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EA200000527A3 - Новые бициклические амино-пиразиноновые соединения, способ их получения и фармацевтические композиции, содержащие их - Google Patents

Новые бициклические амино-пиразиноновые соединения, способ их получения и фармацевтические композиции, содержащие их

Info

Publication number
EA200000527A3
EA200000527A3 EA200000527A EA200000527A EA200000527A3 EA 200000527 A3 EA200000527 A3 EA 200000527A3 EA 200000527 A EA200000527 A EA 200000527A EA 200000527 A EA200000527 A EA 200000527A EA 200000527 A3 EA200000527 A3 EA 200000527A3
Authority
EA
Eurasian Patent Office
Prior art keywords
group
preparation
pharmaceutical compositions
compositions containing
bicyclic amino
Prior art date
Application number
EA200000527A
Other languages
English (en)
Other versions
EA003209B1 (ru
EA200000527A2 (ru
Inventor
Nanteuil Guillaumm De
Philippe Gloanec
Tony Verbeuren
Alain Rupin
Marie-Odile Vallez
Original Assignee
Адир Э Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Адир Э Компани filed Critical Адир Э Компани
Publication of EA200000527A2 publication Critical patent/EA200000527A2/ru
Publication of EA200000527A3 publication Critical patent/EA200000527A3/ru
Publication of EA003209B1 publication Critical patent/EA003209B1/ru

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

(57) 1. Соединение формулы (I)где Rобозначает атом водорода, необязательно замещенную алкильную, циклоалкильную или гетероциклоалкильную группу или группу формулы (G)где Aобозначает одинарную связь, -СН-, -СН-СН- или -N(СН)-группу или атом кислорода или серы, и Xи Х, которые могут быть одинаковыми или могут различаться, обозначают, каждый, атом углерода или азота,R обозначает атом водорода или линейную или разветвленную (C-С) алкильную группу,обозначает насыщенное кольцо, содержащее от 4 до7 членов в кольце,n обозначает целое число, при этом 1≤ n ≤6,Ar обозначает арильную или гетероарильную группу,его изомеры, его N-оксиды и их соли присоединения фармацевтически приемлемых кислоты или основания.
EA200000527A 1999-06-15 2000-06-14 Новые бициклические аминопиразиноновые соединения, способ их получения и фармацевтические композиции, содержащие их EA003209B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9907538A FR2795072B1 (fr) 1999-06-15 1999-06-15 Nouveaux derives bicycliques d'amino-pyrazinones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (3)

Publication Number Publication Date
EA200000527A2 EA200000527A2 (ru) 2000-12-25
EA200000527A3 true EA200000527A3 (ru) 2001-04-23
EA003209B1 EA003209B1 (ru) 2003-02-27

Family

ID=9546789

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200000527A EA003209B1 (ru) 1999-06-15 2000-06-14 Новые бициклические аминопиразиноновые соединения, способ их получения и фармацевтические композиции, содержащие их

Country Status (23)

Country Link
US (1) US6277851B1 (ru)
EP (1) EP1069132B1 (ru)
JP (1) JP3364472B2 (ru)
KR (1) KR100456796B1 (ru)
CN (1) CN1147489C (ru)
AT (1) ATE251177T1 (ru)
AU (1) AU766194B2 (ru)
BR (1) BR0002643A (ru)
CA (1) CA2312206C (ru)
DE (1) DE60005609T2 (ru)
DK (1) DK1069132T3 (ru)
EA (1) EA003209B1 (ru)
ES (1) ES2208239T3 (ru)
FR (1) FR2795072B1 (ru)
HK (1) HK1032236A1 (ru)
HU (1) HUP0002277A3 (ru)
NO (1) NO316650B1 (ru)
NZ (1) NZ505149A (ru)
PL (1) PL199522B1 (ru)
PT (1) PT1069132E (ru)
SE (1) SE1069132T5 (ru)
SI (1) SI1069132T1 (ru)
ZA (1) ZA200003034B (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001064678A2 (en) * 2000-02-29 2001-09-07 Bristol-Myers Squibb Pharma Company Inhibitors of hepatitis c virus ns3 protease
FR2818277B1 (fr) * 2000-12-14 2003-01-24 Servier Lab Nouveaux derives bicycliques d'amino-pyrazinones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US7037911B2 (en) * 2002-06-26 2006-05-02 Bristol-Myers Squibb Company Amino-bicyclic pyrazinones and pyridinones as coagulation serine protease inhibitors
FR2867780B1 (fr) * 2004-03-19 2006-05-19 Servier Lab Nouveaux derives de 4-oxo-4,6,7,8-tetrahydropyrrolo (1,2-a) pyrazine-6-carboxamides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US20140350034A1 (en) * 2012-01-27 2014-11-27 Novartis Ag Aminopyridine derivatives as plasma kallikrein inhibitors

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05117276A (ja) * 1991-10-23 1993-05-14 Sumitomo Pharmaceut Co Ltd 新規な3環性キノキサリンジオン誘導体
WO1996019483A1 (en) * 1994-12-22 1996-06-27 Biochem Pharma Inc. Low molecular weight bicyclic thrombin inhibitors
WO1996030396A1 (en) * 1995-03-24 1996-10-03 Molecumetics Ltd. β-SHEET MIMETICS AND USE THEREOF AS PROTEASE INHIBITORS
WO1997030708A1 (en) * 1996-02-22 1997-08-28 Merck & Co., Inc. Pyridinone thrombin inhibitors
US6124291A (en) * 1996-06-18 2000-09-26 Warner-Lambert Company Pyrrolo[1,2-a]pyrazine-1,4-dione serine protease inhibitors
WO1998009987A1 (en) * 1996-09-06 1998-03-12 Biochem Pharma, Inc. Lactam inhibitors of thrombin
DE69719775T2 (de) * 1996-10-24 2004-02-05 Merck & Co., Inc. Thrombin inhibitoren
US5792779A (en) * 1997-02-19 1998-08-11 Merck & Co., Inc. Pyridinone thrombin inhibitors
AU740447B2 (en) * 1997-09-23 2001-11-01 Merck & Co., Inc. Thrombin inhibitors

Also Published As

Publication number Publication date
ATE251177T1 (de) 2003-10-15
NO20002941L (no) 2000-12-18
CA2312206A1 (fr) 2000-12-15
EA003209B1 (ru) 2003-02-27
DE60005609T2 (de) 2004-08-05
FR2795072B1 (fr) 2001-07-27
NZ505149A (en) 2001-01-26
HUP0002277A2 (hu) 2001-05-28
PT1069132E (pt) 2004-02-27
AU766194B2 (en) 2003-10-09
HK1032236A1 (en) 2001-07-13
JP3364472B2 (ja) 2003-01-08
SI1069132T1 (en) 2003-12-31
CN1277198A (zh) 2000-12-20
KR100456796B1 (ko) 2004-11-10
PL340784A1 (en) 2000-12-18
DE60005609D1 (de) 2003-11-06
CN1147489C (zh) 2004-04-28
ES2208239T3 (es) 2004-06-16
EP1069132A1 (fr) 2001-01-17
EA200000527A2 (ru) 2000-12-25
PL199522B1 (pl) 2008-09-30
BR0002643A (pt) 2001-01-02
DK1069132T3 (da) 2004-02-02
CA2312206C (fr) 2004-07-06
HU0002277D0 (en) 2000-08-28
AU4086500A (en) 2000-12-21
NO20002941D0 (no) 2000-06-08
SE1069132T3 (sv) 2003-12-09
NO316650B1 (no) 2004-03-22
JP2001026592A (ja) 2001-01-30
SE1069132T5 (sv) 2004-01-07
ZA200003034B (en) 2001-01-11
FR2795072A1 (fr) 2000-12-22
US6277851B1 (en) 2001-08-21
EP1069132B1 (fr) 2003-10-01
KR20010066846A (ko) 2001-07-11
HUP0002277A3 (en) 2002-12-28

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU