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DOP2007000104A - 2-alcoxi-3,4,5-trihidroxi-alquilamida-benzazepinas, su pre-paración, composiciones que las contienen y utilización - Google Patents

2-alcoxi-3,4,5-trihidroxi-alquilamida-benzazepinas, su pre-paración, composiciones que las contienen y utilización

Info

Publication number
DOP2007000104A
DOP2007000104A DO2007000104A DO2007000104A DOP2007000104A DO P2007000104 A DOP2007000104 A DO P2007000104A DO 2007000104 A DO2007000104 A DO 2007000104A DO 2007000104 A DO2007000104 A DO 2007000104A DO P2007000104 A DOP2007000104 A DO P2007000104A
Authority
DO
Dominican Republic
Prior art keywords
compositions
trihidroxi
benzazepinas
alquilamida
alcoxi
Prior art date
Application number
DO2007000104A
Other languages
English (en)
Inventor
Alain Commercon
Jidong Zhang
Frederico Nardi
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of DOP2007000104A publication Critical patent/DOP2007000104A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invención se refiere particularmente a 2-alcoxi-3,4,5-trihidroxi-alquilamida-benzazepinas, su preparación, composiciones que las contienen y su utilización como medicamento, en particular como agentes anticancerí-genos
DO2007000104A 2006-05-24 2007-05-24 2-alcoxi-3,4,5-trihidroxi-alquilamida-benzazepinas, su pre-paración, composiciones que las contienen y utilización DOP2007000104A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0604733A FR2901554B1 (fr) 2006-05-24 2006-05-24 2-alcoxy-3,4,5-trihydroxy-alkylamide-benzazepine, leur preparation, compositions les contenant et utilisation

Publications (1)

Publication Number Publication Date
DOP2007000104A true DOP2007000104A (es) 2007-11-15

Family

ID=37487536

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2007000104A DOP2007000104A (es) 2006-05-24 2007-05-24 2-alcoxi-3,4,5-trihidroxi-alquilamida-benzazepinas, su pre-paración, composiciones que las contienen y utilización

Country Status (24)

Country Link
US (1) US7994162B2 (es)
EP (1) EP2035387A2 (es)
JP (1) JP2009537614A (es)
KR (1) KR20090010071A (es)
CN (1) CN101454290A (es)
AR (1) AR061103A1 (es)
AU (1) AU2007253196A1 (es)
BR (1) BRPI0712925A2 (es)
CA (1) CA2649336A1 (es)
CR (1) CR10382A (es)
DO (1) DOP2007000104A (es)
EA (1) EA200870565A1 (es)
EC (1) ECSP088893A (es)
FR (1) FR2901554B1 (es)
GT (1) GT200800249A (es)
IL (2) IL194972A0 (es)
MA (1) MA30561B1 (es)
MX (1) MX2008014844A (es)
NO (1) NO20085285L (es)
PE (1) PE20080705A1 (es)
TN (1) TNSN08402A1 (es)
TW (1) TW200812971A (es)
UY (1) UY30368A1 (es)
WO (1) WO2007135293A2 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2878528B1 (fr) 2004-11-29 2008-05-16 Aventis Pharma Sa 2-alcoxy-3,4,5-trihydroxy-alkylamides, leur preparation, compositions les contenant et utilisation
CN102924462B (zh) * 2012-10-24 2015-01-14 华东师范大学 1,2,3,4,5,9-取代苯并吖庚因类化合物的合成方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4692522A (en) * 1985-04-01 1987-09-08 Merck & Co., Inc. Benzofused lactams useful as cholecystokinin antagonists
US4831135A (en) 1986-06-18 1989-05-16 The Regents Of The University Of California Bengamide anthelmintics
US5283241A (en) 1992-08-28 1994-02-01 Merck & Co., Inc. Benzo-fused lactams promote release of growth hormone
GB9411841D0 (en) 1994-06-14 1994-08-03 Pharma Mar Sa New antitumoral compounds from jaspis sponge
JP2002241368A (ja) 1997-02-18 2002-08-28 Shionogi & Co Ltd 新規ベンゾラクタム誘導体およびそれを含有する医薬組成物
CO5140099A1 (es) 1998-11-17 2002-03-22 Novartis Ag Ciertas caprolactamas sustituidas, composiciones farmaceuticas que las contienen, y su uso en el tratamiento de tumores
US6239127B1 (en) 1999-11-17 2001-05-29 Novartis Ag Certain substituted caprolactams, pharmaceutical compositions containing them and a process for their preparation
CA2405892C (en) * 2000-05-11 2009-07-07 Frederick Ray Kinder Jr. Substituted caprolactam carbonates and ethers and their use as anti-tumor agents
JP2004514122A (ja) 2000-11-14 2004-05-13 ノバルティス　アクチエンゲゼルシャフト 抗増殖性化合物をスクリーニングしかつ腫瘍増殖を阻害する方法
WO2002072555A1 (en) 2001-03-12 2002-09-19 Novartis Ag Process for preparing certain substituted caprolactams
JP2004262793A (ja) 2003-02-28 2004-09-24 Noyaku Bio Technology Kaihatsu Gijutsu Kenkyu Kumiai 化合物ｎ−９０１１、その製造法及び用途
WO2005014574A1 (en) * 2003-07-25 2005-02-17 Novartis Ag Substituted lactams and their use as anti-cancer agents
US7153846B2 (en) 2003-10-24 2006-12-26 Sanofi-Aventis Deutschland Gmbh Bengamide derivatives, process for preparing them, and their use
DE10349669B3 (de) 2003-10-24 2005-05-25 Aventis Pharma Deutschland Gmbh Bengamide-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung
FR2878528B1 (fr) * 2004-11-29 2008-05-16 Aventis Pharma Sa 2-alcoxy-3,4,5-trihydroxy-alkylamides, leur preparation, compositions les contenant et utilisation
FR2878525B1 (fr) 2004-11-29 2007-02-23 Aventis Pharma Sa Bengamides possedant un cycle caprolactame substitue, procede de preparation, compositions les contenant et utilisation

Also Published As

Publication number Publication date
NO20085285L (no) 2008-12-17
EA200870565A1 (ru) 2009-06-30
CR10382A (es) 2009-02-26
KR20090010071A (ko) 2009-01-28
PE20080705A1 (es) 2008-07-30
WO2007135293A2 (fr) 2007-11-29
IL194972A0 (en) 2009-08-03
FR2901554A1 (fr) 2007-11-30
IL195148A0 (en) 2009-09-22
FR2901554B1 (fr) 2011-04-01
AR061103A1 (es) 2008-08-06
WO2007135293A3 (fr) 2008-05-02
AU2007253196A1 (en) 2007-11-29
TW200812971A (en) 2008-03-16
ECSP088893A (es) 2008-12-30
CA2649336A1 (fr) 2007-11-29
CN101454290A (zh) 2009-06-10
US7994162B2 (en) 2011-08-09
BRPI0712925A2 (pt) 2013-01-08
UY30368A1 (es) 2008-01-02
US20090099152A1 (en) 2009-04-16
EP2035387A2 (fr) 2009-03-18
TNSN08402A1 (en) 2010-04-14
MA30561B1 (fr) 2009-07-01
GT200800249A (es) 2009-05-15
JP2009537614A (ja) 2009-10-29
MX2008014844A (es) 2009-02-17

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