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DOP2017000244A - Derivados de pirazol útiles como inhibidores de proteína activadora de 5-lipoxigenasa (flap) - Google Patents

Derivados de pirazol útiles como inhibidores de proteína activadora de 5-lipoxigenasa (flap)

Info

Publication number
DOP2017000244A
DOP2017000244A DO2017000244A DO2017000244A DOP2017000244A DO P2017000244 A DOP2017000244 A DO P2017000244A DO 2017000244 A DO2017000244 A DO 2017000244A DO 2017000244 A DO2017000244 A DO 2017000244A DO P2017000244 A DOP2017000244 A DO P2017000244A
Authority
DO
Dominican Republic
Prior art keywords
flap
inhibitors
useful
activating protein
lipoxygenase activating
Prior art date
Application number
DO2017000244A
Other languages
English (en)
Inventor
Olof Broddefalk Johan
Fredrik Emtenas Hans
Lars Granberg Kenneth
Anita Lemurell Malin
Tor Pettersen Daniel
Thomas Plowright Alleyn
Johan Andreas Ulander Lars
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of DOP2017000244A publication Critical patent/DOP2017000244A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C07D231/40—Acylated on said nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/44—Oxygen and nitrogen or sulfur and nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/44—Oxygen and nitrogen or sulfur and nitrogen atoms
    • C07D231/46—Oxygen atom in position 3 or 5 and nitrogen atom in position 4
    • C07D231/50—Acylated on said nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente solicitud se refiere a compuestos de fórmula (I) a su utilidad para tratar y/o prevenir afecciones clínicas incluyendo enfermedades cardiovasculares (ECV), a métodos para su uso terapéutico, a composiciones farmacéuticas que los contienen y a procesos para preparar dichos compuestos.
DO2017000244A 2015-05-04 2017-10-20 Derivados de pirazol útiles como inhibidores de proteína activadora de 5-lipoxigenasa (flap) DOP2017000244A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562156424P 2015-05-04 2015-05-04

Publications (1)

Publication Number Publication Date
DOP2017000244A true DOP2017000244A (es) 2017-11-15

Family

ID=55910253

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2017000244A DOP2017000244A (es) 2015-05-04 2017-10-20 Derivados de pirazol útiles como inhibidores de proteína activadora de 5-lipoxigenasa (flap)

Country Status (38)

Country Link
US (6) US10183947B2 (es)
EP (2) EP3670499B1 (es)
JP (1) JP6564062B2 (es)
KR (1) KR102623474B1 (es)
CN (1) CN107646036B (es)
AR (1) AR104512A1 (es)
AU (1) AU2016258874B2 (es)
BR (1) BR112017022757B1 (es)
CA (1) CA2983668C (es)
CL (1) CL2017002660A1 (es)
CO (1) CO2017011506A2 (es)
CR (1) CR20170513A (es)
CY (2) CY1122689T1 (es)
DK (2) DK3670499T3 (es)
DO (1) DOP2017000244A (es)
EA (1) EA032221B1 (es)
ES (2) ES2902139T3 (es)
GT (1) GT201700220A (es)
HK (1) HK1245255A1 (es)
HR (2) HRP20211993T1 (es)
HU (2) HUE047445T2 (es)
IL (1) IL255069B (es)
LT (1) LT3670499T (es)
ME (1) ME03663B (es)
MX (1) MX2017013571A (es)
MY (1) MY186647A (es)
PE (1) PE20180247A1 (es)
PH (1) PH12017502112B1 (es)
PL (2) PL3292105T3 (es)
PT (2) PT3670499T (es)
RS (2) RS62729B1 (es)
SG (1) SG11201708558RA (es)
SI (2) SI3670499T1 (es)
SV (1) SV2017005549A (es)
TN (1) TN2017000458A1 (es)
TW (1) TWI718146B (es)
WO (1) WO2016177703A1 (es)
ZA (1) ZA201708189B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2902139T3 (es) 2015-05-04 2022-03-25 Astrazeneca Ab Derivados de pirazol útiles como inhibidores de la proteína activadora de 5-lipoxigenasa (FLAP)
ES2933178T3 (es) * 2016-10-28 2023-02-02 Astrazeneca Ab Forma cristalina de (1r,2r)-2-[4-(3-metil-1h-pirazol-5-il)benzoil]-n-(4-oxo-4,5,6,7-tetrahidropirazolo[1,5-a]pirazin-3-il)ciclohexanocarboxamida
CN110169969B (zh) * 2019-06-28 2022-05-27 南京医科大学 Mk571在制备预防和治疗心脏病药物中应用
CN111084775A (zh) * 2020-02-17 2020-05-01 牡丹江医学院 一种用于治疗癫痫的药物组合物
CN111419800B (zh) * 2020-04-23 2021-03-19 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 用于治疗红斑狼疮的药物制剂及其制备方法
CN111643498B (zh) * 2020-07-20 2021-05-07 黑龙江中医药大学 一种治疗肾结石的药物组合物及其用途
CN111714499B (zh) * 2020-07-27 2021-05-11 黑龙江中医药大学 一种用于治疗多囊卵巢综合征的药物组合物

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL109254A (en) 1993-04-29 1999-03-12 Zeneca Ltd History of the tetrahydropyran and tetrahydropuran site preparation and pharmaceutical preparations containing them
US5773422A (en) 1996-01-29 1998-06-30 Komer; Gene Avermectin formulation
CA2572750A1 (en) * 2003-09-10 2005-03-17 Anil Koul Heterobicyclic compounds as pharmaceutically active agents
GB2431927B (en) * 2005-11-04 2010-03-17 Amira Pharmaceuticals Inc 5-Lipoxygenase-activating protein (FLAP) inhibitors
TW200815351A (en) * 2006-05-02 2008-04-01 Astrazeneca Ab Novel compounds
WO2008097930A1 (en) * 2007-02-05 2008-08-14 Amira Pharmaceuticals, Inc. Reverse indoles as 5-lipoxygenase-activating protein (flap) inhibitors
GB0702456D0 (en) * 2007-02-08 2007-03-21 Astrazeneca Ab New combination
CN101686980A (zh) * 2007-04-20 2010-03-31 先灵公司 四氢吡啶并[4,3-d]嘧啶酮衍生物及其使用方法
US9096546B2 (en) * 2007-05-10 2015-08-04 Albany Molecular Research, Inc. Aryl- and heteroaryl-substituted tetrahydrobenzo-1,4-diazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
JP2010540641A (ja) * 2007-10-05 2010-12-24 アミラ ファーマシューティカルス，インコーポレーテッド ５−リポキシゲナーゼ活性化タンパク質（ｆｌａｐ）阻害剤
ES2902139T3 (es) * 2015-05-04 2022-03-25 Astrazeneca Ab Derivados de pirazol útiles como inhibidores de la proteína activadora de 5-lipoxigenasa (FLAP)

Also Published As

Publication number Publication date
PH12017502112A1 (en) 2018-05-07
US10508119B2 (en) 2019-12-17
EP3292105B1 (en) 2019-10-02
US20230219967A1 (en) 2023-07-13
ES2902139T3 (es) 2022-03-25
MY186647A (en) 2021-08-03
CN107646036A (zh) 2018-01-30
WO2016177703A1 (en) 2016-11-10
RS62729B1 (sr) 2022-01-31
PT3670499T (pt) 2021-12-24
US12024523B2 (en) 2024-07-02
EP3292105A1 (en) 2018-03-14
AU2016258874B2 (en) 2020-04-30
DK3292105T3 (da) 2019-12-09
ES2760466T3 (es) 2020-05-14
HRP20192172T1 (hr) 2020-02-21
CY1125179T1 (el) 2023-03-24
GT201700220A (es) 2018-12-19
ME03663B (me) 2020-07-20
US11001589B2 (en) 2021-05-11
CL2017002660A1 (es) 2018-04-13
PL3670499T3 (pl) 2022-02-14
LT3670499T (lt) 2021-12-27
TN2017000458A1 (en) 2019-04-12
BR112017022757B1 (pt) 2023-02-23
EA032221B1 (ru) 2019-04-30
US20180237439A1 (en) 2018-08-23
US20210355127A1 (en) 2021-11-18
US20190084991A1 (en) 2019-03-21
NZ737672A (en) 2020-11-27
SI3292105T1 (sl) 2020-01-31
KR20180002784A (ko) 2018-01-08
CA2983668A1 (en) 2016-11-10
EA201792341A1 (ru) 2018-05-31
AU2016258874A1 (en) 2017-12-14
JP6564062B2 (ja) 2019-08-21
CA2983668C (en) 2023-06-27
AR104512A1 (es) 2017-07-26
CY1122689T1 (el) 2021-03-12
SG11201708558RA (en) 2017-11-29
PH12017502112B1 (en) 2018-05-07
CN107646036B (zh) 2020-05-19
PE20180247A1 (es) 2018-02-02
US10183947B2 (en) 2019-01-22
SV2017005549A (es) 2018-03-12
ZA201708189B (en) 2018-11-28
PL3292105T3 (pl) 2020-04-30
PT3292105T (pt) 2019-12-13
TW201713625A (zh) 2017-04-16
KR102623474B1 (ko) 2024-01-09
BR112017022757A2 (pt) 2018-07-17
CO2017011506A2 (es) 2018-01-31
RS59671B1 (sr) 2020-01-31
IL255069B (en) 2019-12-31
HUE056875T2 (hu) 2022-03-28
HRP20211993T1 (hr) 2022-04-01
HK1245255A1 (zh) 2018-08-24
TWI718146B (zh) 2021-02-11
MX2017013571A (es) 2018-02-26
EP3670499B1 (en) 2021-09-29
EP3670499A1 (en) 2020-06-24
JP2018514535A (ja) 2018-06-07
HUE047445T2 (hu) 2020-04-28
IL255069A0 (en) 2017-12-31
US20240317767A1 (en) 2024-09-26
DK3670499T3 (da) 2022-01-03
SI3670499T1 (sl) 2022-02-28
US11691978B2 (en) 2023-07-04
US20200157113A1 (en) 2020-05-21
CR20170513A (es) 2018-02-13

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