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DK3224268T3 - Nye 2'- og/eller 5'-aminosyreesterphosphoramidat 3'-deoxyadenosinderivater som anti-cancerforbindelser - Google Patents

Nye 2'- og/eller 5'-aminosyreesterphosphoramidat 3'-deoxyadenosinderivater som anti-cancerforbindelser Download PDF

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Publication number
DK3224268T3
DK3224268T3 DK15804216.8T DK15804216T DK3224268T3 DK 3224268 T3 DK3224268 T3 DK 3224268T3 DK 15804216 T DK15804216 T DK 15804216T DK 3224268 T3 DK3224268 T3 DK 3224268T3
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DK
Denmark
Prior art keywords
sterphosphoramidate
deoxyadenosin
derivatives
new
amino acid
Prior art date
Application number
DK15804216.8T
Other languages
English (en)
Inventor
Hugh Griffith
Christopher Mcguigan
Valentina Ferrari
Michaela Serpi
Antunez Carmen Jimenez
Original Assignee
NuCana plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54771155&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK3224268(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB1421211.2A external-priority patent/GB201421211D0/en
Priority claimed from GBGB1519316.2A external-priority patent/GB201519316D0/en
Application filed by NuCana plc filed Critical NuCana plc
Application granted granted Critical
Publication of DK3224268T3 publication Critical patent/DK3224268T3/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/173—Purine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DK15804216.8T 2014-11-28 2015-11-27 Nye 2'- og/eller 5'-aminosyreesterphosphoramidat 3'-deoxyadenosinderivater som anti-cancerforbindelser DK3224268T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1421211.2A GB201421211D0 (en) 2014-11-28 2014-11-28 Chemical compounds
GBGB1519316.2A GB201519316D0 (en) 2015-11-02 2015-11-02 Chemical compounds
PCT/GB2015/053628 WO2016083830A1 (en) 2014-11-28 2015-11-27 New 2' and/or 5' amino-acid ester phosphoramidate 3'-deoxy adenosine derivatives as anti-cancer compounds

Publications (1)

Publication Number Publication Date
DK3224268T3 true DK3224268T3 (da) 2019-09-02

Family

ID=54771155

Family Applications (1)

Application Number Title Priority Date Filing Date
DK15804216.8T DK3224268T3 (da) 2014-11-28 2015-11-27 Nye 2'- og/eller 5'-aminosyreesterphosphoramidat 3'-deoxyadenosinderivater som anti-cancerforbindelser

Country Status (25)

Country Link
US (3) US10570168B2 (da)
EP (2) EP3224268B1 (da)
JP (2) JP6646668B2 (da)
KR (2) KR102548806B1 (da)
CN (2) CN107207554B (da)
AU (2) AU2015352203B2 (da)
CA (1) CA2962373C (da)
CL (1) CL2017001336A1 (da)
CY (1) CY1122074T1 (da)
DK (1) DK3224268T3 (da)
EA (1) EA031727B1 (da)
ES (1) ES2742167T3 (da)
HR (1) HRP20191461T1 (da)
HU (1) HUE046850T2 (da)
IL (4) IL291927A (da)
LT (1) LT3224268T (da)
ME (1) ME03462B (da)
MX (3) MX2017006942A (da)
PH (1) PH12017500944A1 (da)
PL (1) PL3224268T3 (da)
PT (1) PT3224268T (da)
RS (1) RS59264B1 (da)
SG (2) SG10202009020VA (da)
SI (1) SI3224268T1 (da)
WO (1) WO2016083830A1 (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2681227B1 (en) 2011-03-01 2016-02-10 Nucana Biomed Limited Phosphoramidate derivatives of 5-fluoro-2'-deoxyuridine for use in the treatment of cancer
PL3224268T3 (pl) * 2014-11-28 2019-11-29 NuCana plc Nowe pochodne 3'-deoksyadenozyny amidofosforanów estrów aminokwasów 2' i/lub 5' jako związki przeciwnowotworowe
GB201522764D0 (en) * 2015-12-23 2016-02-03 Nucana Biomed Ltd Formulations of phosphate derivatives
GB201609600D0 (en) * 2016-06-01 2016-07-13 Nucuna Biomed Ltd Cancer treatments
GB201609601D0 (en) * 2016-06-01 2016-07-13 Nucana Biomed Ltd Phosphoramidate compounds
GB201709471D0 (en) * 2017-06-14 2017-07-26 Nucana Biomed Ltd Diastereoselective synthesis of hosphate derivatives
GB201720279D0 (en) 2017-12-05 2018-01-17 Nucana Biomed Ltd Anticancer compounds
CN110669088B (zh) * 2018-07-02 2023-03-28 成都阿奇生物医药科技有限公司 N-(2-乙基胺)苯磺酰胺基虫草素衍生物及其制备方法和应用
GB201904544D0 (en) 2019-04-01 2019-05-15 NuCana plc Anticancer compounds
CN111888373A (zh) * 2019-05-05 2020-11-06 上海医药集团股份有限公司 一种虫草素或其药学上可接受的盐的应用
WO2023218202A2 (en) 2022-05-12 2023-11-16 NuCana plc Cancer treatment
CN115181148B (zh) * 2022-07-12 2023-07-14 南京工业大学 一种基于虫草素经衍生化具有抗肿瘤效应的化合物
GB2627905A (en) * 2022-07-12 2024-09-04 Nanjing University Of Technology Cordycepin-derivatized compound with anti-tumor effect

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4357324A (en) 1981-02-24 1982-11-02 The United States Of America As Represented By The Department Of Health And Human Services Prodrug derivatives of 9β-D-arabinofuranosyl-2-fluoroadenine
GB0317009D0 (en) 2003-07-21 2003-08-27 Univ Cardiff Chemical compounds
CA2589935A1 (en) * 2004-12-09 2006-06-15 Regents Of The University Of Minnesota Nucleosides with antiviral and anticancer activity
GB0505781D0 (en) 2005-03-21 2005-04-27 Univ Cardiff Chemical compounds
WO2006121820A1 (en) * 2005-05-05 2006-11-16 Valeant Research & Development Phosphoramidate prodrugs for treatment of viral infection
GB0623493D0 (en) 2006-11-24 2007-01-03 Univ Cardiff Chemical compounds
JP2012514657A (ja) 2009-01-09 2012-06-28 ユニバーシテイ・カレツジ・オブ・カーデイフ・コンサルタンツ・リミテツド ウィルス感染を治療するためのグアノシンヌクレオシド化合物のホスホルアミダート誘導体
KR101774429B1 (ko) 2009-02-06 2017-09-04 코크리스탈 파마, 아이엔씨. 암 및 바이러스 감염 치료용 퓨린 뉴클레오시드 모노포스페이트 프로드럭
AU2010226466A1 (en) 2009-03-20 2011-10-20 Alios Biopharma, Inc. Substituted nucleoside and nucleotide analogs
CN103052646A (zh) 2010-07-19 2013-04-17 吉里德科学公司 用于制备非对映异构体纯氨基磷酸酯前药的方法
US20120070411A1 (en) * 2010-09-22 2012-03-22 Alios Biopharma, Inc. Substituted nucleotide analogs
EA025341B1 (ru) 2010-09-22 2016-12-30 Алиос Биофарма, Инк. Замещенные аналоги нуклеотидов
GB201016855D0 (en) 2010-10-06 2010-11-17 Nucana Biomed Ltd Chemical compounds
EP2681227B1 (en) 2011-03-01 2016-02-10 Nucana Biomed Limited Phosphoramidate derivatives of 5-fluoro-2'-deoxyuridine for use in the treatment of cancer
EP2776438A4 (en) * 2011-11-10 2015-04-29 Inhibitex Inc SUBSTITUTED PURIN NUCLEOSIDES, PHOSPHORAMIDATE AND PHOSPHORDIAMIDATE DERIVATIVES FOR THE TREATMENT OF VIRUS INFECTIONS
PL3043803T3 (pl) * 2013-09-11 2022-11-07 Emory University Kompozycje nukleotydowe i nukleozydowe oraz ich zastosowanie
BR112016011949A8 (pt) 2013-11-27 2020-04-28 Idenix Pharmaceuticals Llc composto, composição farmacêutica, e, uso dos mesmos”
ES2655820T3 (es) 2014-06-25 2018-02-21 NuCana plc Formulación que comprende un profármaco de gemcitabina
CN105646629A (zh) 2014-11-25 2016-06-08 广州市恒诺康医药科技有限公司 L-核苷类化合物及其应用
PL3224268T3 (pl) 2014-11-28 2019-11-29 NuCana plc Nowe pochodne 3'-deoksyadenozyny amidofosforanów estrów aminokwasów 2' i/lub 5' jako związki przeciwnowotworowe
WO2016145142A1 (en) 2015-03-10 2016-09-15 Emory University Nucleotide and nucleoside therapeutics compositions and uses related thereto
EA201792509A1 (ru) 2015-05-14 2018-05-31 НУКАНА ПиЭлСи Лечение рака
GB201522764D0 (en) 2015-12-23 2016-02-03 Nucana Biomed Ltd Formulations of phosphate derivatives
GB201609600D0 (en) 2016-06-01 2016-07-13 Nucuna Biomed Ltd Cancer treatments
GB201609601D0 (en) 2016-06-01 2016-07-13 Nucana Biomed Ltd Phosphoramidate compounds
GB201609602D0 (en) 2016-06-01 2016-07-13 Nucuna Biomed Ltd Chemical compounds
GB201709471D0 (en) 2017-06-14 2017-07-26 Nucana Biomed Ltd Diastereoselective synthesis of hosphate derivatives
GB201720279D0 (en) 2017-12-05 2018-01-17 Nucana Biomed Ltd Anticancer compounds

Also Published As

Publication number Publication date
US20170253629A1 (en) 2017-09-07
HUE046850T2 (hu) 2020-03-30
US20200181189A1 (en) 2020-06-11
JP2017535587A (ja) 2017-11-30
BR112017011187A2 (pt) 2018-01-02
WO2016083830A1 (en) 2016-06-02
CN107207554B (zh) 2020-09-11
SG10202009020VA (en) 2020-10-29
AU2015352203B2 (en) 2019-08-15
EA201791182A1 (ru) 2017-09-29
CL2017001336A1 (es) 2017-12-15
MX2022008744A (es) 2022-07-27
IL291927A (en) 2022-06-01
NZ730919A (en) 2021-02-26
EA031727B1 (ru) 2019-02-28
RS59264B1 (sr) 2019-10-31
IL276109B (en) 2022-05-01
EP3224268B1 (en) 2019-06-26
CY1122074T1 (el) 2020-11-25
IL292062A (en) 2022-06-01
PL3224268T3 (pl) 2019-11-29
CN111909231A (zh) 2020-11-10
JP6646668B2 (ja) 2020-02-14
ES2742167T3 (es) 2020-02-13
US11352387B2 (en) 2022-06-07
IL251353A0 (en) 2017-05-29
ME03462B (me) 2020-01-20
MX2020010375A (es) 2022-07-19
NZ767066A (en) 2022-03-25
CA2962373C (en) 2023-04-25
SI3224268T1 (sl) 2019-10-30
AU2019232929A1 (en) 2019-10-10
CA2962373A1 (en) 2016-06-02
EP3224268A1 (en) 2017-10-04
SG11201702369UA (en) 2017-04-27
MX2017006942A (es) 2017-08-24
KR102548806B1 (ko) 2023-06-27
LT3224268T (lt) 2019-09-25
IL276109A (en) 2020-08-31
AU2015352203A1 (en) 2017-04-27
US12054510B2 (en) 2024-08-06
CN107207554A (zh) 2017-09-26
KR20230098915A (ko) 2023-07-04
AU2019232929B2 (en) 2020-09-10
JP6978524B2 (ja) 2021-12-08
PH12017500944A1 (en) 2017-11-20
HRP20191461T1 (hr) 2019-11-15
KR20170087465A (ko) 2017-07-28
US10570168B2 (en) 2020-02-25
IL292062B2 (en) 2023-06-01
IL251353B (en) 2020-08-31
US20220306675A1 (en) 2022-09-29
EP3683225A1 (en) 2020-07-22
JP2020075928A (ja) 2020-05-21
PT3224268T (pt) 2019-09-04

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