en) 2001-07-19
HUP0203405A2 (en) 2003-02-28
EP1144399A3 (en) 2002-09-11
EP1144399A2 (en) 2001-10-17
CN1367785A (en) 2002-09-04
IL143263A0 (en) 2002-04-21
CA2351690A1 (en) 2000-06-15
WO2000034261A3 (en) 2002-01-31
CZ20012063A3 (en) 2001-10-17
NO20012835D0 (en) 2001-06-08
AU2353900A (en) 2000-06-26
ZA200104322B (en) 2002-10-25

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