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DK3157956T3 - Ikke-humane dyr med et humaniseret gen med programmeret celledød 1 - Google Patents

Ikke-humane dyr med et humaniseret gen med programmeret celledød 1 Download PDF

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Publication number
DK3157956T3
DK3157956T3 DK15738177.3T DK15738177T DK3157956T3 DK 3157956 T3 DK3157956 T3 DK 3157956T3 DK 15738177 T DK15738177 T DK 15738177T DK 3157956 T3 DK3157956 T3 DK 3157956T3
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Denmark
Prior art keywords
cell death
human animals
programmed cell
humanized gene
humanized
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Application number
DK15738177.3T
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English (en)
Inventor
Elena Burova
Alexander O Mujica
Ka-Man Venus Lai
Andrew J Murphy
Original Assignee
Regeneron Pharma
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Publication of DK3157956T3 publication Critical patent/DK3157956T3/da

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    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • A—HUMAN NECESSITIES
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
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DK15738177.3T 2014-06-19 2015-06-19 Ikke-humane dyr med et humaniseret gen med programmeret celledød 1 DK3157956T3 (da)

Applications Claiming Priority (4)

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