DK3331863T3 - Hidtil ukendte forbindelser som ror-gamma-modulatorer - Google Patents

Hidtil ukendte forbindelser som ror-gamma-modulatorer Download PDF

Info

Publication number: DK3331863T3
Authority: DK; Denmark
Prior art keywords: rod; gamma modulators; unknown connections; unknown; connections
Prior art date: 2015-08-03

Application number

DK16756806.2T

Other languages

English (en)

Inventor

Sanjib Das

Laxmikant Atmaram Gharat

Rajendra Laxman Harde

Sandeep Yadunath Shelke

Shailesh Ramesh Pardeshi

Abraham Thomas

Neelima Khairatkar-Joshi

Daisy Manish Shah

Malini Bajpai

Original Assignee

Glenmark Pharmaceuticals Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2015-08-03

Filing date

2016-08-02

Publication date

2020-04-27

2016-08-02 Application filed by Glenmark Pharmaceuticals Sa filed Critical Glenmark Pharmaceuticals Sa

2020-04-27 Application granted granted Critical

2020-04-27 Publication of DK3331863T3 publication Critical patent/DK3331863T3/da

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
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- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
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- C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
- C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/18—Oxygen or sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Rheumatology (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Epidemiology (AREA)
Dermatology (AREA)
Physical Education & Sports Medicine (AREA)
Anesthesiology (AREA)
Orthopedic Medicine & Surgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Transplantation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

DK16756806.2T 2015-08-03 2016-08-02 Hidtil ukendte forbindelser som ror-gamma-modulatorer DK3331863T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IN2930MU2015		2015-08-03
PCT/IB2016/054639 WO2017021879A1 (en)	2015-08-03	2016-08-02	Novel compounds as ror gamma modulators

Publications (1)

Publication Number	Publication Date
DK3331863T3 true DK3331863T3 (da)	2020-04-27

Family

ID=56799510

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK16756806.2T DK3331863T3 (da)	2015-08-03	2016-08-02	Hidtil ukendte forbindelser som ror-gamma-modulatorer

Country Status (26)

Country	Link
US (3)	US9975887B2 (da)
EP (2)	EP3331863B1 (da)
JP (1)	JP6661749B2 (da)
KR (1)	KR102229608B1 (da)
CN (1)	CN108026050B (da)
AU (1)	AU2016303540B2 (da)
BR (1)	BR112018001469B1 (da)
CA (1)	CA2993304C (da)
CL (1)	CL2018000289A1 (da)
CY (1)	CY1122916T1 (da)
DK (1)	DK3331863T3 (da)
EA (1)	EA034201B1 (da)
ES (1)	ES2791496T3 (da)
HK (1)	HK1254692A1 (da)
HU (1)	HUE048902T2 (da)
IL (1)	IL256805B (da)
MX (2)	MX2020001361A (da)
NZ (1)	NZ739228A (da)
PE (1)	PE20180686A1 (da)
PH (1)	PH12018500251A1 (da)
PL (1)	PL3331863T3 (da)
PT (1)	PT3331863T (da)
SI (1)	SI3331863T1 (da)
UA (1)	UA122148C2 (da)
WO (1)	WO2017021879A1 (da)
ZA (1)	ZA201800506B (da)

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CN111024099B (zh)	2013-06-13	2023-10-27	移动眼视力科技有限公司	用于导航的移动装置、非暂时性机器可读介质和设备
GB201513742D0 (en)	2015-08-03	2015-09-16	Heptares Therapeutics Ltd	Muscarinic agonists
WO2017023905A1 (en)	2015-08-03	2017-02-09	Bristol-Myers Squibb Company	Heterocyclic compounds useful as modulators of tnf alpha
MX2018003318A (es)	2015-09-18	2018-05-16	Kaken Pharma Co Ltd	Derivado de biarilo y medicamento que contiene el mismo.
WO2018042342A1 (en) *	2016-08-30	2018-03-08	Glenmark Pharmaceuticals S.A.	1,2,3-benzotriazole derivatives as ror gamma t modulators
TWI705958B (zh)	2016-12-05	2020-10-01	荷蘭商領導醫藥控股責任有限公司	ＲＯＲγ調節子
WO2018193297A1 (en)	2017-04-21	2018-10-25	Cadila Healthcare Limited	Novel compounds as ror-gamma modulators
CN107805242A (zh) *	2017-10-31	2018-03-16	长春海谱润斯科技有限公司	一种吡嗪联嘧啶衍生物及其有机发光器件
WO2019119207A1 (en) *	2017-12-18	2019-06-27	Merck Sharp & Dohme Corp.	Purine inhibitors of human phosphatidylinositol 3-kinase delta
JP2021528398A (ja) *	2018-06-18	2021-10-21	ヤンセンファーマシューティカエヌ．ベー．	ＲＯＲγＴのモジュレーターとしての６−アミノピリジン−３−イルピラゾール
WO2019243999A1 (en) *	2018-06-18	2019-12-26	Janssen Pharmaceutica Nv	Phenyl substituted pyrazoles as modulators of roryt
AU2020361747A1 (en)	2019-10-11	2022-04-28	Glenmark Specialty S.A.	An inhalable dry powder composition for pulmonary diseases
EP4208449A1 (en)	2020-09-03	2023-07-12	Glenmark Specialty S.A.	Polymorphic forms of a rorgamma inhibiting compound and processes for its preparation
TW202404957A (zh) *	2022-06-29	2024-02-01	大陸商上海翰森生物醫藥科技有限公司	雜環類衍生物抑制劑、其製備方法和應用

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CN102105459B (zh)	2008-07-24	2014-09-10	内尔维阿诺医学科学有限公司	作为蛋白激酶抑制剂的3,4-二芳基吡唑类
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WO2012064744A2 (en)	2010-11-08	2012-05-18	Lycera Corporation	Tetrahydroquinoline and related bicyclic compounds for inhibition of rorϒ activity and the treatment of disease
WO2012100732A1 (en)	2011-01-24	2012-08-02	Glaxo Group Limited	Retinoid-related orphan receptor gamma modulators, composition containing them and uses thereof
WO2012100734A1 (en)	2011-01-24	2012-08-02	Glaxo Group Limited	Compounds useful as retinoid-related orphan receptor gamma modulators
EP2511263A1 (en)	2011-04-14	2012-10-17	Phenex Pharmaceuticals AG	Pyrrolo sulfonamide compounds for modulation of orphan nuclear receptor RAR-related orphan receptor-gamma (RORgamma, NR1F3) activity and for the treatment of chronic inflammatory and autoimmune diseases
US9586928B2 (en) *	2011-05-16	2017-03-07	The Scripps Research Institute	Modulators of the nuclear hormone receptor ROR
WO2013029338A1 (en) *	2011-09-01	2013-03-07	Glaxo Group Limited	Novel compounds
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WO2014125426A1 (en) *	2013-02-15	2014-08-21	Aurigene Discovery Technologies Limited	Trisubstituted heterocyclic derivatives as ror gamma modulators
WO2015008234A1 (en)	2013-07-17	2015-01-22	Glenmark Pharmaceuticals S.A.	Bicyclic heterocyclic compounds as ror gamma modulators
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WO2017023905A1 (en)	2015-08-03	2017-02-09	Bristol-Myers Squibb Company	Heterocyclic compounds useful as modulators of tnf alpha
GB201513742D0 (en)	2015-08-03	2015-09-16	Heptares Therapeutics Ltd	Muscarinic agonists
AR105556A1 (es)	2015-08-03	2017-10-18	Hoffmann La Roche	Derivados de etinilo

2016
- 2016-08-02 US US15/318,513 patent/US9975887B2/en active Active
- 2016-08-02 PE PE2018000176A patent/PE20180686A1/es unknown
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Also Published As

Publication number	Publication date
KR102229608B1 (ko)	2021-03-19
CY1122916T1 (el)	2021-10-29
PT3331863T (pt)	2020-05-22
AU2016303540B2 (en)	2019-07-11
EA034201B1 (ru)	2020-01-16
PE20180686A1 (es)	2018-04-23
CN108026050A (zh)	2018-05-11
US10988467B2 (en)	2021-04-27
EP3686187A1 (en)	2020-07-29
JP2018522047A (ja)	2018-08-09
EP3331863A1 (en)	2018-06-13
WO2017021879A1 (en)	2017-02-09
ZA201800506B (en)	2019-07-31
US20170233380A1 (en)	2017-08-17
AU2016303540A1 (en)	2018-02-08
MX2020001361A (es)	2021-09-13
IL256805B (en)	2018-07-31
BR112018001469B1 (pt)	2023-04-25
ES2791496T3 (es)	2020-11-04
EP3331863B1 (en)	2020-03-11
CA2993304A1 (en)	2017-02-09
US10344024B2 (en)	2019-07-09
JP6661749B2 (ja)	2020-03-11
PL3331863T3 (pl)	2020-08-10
BR112018001469A2 (pt)	2018-09-11
KR20180032645A (ko)	2018-03-30
UA122148C2 (uk)	2020-09-25
CA2993304C (en)	2021-06-22
HUE048902T2 (hu)	2020-08-28
MX2018001464A (es)	2018-05-28
NZ739228A (en)	2019-11-29
US20180237428A1 (en)	2018-08-23
US9975887B2 (en)	2018-05-22
CN108026050B (zh)	2021-04-30
SI3331863T1 (sl)	2020-07-31
US20190256508A1 (en)	2019-08-22
PH12018500251A1 (en)	2018-08-13
HK1254692A1 (zh)	2019-07-26
EA201890072A1 (ru)	2018-07-31
CL2018000289A1 (es)	2018-07-06

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