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DK605989A - Propenonoximethere og fremgangsmaade til fremstilling deraf samt farmaceutiske midler indeholdende dem - Google Patents

Propenonoximethere og fremgangsmaade til fremstilling deraf samt farmaceutiske midler indeholdende dem Download PDF

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Publication number
DK605989A
DK605989A DK605989A DK605989A DK605989A DK 605989 A DK605989 A DK 605989A DK 605989 A DK605989 A DK 605989A DK 605989 A DK605989 A DK 605989A DK 605989 A DK605989 A DK 605989A
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DK
Denmark
Prior art keywords
propenonoxymethers
procedures
preparing
pharmaceutical agents
agents containing
Prior art date
Application number
DK605989A
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English (en)
Other versions
DK174434B1 (da
DK605989D0 (da
Inventor
Christian Congy
Patrick Gueule
Bernard Labeeuw
Murielle Rinaldi
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of DK605989D0 publication Critical patent/DK605989D0/da
Publication of DK605989A publication Critical patent/DK605989A/da
Application granted granted Critical
Publication of DK174434B1 publication Critical patent/DK174434B1/da

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/15Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C249/00Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C249/04Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes
    • C07C249/08Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes by reaction of hydroxylamines with carbonyl compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32Oximes
    • C07C251/50Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals
    • C07C251/58Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/74Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/835Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups having unsaturation outside an aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00Systems containing at least three condensed rings
    • C07C2603/02Ortho- or ortho- and peri-condensed systems
    • C07C2603/04Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/24Anthracenes; Hydrogenated anthracenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
DK198906059A 1988-12-02 1989-11-30 Propenonoximethere og fremgangsmåde til fremstilling deraf, farmaceutiske midler indeholdende dem samt mellem produkter til brug ved fremgangsmåden DK174434B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8815860A FR2639942B1 (fr) 1988-12-02 1988-12-02 Ethers oximes de propenone, procede pour leur preparation et compositions pharmaceutiques les contenant
FR8815860 1988-12-02

Publications (3)

Publication Number Publication Date
DK605989D0 DK605989D0 (da) 1989-11-30
DK605989A true DK605989A (da) 1990-06-03
DK174434B1 DK174434B1 (da) 2003-03-03

Family

ID=9372544

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198906059A DK174434B1 (da) 1988-12-02 1989-11-30 Propenonoximethere og fremgangsmåde til fremstilling deraf, farmaceutiske midler indeholdende dem samt mellem produkter til brug ved fremgangsmåden

Country Status (21)

Country Link
US (2) US5166416A (da)
EP (1) EP0373998B1 (da)
JP (1) JP2562503B2 (da)
KR (1) KR0156910B1 (da)
AR (1) AR245704A1 (da)
AU (2) AU623706B2 (da)
CA (1) CA2004350C (da)
CZ (1) CZ419091A3 (da)
DE (1) DE68908374T2 (da)
DK (1) DK174434B1 (da)
ES (1) ES2059804T3 (da)
FI (1) FI94752C (da)
FR (1) FR2639942B1 (da)
HK (1) HK1001557A1 (da)
HU (1) HU211463A9 (da)
IE (1) IE63400B1 (da)
IL (1) IL92519A (da)
NO (1) NO171269C (da)
NZ (2) NZ240166A (da)
PT (1) PT92446B (da)
ZA (1) ZA899201B (da)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU207988B (en) * 1988-10-20 1993-07-28 Biorex Kutato Fejlesztoe Kft Process for producing halogenides of o-/3-amino-2-hydroxy-propyl/hydroximic acid and pharmaceutical compositions containing them as active components
FR2639942B1 (fr) * 1988-12-02 1991-03-29 Sanofi Sa Ethers oximes de propenone, procede pour leur preparation et compositions pharmaceutiques les contenant
IL103106A (en) * 1991-09-25 1998-06-15 Sanofi Elf Sites of tynocyclopentanone oximes, their preparation and pharmaceutical preparations containing them
HU213421B (en) * 1993-04-09 1997-06-30 Egyt Gyogyszervegyeszeti Gyar New basic ethers, pharmaceutical compns. containing the said compds. and process for prepg. them
US5844000A (en) * 1997-06-12 1998-12-01 Sanofi Propenone oxime ethers and pharmaceutical compositions containing them
FR2765107B1 (fr) * 1997-06-26 2000-03-24 Sanofi Sa Utilisation d'un antagoniste specifique des recepteurs 5ht2 pour la preparation de medicaments utiles dans le traitement du syndrome d'apnee du sommeil
FR2787328A1 (fr) * 1998-12-22 2000-06-23 Sanofi Sa Utilisation d'un antagoniste des recepteurs 5ht2a pour la preparation de medicaments utiles dans le traitement des ronflements et du syndrome de haute resistance ou de resistance des voies aeriennes superieures
CN1674901A (zh) * 2002-08-05 2005-09-28 桑多斯股份公司 新的地氯雷他定半富马酸盐及其多晶型物
US20050070577A1 (en) * 2003-07-03 2005-03-31 Pfizer Inc. Compositions containing a serotonin selective reuptake inhibitor and a 5-HT2A receptor antagonist
PT1691811E (pt) 2003-12-11 2014-10-30 Sunovion Pharmaceuticals Inc Combinação de um sedativo e de um modulador de neurotransmissores e métodos para melhorar a qualidade do sono e tratamento da depressão
ATE423761T1 (de) * 2003-12-26 2009-03-15 Allergan Inc Disubstituierte chalcogenoxime mit antagonistischer wirkung am rar(gamma)- retinoidrezeptor
EP1799306B1 (en) 2004-09-30 2011-02-23 F. Hoffmann-La Roche AG Compositions and methods for treating cognitive disorders
US20090076159A1 (en) * 2007-09-19 2009-03-19 Protia, Llc Deuterium-enriched eplivanserin
EP2236511A4 (en) 2007-12-21 2011-04-13 Alla Chem Llc LIGANDS OF ALPHA ADRENOCEPTORS AND OF DOPAMINE, HISTAMIN, IMIDAZOLIN AND SEROTONIN RECEPTORS AND THEIR APPLICATION THEREOF
EP2266554A1 (en) 2009-05-26 2010-12-29 Sanofi-Aventis Method of treating sleep disorders using eplivanserin
EP2186511A1 (en) 2008-11-13 2010-05-19 Sanofi-Aventis Method of treating sleep disorders using eplivanserin
WO2010055461A1 (en) * 2008-11-13 2010-05-20 Sanofi-Aventis Method of treating sleep disorders using eplivanserin
FR2938534B1 (fr) * 2008-11-14 2012-10-26 Sanofi Aventis Procede de preparation de l'hemifumarate d'eplivanserine
EP2397460A4 (en) * 2009-02-10 2012-07-18 Nippon Soda Co NITROGEN-CONTAINING COMPOUNDS AND AGENTS FOR CONTROLLING HARMFUL ORGANISMS
EP2255726A1 (en) 2009-05-26 2010-12-01 Sanofi-Aventis Spectral profile of SWS enhancing drugs
EP2255807A1 (en) 2009-05-26 2010-12-01 Sanofi-Aventis Method of treating sleep disorders using the combination of eplivanserin and zolpidem
EP2269600A1 (en) 2009-07-02 2011-01-05 Sanofi-Aventis Treatment of sleep disorders using eplivanserin in COPD patients
CN101941919B (zh) * 2009-07-07 2014-07-02 天津药物研究院 一种制备顺式肟及肟醚衍生物的方法
CN106883141B (zh) * 2017-03-15 2018-08-10 何黎琴 一种丹皮酚肟醚类化合物、其制备方法及医药用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1094374A (en) * 1963-11-21 1967-12-13 Gen Aniline & Film Corp Diazotype materials
NL7503312A (nl) * 1975-03-20 1976-09-22 Philips Nv Verbindingen met antidepressieve werking.
NL7503310A (nl) * 1975-03-20 1976-09-22 Philips Nv Verbindingen met antidepressieve werking.
NL7503311A (nl) * 1975-03-20 1976-09-22 Philips Nv Verbindingen met antidepressieve werking.
US4279930A (en) * 1978-10-10 1981-07-21 The Upjohn Company Process for treating inflammation
AU532700B2 (en) * 1979-04-02 1983-10-13 Sumitomo Chemical Company, Limited Diphenylalkanoether
FI92189C (fi) * 1986-03-17 1994-10-10 Eisai Co Ltd Menetelmä lääkeaineina käyttökelpoisen difenyylimetaanijohdannaisen valmistamiseksi
GB8617648D0 (en) * 1986-07-18 1986-08-28 Ici Plc Fungicides
KR0139296B1 (ko) * 1988-11-21 1998-05-15 가와무라 시게꾸니 칼콘 유도체 및 그 제조 방법
FR2639942B1 (fr) * 1988-12-02 1991-03-29 Sanofi Sa Ethers oximes de propenone, procede pour leur preparation et compositions pharmaceutiques les contenant

Also Published As

Publication number Publication date
AR245704A1 (es) 1994-02-28
PT92446A (pt) 1990-06-29
EP0373998B1 (fr) 1993-08-11
HU211463A9 (en) 1995-11-28
FI94752B (fi) 1995-07-14
PT92446B (pt) 1995-07-18
CA2004350A1 (en) 1990-06-02
NZ231606A (en) 1992-02-25
US5290951A (en) 1994-03-01
FI94752C (fi) 1995-10-25
HK1001557A1 (en) 1998-06-26
JP2562503B2 (ja) 1996-12-11
CZ419091A3 (en) 1993-05-12
NZ240166A (en) 1992-02-25
DE68908374T2 (de) 1994-01-05
IL92519A (en) 1994-05-30
KR900009572A (ko) 1990-07-04
IE63400B1 (en) 1995-04-19
AU623706B2 (en) 1992-05-21
JPH02262552A (ja) 1990-10-25
ZA899201B (en) 1990-09-26
NO171269B (no) 1992-11-09
FI895757A0 (fi) 1989-12-01
EP0373998A1 (fr) 1990-06-20
AU4568889A (en) 1990-06-07
NO894786D0 (no) 1989-11-30
FR2639942A1 (fr) 1990-06-08
DK174434B1 (da) 2003-03-03
KR0156910B1 (ko) 1998-12-01
NO171269C (no) 1993-02-17
DE68908374D1 (de) 1993-09-16
FR2639942B1 (fr) 1991-03-29
AU1218392A (en) 1992-05-28
AU640310B2 (en) 1993-08-19
CA2004350C (en) 1997-06-03
US5166416A (en) 1992-11-24
NO894786L (no) 1990-06-05
DK605989D0 (da) 1989-11-30
IE893848L (en) 1990-06-02
ES2059804T3 (es) 1994-11-16

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