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DK62586A - Fibrinolytisk enzym - Google Patents

Fibrinolytisk enzym Download PDF

Info

Publication number
DK62586A
DK62586A DK62586A DK62586A DK62586A DK 62586 A DK62586 A DK 62586A DK 62586 A DK62586 A DK 62586A DK 62586 A DK62586 A DK 62586A DK 62586 A DK62586 A DK 62586A
Authority
DK
Denmark
Prior art keywords
enzym
fibrinolytic
fibrinolytic enzym
Prior art date
Application number
DK62586A
Other languages
English (en)
Other versions
DK62586D0 (da
Inventor
Jeffery Hugh Robinson
Michael Joseph Browne
Arthur William Russell Tyrrell
Original Assignee
Beecham Group Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB858503358A external-priority patent/GB8503358D0/en
Priority claimed from GB868600979A external-priority patent/GB8600979D0/en
Application filed by Beecham Group Plc filed Critical Beecham Group Plc
Publication of DK62586D0 publication Critical patent/DK62586D0/da
Publication of DK62586A publication Critical patent/DK62586A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK62586A 1985-02-09 1986-02-07 Fibrinolytisk enzym DK62586A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB858503358A GB8503358D0 (en) 1985-02-09 1985-02-09 Compounds
GB868600979A GB8600979D0 (en) 1986-01-16 1986-01-16 Compounds

Publications (2)

Publication Number Publication Date
DK62586D0 DK62586D0 (da) 1986-02-07
DK62586A true DK62586A (da) 1986-08-10

Family

ID=26288793

Family Applications (1)

Application Number Title Priority Date Filing Date
DK62586A DK62586A (da) 1985-02-09 1986-02-07 Fibrinolytisk enzym

Country Status (6)

Country Link
EP (1) EP0201153A3 (da)
AU (1) AU5330286A (da)
DK (1) DK62586A (da)
ES (4) ES8706724A1 (da)
GR (1) GR860364B (da)
PT (1) PT81999B (da)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4661469A (en) * 1984-08-08 1987-04-28 Survival Technology, Inc. t-PA composition capable of being absorbed into the blood stream and method of administration
EP0191814B1 (en) * 1984-08-08 1992-11-04 Survival Technology, Inc. Protein absorption enhancing agents
US5736134A (en) * 1985-04-22 1998-04-07 Genentech, In.C Tissue plasminogen activator variants
ATE68825T1 (de) * 1985-04-22 1991-11-15 Genentech Inc Plasminogenaktivator-mutante des menschlichen gewebes, verfahren und zwischenprodukte dafuer und diese mutante verwendende zusammensetzungen.
US5756093A (en) * 1985-04-22 1998-05-26 Genentech, Inc. Tissue plasminogen activator variants
US5714372A (en) * 1985-04-22 1998-02-03 Genentech, Inc. Tissue plasminogen activator variants
US4929444A (en) * 1985-05-28 1990-05-29 Burroughs Wellcome Co. Low pH pharmaceutical formulation containing t-PA
ATE74379T1 (de) * 1985-12-23 1992-04-15 Chiron Corp Peptidplasminogenaktivatoren.
DK43387A (da) * 1986-01-29 1987-07-30 Beecham Group Plc Fibrinolytisk enzym
AU7090887A (en) * 1986-04-02 1987-10-08 Beecham Group Plc Plasminogen activators modified in first kringle domain
PT84589B (en) * 1986-04-02 1989-05-09 Beecham Group Plc Process for preparing a fibrinolytic enzyme
GB8619098D0 (en) * 1986-08-05 1986-09-17 Wellcome Found Combination
DK323587D0 (da) * 1987-06-25 1987-06-25 Novo Industri As Protein
WO1988005081A2 (en) * 1986-12-30 1988-07-14 Cetus Corporation Novel plasminogen activator
US5302390A (en) * 1987-07-01 1994-04-12 Beecham Group Plc Hybrid proteins of human plasminogen and human t-PA, pharmaceutical compositions and methods of treatment
IL87276A (en) * 1987-08-03 1995-07-31 Fujisawa Pharmaceutical Co Analog of a tissue plasminogen activator containing the Pringle 2 and protease regions only, DNA encoding it, processes for its preparation, and pharmaceutical preparations containing it
US5108901A (en) * 1988-09-02 1992-04-28 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
US5258180A (en) * 1988-09-02 1993-11-02 Genetech, Inc. Tissue plasminogen activator having fibrin specific properties and deletion of amino acids 466-970, compositions and methods of treatment
US5262170A (en) * 1988-09-02 1993-11-16 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
US5714145A (en) * 1988-09-02 1998-02-03 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
US5580560A (en) * 1989-11-13 1996-12-03 Novo Nordisk A/S Modified factor VII/VIIa
US5087572A (en) * 1989-12-01 1992-02-11 Genentech, Inc. Dna encoding human plasminogen modified at the cleavage site
US5190756A (en) * 1989-12-01 1993-03-02 Genentech, Inc. Methods and materials for expression of human plasminogen variant
AU664469B2 (en) * 1992-06-03 1995-11-16 Genentech Inc. Tissue plasminogen activator glycosylation variants with improved therapeutic properties
ES2066697B1 (es) * 1992-12-29 1995-08-16 Azkoyen Ind Sa Perfeccionamientos introducidos en columnas expendedoras automaticas de productos.
WO1997033984A1 (en) * 1996-03-12 1997-09-18 Novo Nordisk A/S Novel achromobacter lyticus protease variants
DE69738521T2 (de) 1996-04-05 2009-05-07 Novartis Vaccines and Diagnostics, Inc., Emeryville Alphaviren-vektors mit einer reduzierten inhibierung der synthese von zellmakromolekülen
US6706504B1 (en) 1996-11-12 2004-03-16 The Scripps Research Institute Tissue type plasminogen activator (t-PA) variants: compositions and methods of use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR241654A1 (es) * 1982-05-05 1992-10-30 Genentech Inc Procedimiento para producir activador de plasminogeno de tejido humano.
US4753879A (en) * 1984-08-27 1988-06-28 Biogen N.V. Modified tissue plasminogen activators
ATE68825T1 (de) * 1985-04-22 1991-11-15 Genentech Inc Plasminogenaktivator-mutante des menschlichen gewebes, verfahren und zwischenprodukte dafuer und diese mutante verwendende zusammensetzungen.

Also Published As

Publication number Publication date
ES8706724A1 (es) 1987-07-01
AU5330286A (en) 1986-08-14
PT81999B (en) 1987-12-22
ES8801706A1 (es) 1988-02-16
ES8801707A1 (es) 1988-02-16
ES557479A0 (es) 1988-02-16
ES557477A0 (es) 1987-10-16
GR860364B (en) 1986-06-10
ES8800354A1 (es) 1987-10-16
EP0201153A2 (en) 1986-11-12
PT81999A (en) 1986-03-01
ES551770A0 (es) 1987-07-01
ES557478A0 (es) 1988-02-16
DK62586D0 (da) 1986-02-07
EP0201153A3 (en) 1987-10-07

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Legal Events

Date Code Title Description
AHB Application shelved due to non-payment