DK3262161T3 - Rekombinante værtsceller til fremstilling af 3-hydroxypropionsyre - Google Patents
Rekombinante værtsceller til fremstilling af 3-hydroxypropionsyre Download PDFInfo
- Publication number
- DK3262161T3 DK3262161T3 DK16710370.4T DK16710370T DK3262161T3 DK 3262161 T3 DK3262161 T3 DK 3262161T3 DK 16710370 T DK16710370 T DK 16710370T DK 3262161 T3 DK3262161 T3 DK 3262161T3
- Authority
- DK
- Denmark
- Prior art keywords
- production
- host cells
- recombinant host
- hydroxypropionic acid
- hydroxypropionic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01081—Hydroxypyruvate reductase (1.1.1.81)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562126377P | 2015-02-27 | 2015-02-27 | |
| PCT/US2016/019629 WO2016138303A1 (en) | 2015-02-27 | 2016-02-25 | Mutant host cells for the production of 3-hydroxypropionic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3262161T3 true DK3262161T3 (da) | 2021-09-13 |
Family
ID=55538611
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16710370.4T DK3262161T3 (da) | 2015-02-27 | 2016-02-25 | Rekombinante værtsceller til fremstilling af 3-hydroxypropionsyre |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US10358664B2 (da) |
| EP (1) | EP3262161B1 (da) |
| CN (1) | CN107406821B (da) |
| DK (1) | DK3262161T3 (da) |
| WO (1) | WO2016138303A1 (da) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107937289B (zh) * | 2017-12-15 | 2021-06-25 | 北京工商大学 | 一株盔状毕赤酵母by27菌株在水果采后病害防治中的应用 |
| JP2022515078A (ja) * | 2018-12-18 | 2022-02-17 | ブラスケム エス．エー． | マロン酸セミアルデヒドからの３－ＨＰおよびアセチル－ＣｏＡ誘導体の共産生経路 |
| CN112779243B (zh) * | 2019-11-08 | 2024-02-02 | 浙江工业大学 | 一种L-天冬氨酸-α-脱羧酶及其应用 |
| EP4108678A4 (en) * | 2020-02-21 | 2024-03-27 | Kikkoman Corporation | DEVICE FOR EVALUATION OF THE CONDITION OF A SAMPLE, SYSTEM COMPRISING SAME, METHOD FOR EVALUATION OF THE CONDITION OF A SAMPLE AND LACTATE DEHYDROGENASE USED FOR THIS PURPOSE |
| CN111471603B (zh) * | 2020-06-08 | 2021-06-25 | 广西大学 | 一种产β-葡萄糖苷酶的生香季也蒙毕赤酵母菌与应用 |
| WO2023049789A2 (en) * | 2021-09-24 | 2023-03-30 | Nitto Denko Corporation | Yeast cells with reduced propensity to degrade acrylic acid |
| WO2023168244A1 (en) * | 2022-03-03 | 2023-09-07 | Cargill, Incorporated | Genetically modified yeast and fermentation processes for the production of 3-hydroxypropionate |
| WO2023168233A1 (en) * | 2022-03-03 | 2023-09-07 | Cargill, Incorporated | Genetically modified yeast and fermentation processes for the production of 3-hydroxypropionate |
| CN116024201B (zh) * | 2022-12-23 | 2024-03-19 | 天津大学 | α-乙酰乳酸脱羧酶突变体及其在生产乙偶姻中的应用 |
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| IL39710A (en) | 1972-06-19 | 1975-04-25 | Imi Inst For Res & Dev | Recovery of acids from aqueous solutions by solvent extraction |
| DK122686D0 (da) | 1986-03-17 | 1986-03-17 | Novo Industri As | Fremstilling af proteiner |
| US4771001A (en) | 1986-03-27 | 1988-09-13 | Neurex Corp. | Production of lactic acid by continuous fermentation using an inexpensive raw material and a simplified method of lactic acid purification |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| IL99552A0 (en) | 1990-09-28 | 1992-08-18 | Ixsys Inc | Compositions containing procaryotic cells,a kit for the preparation of vectors useful for the coexpression of two or more dna sequences and methods for the use thereof |
| US5210296A (en) | 1990-11-19 | 1993-05-11 | E. I. Du Pont De Nemours And Company | Recovery of lactate esters and lactic acid from fermentation broth |
| US5132456A (en) | 1991-05-07 | 1992-07-21 | The Regents Of The University Of California | Sorption of carboxylic acid from carboxylic salt solutions at PHS close to or above the pKa of the acid, with regeneration with an aqueous solution of ammonia or low-molecular-weight alkylamine |
| US5420304A (en) | 1992-03-19 | 1995-05-30 | Biopak Technology, Ltd. | Method to produce cyclic esters |
| AT398982B (de) | 1993-02-18 | 1995-02-27 | Vogelbusch Gmbh | Verfahren zur abtrennung und reinigung von milchsäure |
| FR2704860B1 (fr) | 1993-05-05 | 1995-07-13 | Pasteur Institut | Sequences de nucleotides du locus cryiiia pour le controle de l'expression de sequences d'adn dans un hote cellulaire. |
| US5510526A (en) | 1993-06-29 | 1996-04-23 | Cargill, Incorporated | Lactic acid production, separation and/or recovery process |
| DE4343591A1 (de) | 1993-12-21 | 1995-06-22 | Evotec Biosystems Gmbh | Verfahren zum evolutiven Design und Synthese funktionaler Polymere auf der Basis von Formenelementen und Formencodes |
| US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
| IL109003A (en) | 1994-03-16 | 1999-09-22 | Yissum Res Dev Co | Process and extractant composition for extracting water-soluble carboxylic and mineral acids |
| JP3167729B2 (ja) | 1994-06-30 | 2001-05-21 | ノボ ノルディスク バイオテック，インコーポレイティド | 無毒、非毒素原性、非病原性の発現系、並びにその中で利用するためのプロモーター及びターミネーター |
| US5955310A (en) | 1998-02-26 | 1999-09-21 | Novo Nordisk Biotech, Inc. | Methods for producing a polypeptide in a bacillus cell |
| AU6188599A (en) | 1998-10-26 | 2000-05-15 | Novozymes A/S | Constructing and screening a dna library of interest in filamentous fungal cells |
| AU3482200A (en) | 1999-02-02 | 2000-08-25 | Bernhard Palsson | Methods for identifying drug targets based on genomic sequence data |
| CN100510096C (zh) | 1999-03-22 | 2009-07-08 | 诺沃奇梅兹有限公司 | 用于在真菌细胞中表达基因的启动子 |
| DE60030403D1 (de) | 1999-08-30 | 2006-10-12 | Wisconsin Alumni Res Found | Herstellung von 3-hydroxypropionsäure in rekombinanten organismen |
| WO2002042418A2 (en) | 2000-11-20 | 2002-05-30 | Cargill, Incorporated | 3-hydroxypropionic acid and other organic compounds |
| EP1362319A2 (en) | 2001-01-10 | 2003-11-19 | The Penn State Research Foundation | Method and system for modeling cellular metabolism |
| US7127379B2 (en) | 2001-01-31 | 2006-10-24 | The Regents Of The University Of California | Method for the evolutionary design of biochemical reaction networks |
| CA2439260C (en) | 2001-03-01 | 2012-10-23 | The Regents Of The University Of California | Models and methods for determining systemic properties of regulated reaction networks |
| US20030224363A1 (en) | 2002-03-19 | 2003-12-04 | Park Sung M. | Compositions and methods for modeling bacillus subtilis metabolism |
| BR0308681A (pt) | 2002-03-25 | 2005-02-01 | Cargill Inc | Métodos de fabricação de derivados de ácido beta-hidroxicarboxìlico |
| JP2005521929A (ja) | 2002-03-29 | 2005-07-21 | ジェノマティカ・インコーポレイテッド | ヒト代謝モデルおよび方法 |
| CN1735691B (zh) | 2002-05-30 | 2010-05-26 | 卡吉尔道有限责任公司 | 利用比氧吸收率作为过程控制的发酵方法 |
| US8027821B2 (en) | 2002-07-10 | 2011-09-27 | The Penn State Research Foundation | Method for determining gene knockouts |
| CA2500761C (en) | 2002-10-15 | 2012-11-20 | Bernhard O. Palsson | Methods and systems to identify operational reaction pathways |
| WO2007032792A2 (en) * | 2005-06-02 | 2007-03-22 | Cargill, Inc. | Genetically modified yeast of the species issatchenkia orientalis and closely related species and fermentation processes using same |
| WO2008027742A1 (en) | 2006-08-30 | 2008-03-06 | Cargill, Incorporated | Beta-alanine/alpha-ketoglutarate aminotransferase for 3-hydroxypropionic acid production |
| US20100021978A1 (en) | 2008-07-23 | 2010-01-28 | Genomatica, Inc. | Methods and organisms for production of 3-hydroxypropionic acid |
| CN107828671B (zh) | 2010-11-22 | 2022-03-08 | 卡吉尔公司 | 用于生产3-羟基丙酸的组合物和方法 |
| KR101860442B1 (ko) | 2011-06-27 | 2018-05-24 | 삼성전자주식회사 | 3-하이드록시프로피온산의 생산을 위한 유전자 조작 |
| JP2013071898A (ja) | 2011-09-27 | 2013-04-22 | Nippon Shokubai Co Ltd | ３−ヒドロキシプロピオン酸類の製造方法 |
| CN105209626B (zh) | 2012-11-30 | 2019-09-03 | 诺维信股份有限公司 | 通过重组酵母生产3-羟基丙酸 |
| BR112016001778A2 (pt) | 2013-07-31 | 2017-09-05 | Novozymes As | Célula transgênica de levedura, composição, e, métodos de produção de 3-hp e de produção de ácido acrílico ou um sal do mesmo |
-
2016
- 2016-02-25 DK DK16710370.4T patent/DK3262161T3/da active
- 2016-02-25 EP EP16710370.4A patent/EP3262161B1/en active Active
- 2016-02-25 US US15/553,241 patent/US10358664B2/en active Active
- 2016-02-25 WO PCT/US2016/019629 patent/WO2016138303A1/en active Application Filing
- 2016-02-25 CN CN201680011830.1A patent/CN107406821B/zh not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP3262161B1 (en) | 2021-06-30 |
| CN107406821A (zh) | 2017-11-28 |
| CN107406821B (zh) | 2021-10-15 |
| US10358664B2 (en) | 2019-07-23 |
| EP3262161A1 (en) | 2018-01-03 |
| WO2016138303A1 (en) | 2016-09-01 |
| US20180237809A1 (en) | 2018-08-23 |
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