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EA200000911A1 - Новые кристаллические формы антивирусного соединения бензимидазола - Google Patents

Новые кристаллические формы антивирусного соединения бензимидазола

Info

Publication number
EA200000911A1
EA200000911A1 EA200000911A EA200000911A EA200000911A1 EA 200000911 A1 EA200000911 A1 EA 200000911A1 EA 200000911 A EA200000911 A EA 200000911A EA 200000911 A EA200000911 A EA 200000911A EA 200000911 A1 EA200000911 A1 EA 200000911A1
Authority
EA
Eurasian Patent Office
Prior art keywords
benzimidazole
crystal forms
new crystal
virus compound
virus
Prior art date
Application number
EA200000911A
Other languages
English (en)
Other versions
EA002970B1 (ru
Inventor
Барри Хауард Картер
Бобби Нил Гловер
Льян-Фенг Хьюанг
Роберт Уильям Ланкастер
Стейси Тодд Лонг
Мишел Кэтрин Риззолио
Эрик Аллен Шмитт
Барри Риддл Сиклз
Original Assignee
Глаксо Груп Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Глаксо Груп Лимитед filed Critical Глаксо Груп Лимитед
Publication of EA200000911A1 publication Critical patent/EA200000911A1/ru
Publication of EA002970B1 publication Critical patent/EA002970B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/052—Imidazole radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Настоящее изобретение относится к физическим формам 5,6-дихлор-2-(изопропиламино)-1-β-L-рибофуранозил-1H-бензимидазола, фармацевтическим композициям и их применению при терапевтическом лечении.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200000911A 1998-04-07 1999-04-01 Новые кристаллические формы противовирусного соединения бензимидазола, способ их получения, их применение, фармацевтическая композиция и способ лечения EA002970B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9807354.7A GB9807354D0 (en) 1998-04-07 1998-04-07 Antiviral compound
PCT/EP1999/002214 WO1999051618A1 (en) 1998-04-07 1999-04-01 Novel crystalline forms of an antiviral benzimidazole compound

Publications (2)

Publication Number Publication Date
EA200000911A1 true EA200000911A1 (ru) 2001-04-23
EA002970B1 EA002970B1 (ru) 2002-12-26

Family

ID=10829932

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200000911A EA002970B1 (ru) 1998-04-07 1999-04-01 Новые кристаллические формы противовирусного соединения бензимидазола, способ их получения, их применение, фармацевтическая композиция и способ лечения

Country Status (28)

Country Link
US (9) US6469160B1 (ru)
EP (1) EP1071693B1 (ru)
JP (1) JP2002510703A (ru)
KR (1) KR20010074472A (ru)
CN (1) CN1303390A (ru)
AP (1) AP2000001947A0 (ru)
AT (1) ATE261452T1 (ru)
AU (1) AU752877B2 (ru)
BR (1) BR9909474A (ru)
CA (1) CA2327494C (ru)
DE (1) DE69915461T2 (ru)
EA (1) EA002970B1 (ru)
EE (1) EE04120B1 (ru)
ES (1) ES2216503T3 (ru)
GB (1) GB9807354D0 (ru)
HR (1) HRP20000669A2 (ru)
HU (1) HUP0101669A3 (ru)
ID (1) ID27109A (ru)
IL (1) IL138697A0 (ru)
IS (1) IS5640A (ru)
NO (1) NO20005005L (ru)
NZ (1) NZ507173A (ru)
PL (1) PL343397A1 (ru)
SK (1) SK14832000A3 (ru)
TR (1) TR200002860T2 (ru)
WO (1) WO1999051618A1 (ru)
YU (1) YU60900A (ru)
ZA (1) ZA200005153B (ru)

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GB9807354D0 (en) * 1998-04-07 1998-06-03 Glaxo Group Ltd Antiviral compound
GB9807355D0 (en) 1998-04-07 1998-06-03 Glaxo Group Ltd Antiviral compound
GB0008939D0 (en) 2000-04-11 2000-05-31 Glaxo Group Ltd Process for preparing substituted benzimidazole compounds
AP2052A (en) 2002-05-16 2009-10-05 Tibotec Pharm Ltd Pseudopolymorphic forms of HIV protease inhibitor
ES2370829T3 (es) * 2004-06-02 2011-12-23 Sandoz Ag Producto intermedio de meropenem en forma cristalina.
WO2007004230A2 (en) * 2005-07-05 2007-01-11 Hetero Drugs Limited A novel process for the preparation of didanosine using novel intermediates
WO2007052289A2 (en) * 2005-07-22 2007-05-10 Rubicon Research Pvt Ltd. Novel dispersible tablet composition
US8188138B2 (en) * 2005-09-21 2012-05-29 4Sc Ag Sulphonylpyrrole hydrochloride salts as histone deacetylases inhibitors
US7728129B2 (en) * 2005-10-31 2010-06-01 Janssen Pharmaceutica Nv Processes for the preparation of piperazinyl and diazapanyl benzamide derivatives
AU2007260356B2 (en) * 2006-06-16 2013-01-24 H. Lundbeck A/S Crystalline forms of 4- [2- (4-methylphenylsulfanyl) -phenyl] piperidine with combined serotonin and norepinephrine reuptake inhibition for the treatment of neuropathic pain
US7919598B2 (en) * 2006-06-28 2011-04-05 Bristol-Myers Squibb Company Crystal structures of SGLT2 inhibitors and processes for preparing same
KR20090084891A (ko) * 2006-10-27 2009-08-05 시그날 파마소티칼 엘엘씨 4-[9-(테트라하이드로-퓨란-3-일)-8-(2,4,6-트리플루오로-페닐아미노)-9ｈ-퓨린-2-일아미노]-사이클로헥산-1-올을 포함하는 고체 형태들, 이들의 조성물들 및 이들의 용도
EP2085397A1 (en) * 2008-01-21 2009-08-05 Esteve Quimica, S.A. Crystalline form of abacavir
US7935817B2 (en) * 2008-03-31 2011-05-03 Apotex Pharmachem Inc. Salt form and cocrystals of adefovir dipivoxil and processes for preparation thereof
AR071318A1 (es) * 2008-04-15 2010-06-09 Basilea Pharmaceutica Ag Benzhidril ester del acido (6r,7r)-7-{2-(5-amino-[1,2,4]tiadiazol-3-il)-2-[(z)-tritiloxiimino]-acetilamino}-3-[(r)-1'-terc-butoxicarbonil-2-oxo-[1,3']bipirrolidinil-(3e)-ilidenometil]-8-oxo-5-tia-1-aza-biciclo[4.2.0]oct-2-eno-2-carboxilico cristalino; su elaboracion y uso
US8097719B2 (en) * 2008-07-15 2012-01-17 Genesen Labs Meropenem intermediate in novel crystalline form and a method of manufacture of meropenem
KR101043794B1 (ko) * 2009-04-13 2011-06-27 청우산업 주식회사 황토판재로 제공되는 기능성 황토방
PL2544679T3 (pl) 2010-03-12 2019-10-31 Omeros Corp Inhibitory PDE10 oraz powiązane kompozycje i sposoby
WO2012030957A2 (en) * 2010-09-01 2012-03-08 Arena Pharmaceuticals, Inc. Non-hygroscopic salts of 5-ht2c agonists
US8940707B2 (en) 2010-10-28 2015-01-27 Viropharma Incorporated Maribavir isomers, compositions, methods of making and methods of using
US8541391B2 (en) 2010-10-28 2013-09-24 Viropharma Incorporated Crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl-1H-benzimidazole
US8546344B2 (en) 2010-10-28 2013-10-01 Viropharma Incorporated Crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl)-1H-benzimidazole
EP2760859A1 (en) * 2011-09-30 2014-08-06 Sunshine Lake Pharma Co., Ltd Crystalline forms of azilsartan and preparation and uses thereof
NZ630810A (en) 2014-04-28 2016-03-31 Omeros Corp Processes and intermediates for the preparation of a pde10 inhibitor
NZ716462A (en) * 2014-04-28 2017-11-24 Omeros Corp Optically active pde10 inhibitor
EP3285760A4 (en) 2015-04-24 2018-09-26 Omeros Corporation Pde10 inhibitors and related compositions and methods
WO2017079678A1 (en) 2015-11-04 2017-05-11 Omeros Corporation Solid state forms of a pde10 inhibitor
CN111303230B (zh) * 2020-03-09 2021-07-13 中国食品药品检定研究院 一种黄体酮共晶物及其制备方法和用途
EP4480956A3 (en) * 2022-10-12 2025-02-19 Takeda Pharmaceutical Company Limited Viral inhibitors, the synthesis thereof, and intermediates thereto

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3399987A (en) * 1965-08-02 1968-09-03 United States Borax Chem 2-alkylaminobenzimidazoles as herbicides
CH443777A (de) * 1965-08-06 1968-02-15 Agripat Sa Verfahren zum Schützen textiler Keratinfasern vor Insektenfrass und Mittel zur Durchführung dieses Verfahrens
US3655901A (en) * 1970-07-30 1972-04-11 Merck & Co Inc Method of inhibiting the formation of phenylethanalamine-n-methyl transferase with 2-aminobenzimidazoles
SE9003151D0 (sv) * 1990-10-02 1990-10-02 Medivir Ab Nucleoside derivatives
US5248672A (en) * 1990-11-01 1993-09-28 The Regents Of The University Of Michigan Polysubstituted benzimidazole nucleosides as antiviral agents
AU5447094A (en) * 1992-10-21 1994-05-09 Regents Of The University Of Michigan, The Polysubstituted benzimidazoles as antiviral agents
GB9413724D0 (en) 1994-07-07 1994-08-24 Wellcome Found Therapeutic nucleosides
GB9600143D0 (en) 1996-01-05 1996-03-06 Wellcome Found Therapeutic compounds
GB9807354D0 (en) * 1998-04-07 1998-06-03 Glaxo Group Ltd Antiviral compound
GB9807355D0 (en) 1998-04-07 1998-06-03 Glaxo Group Ltd Antiviral compound

Also Published As

Publication number Publication date
EE200000584A (et) 2002-04-15
KR20010074472A (ko) 2001-08-04
TR200002860T2 (tr) 2000-12-21
ID27109A (id) 2001-03-01
PL343397A1 (en) 2001-08-13
HUP0101669A2 (hu) 2001-10-28
GB9807354D0 (en) 1998-06-03
ES2216503T3 (es) 2004-10-16
US20110118203A1 (en) 2011-05-19
US20100179101A1 (en) 2010-07-15
US20020177703A1 (en) 2002-11-28
HUP0101669A3 (en) 2003-07-28
US7297683B2 (en) 2007-11-20
EP1071693B1 (en) 2004-03-10
CN1303390A (zh) 2001-07-11
CA2327494C (en) 2010-10-26
US20160030460A1 (en) 2016-02-04
EP1071693A1 (en) 2001-01-31
US20170002035A1 (en) 2017-01-05
US20080103186A1 (en) 2008-05-01
YU60900A (sh) 2003-07-07
BR9909474A (pt) 2000-12-19
CA2327494A1 (en) 1999-10-14
US9163052B2 (en) 2015-10-20
US7714123B2 (en) 2010-05-11
ZA200005153B (en) 2001-09-26
JP2002510703A (ja) 2002-04-09
EE04120B1 (et) 2003-08-15
NO20005005D0 (no) 2000-10-04
EA002970B1 (ru) 2002-12-26
DE69915461D1 (de) 2004-04-15
AP2000001947A0 (en) 2000-12-31
US20130261294A1 (en) 2013-10-03
NO20005005L (no) 2000-12-06
NZ507173A (en) 2003-07-25
WO1999051618A1 (en) 1999-10-14
AU3603499A (en) 1999-10-25
AU752877B2 (en) 2002-10-03
DE69915461T2 (de) 2005-03-03
US6469160B1 (en) 2002-10-22
IS5640A (is) 2000-09-26
HRP20000669A2 (en) 2001-08-31
ATE261452T1 (de) 2004-03-15
US20180044366A1 (en) 2018-02-15
IL138697A0 (en) 2001-10-31
SK14832000A3 (sk) 2001-07-10

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU