DK321688A - Heterocykliske forbindelser - Google Patents

Heterocykliske forbindelser

Info

Publication number: DK321688A
Authority: DK; Denmark
Prior art keywords: heterocyclic compounds; heterocyclic; compounds
Prior art date: 1987-06-24

Application number

DK321688A

Other languages

English (en)

Other versions

DK321688D0 (da

DK168600B1 (da

Inventor

Klaus Peter Boegesoe

Klaus Gundertofte Jensen

Ejner Knud Moltzen

Henrik Pedersen

Original Assignee

Lundbeck & Co As H

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-06-24

Filing date

1988-06-13

Publication date

1988-12-25

1988-06-13 Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H

1988-06-13 Publication of DK321688D0 publication Critical patent/DK321688D0/da

1988-12-25 Publication of DK321688A publication Critical patent/DK321688A/da

1994-05-02 Application granted granted Critical

1994-05-02 Publication of DK168600B1 publication Critical patent/DK168600B1/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurology (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

DK321688A 1987-06-24 1988-06-13 Piperidin-3-yl eller (1,2,5,6-tetrahydro-pyrid-3-yl)-substituerede heterocykliske forbindelser, farmaceutiske kompositioner deraf, og fremgangsmåder til deres fremstilling DK168600B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB878714789A GB8714789D0 (en)	1987-06-24	1987-06-24	Heterocyclic compounds
GB8714789		1987-06-24

Publications (3)

Publication Number	Publication Date
DK321688D0 DK321688D0 (da)	1988-06-13
DK321688A true DK321688A (da)	1988-12-25
DK168600B1 DK168600B1 (da)	1994-05-02

Family

ID=10619472

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK321688A DK168600B1 (da)	1987-06-24	1988-06-13	Piperidin-3-yl eller (1,2,5,6-tetrahydro-pyrid-3-yl)-substituerede heterocykliske forbindelser, farmaceutiske kompositioner deraf, og fremgangsmåder til deres fremstilling

Country Status (19)

Country	Link
US (3)	US4866077A (da)
EP (1)	EP0296721B1 (da)
JP (1)	JP2703268B2 (da)
AU (1)	AU615917B2 (da)
BR (1)	BR1100658A (da)
CA (1)	CA1340458C (da)
DE (1)	DE3881970T2 (da)
DK (1)	DK168600B1 (da)
ES (1)	ES2056928T3 (da)
FI (1)	FI93356C (da)
GB (1)	GB8714789D0 (da)
HK (1)	HK84194A (da)
HU (1)	HU210809A9 (da)
IE (1)	IE61694B1 (da)
IL (1)	IL86618A (da)
NO (1)	NO174051C (da)
NZ (1)	NZ224868A (da)
PT (1)	PT87820B (da)
ZA (1)	ZA884339B (da)

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ES2053748T3 (es) *	1987-09-10	1994-08-01	Merck Sharp & Dohme	Oxazoles y tiazoles para el tratamiento de la demencia senil.
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US5328925A (en) *	1989-02-22	1994-07-12	Novo Nordisk A/S	Piperidine compounds and their use
US5043345A (en) *	1989-02-22	1991-08-27	Novo Nordisk A/S	Piperidine compounds and their preparation and use
US5260311A (en) *	1989-02-22	1993-11-09	Novo Nordisk A/S	Piperidine compounds and their use
US5264444A (en) *	1989-02-22	1993-11-23	Novo Nordisk A/S	Piperidine compounds and use
EP0402056A3 (en) *	1989-06-06	1991-09-04	Beecham Group p.l.c.	Azabicyclic compounds, process for their preparation and pharmaceutical compositions containing them
ATE136031T1 (de) *	1989-10-07	1996-04-15	Beecham Group Plc	Azabizyklische verbindungen, verfahren und zwischenprodukte zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen
US5200419A (en) *	1990-05-21	1993-04-06	Warner-Lambert Company	Substituted tetrazoles and derivatives thereof acting at muscarinic receptors
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US5376668A (en) *	1990-08-21	1994-12-27	Novo Nordisk A/S	Heterocyclic compounds
DK198590D0 (da) *	1990-08-21	1990-08-21	Novo Nordisk As	Heterocykliske forbindelser, deres fremstilling og anvendelse
USRE35822E (en) *	1990-08-21	1998-06-09	Novo Nordisk A/S	Heterocyclic compounds
US5418240A (en) *	1990-08-21	1995-05-23	Novo Nordisk A/S	Heterocyclic compounds and their preparation and use
DK198490D0 (da) *	1990-08-21	1990-08-21	Novo Nordisk As	Heterocykliske forbindelser, deres fremstilling og anvendelse
DK198390D0 (da) *	1990-08-21	1990-08-21	Novo Nordisk As	Heterocykliske forbindelser, deres fremstilling og anvendelse
US5527813A (en) *	1990-08-21	1996-06-18	Novo Nordisk A/S	Heterocyclic compounds and their preparation and use
ES2113939T3 (es) *	1990-11-29	1998-05-16	Allergan Inc	Uso de derivados de piridina en el tratamiento de la hipertension ocular.
AU654013B2 (en) *	1991-03-13	1994-10-20	Regents Of The University Of Minnesota	2-hydroxy-3(4-iodophenyl)-1-(4-phenylpiperidinyl) propane
IE922270A1 (en) *	1991-07-26	1993-01-27	Akzo Nv	Pyrazole derivatives
US5641791A (en) *	1991-08-13	1997-06-24	Novo Nordisk A.S	Heterocyclic compounds and their preparation and use
US5175166A (en) *	1991-08-27	1992-12-29	The University Of Toledo	Muscarinic agonists
WO1993014089A1 (en) *	1992-01-13	1993-07-22	Novo Nordisk A/S	Heterocyclic compounds and their preparation and use
US5330994A (en) *	1992-03-24	1994-07-19	Warner-Lambert Company	Tetrahydropyridine isoxazoline derivatives
DE69325662T2 (de) *	1992-10-23	2000-02-10	Merck Sharp & Dohme Ltd., Hoddesdon	Dopamin rezeptor subtyp liganden
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US5612351A (en) *	1994-11-08	1997-03-18	Novo Nordisk A/S	Method of treating urinary bladder dysfunctions
US5668148A (en) *	1995-04-20	1997-09-16	Merck & Co., Inc.	Alpha1a adrenergic receptor antagonists
JPH11508539A (ja) *	1995-06-29	1999-07-27	ノボノルディスクアクティーゼルスカブ	新規の置換アザ環式化合物
EA000531B1 (ru) *	1995-11-06	1999-10-28	Х.Лундбекк А/С	Активное вещество при производстве фармацевтического препарата для лечения травматического повреждения головного мозга
EP0910566B1 (en) *	1996-04-24	2003-09-17	Novo Nordisk A/S	Heterocyclic compounds and their preparation and use
US5733912A (en) *	1997-02-19	1998-03-31	Abbott Laboratories	7A-heterocycle substituted hexahydro-1H-pyrrolizine compounds useful in controlling chemical synaptic transmission
WO1998053820A1 (en) *	1997-05-29	1998-12-03	H. Lundbeck A/S	Treatment of schizophrenia and psychosis
AR013096A1 (es) *	1997-07-01	2000-12-13	Lundbeck & Co As H	Sal de adicion de acido maleico de 5-(2-etil-2-h-tetrazol-5-il)-1-metil- 1,2,3,6-tetrahidropiridina, composicion farmaceutica que la contiene, su usoen terapia y metodo de preparacion de la misma.
AU9432498A (en) *	1997-10-02	1999-04-27	H. Lundbeck A/S	Granular preparations of 5-(2-ethyl- 2(h)-tetrazol- 5-yl)-1-methyl-1, 2,3,6-tetrahydropyridine
BR9913348A (pt) *	1998-07-27	2001-06-12	Lilly Co Eli	Tratamento dos distúrbios da ansiedade
AU6686700A (en) *	1999-08-23	2001-03-19	H. Lundbeck A/S	Treatment of urinary incontinence
US20030220371A1 (en) *	2000-04-12	2003-11-27	Kallander Lara S.	Compounds and methods
MXPA03008089A (es) *	2001-04-05	2004-01-22	Torrent Pharmaceuticals Ltd	Compuestos heterociclicos para complicaciones relacionadas con el envejecimiento y vasculares diabeticas.
US20030069597A1 (en) *	2001-10-10	2003-04-10	Scimed Life Systems, Inc.	Loading tool
IL162079A0 (en) *	2001-11-19	2005-11-20	Upjohn Co	3,4-Disubstituted, 3,5-disubstituted and substituted and 3,4,5-substituted piperidines and piperazines
JP2006511621A (ja)	2002-12-18	2006-04-06	エフ　エム　シー　コーポレーション	Ｎ―（置換アリールメチル）―４―（二置換メチル）ピペリジン及びピペラジン
CA2509212A1 (en) *	2002-12-20	2004-07-15	Merck & Co., Inc.	Mitotic kinesin inhibitors
CA2556589A1 (en) *	2004-02-24	2005-09-01	Bioaxone Therapeutique Inc.	4-substituted piperidine derivatives
US20060224175A1 (en) *	2005-03-29	2006-10-05	Vrba Anthony C	Methods and apparatuses for disposition of a medical device onto an elongate medical device
US7678363B2 (en) *	2005-08-26	2010-03-16	Braincells Inc	Methods of treating psychiatric conditions comprising administration of muscarinic agents in combination with SSRIs
EP2258359A3 (en)	2005-08-26	2011-04-06	Braincells, Inc.	Neurogenesis by muscarinic receptor modulation with sabcomelin
EP1940389A2 (en)	2005-10-21	2008-07-09	Braincells, Inc.	Modulation of neurogenesis by pde inhibition
US20070112017A1 (en)	2005-10-31	2007-05-17	Braincells, Inc.	Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en)	2006-03-08	2010-08-26	Braincells, Inc.	Modulation of neurogenesis by nootropic agents
WO2007134136A2 (en)	2006-05-09	2007-11-22	Braincells, Inc.	Neurogenesis by modulating angiotensin
AU2007249435A1 (en)	2006-05-09	2007-11-22	Braincells, Inc.	5 HT receptor mediated neurogenesis
EP2068872A1 (en)	2006-09-08	2009-06-17	Braincells, Inc.	Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en)	2006-09-19	2010-07-22	Braincells, Inc.	Modulation of neurogenesis by ppar agents
US8084473B2 (en)	2007-04-24	2011-12-27	Solvay Pharmaceuticals B.V.	Heterocyclic compounds with affinity to muscarinic receptors
AU2008240704A1 (en) *	2007-04-24	2008-10-30	Solvay Pharmaceuticals B.V.	Heterocyclic compounds with affinity to muscarinic receptors
US20110294835A1 (en)	2008-05-15	2011-12-01	The Board Of Trustees Of The University Of Illinois	Muscarinic Agonists as Cognitive Enhancers
US20100216805A1 (en)	2009-02-25	2010-08-26	Braincells, Inc.	Modulation of neurogenesis using d-cycloserine combinations
TW201102380A (en) *	2009-05-07	2011-01-16	Torrent Pharmaceuticals Ltd	Novel heterocyclic compounds
EP2593447B1 (de)	2010-07-15	2016-08-17	Bayer Intellectual Property GmbH	3-pyridyl-heteroarylcarboxamidverbindungen als schädlingsbekämpfungsmittel
BR112013009823A2 (pt)	2010-10-22	2016-07-05	Bayer Ip Gmbh	novos compostos heterocíclicos como pesticidas
WO2012149524A1 (en)	2011-04-29	2012-11-01	The University Of Toledo	Muscarinic agonists as enhancers of working memory and cognitive flexibility
CN103848850B (zh) *	2013-08-28	2016-03-23	沈阳东瑞精细化工有限公司	一种舒巴坦的制备方法
US10106525B2 (en)	2015-01-26	2018-10-23	BioAxone BioSciences, Inc.	Rho kinase inhibitor BA-1049 (R) and active metabolites thereof
US10149856B2 (en)	2015-01-26	2018-12-11	BioAxone BioSciences, Inc.	Treatment of cerebral cavernous malformations and cerebral aneurysms with rho kinase inhibitors
US10857157B2 (en)	2015-01-26	2020-12-08	BioAxone BioSciences, Inc.	Treatment of cerebral cavernous malformations and cerebral aneurysms with rho kinase inhibitors
US11198680B2 (en)	2016-12-21	2021-12-14	BioAxone BioSciences, Inc.	Rho kinase inhibitor BA-1049 (R) and active metabolites thereof
WO2019014322A1 (en)	2017-07-11	2019-01-17	BioAxone BioSciences, Inc.	KINASE INHIBITORS FOR THE TREATMENT OF DISEASES

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US2659739A (en)	1950-04-14	1953-11-17	Eastman Kodak Co	1-hydroxy-4-beta-cyanopropylamino-anthraquinone and process for preparing same
BE845612A (fr) *	1976-03-23	1977-02-28		Derives de tetrazole-5-carboxamide et leur preparation
US4431653A (en) *	1982-03-18	1984-02-14	Hoffmann-La Roche Inc.	Penicillanic acid derivatives
DE3421072A1 (de) *	1984-06-06	1985-12-12	Heinrich Mack Nachf., 7918 Illertissen	1,4:3,6-dianhydro-hexit-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4650805A (en) *	1985-12-02	1987-03-17	Warner-Lambert Company	4-(1,2,5,6-Tetrahydro-1-alkyl-3-pyridinyl)-2-thiazolamines and 4-(hexahydro-1-alkyl-3-pyridinyl)-2-thiazolamines having anti-psychotic activity
NZ219646A (en) *	1986-03-27	1990-10-26	Merck Sharp & Dohme	Oxadiazole derivatives of azacyclics for treating cns disorders
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IL83275A (en) *	1986-09-08	1994-02-27	Novo Nordisk As	Compounds 1,2, 4-Oxadiazolyl Pipridine Transformed, their preparation and pharmaceutical preparations containing them
IE63906B1 (en) *	1987-11-13	1995-06-14	Novo Nordisk As	Azabicyclic compounds and their preparation and use
EP0372125A1 (en) *	1988-11-08	1990-06-13	Akzo N.V.	Oxazole and thiazole derivatives

1987
- 1987-06-24 GB GB878714789A patent/GB8714789D0/en active Pending
1988
- 1988-05-27 EP EP88304899A patent/EP0296721B1/en not_active Expired - Lifetime
- 1988-05-27 ES ES88304899T patent/ES2056928T3/es not_active Expired - Lifetime
- 1988-05-27 DE DE88304899T patent/DE3881970T2/de not_active Expired - Lifetime
- 1988-05-30 IE IE163188A patent/IE61694B1/en not_active IP Right Cessation
- 1988-06-01 NZ NZ224868A patent/NZ224868A/en unknown
- 1988-06-03 IL IL86618A patent/IL86618A/xx not_active IP Right Cessation
- 1988-06-13 DK DK321688A patent/DK168600B1/da not_active IP Right Cessation
- 1988-06-17 ZA ZA884339A patent/ZA884339B/xx unknown
- 1988-06-22 US US07/209,994 patent/US4866077A/en not_active Ceased
- 1988-06-22 CA CA000570135A patent/CA1340458C/en not_active Expired - Lifetime
- 1988-06-23 AU AU18282/88A patent/AU615917B2/en not_active Expired
- 1988-06-23 NO NO882799A patent/NO174051C/no not_active IP Right Cessation
- 1988-06-23 FI FI883064A patent/FI93356C/fi active IP Right Grant
- 1988-06-24 PT PT87820A patent/PT87820B/pt not_active IP Right Cessation
- 1988-06-24 JP JP63155095A patent/JP2703268B2/ja not_active Expired - Lifetime
1989
- 1989-04-26 US US07/343,848 patent/US4925858A/en not_active Expired - Lifetime
1994
- 1994-08-18 HK HK84194A patent/HK84194A/xx not_active IP Right Cessation
1995
- 1995-03-08 HU HU95P/P00089P patent/HU210809A9/hu unknown
1996
- 1996-05-13 US US08/648,240 patent/USRE36374E/en not_active Expired - Lifetime
1997
- 1997-05-07 BR BR1100658-7A patent/BR1100658A/pt active IP Right Grant

Also Published As

Publication number	Publication date
FI883064A0 (fi)	1988-06-23
ES2056928T3 (es)	1994-10-16
NO174051B (no)	1993-11-29
AU615917B2 (en)	1991-10-17
CA1340458C (en)	1999-03-23
US4925858A (en)	1990-05-15
FI883064A (fi)	1988-12-25
DE3881970T2 (de)	1993-11-11
DK321688D0 (da)	1988-06-13
ZA884339B (en)	1989-05-30
FI93356B (fi)	1994-12-15
EP0296721B1 (en)	1993-06-23
NO882799L (no)	1988-12-27
DK168600B1 (da)	1994-05-02
IL86618A0 (en)	1988-11-30
NO882799D0 (no)	1988-06-23
AU1828288A (en)	1989-01-05
IE881631L (en)	1988-12-24
HU210809A9 (en)	1995-08-28
JP2703268B2 (ja)	1998-01-26
USRE36374E (en)	1999-11-02
NZ224868A (en)	1990-07-26
PT87820B (pt)	1992-10-30
FI93356C (fi)	1995-03-27
IE61694B1 (en)	1994-11-16
US4866077A (en)	1989-09-12
EP0296721A2 (en)	1988-12-28
PT87820A (pt)	1989-05-31
NO174051C (no)	1994-03-09
HK84194A (en)	1994-08-26
DE3881970D1 (de)	1993-07-29
GB8714789D0 (en)	1987-07-29
BR1100658A (pt)	1999-08-31
JPS6422869A (en)	1989-01-25
IL86618A (en)	1992-07-15
EP0296721A3 (en)	1990-04-25

Publication	Publication Date	Title
DK321688D0 (da)	1988-06-13	Heterocykliske forbindelser
DK93887A (da)	1987-08-26	Heterocycliske forbindelser
FI96203C (fi)	1996-05-27	Heterosyklisiä yhdisteitä
DK85993A (da)	1993-07-20	2-anilino-4-formyl-pyrimidinforbindelser
BA98296A (bs)	2001-09-14	Piperazinil-heterociklicna jedinjenja
DK517989D0 (da)	1989-10-18	Heterocykliske forbindelser
LV10443A (lv)	1995-02-20	Heterocikliskie savienojumi
DK287688D0 (da)	1988-05-25	Heterocycliske forbindelser
NO168305C (no)	1992-02-05	Heterocykliske forbindelser
BR9006799A (pt)	1991-08-06	Compostos heterociclicos
DK227487A (da)	1987-11-04	Substituerede heterocycliske forbindelser
DK64788A (da)	1988-08-11	Heterocycliske forbindelser
PT86766A (pt)	1988-03-01	Arylpiperazinyl-alkylene-phenyl-heterocyclic compounds
PT87657A (pt)	1988-07-01	Novel heterocyclic pesticidal compounds
DK499987D0 (da)	1987-09-23	Heterocycliske forbindelser
IT1221792B (it)	1990-07-12	Composti metossimetilici
IT8721345A0 (it)	1987-07-20	Perossiacidi eterociclici
DK507289D0 (da)	1989-10-12	Heterocykliske forbindelser
DK429588A (da)	1989-02-04	Heterocykliske forbindelser
DK343587D0 (da)	1987-07-03	Acylerede heterocycliske forbindelser
DK45887D0 (da)	1987-01-28	Heterocykliske forbindelser
DK565289A (da)	1990-05-12	Heterocykliske forbindelser
LV5744A4 (lv)	1996-10-20	Heterocikliskie savienojumi
NO930427D0 (no)	1993-02-08	Heterocykliske forbindelser
NO892041D0 (no)	1989-05-22	Heterocykliske forbindelser.

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Date	Code	Title	Description
1994-05-02	B1	Patent granted (law 1993)
2008-06-30	PUP	Patent expired