DK3233863T3 - Kondenserede ringheteroarylforbindelser og anvendelse deraf som trk-hæmmere - Google Patents
Kondenserede ringheteroarylforbindelser og anvendelse deraf som trk-hæmmere Download PDFInfo
- Publication number
- DK3233863T3 DK3233863T3 DK15869420.8T DK15869420T DK3233863T3 DK 3233863 T3 DK3233863 T3 DK 3233863T3 DK 15869420 T DK15869420 T DK 15869420T DK 3233863 T3 DK3233863 T3 DK 3233863T3
- Authority
- DK
- Denmark
- Prior art keywords
- heterorayl
- compounds
- fused ring
- trk inhibitors
- trk
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462092193P | 2014-12-15 | 2014-12-15 | |
| PCT/IB2015/002521 WO2016097869A1 (en) | 2014-12-15 | 2015-12-14 | Fused ring heteroaryl compounds and their use as trk inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3233863T3 true DK3233863T3 (da) | 2024-07-15 |
Family
ID=56110505
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK15869420.8T DK3233863T3 (da) | 2014-12-15 | 2015-12-14 | Kondenserede ringheteroarylforbindelser og anvendelse deraf som trk-hæmmere |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9701681B2 (da) |
| EP (2) | EP3233863B1 (da) |
| JP (1) | JP6609631B2 (da) |
| KR (2) | KR102659741B1 (da) |
| CN (1) | CN107207514B (da) |
| AU (1) | AU2015365587B2 (da) |
| BR (1) | BR112017012755B1 (da) |
| CA (1) | CA2971024C (da) |
| DK (1) | DK3233863T3 (da) |
| ES (1) | ES2983908T3 (da) |
| FI (1) | FI3233863T3 (da) |
| HR (1) | HRP20240937T1 (da) |
| MX (1) | MX2017007748A (da) |
| RU (1) | RU2708674C2 (da) |
| WO (1) | WO2016097869A1 (da) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2350075T1 (sl) | 2008-09-22 | 2014-06-30 | Array Biopharma, Inc. | Substituirane imidazo (1,2b)piridazinske spojine kot Trk kinazni inhibitorji |
| MY169791A (en) | 2008-10-22 | 2019-05-15 | Array Biopharma Inc | Substituted pyrazolo [1,5-a] pyrimidine compounds as trk kinase inhibitors |
| AR077468A1 (es) | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa |
| SI3205654T1 (sl) * | 2010-05-20 | 2019-07-31 | Array Biopharma, Inc. | Makrociklične spojine kot inhibitorji TRK kinaze |
| US9714258B2 (en) | 2014-01-24 | 2017-07-25 | Tp Therapeutics, Inc. | Diaryl macrocycles as modulators of protein kinases |
| HRP20230271T1 (hr) | 2014-11-16 | 2023-06-09 | Array Biopharma, Inc. | Kristalni oblik (s)-n-(5-((r)-2-(2,5-difluorofenil)-pirolidin-1-il)-pirazolo[1,5-a]pirimidin-3-il)-3-hidroksipirolidin-1-karboksamid hidrogen sulfata |
| KR102599788B1 (ko) | 2015-07-02 | 2023-11-07 | 터닝 포인트 테라퓨틱스, 인크. | 단백질 키나제의 조절물질로서 키랄 디아릴 매크로사이클 |
| WO2017035354A1 (en) | 2015-08-26 | 2017-03-02 | Blueprint Medicines Corporation | Compounds and compositions useful for treating disorders related to ntrk |
| CA3003153A1 (en) | 2015-10-26 | 2017-05-04 | Loxo Oncology, Inc. | Point mutations in trk inhibitor-resistant cancer and methods relating to the same |
| CN108431008A (zh) | 2015-11-19 | 2018-08-21 | 蓝图药品公司 | 可用于治疗与ntrk相关的病症的化合物和组合物 |
| US10045991B2 (en) | 2016-04-04 | 2018-08-14 | Loxo Oncology, Inc. | Methods of treating pediatric cancers |
| AU2017246554B2 (en) | 2016-04-04 | 2022-08-18 | Loxo Oncology, Inc. | Liquid formulations of (S)-N-(5-((R)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo(1,5-a)pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide |
| PL3800189T3 (pl) | 2016-05-18 | 2023-10-23 | Loxo Oncology, Inc. | Wytwarzanie (s)-n-(5-((r)-2-(2,5-difluorofenylo)pirolidyn-1-ylo)pirazolo[1,5-a]pirymidyn-3-ylo)-3-hydroksypirolidyno-1-karboksyamidu |
| JOP20190092A1 (ar) | 2016-10-26 | 2019-04-25 | Array Biopharma Inc | عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها |
| JP7046940B2 (ja) * | 2016-10-28 | 2022-04-04 | チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッド | 神経栄養因子チロシンキナーゼ受容体阻害剤として用いられるアミノピラゾロピリミジン化合物 |
| MX2019008078A (es) | 2017-02-14 | 2019-11-05 | Res Triangle Inst | Moduladores de receptores neuropeptido basados en prolina. |
| JOP20190213A1 (ar) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | مركبات حلقية ضخمة كمثبطات لكيناز ros1 |
| US10800760B2 (en) | 2017-05-31 | 2020-10-13 | Nantbio, Inc. | Trk inhibition |
| US10738033B2 (en) | 2017-05-31 | 2020-08-11 | Nantbio, Inc. | Trk inhibition |
| EP3700576A1 (en) | 2017-10-26 | 2020-09-02 | Array Biopharma Inc. | Formulations of a macrocyclic trk kinase inhibitor |
| HUE059313T2 (hu) * | 2017-12-15 | 2022-11-28 | Pyramid Biosciences Inc | 5-(2-(2,5-difluorofenil)pirrolidin-1-il)-3-(1H-pirazol-1- il)pirazolo[l,5-A]pirimidin származékok és rokon vegyületek mint TRK kináz inhibitorok a rák kezelésére |
| CN108218754B (zh) * | 2018-01-23 | 2021-05-07 | 广东赛烽医药科技有限公司 | 一种2-(2,5-二氟苯基)吡咯烷的制备方法 |
| WO2019165967A1 (zh) * | 2018-02-28 | 2019-09-06 | 南京明德新药研发有限公司 | 吡唑并嘧啶衍生物及其用途 |
| WO2019174598A1 (en) * | 2018-03-14 | 2019-09-19 | Fochon Pharmaceuticals, Ltd. | SUBSTITUTED (2-AZABICYCLO [3.1.0] HEXAN-2-YL) PYRAZOLO [1, 5-a] PYRIMIDINE AND IMIDAZO [1, 2-b] PYRIDAZINE COMPOUNDS AS TRK KINASES INHIBITORS |
| WO2019191659A1 (en) | 2018-03-29 | 2019-10-03 | Loxo Oncology, Inc. | Treatment of trk-associated cancers |
| CN108484361B (zh) * | 2018-05-11 | 2022-09-30 | 弈柯莱生物科技(上海)股份有限公司 | (s)-4-氯-1-(2,5)-二氟苯基丁-1-醇及其制备方法和应用 |
| WO2019233461A1 (zh) * | 2018-06-08 | 2019-12-12 | 江苏威凯尔医药科技有限公司 | 原肌球蛋白受体激酶抑制剂及其制备方法和应用 |
| CN110577532B (zh) * | 2018-06-08 | 2022-06-03 | 江苏威凯尔医药科技有限公司 | 原肌球蛋白受体激酶抑制剂及其制备方法和应用 |
| CN110294761B (zh) * | 2018-06-08 | 2020-09-08 | 南京雷正医药科技有限公司 | 作为Trk激酶抑制剂的取代的吡唑并[1,5-a]嘧啶化合物 |
| GB201811825D0 (en) | 2018-07-19 | 2018-09-05 | Benevolentai Bio Ltd | Organic compounds |
| CN108794370A (zh) * | 2018-07-31 | 2018-11-13 | 上海弈柯莱生物医药科技有限公司 | 一种拉罗替尼中间体的制备方法 |
| CN110857304B (zh) * | 2018-08-24 | 2021-05-18 | 北京富龙康泰生物技术有限公司 | Trk抑制剂、其制备方法和用途 |
| CN109053525B (zh) * | 2018-09-25 | 2020-05-05 | 成都福柯斯医药技术有限公司 | 一种(r)-2-(2-取代-5-氟苯)吡咯烷的制备方法 |
| JP2022502515A (ja) * | 2018-10-15 | 2022-01-11 | ニンバス ラクシュミ， インコーポレイテッド | Ｔｙｋ２阻害剤およびその使用 |
| CN111138333B (zh) * | 2018-11-02 | 2023-05-23 | 上海复星星泰医药科技有限公司 | 一种(r)-2-(2,5-二氟苯基)-吡咯烷的制备方法 |
| CA3122136A1 (en) * | 2018-12-07 | 2021-06-11 | Betta Pharmaceuticals Co., Ltd | Tyrosine kinase inhibitors, compositions and methods there of |
| CN111302995A (zh) * | 2018-12-12 | 2020-06-19 | 上海复星星泰医药科技有限公司 | 一种2-(2,5-二氟苯基)-吡咯烷消旋体的制备方法 |
| CN109593803A (zh) * | 2018-12-24 | 2019-04-09 | 上海健康医学院 | (r)-2-(2,5-二氟苯基)吡咯烷或其盐的制备方法 |
| CN111362946A (zh) * | 2018-12-25 | 2020-07-03 | 上海度德医药科技有限公司 | 一种药物化合物及其组合物和应用 |
| US20220177477A1 (en) * | 2019-03-19 | 2022-06-09 | Central China Normal University | Pyrazolopyrimidine compound, pharmaceutical composition, and application therefor |
| CA3142088C (en) * | 2019-05-08 | 2023-02-28 | Tyk Medicines, Inc. | Compound used as kinase inhibitor and application thereof |
| CN114258394B (zh) * | 2019-08-28 | 2024-04-23 | 南京再明医药有限公司 | 一种致癌性融合激酶抑制剂的晶型及其应用 |
| CN114641478B (zh) * | 2019-10-30 | 2024-07-02 | 南京再明医药有限公司 | 吡唑并嘧啶类化合物的制备方法及其中间体 |
| CN112979654B (zh) * | 2019-12-16 | 2024-03-19 | 赛诺哈勃药业（成都）有限公司 | 杂芳基稠环化合物、其制备方法及应用 |
| BR112022013156A2 (pt) | 2020-01-22 | 2022-10-18 | Benevolentai Bio Ltd | Composições farmacêuticas e seus usos |
| CN111302997B (zh) * | 2020-04-15 | 2022-03-29 | 江苏恒沛药物科技有限公司 | “一锅法”制备拉罗替尼中间体的方法 |
| MX2022012437A (es) * | 2020-04-15 | 2022-10-27 | Pyramid Biosciences Inc | Metodos para preparar inhibidores del receptor de la tirosina quinasa. |
| CN111393347B (zh) * | 2020-04-30 | 2020-11-17 | 安徽德信佳生物医药有限公司 | 一种拉洛替尼中间体的合成方法 |
| WO2021249450A1 (zh) * | 2020-06-11 | 2021-12-16 | 贝达药业股份有限公司 | 酪氨酸激酶抑制剂的盐型、晶型、药物组合物及其用途 |
| CN114437075A (zh) * | 2020-11-03 | 2022-05-06 | 上海瑶琪生物科技有限公司 | 用作ntrk激酶抑制剂的化合物及其应用 |
| KR102541026B1 (ko) | 2020-11-11 | 2023-06-12 | 주식회사 한독 | Trk 억제제 화합물의 제조 방법 |
| CN116102464B (zh) * | 2021-11-10 | 2024-11-05 | 凯特立斯（深圳）科技有限公司 | 一种不对称氢化制备氨基醇的方法及其应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2010012457A (es) | 2008-05-13 | 2010-12-07 | Irm Llc | Heterociclos que contienen nitrogeno fusionado y composiciones de los mismos como inhibidores de cinasa. |
| MY169791A (en) | 2008-10-22 | 2019-05-15 | Array Biopharma Inc | Substituted pyrazolo [1,5-a] pyrimidine compounds as trk kinase inhibitors |
| CN102271515B (zh) * | 2008-10-31 | 2014-07-02 | 健泰科生物技术公司 | 吡唑并嘧啶jak抑制剂化合物和方法 |
| AR077468A1 (es) * | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa |
| US8865726B2 (en) | 2009-09-03 | 2014-10-21 | Array Biopharma Inc. | Substituted pyrazolo[1,5-a]pyrimidine compounds as mTOR inhibitors |
| SI3205654T1 (sl) * | 2010-05-20 | 2019-07-31 | Array Biopharma, Inc. | Makrociklične spojine kot inhibitorji TRK kinaze |
| WO2012034095A1 (en) | 2010-09-09 | 2012-03-15 | Irm Llc | Compounds and compositions as trk inhibitors |
| US8946415B2 (en) * | 2012-03-09 | 2015-02-03 | Lexicon Pharmaceuticals, Inc. | Pyrazolo[1,5-a]pyrimidine-based compounds, compositions comprising them, and methods of their use |
-
2015
- 2015-12-14 WO PCT/IB2015/002521 patent/WO2016097869A1/en active Application Filing
- 2015-12-14 FI FIEP15869420.8T patent/FI3233863T3/fi active
- 2015-12-14 ES ES15869420T patent/ES2983908T3/es active Active
- 2015-12-14 DK DK15869420.8T patent/DK3233863T3/da active
- 2015-12-14 EP EP15869420.8A patent/EP3233863B1/en active Active
- 2015-12-14 BR BR112017012755-5A patent/BR112017012755B1/pt active IP Right Grant
- 2015-12-14 EP EP24169331.6A patent/EP4420732A2/en active Pending
- 2015-12-14 CA CA2971024A patent/CA2971024C/en active Active
- 2015-12-14 CN CN201580075880.1A patent/CN107207514B/zh active Active
- 2015-12-14 JP JP2017533343A patent/JP6609631B2/ja active Active
- 2015-12-14 RU RU2017125025A patent/RU2708674C2/ru active
- 2015-12-14 KR KR1020177018519A patent/KR102659741B1/ko active IP Right Grant
- 2015-12-14 HR HRP20240937TT patent/HRP20240937T1/hr unknown
- 2015-12-14 US US14/968,208 patent/US9701681B2/en active Active
- 2015-12-14 KR KR1020247012821A patent/KR20240055170A/ko active Search and Examination
- 2015-12-14 AU AU2015365587A patent/AU2015365587B2/en active Active
- 2015-12-14 MX MX2017007748A patent/MX2017007748A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2708674C2 (ru) | 2019-12-11 |
| CN107207514A (zh) | 2017-09-26 |
| KR102659741B1 (ko) | 2024-04-23 |
| RU2017125025A3 (da) | 2019-06-21 |
| CA2971024C (en) | 2023-09-26 |
| FI3233863T3 (fi) | 2024-07-10 |
| JP2017538766A (ja) | 2017-12-28 |
| EP3233863B1 (en) | 2024-04-10 |
| EP4420732A2 (en) | 2024-08-28 |
| HRP20240937T1 (hr) | 2024-10-25 |
| AU2015365587A1 (en) | 2017-08-03 |
| KR20240055170A (ko) | 2024-04-26 |
| AU2015365587B2 (en) | 2020-07-23 |
| RU2017125025A (ru) | 2019-01-17 |
| US9701681B2 (en) | 2017-07-11 |
| ES2983908T3 (es) | 2024-10-28 |
| KR20170095919A (ko) | 2017-08-23 |
| MX2017007748A (es) | 2018-01-30 |
| BR112017012755A2 (pt) | 2017-12-26 |
| CN107207514B (zh) | 2020-01-24 |
| CA2971024A1 (en) | 2016-06-23 |
| WO2016097869A1 (en) | 2016-06-23 |
| BR112017012755B1 (pt) | 2023-11-14 |
| EP3233863A4 (en) | 2018-06-06 |
| JP6609631B2 (ja) | 2019-11-20 |
| US20160168156A1 (en) | 2016-06-16 |
| EP3233863A1 (en) | 2017-10-25 |
| WO2016097869A4 (en) | 2016-08-04 |
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