[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

DK3423104T3 - Amanitin-konjugater - Google Patents

Amanitin-konjugater Download PDF

Info

Publication number
DK3423104T3
DK3423104T3 DK17707350.9T DK17707350T DK3423104T3 DK 3423104 T3 DK3423104 T3 DK 3423104T3 DK 17707350 T DK17707350 T DK 17707350T DK 3423104 T3 DK3423104 T3 DK 3423104T3
Authority
DK
Denmark
Prior art keywords
amanitin conjugates
amanitin
conjugates
Prior art date
Application number
DK17707350.9T
Other languages
English (en)
Other versions
DK3423104T5 (da
Inventor
Christian Lutz
Jan Anderl
CHRISTOPH MüLLER
Werner Simon
Susanne Werner-Simon
Torsten Hechler
Michael Kulke
Original Assignee
Heidelberg Pharma Res Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Heidelberg Pharma Res Gmbh filed Critical Heidelberg Pharma Res Gmbh
Application granted granted Critical
Publication of DK3423104T3 publication Critical patent/DK3423104T3/da
Publication of DK3423104T5 publication Critical patent/DK3423104T5/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6817—Toxins
    • A61K47/6831—Fungal toxins, e.g. alpha sarcine, mitogillin, zinniol or restrictocin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Steroid Compounds (AREA)
DK17707350.9T 2016-03-03 2017-03-02 Amanitin-konjugater DK3423104T5 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16000511.2A EP3222292A1 (en) 2016-03-03 2016-03-03 Amanitin conjugates
PCT/EP2017/054911 WO2017149077A1 (en) 2016-03-03 2017-03-02 Amanitin conjugates

Publications (2)

Publication Number Publication Date
DK3423104T3 true DK3423104T3 (da) 2022-08-29
DK3423104T5 DK3423104T5 (da) 2022-09-05

Family

ID=55456549

Family Applications (1)

Application Number Title Priority Date Filing Date
DK17707350.9T DK3423104T5 (da) 2016-03-03 2017-03-02 Amanitin-konjugater

Country Status (25)

Country Link
US (2) US11590238B2 (da)
EP (2) EP3222292A1 (da)
JP (2) JP7084313B2 (da)
KR (1) KR102466933B1 (da)
CN (1) CN108778341B (da)
AU (1) AU2017228020B2 (da)
BR (1) BR112018067615A2 (da)
CA (1) CA3015138A1 (da)
CL (1) CL2018002502A1 (da)
CO (1) CO2018009533A2 (da)
DK (1) DK3423104T5 (da)
ES (1) ES2925006T3 (da)
HR (1) HRP20220948T1 (da)
HU (1) HUE059360T2 (da)
LT (1) LT3423104T (da)
MX (1) MX2018010247A (da)
NZ (1) NZ745508A (da)
PL (1) PL3423104T3 (da)
PT (1) PT3423104T (da)
RS (1) RS63451B1 (da)
RU (1) RU2753416C2 (da)
SG (2) SG10201913942SA (da)
SI (1) SI3423104T1 (da)
WO (1) WO2017149077A1 (da)
ZA (1) ZA201805336B (da)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2017204139B2 (en) 2016-06-17 2018-08-09 Vor Biopharma, Inc. Compositions and methods for the depletion of cells
AU2017380099B2 (en) 2016-12-23 2024-07-11 Heidelberg Pharma Research Gmbh Amanitin antibody conjugates
AU2018209452B2 (en) 2017-01-20 2024-11-07 Heidelberg Pharma Research Gmbh Compositions and methods for the depletion of CD137+ cells
CN114191564A (zh) * 2017-08-18 2022-03-18 四川百利药业有限责任公司 一种非天然鹅膏毒肽类抗体偶联物
KR20190043031A (ko) * 2017-10-17 2019-04-25 한국화학연구원 아마톡신 유도체 및 이의 제조방법
WO2019090242A1 (en) * 2017-11-04 2019-05-09 Advanced Proteome Therapeutics Inc. Composition and method for modifying polypeptides
EP3740233A4 (en) * 2018-01-18 2021-11-24 Magenta Therapeutics, Inc. COMPOSITIONS AND METHODS FOR DEPLOYING CD134 + CELLS
JP2021521202A (ja) * 2018-04-13 2021-08-26 ハイデルベルク ファルマ リサーチ ゲゼルシャフト ミット ベシュレンクテル ハフツング 固形腫瘍の治療のための標的化されたアマトキシン複合体
EP3801635A4 (en) * 2018-06-07 2022-04-06 Magenta Therapeutics, Inc. THERAPEUTIC METHODS USING ANTIBODY-DRUG CONJUGATE (ADC)
CA3107383A1 (en) 2018-07-23 2020-01-30 Magenta Therapeutics, Inc. Use of anti-cd5 antibody drug conjugate (adc) in allogeneic cell therapy
CN112739339A (zh) * 2018-07-23 2021-04-30 美真达治疗公司 抗cd137抗体药物缀合物(adc)在同种异体细胞疗法中的用途
WO2020127968A1 (en) 2018-12-20 2020-06-25 Marino Stephen F Protein-drug conjugate comprising a monomeric form of proteinase 3
CA3125751A1 (en) * 2019-01-07 2020-07-16 Magenta Therapeutics, Inc. Use of an anti-cd45 antibody drug conjugate (adc) in cell therapy
EP3958908A1 (en) * 2019-04-24 2022-03-02 Heidelberg Pharma Research GmbH Amatoxin antibody-drug conjugates and uses thereof
BR112021023226A2 (pt) 2019-05-23 2022-01-04 Heidelberg Pharma Res Gmbh Composto, conjugado, método para sintetizar os conjugados e composição farmacêutica
EP3792250A1 (en) * 2019-09-13 2021-03-17 Pure Bioorganics SIA Synthesis of alpha-amanitin and its derivatives
US20220298204A1 (en) * 2019-07-05 2022-09-22 Pure Bioorganics Sia Synthesis of a-amanitin and its derivatives
AR120218A1 (es) * 2019-10-15 2022-02-02 Heidelberg Pharma Res Gmbh Conjugados de amatoxina y anticuerpo específico de linfocitos b
EP4161946A1 (en) * 2020-06-09 2023-04-12 Heidelberg Pharma Research GmbH Method for synthesis of thioether-containing peptides
CA3195572A1 (en) 2020-11-04 2022-05-12 Heidelberg Pharma Research Gmbh Composition comprising a combination of immune checkpoint inhibitor and antibody-amatoxin conjugate for use in cancer therapy
CN116615219A (zh) * 2020-12-22 2023-08-18 中外制药株式会社 包括利用混合溶剂的冷冻干燥工序的药品的制造方法
AR125130A1 (es) 2021-03-19 2023-06-14 Heidelberg Pharma Res Gmbh Conjugados de amatoxina y anticuerpo específicos de linfocitos b
US20240165257A1 (en) 2022-11-01 2024-05-23 Heidelberg Pharma Research Gmbh Anti-gucy2c antibody and uses thereof
WO2024121632A1 (en) 2022-12-09 2024-06-13 Crispr Therapeutics Ag Use of anti-cd117 antibody drug conjugate (adc)

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0463151T3 (da) 1990-01-12 1996-07-01 Cell Genesys Inc Frembringelse af xenogene antistoffer
US6214345B1 (en) 1993-05-14 2001-04-10 Bristol-Myers Squibb Co. Lysosomal enzyme-cleavable antitumor drug conjugates
US6613879B1 (en) 1999-05-14 2003-09-02 Boehringer Ingelheim Pharma Kg FAP-activated anti-tumour compounds
ATE521366T1 (de) 2006-05-27 2011-09-15 Faulstich Heinz Dr Anwendung von amatoxin-konjugaten und phallotoxin-konjugaten mit makromolekülen zur krebstherapie und therapie von entzündungen
TW200942243A (en) 2008-03-05 2009-10-16 Biocryst Pharm Inc Antiviral therapeutic agents
CL2009000505A1 (es) 2008-03-05 2010-01-15 Biocryst Pharm Inc Compuestos derivados de triciclos nitrogenados, inhibodores de polimerasas de adn y arn virales; composicion farmaceutica que los comprende; y uso en el tratamiento de infecciones virales y cancer.
KR20110140124A (ko) 2009-04-08 2011-12-30 하인즈 파울스티히 암치료용 아미톡신-활성 표적 결합 부위
SI3192529T1 (sl) 2009-04-08 2020-07-31 Faulstich, Heinz Dr. Z amatoksinom ojačane vezne komponente terapevtske celične površine, zasnovane za zdravljenje tumorjev
AU2010283632B2 (en) 2009-08-10 2016-08-25 Ucl Business Plc Reversible covalent linkage of functional molecules
CN102933236B (zh) 2010-04-15 2014-10-08 斯皮罗根有限公司 吡咯并苯二氮卓类及其结合物
ES2402254T3 (es) * 2010-09-30 2013-04-30 Heidelberg Pharma Ag Conjugados de amatoxinas con ligadores mejorados
EP2497499A1 (en) 2011-03-10 2012-09-12 Heidelberg Pharma GmbH Amatoxin-conjugates with improved linkages
KR20150027072A (ko) * 2012-06-04 2015-03-11 아이알엠 엘엘씨 부위-특이적 표지 방법 및 이에 의해 생산된 분자
EP2684865A1 (en) 2012-07-13 2014-01-15 Heidelberg Pharma GmbH Methods for synthesizing amatoxin building block and amatoxins
MA37975B2 (fr) 2012-09-11 2021-03-31 Genzyme Corp Inhibiteurs de synthase de glucosylcéramide
PE20150650A1 (es) * 2012-09-12 2015-05-26 Genzyme Corp Polipeptidos que contienen fc con glicosilacion alterada y funcion efectora reducida
US20150218220A1 (en) * 2012-09-12 2015-08-06 Brian Alan MENDELSOHN Amatoxin derivatives and cell-permeable conjugates thereof as inhibitors of rna polymerase
CN105377304B (zh) * 2014-03-10 2018-05-15 海德堡医药有限责任公司 鹅膏毒肽衍生物
BR112017019300B1 (pt) * 2015-03-09 2023-02-23 Heidelberg Pharma Gmbh Conjugado de fórmula genérica (ama l x s)n ab, método para sintetizar um conjugado de fórmula genérica (ama l x s)n ab, kit, composição farmacêutica e uso da composição farmacêutica
US11166912B2 (en) 2016-03-03 2021-11-09 Ctt Pharma Inc. Orally administrable composition

Also Published As

Publication number Publication date
JP2019511484A (ja) 2019-04-25
KR20180114191A (ko) 2018-10-17
HRP20220948T1 (hr) 2022-10-28
EP3423104A1 (en) 2019-01-09
NZ745508A (en) 2023-05-26
US20230233703A1 (en) 2023-07-27
KR102466933B1 (ko) 2022-11-11
JP2022028756A (ja) 2022-02-16
ES2925006T3 (es) 2022-10-13
EP3222292A1 (en) 2017-09-27
DK3423104T5 (da) 2022-09-05
PT3423104T (pt) 2022-08-22
JP7362714B2 (ja) 2023-10-17
RU2753416C2 (ru) 2021-08-16
CO2018009533A2 (es) 2018-09-20
WO2017149077A1 (en) 2017-09-08
BR112018067615A2 (pt) 2018-12-26
AU2017228020B2 (en) 2024-05-16
HUE059360T2 (hu) 2022-11-28
US11590238B2 (en) 2023-02-28
JP7084313B2 (ja) 2022-06-14
RS63451B1 (sr) 2022-08-31
SG10201913942SA (en) 2020-03-30
US20210138081A1 (en) 2021-05-13
RU2018131636A3 (da) 2020-04-08
PL3423104T3 (pl) 2022-09-19
ZA201805336B (en) 2023-09-27
EP3423104B1 (en) 2022-05-18
MX2018010247A (es) 2018-12-19
AU2017228020A1 (en) 2018-09-06
LT3423104T (lt) 2022-08-10
RU2018131636A (ru) 2020-04-03
SI3423104T1 (sl) 2022-09-30
CN108778341B (zh) 2022-11-01
CA3015138A1 (en) 2017-09-08
CL2018002502A1 (es) 2019-02-22
SG11201807472TA (en) 2018-09-27
CN108778341A (zh) 2018-11-09

Similar Documents

Publication Publication Date Title
DK3423104T5 (da) Amanitin-konjugater
DK3579883T3 (da) Pyrrolobenzodiazepin-antistofkonjugater
DK3592393T3 (da) Frigørbare konjugater
DK3525830T3 (da) Pyrrolobenzodiazepin-konjugater
DK3268047T3 (da) Amatoxin/antistof-konjugater
PT3558390T (pt) Conjugados amanitina anticorpo
MA50755A (fr) Conjugués anticorps-médicaments mult-médicaments
DK3405050T3 (da) Børnesikret snusbeholder
DK3297649T3 (da) Peptid-oligonukleotid-konjugater
DK3119885T3 (da) Antistof-fynomer-konjugater
DK3324980T3 (da) Multimålrettede enkeltenhedskonjugater
DK3137114T3 (da) Anti-PTK7-antistof-lægemiddelkonjugater
DK3148591T3 (da) Nanopartikel-lægemiddelkonjugater
DK3436823T3 (da) Antigen-array
DK3612537T3 (da) Pyrrolobenzodiazepinkonjugater
DK3668874T3 (da) Pyrrolobenzodiazepin-konjugater
DK3335532T3 (da) Tandharve
DK3684416T3 (da) Psma-målrettede amanitinkonjugater
DK3445708T3 (da) Stigbøjle
DK3402792T3 (da) Quinolin-2-on-derivater
DK3478323T3 (da) Spaltbare polymer-lægemiddelkonjugater
DK3544634T3 (da) MET-antistof-lægemiddelkonjugater
FI20165515A (fi) Muunneltuja dekstraanikonjugaatteja
DE112017006386A5 (de) Schraubarbeitszylinder
DE112017000734A5 (de) Glycolsensor