DK3494962T3 - Flydende inhalationsformulering omfattende RPL554 - Google Patents

Flydende inhalationsformulering omfattende RPL554 Download PDF

Info

Publication number: DK3494962T3
Authority: DK; Denmark
Prior art keywords: rpl554; inhalation formulation; liquid inhalation; liquid; formulation
Prior art date: 2014-09-15

Application number

DK19152629.2T

Other languages

English (en)

Inventor

Peter Lionel Spargo

Edward James French

Phillip A Haywood

Original Assignee

Verona Pharma Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-09-15

Filing date

2015-09-15

Publication date

2021-06-21

2014-09-15 Priority claimed from GBGB1416274.7A external-priority patent/GB201416274D0/en

2015-03-19 Priority claimed from GBGB1504662.6A external-priority patent/GB201504662D0/en

2015-09-15 Application filed by Verona Pharma Plc filed Critical Verona Pharma Plc

2021-06-21 Application granted granted Critical

2021-06-21 Publication of DK3494962T3 publication Critical patent/DK3494962T3/da

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Pulmonology (AREA)
Immunology (AREA)
Dispersion Chemistry (AREA)
Otolaryngology (AREA)
Dermatology (AREA)
Oil, Petroleum & Natural Gas (AREA)
Inorganic Chemistry (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Urology & Nephrology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Ophthalmology & Optometry (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Transplantation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK19152629.2T 2014-09-15 2015-09-15 Flydende inhalationsformulering omfattende RPL554 DK3494962T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB1416274.7A GB201416274D0 (en)	2014-09-15	2014-09-15	Formulation
GBGB1504662.6A GB201504662D0 (en)	2015-03-19	2015-03-19	Formulation
EP17207623.4A EP3332767B1 (en)	2014-09-15	2015-09-15	Liquid inhalation formulation comprising rpl554

Publications (1)

Publication Number	Publication Date
DK3494962T3 true DK3494962T3 (da)	2021-06-21

Family

ID=54196992

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
DK17207623.4T DK3332767T3 (da)	2014-09-15	2015-09-15	Flydende inhalationsformulering, der omfatter RPL554
DK19152629.2T DK3494962T3 (da)	2014-09-15	2015-09-15	Flydende inhalationsformulering omfattende RPL554
DK15770593.0T DK3193835T3 (da)	2014-09-15	2015-09-15	Flydende inhalationsformulering, der omfatter RPL554

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK17207623.4T DK3332767T3 (da)	2014-09-15	2015-09-15	Flydende inhalationsformulering, der omfatter RPL554

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK15770593.0T DK3193835T3 (da)	2014-09-15	2015-09-15	Flydende inhalationsformulering, der omfatter RPL554

Country Status (26)

Country	Link
US (2)	US9956171B2 (da)
EP (3)	EP3193835B1 (da)
JP (2)	JP6860477B2 (da)
KR (1)	KR102379309B1 (da)
CN (3)	CN111249260B (da)
AU (3)	AU2015316592B2 (da)
CA (1)	CA2959943C (da)
CY (3)	CY1120264T1 (da)
DK (3)	DK3332767T3 (da)
ES (3)	ES2875584T3 (da)
HK (1)	HK1249415B (da)
HR (3)	HRP20180833T1 (da)
HU (3)	HUE055527T2 (da)
IL (1)	IL250895B (da)
LT (3)	LT3494962T (da)
MX (1)	MX2017003102A (da)
MY (1)	MY196072A (da)
NO (1)	NO3193835T3 (da)
PH (1)	PH12017500479B1 (da)
PL (3)	PL3332767T3 (da)
PT (3)	PT3332767T (da)
RS (3)	RS62252B1 (da)
RU (1)	RU2699995C2 (da)
SG (1)	SG11201701854WA (da)
SI (3)	SI3332767T1 (da)
WO (1)	WO2016042313A1 (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2015173551A1 (en)	2014-05-12	2015-11-19	Verona Pharma Plc	New treatment
SG11201701854WA (en) *	2014-09-15	2017-04-27	Verona Pharma Plc	Liquid inhalation formulation comprising rpl554
GB201502260D0 (en)	2015-02-11	2015-04-01	Verona Pharma Plc	Salt of Pyrimido[6,1-A]Isoquinolin-4-one compound
US10947272B2 (en)	2015-07-24	2021-03-16	Hoffmann-La Roche Inc.	BACE1 inhibitor peptides
GB201613054D0 (en)	2016-07-28	2016-09-14	Verona Pharma Plc	New compound and process
GB2578093B (en)	2018-10-09	2020-11-18	Verona Pharma Plc	Liquid pharmaceutical composition comprising RPL554 and HFA-134A
JP6994061B2 (ja) *	2019-02-15	2022-01-14	ノバルティスアーゲー	４－（７－ヒドロキシ－２－イソプロピル－４－オキソ－４ｈ－キナゾリン－３－イル）－ベンゾニトリルの製剤
GB201911517D0 (en)	2019-08-12	2019-09-25	Verona Pharma Plc	Pharmaceutical composition
CA3167378A1 (en)	2020-01-15	2021-07-22	Chia Tai Tianqing Pharmaceutical Group Co., Ltd	Pharmaceutical composition of tricyclic pde3/pde4 dual inhibitor compound
GB202002786D0 (en)	2020-02-27	2020-04-15	Verona Pharma Plc	Liquid pharmaceutical composition
GB202202297D0 (en) *	2022-02-21	2022-04-06	Verona Pharma Plc	Formulation production process
WO2024033627A1 (en) *	2022-08-08	2024-02-15	Verona Pharma Plc	Liquid pharmaceutical composition
WO2024033626A1 (en) *	2022-08-08	2024-02-15	Verona Pharma Plc	Ensifentrine (rpl-554) for decreasing the frequency and/or severity of copd exacerbations
TW202421154A (zh) *	2022-10-28	2024-06-01	大陸商江蘇恆瑞醫藥股份有限公司	一種包含異喹啉酮類化合物的醫藥組成物及其製備方法
EP4378942A1 (en)	2022-12-02	2024-06-05	Sandoz AG	Crystal form of a pde3/4 inhibitor

Family Cites Families (19)

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GB9410222D0 (en)	1994-05-21	1994-07-06	Glaxo Wellcome Australia Ltd	Medicaments
DE69804998T2 (de)	1997-10-09	2002-12-12	Schering Corp., Kenilworth	Mometasonfuroat-suspensionen zum zerstäuben
SE9704186D0 (sv)	1997-11-14	1997-11-14	Astra Ab	New composition of matter
DK1165558T3 (da)	1999-03-31	2004-02-09	Vernalis Ltd	Pyrimido[6,1-a]isoquinolin-4-on-derivater
US6630169B1 (en) *	1999-03-31	2003-10-07	Nektar Therapeutics	Particulate delivery systems and methods of use
GB0008660D0 (en) *	2000-04-07	2000-05-31	Arakis Ltd	The treatment of respiratory diseases
GB0122031D0 (en)	2001-09-12	2001-10-31	Pfizer Ltd	Use of pde4 inhibitors in a dry powder inhaler
US7579505B2 (en)	2004-12-17	2009-08-25	Cipla Limited	Crystalline levosalbutamol sulphate and polymorphic forms thereof
ITMI20051999A1 (it)	2005-10-21	2007-04-22	Eratech S R L	Formulazioni inalatorie di farmaci in fora di polvere secca per somministrazione come tale o con nebulizzatore e dotate di elevata erogabilita' respirabilita' e stabilita'
WO2011161018A1 (en)	2010-06-22	2011-12-29	Chiesi Farmaceutici S.P.A.	Alkaloid aminoester derivatives and medicinal compositions thereof
EP2603509B1 (en) *	2010-08-09	2014-06-18	Verona Pharma PLC	Crystalline form of pyrimido[6,1-a] isoquinolin-4-one compound
US8945605B2 (en)	2011-06-07	2015-02-03	Parion Sciences, Inc.	Aerosol delivery systems, compositions and methods
AU2012267938B2 (en) *	2011-06-07	2017-05-04	Parion Sciences, Inc.	Methods of treatment
EP2647627A1 (en) *	2012-04-02	2013-10-09	Almirall, S.A.	Salts of 5-[(1r)-2-({2-[4-(2,2-difluoro-2-phenylethoxy)phenyl] ethyl}amino)-1-hydroxyethyl]-8-hydroxyquinolin-2(1h)-one.
WO2014037727A1 (en) *	2012-09-06	2014-03-13	Verona Pharma Plc	Carcainium salts
DK2968312T3 (da) *	2013-03-15	2018-05-07	Verona Pharma Plc	Lægemiddelkombination
WO2015173551A1 (en)	2014-05-12	2015-11-19	Verona Pharma Plc	New treatment
SG11201701854WA (en) *	2014-09-15	2017-04-27	Verona Pharma Plc	Liquid inhalation formulation comprising rpl554
GB201502260D0 (en) *	2015-02-11	2015-04-01	Verona Pharma Plc	Salt of Pyrimido[6,1-A]Isoquinolin-4-one compound

2015
- 2015-09-15 SG SG11201701854WA patent/SG11201701854WA/en unknown
- 2015-09-15 EP EP15770593.0A patent/EP3193835B1/en active Active
- 2015-09-15 RS RS20211044A patent/RS62252B1/sr unknown
- 2015-09-15 SI SI201530774T patent/SI3332767T1/sl unknown
- 2015-09-15 PL PL17207623T patent/PL3332767T3/pl unknown
- 2015-09-15 ES ES19152629T patent/ES2875584T3/es active Active
- 2015-09-15 WO PCT/GB2015/052668 patent/WO2016042313A1/en active Application Filing
- 2015-09-15 PT PT17207623T patent/PT3332767T/pt unknown
- 2015-09-15 RS RS20190765A patent/RS58897B1/sr unknown
- 2015-09-15 CN CN202010090019.5A patent/CN111249260B/zh active Active
- 2015-09-15 NO NO15770593A patent/NO3193835T3/no unknown
- 2015-09-15 MX MX2017003102A patent/MX2017003102A/es active IP Right Grant
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- 2015-09-15 ES ES15770593.0T patent/ES2670025T3/es active Active
- 2015-09-15 LT LTEP19152629.2T patent/LT3494962T/lt unknown
- 2015-09-15 PT PT157705930T patent/PT3193835T/pt unknown
- 2015-09-15 HU HUE19152629A patent/HUE055527T2/hu unknown
- 2015-09-15 HU HUE15770593A patent/HUE038433T2/hu unknown
- 2015-09-15 DK DK19152629.2T patent/DK3494962T3/da active
- 2015-09-15 RS RS20180519A patent/RS57227B1/sr unknown
- 2015-09-15 EP EP17207623.4A patent/EP3332767B1/en active Active
- 2015-09-15 JP JP2017514346A patent/JP6860477B2/ja active Active
- 2015-09-15 DK DK15770593.0T patent/DK3193835T3/da active
- 2015-09-15 CN CN201811561721.4A patent/CN110051627A/zh active Pending
- 2015-09-15 LT LTEP15770593.0T patent/LT3193835T/lt unknown
- 2015-09-15 US US15/509,943 patent/US9956171B2/en active Active
- 2015-09-15 ES ES17207623T patent/ES2730810T3/es active Active
- 2015-09-15 CN CN201580053062.1A patent/CN106794157B/zh active Active
- 2015-09-15 PL PL19152629T patent/PL3494962T3/pl unknown
- 2015-09-15 HU HUE17207623A patent/HUE045303T2/hu unknown
- 2015-09-15 SI SI201531657T patent/SI3494962T1/sl unknown
- 2015-09-15 EP EP19152629.2A patent/EP3494962B1/en active Active
- 2015-09-15 MY MYPI2017000391A patent/MY196072A/en unknown
- 2015-09-15 PT PT191526292T patent/PT3494962T/pt unknown
- 2015-09-15 LT LTEP17207623.4T patent/LT3332767T/lt unknown
- 2015-09-15 CA CA2959943A patent/CA2959943C/en active Active
- 2015-09-15 AU AU2015316592A patent/AU2015316592B2/en active Active
2017
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- 2017-03-14 PH PH12017500479A patent/PH12017500479B1/en unknown
2018
- 2018-03-21 US US15/927,517 patent/US10945950B2/en active Active
- 2018-05-03 CY CY20181100455T patent/CY1120264T1/el unknown
- 2018-05-25 HR HRP20180833TT patent/HRP20180833T1/hr unknown
- 2018-07-10 HK HK18108909.3A patent/HK1249415B/zh unknown
- 2018-12-20 JP JP2018238014A patent/JP6795574B2/ja active Active
- 2018-12-24 AU AU2018286571A patent/AU2018286571B2/en active Active
2019
- 2019-06-18 CY CY20191100622T patent/CY1121698T1/el unknown
- 2019-06-19 HR HRP20191122TT patent/HRP20191122T1/hr unknown
2020
- 2020-05-11 AU AU2020203081A patent/AU2020203081B2/en active Active
2021
- 2021-06-30 HR HRP20211035TT patent/HRP20211035T1/hr unknown
- 2021-08-10 CY CY20211100720T patent/CY1124546T1/el unknown

Also Published As

Publication number	Publication date
US10945950B2 (en)	2021-03-16
AU2018286571A1 (en)	2019-01-24
RU2017108432A3 (da)	2019-04-01
EP3494962A1 (en)	2019-06-12
MY196072A (en)	2023-03-13
CN110051627A (zh)	2019-07-26
JP2017528479A (ja)	2017-09-28
KR20170054406A (ko)	2017-05-17
EP3332767B1 (en)	2019-03-20
NO3193835T3 (da)	2018-08-04
KR102379309B1 (ko)	2022-03-28
HRP20191122T1 (hr)	2019-09-20
LT3193835T (lt)	2018-06-11
CA2959943A1 (en)	2016-03-24
SG11201701854WA (en)	2017-04-27
JP6860477B2 (ja)	2021-04-14
HUE055527T2 (hu)	2021-12-28
PL3494962T3 (pl)	2021-12-06
SI3494962T1 (sl)	2021-09-30
ES2875584T3 (es)	2021-11-10
EP3332767A1 (en)	2018-06-13
NZ767295A (en)	2024-01-26
HK1249415B (zh)	2019-11-22
IL250895B (en)	2019-08-29
PH12017500479A1 (en)	2017-07-31
CN111249260A (zh)	2020-06-09
CA2959943C (en)	2022-08-16
SI3193835T1 (en)	2018-06-29
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PL3332767T3 (pl)	2019-10-31
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US20180369139A1 (en)	2018-12-27
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AU2020203081B2 (en)	2021-08-05
AU2018286571B2 (en)	2020-04-02
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SI3332767T1 (sl)	2019-07-31
NZ729796A (en)	2024-01-26
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JP6795574B2 (ja)	2020-12-02
ES2670025T3 (es)	2018-05-29
HRP20180833T1 (hr)	2018-06-29
PT3494962T (pt)	2021-06-22
IL250895A0 (en)	2017-04-30
CY1120264T1 (el)	2019-07-10
AU2015316592B2 (en)	2020-04-02
RS58897B1 (sr)	2019-08-30
RU2699995C2 (ru)	2019-09-12
RS57227B1 (sr)	2018-07-31
HUE045303T2 (hu)	2019-12-30
PH12017500479B1 (en)	2017-07-31
US9956171B2 (en)	2018-05-01
CY1124546T1 (el)	2022-07-22
LT3494962T (lt)	2021-07-26
PT3332767T (pt)	2019-06-27
EP3494962B1 (en)	2021-05-26
CN106794157B (zh)	2021-03-09
AU2015316592A1 (en)	2017-03-23
HUE038433T2 (hu)	2018-10-29
US20170239178A1 (en)	2017-08-24
RS62252B1 (sr)	2021-09-30
WO2016042313A1 (en)	2016-03-24
BR112017005050A2 (pt)	2018-01-23
AU2020203081A1 (en)	2020-05-28
DK3332767T3 (da)	2019-06-24
DK3193835T3 (da)	2018-05-07

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DK3236749T3 (da)	2019-08-05	Flydende tribenuron-holdige herbicidsammensætninger
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DK3193840T3 (da)	2021-08-16	Arimoclomol-formulering
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DK3102275T3 (da)	2020-04-06	Nasal dilatator
FR3021528B1 (fr)	2017-12-08	Formulation cosmetique
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DK3200762T3 (da)	2019-05-06	Inhalationsanordning
DK3148513T3 (da)	2020-05-25	Ceritinib-formulering
FI20145982A (fi)	2016-05-11	Potilasalusta
DK3193856T3 (da)	2021-09-06	Formulering
DK3441063T3 (da)	2021-08-30	Flydende thioureylensammensætninger
UA31168S (uk)	2016-01-12	Інгалятор
UA30864S (uk)	2015-11-25	Інгалятор
UA30748S (uk)	2015-11-10	Інгалятор
TH1501007686A (th)	2017-08-31	สูตรตำรับของเหลวเสถียร
UA28875S (uk)	2015-02-10	Шприц
UA28872S (uk)	2015-02-10	Шприц
TH1501006804A (th)	2017-03-23	องค์ประกอบของเหลวไอออนิก
ES1112405Y (es)	2014-09-09	Mosquetón
UA30163S (uk)	2015-08-25	Спринцівка
UA30164S (uk)	2015-08-25	Спринцівка
TH1501007638A (th)	2017-08-10	สารรักษาความชุ่มชื้น