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DK349486D0 - 4-substituerede 2-amino-5-hydroxypyrimidin-forbindelser og deres anvendelse til behandling af pulmonale, allergiske, inflammatoriske og cardiovasculaere sygdomme - Google Patents

4-substituerede 2-amino-5-hydroxypyrimidin-forbindelser og deres anvendelse til behandling af pulmonale, allergiske, inflammatoriske og cardiovasculaere sygdomme

Info

Publication number
DK349486D0
DK349486D0 DK349486A DK349486A DK349486D0 DK 349486 D0 DK349486 D0 DK 349486D0 DK 349486 A DK349486 A DK 349486A DK 349486 A DK349486 A DK 349486A DK 349486 D0 DK349486 D0 DK 349486D0
Authority
DK
Denmark
Prior art keywords
pulmonal
allergic
inflammatory
amino
substituted
Prior art date
Application number
DK349486A
Other languages
English (en)
Other versions
DK349486A (da
DK162986B (da
DK162986C (da
Inventor
John Lawrence Lamattina
Frederick Judson Walker
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of DK349486D0 publication Critical patent/DK349486D0/da
Publication of DK349486A publication Critical patent/DK349486A/da
Publication of DK162986B publication Critical patent/DK162986B/da
Application granted granted Critical
Publication of DK162986C publication Critical patent/DK162986C/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32One oxygen, sulfur or nitrogen atom
    • C07D239/34One oxygen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK349486A 1985-07-24 1986-07-23 4-substituerede 2-amino-5-hydroxypyrimidin-forbindelser og farmaceutiske praeparater indeholdende disse DK162986C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/758,199 US4711888A (en) 1985-07-24 1985-07-24 Hydroxy and alkoxy pyrimidines
US75819985 1985-07-24

Publications (4)

Publication Number Publication Date
DK349486D0 true DK349486D0 (da) 1986-07-23
DK349486A DK349486A (da) 1987-01-25
DK162986B DK162986B (da) 1992-01-06
DK162986C DK162986C (da) 1992-06-01

Family

ID=25050889

Family Applications (1)

Application Number Title Priority Date Filing Date
DK349486A DK162986C (da) 1985-07-24 1986-07-23 4-substituerede 2-amino-5-hydroxypyrimidin-forbindelser og farmaceutiske praeparater indeholdende disse

Country Status (25)

Country Link
US (1) US4711888A (da)
EP (1) EP0210044B1 (da)
JP (1) JPH0647579B2 (da)
KR (1) KR890001549B1 (da)
CN (1) CN1006792B (da)
AU (1) AU569194B2 (da)
CA (1) CA1265519A (da)
DD (1) DD248588A5 (da)
DE (1) DE3673718D1 (da)
DK (1) DK162986C (da)
EG (1) EG18181A (da)
ES (1) ES2000734A6 (da)
FI (1) FI89911C (da)
GR (1) GR861917B (da)
HU (1) HU196764B (da)
IE (1) IE63404B1 (da)
IL (1) IL79471A0 (da)
NO (1) NO173442C (da)
NZ (1) NZ216951A (da)
PH (1) PH22484A (da)
PL (2) PL150617B1 (da)
PT (1) PT83036B (da)
SU (1) SU1574171A3 (da)
YU (1) YU45020B (da)
ZA (1) ZA865489B (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2087056T3 (es) * 1986-01-13 1996-07-16 American Cyanamid Co 2-pirimidinaminas sustituidas en las posiciones 4, 5 y 6.
US4959365A (en) * 1986-10-31 1990-09-25 Pfizer Inc. Topical compositions of lipophilic pharmaceuticals agents
HU199683B (en) * 1987-07-22 1990-03-28 Egyt Gyogyszervegyeszeti Gyar Process for producing pharmaceutical compositions analgesic, antiphlogistic, antipyretic, antianginic and/or antioxidative activity
WO1989005295A1 (en) * 1987-12-02 1989-06-15 Pfizer Inc. Acyl derivatives of hydroxypyrimidines
ATE96321T1 (de) * 1988-12-14 1993-11-15 Pfizer Derivate von 5-hydroxy- und 5-methoxy-2-aminopyrimidin als inhibitoren der interleukin-1produktion.
US5071852A (en) * 1988-12-14 1991-12-10 Pfizer Inc. Derivatives of 5-hydroxy and 5-methoxy 2-amino-pyrimidines as inhibitors of interleukin-1 production
US4940712A (en) * 1989-05-26 1990-07-10 Pfizer Inc. Derivatives of hydroxyprimidines as leukotriene synthesis inhibitors
US5248682A (en) * 1991-01-31 1993-09-28 Warner-Lambert Company 2-substituted-4,6-di-tertiary-butyl-5-hydroxy-1,3-pyrimidines useful as antiinflammatory agents
US5356898A (en) * 1991-01-31 1994-10-18 Warner-Lambert Company Substituted 4,6-di-tertiary-butyl 5-hydroxy-pyrimidines
US5177079A (en) * 1991-01-31 1993-01-05 Warner-Lambert Company 2-substituted-4,6-di-tertiarybutyl-5-hydroxy-1,3-pyrimidines useful as antiinflammatory agents
US5270319A (en) * 1991-09-09 1993-12-14 Warner-Lambert Company 5-hydroxy-2-pyrimidinylmethylene derivatives useful as antiinflammatory agents
US5196431A (en) * 1992-02-24 1993-03-23 Warner-Lambert Company 2-substituted amino-4, 6-di-tertiary-buthyl-5-hydroxy-1, 3-pyrimidines as antiinflammatory agents
US5220025A (en) * 1992-02-24 1993-06-15 Warner-Lambert Company 2-substituted amino-4, 6-di-tertiary-butyl-5-hydroxy-1, 3-pyrimidines as antiinflammatory agents
US6087500A (en) * 1996-05-16 2000-07-11 Nissan Chemical Industries, Ltd. Methods for producing pyrimidine compounds
US5958934A (en) * 1996-05-23 1999-09-28 Syntex (U.S.A.) Inc. Aryl pyrimidine derivatives and uses thereof
TW440563B (en) * 1996-05-23 2001-06-16 Hoffmann La Roche Aryl pyrimidine derivatives and a pharmaceutical composition thereof
US5952331A (en) * 1996-05-23 1999-09-14 Syntex (Usa) Inc. Aryl pyrimidine derivatives
US6489344B1 (en) 1998-06-19 2002-12-03 Chiron Corporation Inhibitors of glycogen synthase kinase 3
US7045519B2 (en) 1998-06-19 2006-05-16 Chiron Corporation Inhibitors of glycogen synthase kinase 3
AU2001280445A1 (en) 2000-06-23 2002-01-08 Vanderbilt University Novel chain-breaking antioxidants
DE102004054080A1 (de) * 2004-11-09 2006-05-11 Wella Ag Haut- oder Haarbehandlungsmittel mit Schutzeffekt
US9133212B1 (en) 2005-06-15 2015-09-15 Vanderbilt University Inhibitors of hemeprotein-catalyzed lipid peroxidation
US8367669B2 (en) * 2005-06-15 2013-02-05 Vanderbilt University Inhibitors of hemeprotein-catalyzed lipid peroxidation
JP2008156048A (ja) * 2006-12-22 2008-07-10 Isamu Nakamura 車両用板材キャリア
US8877766B2 (en) 2013-02-15 2014-11-04 Peter F. Kador Neuroprotective multifunctional antioxidants and their monofunctional analogs

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN153791B (da) * 1979-03-10 1984-08-18 Soc D Etudes Prod Chimique
US4659363A (en) * 1983-07-25 1987-04-21 Ciba-Geigy Corporation N-(2-nitrophenyl)-2-aminopyrimidine derivatives, the preparation and use thereof
US4554276A (en) * 1983-10-03 1985-11-19 Pfizer Inc. 2-Amino-5-hydroxy-4-methylpyrimidine derivatives
EP0164204A1 (en) * 1984-05-12 1985-12-11 FISONS plc Novel pharmaceutically useful pyrimidines

Also Published As

Publication number Publication date
NO862956D0 (no) 1986-07-23
DK349486A (da) 1987-01-25
NZ216951A (en) 1989-06-28
AU569194B2 (en) 1988-01-21
EG18181A (en) 1992-09-30
EP0210044B1 (en) 1990-08-29
DK162986B (da) 1992-01-06
SU1574171A3 (ru) 1990-06-23
JPH0647579B2 (ja) 1994-06-22
IE63404B1 (en) 1995-04-19
FI89911B (fi) 1993-08-31
DK162986C (da) 1992-06-01
IE861952L (en) 1987-01-24
ES2000734A6 (es) 1988-03-16
ZA865489B (en) 1988-03-30
US4711888A (en) 1987-12-08
PL271856A1 (en) 1988-09-29
CN1006792B (zh) 1990-02-14
HU196764B (en) 1989-01-30
CA1265519A (en) 1990-02-06
YU45020B (en) 1991-06-30
HUT41745A (en) 1987-05-28
PL150617B1 (en) 1990-06-30
FI89911C (fi) 1993-12-10
PL260784A1 (en) 1988-08-18
PT83036B (pt) 1989-01-30
NO173442C (no) 1993-12-15
DE3673718D1 (de) 1990-10-04
YU132186A (en) 1988-04-30
IL79471A0 (en) 1986-10-31
AU6044786A (en) 1987-04-30
KR870001173A (ko) 1987-03-11
DD248588A5 (de) 1987-08-12
NO173442B (no) 1993-09-06
NO862956L (no) 1987-01-26
PT83036A (en) 1986-08-01
EP0210044A2 (en) 1987-01-28
PL151571B1 (en) 1990-09-28
CN86104539A (zh) 1987-01-21
PH22484A (en) 1988-09-12
FI863029A (fi) 1987-01-25
GR861917B (en) 1986-11-24
JPS6226276A (ja) 1987-02-04
FI863029A0 (fi) 1986-07-23
EP0210044A3 (en) 1987-10-21
KR890001549B1 (ko) 1989-05-08

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