DK3728585T3 - Hidtil ukendte fremgangsmåder til fremstilling af oligonukleotider - Google Patents

Hidtil ukendte fremgangsmåder til fremstilling af oligonukleotider Download PDF

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Publication number: DK3728585T3
Authority: DK; Denmark
Prior art keywords: novel methods; making oligonucleotides; oligonucleotides; making; novel
Prior art date: 2017-12-19

Application number

DK18822043.8T

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English (en)

Inventor

Andreas Crameri

David Graham Tew

Original Assignee

Glaxosmithkline Ip Dev Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2017-12-19

Filing date

2018-12-17

Publication date

2022-05-23

2018-12-17 Application filed by Glaxosmithkline Ip Dev Ltd filed Critical Glaxosmithkline Ip Dev Ltd

2022-05-23 Application granted granted Critical

2022-05-23 Publication of DK3728585T3 publication Critical patent/DK3728585T3/da

Links

108091034117 Oligonucleotide Proteins 0.000 title 1
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title 1

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- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
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- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N9/1241—Nucleotidyltransferases (2.7.7)
- C12N9/1264—DNA nucleotidylexotransferase (2.7.7.31), i.e. terminal nucleotidyl transferase
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- C12Y605/00—Ligases forming phosphoric ester bonds (6.5)
- C12Y605/01—Ligases forming phosphoric ester bonds (6.5) forming phosphoric ester bonds (6.5.1)
- C12Y605/01003—RNA ligase (ATP) (6.5.1.3)

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Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Crystallography & Structural Chemistry (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK18822043.8T 2017-12-19 2018-12-17 Hidtil ukendte fremgangsmåder til fremstilling af oligonukleotider DK3728585T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB1721307.5A GB201721307D0 (en)	2017-12-19	2017-12-19	Novel processes for the production of oligonucleotides
PCT/EP2018/085179 WO2019121500A1 (en)	2017-12-19	2018-12-17	Novel processes for the production of oligonucleotides

Publications (1)

Publication Number	Publication Date
DK3728585T3 true DK3728585T3 (da)	2022-05-23

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ID=61009182

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK18822043.8T DK3728585T3 (da)	2017-12-19	2018-12-17	Hidtil ukendte fremgangsmåder til fremstilling af oligonukleotider

Country Status (11)

Country	Link
US (1)	US20240287566A1 (da)
EP (2)	EP4015631A1 (da)
JP (2)	JP7065970B2 (da)
KR (3)	KR20240033153A (da)
CN (2)	CN118516431A (da)
BR (1)	BR112020012252A2 (da)
CA (1)	CA3085237A1 (da)
DK (1)	DK3728585T3 (da)
ES (1)	ES2914591T3 (da)
GB (1)	GB201721307D0 (da)
WO (1)	WO2019121500A1 (da)

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EP4065723A4 (en) *	2019-11-29	2024-01-17	MGI Holdings Co., Limited	ENZYMATIC SYNTHESIS OF OLIGONUCLEOTIDES
US20230295707A1 (en) *	2022-03-21	2023-09-21	Abclonal Science, Inc.	T4 DNA Ligase Variants with Increased Ligation Efficiency
IL315519A (en)	2022-04-08	2024-11-01	Glaxosmithkline Intellectual Property Development Ltd	New processes for the production of polynucleotides including oligonucleotides
WO2024025200A1 (ko)	2022-07-28	2024-02-01	주식회사 엘지에너지솔루션	슬롯 다이 코터
CN117660374A (zh) *	2022-09-08	2024-03-08	凯莱英医药集团（天津）股份有限公司	Rna连接酶在寡核苷酸制备上的应用
CN115724998A (zh) *	2022-10-28	2023-03-03	深圳先进技术研究院	一种基于共振能量转移的全遗传编码nmn蛋白探针及其应用
CN118166051A (zh) *	2022-12-08	2024-06-11	凯莱英生命科学技术(天津)有限公司	双链rna的合成方法及rna连接酶在双链rna合成中的应用
CN117247911B (zh) *	2023-08-22	2024-06-07	武汉爱博泰克生物科技有限公司	大肠杆菌dna连接酶突变体及其在毕赤酵母中表达纯化方法
CN117106782B (zh) *	2023-10-16	2024-04-26	吉林凯莱英医药化学有限公司	gRNA及其生物合成方法

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GB201612011D0 (en) *	2016-07-11	2016-08-24	Glaxosmithkline Ip Dev Ltd	Novel processes for the production of oligonucleotides

2017
- 2017-12-19 GB GBGB1721307.5A patent/GB201721307D0/en not_active Ceased
2018
- 2018-12-17 EP EP22154581.7A patent/EP4015631A1/en active Pending
- 2018-12-17 JP JP2020533192A patent/JP7065970B2/ja active Active
- 2018-12-17 KR KR1020247006894A patent/KR20240033153A/ko active Application Filing
- 2018-12-17 US US16/771,362 patent/US20240287566A1/en active Pending
- 2018-12-17 EP EP18822043.8A patent/EP3728585B1/en active Active
- 2018-12-17 CA CA3085237A patent/CA3085237A1/en active Pending
- 2018-12-17 ES ES18822043T patent/ES2914591T3/es active Active
- 2018-12-17 CN CN202410777781.9A patent/CN118516431A/zh active Pending
- 2018-12-17 KR KR1020207020495A patent/KR102417049B1/ko active IP Right Grant
- 2018-12-17 CN CN201880082633.8A patent/CN111479923B/zh active Active
- 2018-12-17 DK DK18822043.8T patent/DK3728585T3/da active
- 2018-12-17 BR BR112020012252-1A patent/BR112020012252A2/pt active Search and Examination
- 2018-12-17 WO PCT/EP2018/085179 patent/WO2019121500A1/en unknown
- 2018-12-17 KR KR1020227022320A patent/KR102643631B1/ko active IP Right Grant
2022
- 2022-04-26 JP JP2022072032A patent/JP7438259B2/ja active Active

Also Published As

Publication number	Publication date
EP3728585B1 (en)	2022-03-16
JP2021507699A (ja)	2021-02-25
JP2022109986A (ja)	2022-07-28
ES2914591T3 (es)	2022-06-14
KR20240033153A (ko)	2024-03-12
KR20220094219A (ko)	2022-07-05
BR112020012252A2 (pt)	2020-11-24
KR102417049B1 (ko)	2022-07-06
JP7065970B2 (ja)	2022-05-12
EP3728585A1 (en)	2020-10-28
KR102643631B1 (ko)	2024-03-05
WO2019121500A1 (en)	2019-06-27
CA3085237A1 (en)	2019-06-27
JP7438259B2 (ja)	2024-02-26
CN118516431A (zh)	2024-08-20
CN111479923B (zh)	2024-06-18
KR20200099564A (ko)	2020-08-24
EP4015631A1 (en)	2022-06-22
GB201721307D0 (en)	2018-01-31
CN111479923A (zh)	2020-07-31
US20240287566A1 (en)	2024-08-29

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