DK3585892T3 - Fremgangsmåder til oprensning af messenger-rna - Google Patents
Fremgangsmåder til oprensning af messenger-rna Download PDFInfo
- Publication number
- DK3585892T3 DK3585892T3 DK18711737.9T DK18711737T DK3585892T3 DK 3585892 T3 DK3585892 T3 DK 3585892T3 DK 18711737 T DK18711737 T DK 18711737T DK 3585892 T3 DK3585892 T3 DK 3585892T3
- Authority
- DK
- Denmark
- Prior art keywords
- purification
- methods
- messenger rna
- messenger
- rna
- Prior art date
Links
- 108020004999 messenger RNA Proteins 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000000746 purification Methods 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
- C12N15/1006—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
- C12N15/1017—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by filtration, e.g. using filters, frits, membranes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1065—Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y201/00—Transferases transferring one-carbon groups (2.1)
- C12Y201/03—Carboxy- and carbamoyltransferases (2.1.3)
- C12Y201/03003—Ornithine carbamoyltransferase (2.1.3.3)
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762463981P | 2017-02-27 | 2017-02-27 | |
| PCT/US2018/019978 WO2018157141A1 (en) | 2017-02-27 | 2018-02-27 | Methods for purification of messenger rna |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3585892T3 true DK3585892T3 (da) | 2022-08-22 |
Family
ID=61683899
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK18711737.9T DK3585892T3 (da) | 2017-02-27 | 2018-02-27 | Fremgangsmåder til oprensning af messenger-rna |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US10975369B2 (da) |
| EP (2) | EP3585892B8 (da) |
| AU (1) | AU2018224318B2 (da) |
| CA (1) | CA3054323A1 (da) |
| DK (1) | DK3585892T3 (da) |
| ES (1) | ES2925083T3 (da) |
| HU (1) | HUE059594T2 (da) |
| IL (1) | IL268856B2 (da) |
| MA (1) | MA47606A (da) |
| WO (1) | WO2018157141A1 (da) |
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| MA49922A (fr) | 2017-08-18 | 2021-06-02 | Modernatx Inc | Procédés pour analyse par clhp |
| MA50803A (fr) | 2017-11-22 | 2020-09-30 | Modernatx Inc | Polynucléotides codant pour l'ornithine transcarbamylase pour le traitement de troubles du cycle de l'urée |
| US20210220449A1 (en) * | 2018-05-15 | 2021-07-22 | Translate Bio, Inc. | Subcutaneous Delivery of Messenger RNA |
| WO2020041793A1 (en) * | 2018-08-24 | 2020-02-27 | Translate Bio, Inc. | Methods for purification of messenger rna |
| KR20210125536A (ko) * | 2019-02-11 | 2021-10-18 | 에트리스 게엠베하 | 접선 유동 여과에 의한 mRNA 정제 |
| CN115515559A (zh) | 2019-12-20 | 2022-12-23 | 翻译生物公司 | 信使rna的直肠递送 |
| US12053551B2 (en) | 2019-12-20 | 2024-08-06 | Translate Bio, Inc. | Process of preparing mRNA-loaded lipid nanoparticles |
| EP4103712A1 (en) * | 2020-02-10 | 2022-12-21 | Translate Bio, Inc. | Methods and compositions for messenger rna purification |
| WO2021173840A1 (en) | 2020-02-25 | 2021-09-02 | Translate Bio, Inc. | Improved processes of preparing mrna-loaded lipid nanoparticles |
| WO2021226461A1 (en) * | 2020-05-07 | 2021-11-11 | Translate Bio, Inc. | Generation of optimized nucleotide sequences |
| US20240342269A1 (en) | 2020-05-07 | 2024-10-17 | Translate Bio, Inc. | Optimized nucleotide sequences encoding sars-cov-2 antigens |
| EP4146680A1 (en) | 2020-05-07 | 2023-03-15 | Translate Bio, Inc. | Composition and methods for treatment of primary ciliary dyskinesia |
| CA3183399A1 (en) * | 2020-05-15 | 2021-11-18 | Translate Bio, Inc. | Lipid nanoparticle formulations for mrna delivery |
| US20230357751A1 (en) | 2020-10-01 | 2023-11-09 | Translate Bio, Inc. | Methods for purification of messenger rna |
| JP2023544197A (ja) | 2020-10-06 | 2023-10-20 | トランスレイト バイオ， インコーポレイテッド | 脂質ナノ粒子の改善された方法および製剤 |
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| KR20230087536A (ko) | 2020-10-12 | 2023-06-16 | 트랜슬레이트 바이오 인코포레이티드 | Mrna-로딩된 지질 나노입자를 제조하는 개선된 프로세스 |
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| BE1030203B1 (fr) * | 2022-01-20 | 2023-08-21 | Quantoom Biosciences S A | Méthodes et systèmes de coiffage de molécules d’acide nucléique |
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-
2018
- 2018-02-27 HU HUE18711737A patent/HUE059594T2/hu unknown
- 2018-02-27 MA MA047606A patent/MA47606A/fr unknown
- 2018-02-27 CA CA3054323A patent/CA3054323A1/en active Pending
- 2018-02-27 ES ES18711737T patent/ES2925083T3/es active Active
- 2018-02-27 DK DK18711737.9T patent/DK3585892T3/da active
- 2018-02-27 WO PCT/US2018/019978 patent/WO2018157141A1/en unknown
- 2018-02-27 EP EP18711737.9A patent/EP3585892B8/en active Active
- 2018-02-27 IL IL268856A patent/IL268856B2/en unknown
- 2018-02-27 AU AU2018224318A patent/AU2018224318B2/en active Active
- 2018-02-27 EP EP22151272.6A patent/EP4008783A1/en active Pending
- 2018-02-27 US US15/907,086 patent/US10975369B2/en active Active
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2020
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| Publication number | Publication date |
|---|---|
| WO2018157141A1 (en) | 2018-08-30 |
| AU2018224318B2 (en) | 2024-06-20 |
| IL268856B1 (en) | 2024-05-01 |
| EP3585892B8 (en) | 2022-07-13 |
| CA3054323A1 (en) | 2018-08-30 |
| IL268856A (en) | 2019-10-31 |
| HUE059594T2 (hu) | 2022-11-28 |
| EP4008783A1 (en) | 2022-06-08 |
| EP3585892A1 (en) | 2020-01-01 |
| AU2018224318A1 (en) | 2019-09-19 |
| EP3585892B1 (en) | 2022-06-01 |
| ES2925083T3 (es) | 2022-10-13 |
| US20180251754A1 (en) | 2018-09-06 |
| IL268856B2 (en) | 2024-09-01 |
| MA47606A (fr) | 2021-04-07 |
| US20210180041A1 (en) | 2021-06-17 |
| US10975369B2 (en) | 2021-04-13 |
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