EA029002B9 - Съедобная композиция - Google Patents
Съедобная композицияInfo
- Publication number
- EA029002B9 EA029002B9 EA201391803A EA201391803A EA029002B9 EA 029002 B9 EA029002 B9 EA 029002B9 EA 201391803 A EA201391803 A EA 201391803A EA 201391803 A EA201391803 A EA 201391803A EA 029002 B9 EA029002 B9 EA 029002B9
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- glucose
- flavonoid
- glucoside
- post
- prandial
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 5
- 229930003935 flavonoid Natural products 0.000 abstract 5
- 235000017173 flavonoids Nutrition 0.000 abstract 5
- 239000008103 glucose Substances 0.000 abstract 5
- 230000000291 postprandial effect Effects 0.000 abstract 4
- 108091006299 SLC2A2 Proteins 0.000 abstract 3
- -1 flavonoid glucoside Chemical class 0.000 abstract 3
- 229930182478 glucoside Natural products 0.000 abstract 3
- TWCMVXMQHSVIOJ-UHFFFAOYSA-N Aglycone of yadanzioside D Natural products COC(=O)C12OCC34C(CC5C(=CC(O)C(O)C5(C)C3C(O)C1O)C)OC(=O)C(OC(=O)C)C24 TWCMVXMQHSVIOJ-UHFFFAOYSA-N 0.000 abstract 2
- PLMKQQMDOMTZGG-UHFFFAOYSA-N Astrantiagenin E-methylester Natural products CC12CCC(O)C(C)(CO)C1CCC1(C)C2CC=C2C3CC(C)(C)CCC3(C(=O)OC)CCC21C PLMKQQMDOMTZGG-UHFFFAOYSA-N 0.000 abstract 2
- 239000008280 blood Substances 0.000 abstract 2
- 210000004369 blood Anatomy 0.000 abstract 2
- 150000002215 flavonoids Chemical class 0.000 abstract 2
- PFOARMALXZGCHY-UHFFFAOYSA-N homoegonol Natural products C1=C(OC)C(OC)=CC=C1C1=CC2=CC(CCCO)=CC(OC)=C2O1 PFOARMALXZGCHY-UHFFFAOYSA-N 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 2
- 102100026189 Beta-galactosidase Human genes 0.000 abstract 1
- 102000058058 Glucose Transporter Type 2 Human genes 0.000 abstract 1
- 108090000604 Hydrolases Proteins 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- 108010059881 Lactase Proteins 0.000 abstract 1
- IOUVKUPGCMBWBT-DARKYYSBSA-N Phloridzin Natural products O[C@H]1[C@@H](O)[C@H](O)[C@H](CO)O[C@H]1OC1=CC(O)=CC(O)=C1C(=O)CCC1=CC=C(O)C=C1 IOUVKUPGCMBWBT-DARKYYSBSA-N 0.000 abstract 1
- 102000000070 Sodium-Glucose Transport Proteins Human genes 0.000 abstract 1
- 108010080361 Sodium-Glucose Transport Proteins Proteins 0.000 abstract 1
- 229920002472 Starch Polymers 0.000 abstract 1
- 229930006000 Sucrose Natural products 0.000 abstract 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 abstract 1
- 102000003673 Symporters Human genes 0.000 abstract 1
- 108090000088 Symporters Proteins 0.000 abstract 1
- 230000009286 beneficial effect Effects 0.000 abstract 1
- 108010005774 beta-Galactosidase Proteins 0.000 abstract 1
- 150000001720 carbohydrates Chemical class 0.000 abstract 1
- 235000014633 carbohydrates Nutrition 0.000 abstract 1
- 235000013305 food Nutrition 0.000 abstract 1
- 230000004190 glucose uptake Effects 0.000 abstract 1
- 230000002641 glycemic effect Effects 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 230000000968 intestinal effect Effects 0.000 abstract 1
- 229940116108 lactase Drugs 0.000 abstract 1
- 235000012054 meals Nutrition 0.000 abstract 1
- IOUVKUPGCMBWBT-UHFFFAOYSA-N phloridzosid Natural products OC1C(O)C(O)C(CO)OC1OC1=CC(O)=CC(O)=C1C(=O)CCC1=CC=C(O)C=C1 IOUVKUPGCMBWBT-UHFFFAOYSA-N 0.000 abstract 1
- 235000019139 phlorizin Nutrition 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- 235000019698 starch Nutrition 0.000 abstract 1
- 239000008107 starch Substances 0.000 abstract 1
- 239000005720 sucrose Substances 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Nutrition Science (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Продукты или пища с высоким содержанием доступных углеводов, таких как сахароза или крахмал, повышают постпрандиальные концентрации глюкозы в крови. Повторяющиеся высокие постпрандиальные "всплески" глюкозы в плазме ассоциируют с повышенным риском развития диабета второго типа. Неконтролируемые колебания уровня глюкозы являются нежелательными и любое снижение или "притупление" постпрандиальной концентрации глюкозы в крови потенциально является благоприятным. Данное изобретение относится к съедобной композиции для замедления поглощения глюкозы в кишечнике через синергетическое ингибирование как активного натрий-глюкозного котранспортера 1 (SGLT1), так и пассивного транспортера глюкозы 2 (GLUT2), приводя к выравниванию или притуплению постпрандиального глюкозного пика. Таким образом, в первом аспекте изобретения предоставлена съедобная композиция, при этом композиция содержит по меньшей мере 5%, в расчете на сухую массу, по меньшей мере одного флавоноидного агликона и по меньшей мере 5%, в расчете на сухую массу, по меньшей мере одного флавоноидного глюкозида, где флавоноидный глюкозид по меньшей мере на 20%, предпочтительно по меньшей мере на 40%, наиболее предпочтительно по меньшей мере на 60% более устойчив к гидролизу с помощью лактазы-флоридзингидролазы, чем кверцетин-4-глюкозид, и где флавоноидный агликон является ингибитором GLUT2 и флавоноидный глюкозид является ингибитором SGLT1.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11168797 | 2011-06-06 | ||
| PCT/EP2012/059956 WO2012168108A1 (en) | 2011-06-06 | 2012-05-29 | An edible composition |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| EA201391803A1 EA201391803A1 (ru) | 2014-03-31 |
| EA029002B1 EA029002B1 (ru) | 2018-01-31 |
| EA029002B9 true EA029002B9 (ru) | 2019-02-28 |
Family
ID=44588275
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201391803A EA029002B9 (ru) | 2011-06-06 | 2012-05-29 | Съедобная композиция |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9387219B2 (ru) |
| EP (1) | EP2717721B1 (ru) |
| CN (1) | CN103813723B (ru) |
| AU (1) | AU2012266581B2 (ru) |
| BR (1) | BR112013030171B1 (ru) |
| CA (1) | CA2835753C (ru) |
| EA (1) | EA029002B9 (ru) |
| WO (1) | WO2012168108A1 (ru) |
| ZA (1) | ZA201308549B (ru) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2944311A1 (de) | 2014-05-16 | 2015-11-18 | BioActive Food GmbH | Kombination von biologisch aktiven Substanzen zur Behandlung von hyperglykämischen Erkrankungen |
| EP3344070B1 (en) * | 2015-09-03 | 2019-12-18 | Unilever PLC | Edible composition |
| CN108882742A (zh) * | 2016-02-10 | 2018-11-23 | Pm国际股份公司 | 用以减少和/或阻止肠道葡萄糖吸收的含有番石榴苷的组合物、膳食补充剂、组合物的用途和膳食补充剂的制备方法 |
| WO2019002498A1 (en) * | 2017-06-30 | 2019-01-03 | Unilever Plc | EDIBLE COMPOSITION |
| CN111973580B (zh) * | 2020-09-15 | 2023-01-24 | 河南大学 | 咖啡酸在制备促进葡萄糖吸收药物方面的应用 |
| CN115645431B (zh) * | 2022-12-12 | 2023-03-21 | 汤臣倍健股份有限公司 | 一种组合物及其应用 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3806210A1 (de) | 1988-02-26 | 1989-09-07 | Robugen Gmbh | Kamille |
| DE69918852T2 (de) * | 1998-10-29 | 2005-07-21 | Merck Patent Gmbh | Zusammensetzung enthaltend eine mischung von bioflavonoiden |
| JP4719372B2 (ja) | 2000-06-21 | 2011-07-06 | 花王株式会社 | Ｐｐａｒ依存的遺伝子転写活性化剤 |
| DE10053496A1 (de) | 2000-10-27 | 2002-05-08 | Peter Fuerst | Zusammensetzungen enthaltend Flavonoide und Phloridzin oder Phloretin |
| PT1379146E (pt) | 2001-03-23 | 2009-09-02 | Nutricia Nv | Preparação para a prevenção da alteração do metabolismo ósseo |
| FR2836336B1 (fr) | 2002-02-26 | 2004-08-27 | Diana Ingredients | Utilisation dans un traitement cosmetique d'une fraction phenolique riche en dihydrochalcones |
| US20040131749A1 (en) * | 2002-08-29 | 2004-07-08 | Archer-Daniels-Midland Company | Phytochemicals from edible bean process streams |
| JP4012814B2 (ja) * | 2002-12-05 | 2007-11-21 | 剛 李 | 苦蕎麦を原料とするアルドース還元酵素阻害剤及びソルビトール降下剤 |
| EP1576893A4 (en) * | 2002-12-24 | 2006-01-04 | Fuji Oil Co Ltd | COMPOSITION CONTAINING HIGH-CONCENTRATED FRAGRANT ISOFLAVONE, AND METHOD FOR THE PRODUCTION THEREOF |
| JP4344913B2 (ja) * | 2003-01-31 | 2009-10-14 | 株式会社フラバミン | ケルセチン組成物、食品保存剤及びその製造方法 |
| DE102004004034A1 (de) * | 2004-01-27 | 2005-08-18 | Lichtwer Pharma Ag | Zwiebelextrakte |
| US7772195B2 (en) * | 2004-07-29 | 2010-08-10 | Board Of Trustees Of Michigan State University | Methods and compositions for the treatment of obesity, insulin related diseases and hypercholesterolemia |
| WO2006074278A2 (en) | 2005-01-05 | 2006-07-13 | Mitsunori Ono | Compositions for treating diabetes or obesity |
| WO2006078848A1 (en) | 2005-01-21 | 2006-07-27 | Western Holdings, Llc | Compositions containing botanical extracts rich in phlorizin and methods for using such compositions in blood glucose modification and to affect aging |
| US20060172012A1 (en) | 2005-01-28 | 2006-08-03 | Finley John W | Anti-inflammatory supplement compositions and regimens to reduce cardiovascular disease risks |
| FR2882933B1 (fr) * | 2005-03-14 | 2007-04-20 | Scalime France Sa | Utilisation d'un extrait d'oignon pour la fabrication d'une composition pour controler la prise de poids |
| WO2006119038A1 (en) | 2005-04-29 | 2006-11-09 | Naturegen, Inc. | Compositions and methods for controlling glucose uptake |
| WO2007019526A2 (en) | 2005-08-05 | 2007-02-15 | Naturegen, Inc. | Compositions and methods for controlling glucose and lipid uptake from foods |
| FR2889955B1 (fr) | 2005-08-31 | 2008-12-19 | Cooperative Agricole Elle Et V | Procede d'obtention d'un extrait vegetal de fruits a pepins, extrait vegetal ainsi obtenu et ses utilisations |
| WO2007124102A2 (en) | 2006-04-21 | 2007-11-01 | Western Holdings, Llc | Preparation and use of phlorizin compositions |
| US7745486B2 (en) | 2006-07-17 | 2010-06-29 | Quercegen Pharma Llc | Quercetin-containing compositions |
| US7943164B2 (en) * | 2007-03-19 | 2011-05-17 | Milton Joseph Ahrens | Composition and method for treating diabetes and metabolic disorders |
| US20100247686A1 (en) | 2007-04-04 | 2010-09-30 | Litao Zhong | Compositions and methods for obesity, diabetes and metabolic syndrome control and management |
| BRPI0721648A2 (pt) | 2007-05-04 | 2013-02-26 | Nutraceutic Et Business Consulting | composiÇço que tem atividade lipolÍtica, mÉtodo de produÇço da mesma e uso da composiÇço |
| WO2009066303A2 (en) | 2007-11-22 | 2009-05-28 | Ganga Raju Gokaraju | New synergistic phytochemical composition for the treatment of obesity |
| KR20090125918A (ko) * | 2008-06-03 | 2009-12-08 | (주)에스에스사이언스 | 항당뇨성 조성물 및 그 제조방법 |
| FR2935096B1 (fr) * | 2008-08-21 | 2010-12-10 | Cooperative Agricole D Elle Et Vire | Compositions riches en acide chlorogenique, leur procede d'obtention et leur utilisation |
| IT1392101B1 (it) | 2008-12-12 | 2012-02-09 | Zuccari Societa A Responsabilita Limitata In Breve Zuccari S R L | Composizione comprendente isoflavoni |
| CN101991593A (zh) | 2009-08-14 | 2011-03-30 | 张景元 | 槲皮苷在制药中的应用 |
| JP5594719B2 (ja) * | 2010-01-06 | 2014-09-24 | 国立大学法人神戸大学 | 筋肉の糖取り込み促進剤 |
-
2012
- 2012-05-29 EA EA201391803A patent/EA029002B9/ru not_active IP Right Cessation
- 2012-05-29 BR BR112013030171-6A patent/BR112013030171B1/pt active IP Right Grant
- 2012-05-29 EP EP12725369.8A patent/EP2717721B1/en active Active
- 2012-05-29 WO PCT/EP2012/059956 patent/WO2012168108A1/en active Application Filing
- 2012-05-29 US US14/122,355 patent/US9387219B2/en active Active
- 2012-05-29 AU AU2012266581A patent/AU2012266581B2/en active Active
- 2012-05-29 CA CA2835753A patent/CA2835753C/en active Active
- 2012-05-29 CN CN201280027352.5A patent/CN103813723B/zh active Active
-
2013
- 2013-11-13 ZA ZA2013/08549A patent/ZA201308549B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR112013030171B1 (pt) | 2021-10-05 |
| CN103813723A (zh) | 2014-05-21 |
| EP2717721B1 (en) | 2017-07-12 |
| EA201391803A1 (ru) | 2014-03-31 |
| ZA201308549B (en) | 2015-02-25 |
| CN103813723B (zh) | 2017-03-15 |
| US20140107052A1 (en) | 2014-04-17 |
| CA2835753C (en) | 2020-03-10 |
| AU2012266581B2 (en) | 2014-10-30 |
| EA029002B1 (ru) | 2018-01-31 |
| CA2835753A1 (en) | 2012-12-13 |
| WO2012168108A1 (en) | 2012-12-13 |
| US9387219B2 (en) | 2016-07-12 |
| EP2717721A1 (en) | 2014-04-16 |
| AU2012266581A1 (en) | 2013-11-21 |
| BR112013030171A2 (pt) | 2016-08-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG TJ TM |
|
| TH4A | Publication of the corrected specification to eurasian patent |