DOP2012000156A - Nuevos derivados de (heterociclo-piperidina condensada)-(piperazini)-1-alcanona o de (heterociclo-pirrolidina condensada)-(piperazinil)-1-alcanona y su utilizacion como inhibidores de p75 - Google Patents
Nuevos derivados de (heterociclo-piperidina condensada)-(piperazini)-1-alcanona o de (heterociclo-pirrolidina condensada)-(piperazinil)-1-alcanona y su utilizacion como inhibidores de p75Info
- Publication number
- DOP2012000156A DOP2012000156A DO2012000156A DO2012000156A DOP2012000156A DO P2012000156 A DOP2012000156 A DO P2012000156A DO 2012000156 A DO2012000156 A DO 2012000156A DO 2012000156 A DO2012000156 A DO 2012000156A DO P2012000156 A DOP2012000156 A DO P2012000156A
- Authority
- DO
- Dominican Republic
- Prior art keywords
- condensed
- heteroycycle
- alcanona
- alcanone
- heterociclo
- Prior art date
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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Abstract
La invención se refiere a derivados de (heterociclo-piperidina condensadas)(piperazinil)-1 -alcanona y a (heterociclo-pirrolidina condensadas)-(piperazinil)-1 - alcanona de fórmula general (l) en la que A, W, n y, R2 son tales como se definen en la reivindicación 1, así como su procedimiento de preparación y su aplicación en terapéutica.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0906023A FR2953839A1 (fr) | 2009-12-14 | 2009-12-14 | Nouveaux derives d'(heterocycle-piperidine condensee)-(piperazinyl)-1alcanone ou d'(heterocycle-pyrrolidine condensee)-(piperazinyl)-1alcanone et leur utilisation comme inhibiteurs de p75 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DOP2012000156A true DOP2012000156A (es) | 2012-09-15 |
Family
ID=42246205
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DO2012000156A DOP2012000156A (es) | 2009-12-14 | 2012-06-06 | Nuevos derivados de (heterociclo-piperidina condensada)-(piperazini)-1-alcanona o de (heterociclo-pirrolidina condensada)-(piperazinil)-1-alcanona y su utilizacion como inhibidores de p75 |
Country Status (41)
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2953839A1 (fr) * | 2009-12-14 | 2011-06-17 | Sanofi Aventis | Nouveaux derives d'(heterocycle-piperidine condensee)-(piperazinyl)-1alcanone ou d'(heterocycle-pyrrolidine condensee)-(piperazinyl)-1alcanone et leur utilisation comme inhibiteurs de p75 |
| EP2606894A1 (en) * | 2011-12-20 | 2013-06-26 | Sanofi | Novel therapeutic use of p75 receptor antagonists |
| KR102279347B1 (ko) | 2016-12-15 | 2021-07-21 | 한국생명공학연구원 | 피리딘계 화합물을 유효성분으로 함유하는 dyrk 관련 질환의 예방 또는 치료용 약학적 조성물 |
| CN107245074B (zh) * | 2017-06-20 | 2019-04-09 | 牡丹江医学院附属红旗医院 | 用于治疗脑梗死的化合物及其制备方法 |
| MA51738A (fr) | 2018-02-05 | 2021-05-12 | Alkermes Inc | Composés pour le traitement de la douleur |
| CA3167675A1 (en) * | 2020-01-13 | 2021-07-22 | Aptabio Therapeutics Inc. | Pyrazole derivatives |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2457869A1 (fr) * | 1979-05-09 | 1980-12-26 | Sanofi Sa | Derives de thieno(2',3'; 4,5) pyrido (1,2-a) pyrazine, leur procede de preparation et leur application therapeutique |
| FR2744448B1 (fr) | 1996-02-02 | 1998-04-24 | Pf Medicament | Nouvelles piperidines derivees d'aryl piperazine, ainsi que leur procede de preparation, les compositions pharmaceutiques et leur utilisation comme medicaments |
| AU728523C (en) * | 1996-10-21 | 2001-08-09 | Nps Pharmaceuticals, Inc. | Neurotrophin antagonist compositions |
| AU749271B2 (en) | 1997-07-01 | 2002-06-20 | Agouron Pharmaceuticals, Inc. | Glucagon antagonists/inverse agonists |
| GB9905010D0 (en) * | 1999-03-04 | 1999-04-28 | Merck Sharp & Dohme | Therapeutic agents |
| CA2369945A1 (en) | 1999-04-06 | 2000-10-12 | James L. Kelley | Neurotrophic thio substituted pyrimidines |
| US6468990B1 (en) * | 1999-05-17 | 2002-10-22 | Queen's University At Kingston | Method of inhibiting binding of nerve growth factor to p75 NTR receptor |
| KR20030011365A (ko) * | 2000-06-29 | 2003-02-07 | 하. 룬트벡 아크티에 셀스카브 | Ｃｎｓ 장애 치료에 유용한 인돌 유도체 |
| GB0117577D0 (en) * | 2001-02-16 | 2001-09-12 | Aventis Pharm Prod Inc | Novel heterocyclic substituted carbonyl derivatives and their use as dopamine D receptor ligands |
| UA77526C2 (en) | 2002-06-07 | 2006-12-15 | Sanofi Aventis | Substituted derivatives of 1-piperazineacylpiperidine, a method for the preparation thereof and their use in therapy |
| TW200413351A (en) * | 2002-08-21 | 2004-08-01 | Astrazeneca Ab | Chemical compounds |
| FR2862967B1 (fr) | 2003-12-01 | 2006-08-04 | Sanofi Synthelabo | Derives de (4-phenylpiperazin-1-yl)acylpiperidine, leur preparation et leur application en therapeutique |
| FR2862968B1 (fr) * | 2003-12-01 | 2006-08-04 | Sanofi Synthelabo | Derives de 4-[(arylmethyl)aminomethyl]piperidine, leur preparation et leur application en therapeutique |
| WO2005070930A2 (en) * | 2004-01-23 | 2005-08-04 | Chiron Corporation | Tetrahydrocarboline compounds as anticancer agents |
| MX2007001399A (es) * | 2004-08-02 | 2007-04-18 | Osi Pharm Inc | Compuestos que inhiben pirrolopirimidina multi-cinasa aril-amino sustituidas. |
| MX2010009727A (es) * | 2008-03-05 | 2010-09-28 | Targacept Inc | Amidas selectivas del subtipo del receptor nicotinico de acetilcolina de diazabicicloalcanos. |
| CN101284838B (zh) * | 2008-06-06 | 2011-05-04 | 天津药物研究院 | 含噻吩并吡啶的哌嗪类衍生物、其制备方法和用途 |
| FR2932482B1 (fr) * | 2008-06-13 | 2010-10-08 | Sanofi Aventis | Nouveaux derives de (phenyl-3,6-dihydro-2h-pyridinyl)- (piperazinyl ponte)-1-alcanone et leur utilisation comme inhibiteurs de p75 |
| FR2932481B1 (fr) | 2008-06-13 | 2010-10-08 | Sanofi Aventis | Derives de 4-{2-°4-phenyl-3,6-dihydro-2h-pyridin-1-yl!-2- oxo-alkyl}-1-piperazin-2-one, leur preparation et leur application en therapeutique. |
| FR2953839A1 (fr) * | 2009-12-14 | 2011-06-17 | Sanofi Aventis | Nouveaux derives d'(heterocycle-piperidine condensee)-(piperazinyl)-1alcanone ou d'(heterocycle-pyrrolidine condensee)-(piperazinyl)-1alcanone et leur utilisation comme inhibiteurs de p75 |
| FR2953836B1 (fr) * | 2009-12-14 | 2012-03-16 | Sanofi Aventis | Nouveaux derives (heterocycle-tetrahydro-pyridine)-(piperazinyl)-1-alcanone et (heterocycle-dihydro-pyrrolidine)-(piperazinyl)-1-alcanone et leur utilisation comme inhibiteurs de p75 |
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2009
- 2009-12-14 FR FR0906023A patent/FR2953839A1/fr active Pending
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2010
- 2010-12-13 TW TW099143563A patent/TW201130850A/zh unknown
- 2010-12-13 KR KR1020127018349A patent/KR101724386B1/ko active IP Right Grant
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- 2010-12-13 BR BR112012014208A patent/BR112012014208A8/pt not_active Application Discontinuation
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- 2010-12-13 CA CA2784152A patent/CA2784152C/fr not_active Expired - Fee Related
- 2010-12-13 WO PCT/FR2010/052685 patent/WO2011080444A1/fr active Application Filing
- 2010-12-13 JP JP2012543873A patent/JP5735979B2/ja active Active
- 2010-12-13 EP EP10801662.7A patent/EP2513108B1/fr active Active
- 2010-12-13 SG SG2012043972A patent/SG181709A1/en unknown
- 2010-12-13 NZ NZ600593A patent/NZ600593A/en not_active IP Right Cessation
- 2010-12-13 PT PT108016627T patent/PT2513108E/pt unknown
- 2010-12-13 ES ES10801662.7T patent/ES2541366T3/es active Active
- 2010-12-13 EA EA201290504A patent/EA021985B1/ru not_active IP Right Cessation
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2012
- 2012-06-05 TN TNP2012000285A patent/TN2012000285A1/fr unknown
- 2012-06-06 DO DO2012000156A patent/DOP2012000156A/es unknown
- 2012-06-06 GT GT201200177A patent/GT201200177A/es unknown
- 2012-06-07 US US13/490,904 patent/US8580790B2/en active Active
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2013
- 2013-03-13 HK HK13103129.3A patent/HK1175783A1/xx not_active IP Right Cessation
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