DK3154995T3 - Separation of 2'-o-fucosyllactose from fermentation broth - Google Patents
Separation of 2'-o-fucosyllactose from fermentation broth Download PDFInfo
- Publication number
- DK3154995T3 DK3154995T3 DK15806229.9T DK15806229T DK3154995T3 DK 3154995 T3 DK3154995 T3 DK 3154995T3 DK 15806229 T DK15806229 T DK 15806229T DK 3154995 T3 DK3154995 T3 DK 3154995T3
- Authority
- DK
- Denmark
- Prior art keywords
- fucosyllactose
- separation
- fermentation broth
- broth
- fermentation
- Prior art date
Links
- HWHQUWQCBPAQQH-BWRPKUOHSA-N 2-fucosyllactose Chemical compound O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@H]([C@H](O)CO)[C@H](O)[C@@H](O)C=O HWHQUWQCBPAQQH-BWRPKUOHSA-N 0.000 title 1
- 230000004151 fermentation Effects 0.000 title 1
- 238000000855 fermentation Methods 0.000 title 1
- 238000000926 separation method Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/06—Separation; Purification
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/0036—Crystallisation on to a bed of product crystals; Seeding
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
- B01D9/0054—Use of anti-solvent
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA201470348 | 2014-06-11 | ||
| PCT/DK2015/050158 WO2015188834A1 (en) | 2014-06-11 | 2015-06-11 | Separation of 2'-o-fucosyllactose from fermentation broth |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3154995T3 true DK3154995T3 (da) | 2023-11-20 |
Family
ID=54832929
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK15806229.9T DK3154995T3 (da) | 2014-06-11 | 2015-06-11 | Separation of 2'-o-fucosyllactose from fermentation broth |
| DKBA201900111U DK201900111U1 (da) | 2014-06-11 | 2019-12-19 | Separation of 2'-o-fucosyllactose from fermentation broth |
| DKBA202000086U DK202000086Y4 (da) | 2014-06-11 | 2020-09-11 | Separation af 2’-FL fra en fermentationskulturopløsning |
| DKBA202100114U DK202100114Y4 (da) | 2014-06-11 | 2021-12-17 | Separation af 2’-FL fra en fermentationskulturopløsning |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DKBA201900111U DK201900111U1 (da) | 2014-06-11 | 2019-12-19 | Separation of 2'-o-fucosyllactose from fermentation broth |
| DKBA202000086U DK202000086Y4 (da) | 2014-06-11 | 2020-09-11 | Separation af 2’-FL fra en fermentationskulturopløsning |
| DKBA202100114U DK202100114Y4 (da) | 2014-06-11 | 2021-12-17 | Separation af 2’-FL fra en fermentationskulturopløsning |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP3154995B1 (da) |
| DE (1) | DE202015009782U1 (da) |
| DK (4) | DK3154995T3 (da) |
| ES (1) | ES2968677T3 (da) |
| WO (1) | WO2015188834A1 (da) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105683387B (zh) * | 2013-09-06 | 2020-02-21 | 格礼卡姆股份公司 | 寡糖的发酵生产 |
| ES2701163T3 (es) | 2014-01-20 | 2019-02-21 | Jennewein Biotechnologie Gmbh | Procedimiento para la purificación eficiente de oligosacáridos de la leche humana (HMO) neutros a partir de la fermentación microbiana |
| EP4151645A3 (en) | 2014-12-16 | 2023-06-21 | Glycom A/S | Separation of 2'-fl from a fermentation broth |
| EP3426670B1 (en) | 2016-03-07 | 2024-08-07 | Glycom A/S | Separation of oligosaccharides from fermentation broth |
| US11312741B2 (en) | 2016-04-19 | 2022-04-26 | Glycom A/S | Separation of oligosaccharides from fermentation broth |
| US11384110B2 (en) | 2016-10-31 | 2022-07-12 | Glycom A/S | Method for removing residual organic solvent from a crystalline oligosaccharide |
| WO2018164937A1 (en) | 2017-03-06 | 2018-09-13 | Dupont Nutrition Biosciences Aps | Process for crystallizing 2'-fucosyllactose and related compositions |
| CN110621685B (zh) * | 2017-03-06 | 2024-07-09 | 因比奥斯公司 | 用于使2’-岩藻糖基乳糖结晶的方法和相关组合物 |
| CN110914284A (zh) | 2017-07-12 | 2020-03-24 | 格礼卡姆股份公司 | 包含中性单糖或寡糖和酸性非碳水化合物组分的无定形混合物 |
| BR112020012207A2 (pt) | 2017-12-21 | 2020-11-24 | Glycom A/S | construção do ácido nucleico para expressão gênica in vitro e in vivo |
| CN113227112A (zh) * | 2018-10-18 | 2021-08-06 | 巴斯夫欧洲公司 | 获得晶体2′-岩藻糖基乳糖的方法 |
| US20230193335A1 (en) | 2020-01-23 | 2023-06-22 | Glycom A/S | Hmo production |
| BR112022014423A2 (pt) | 2020-01-23 | 2022-09-27 | Glycom As | Produção de hmo |
| EP4093748A1 (en) | 2020-01-23 | 2022-11-30 | Glycom A/S | Hmo production |
| WO2021148614A1 (en) | 2020-01-23 | 2021-07-29 | Glycom A/S | Hmo production |
| BR112022017283A2 (pt) * | 2020-03-12 | 2022-10-11 | Glycom As | Cristalização de 2?-fl |
| DK180952B1 (en) | 2020-12-22 | 2022-08-10 | Glycom As | A dfl-producing strain |
| US20240102063A1 (en) | 2021-01-22 | 2024-03-28 | Glycom A/S | New major facilitator superfamily (mfs) protein (fred) in production of sialylated hmos |
| CN112920234B (zh) * | 2021-01-27 | 2022-03-29 | 南开大学 | 一种2′-岩藻糖基乳糖的富集纯化方法 |
| DK181310B1 (en) | 2021-05-17 | 2023-08-08 | Dsm Ip Assets Bv | Cell factories for lnt-ii production |
| DK181497B1 (en) | 2021-05-17 | 2024-03-12 | Dsm Ip Assets Bv | ENHANCING FORMATION OF THE HMOS LNT AND/OR LNnT BY MODIFYING LACTOSE IMPORT IN THE CELL |
| US20240327886A1 (en) | 2021-05-17 | 2024-10-03 | Dsm Ip Assets B.V. | Methods of producing hmo blend profiles with lnfp-i and lnt as the predominant compounds |
| DK181242B1 (en) | 2021-05-17 | 2023-05-30 | Dsm Ip Assets Bv | GENETICALLY ENGINEERED CELLS COMPRISING A RECOMBINANT NUCLEIC ACID SEQUNCE ENCODING AN α-1,2-FUCOSYLTRANSFERASE CAPABLE OF PRODUCING LNFP-I, NUCLEIC ACID SEQUENCES ENCODING SAME AND METHODS FOR USE OF SAME |
| EP4341418A2 (en) | 2021-05-17 | 2024-03-27 | DSM IP Assets B.V. | Methods of producing hmo blend profiles with lnfp-i and 2'-fl as the predominant compounds |
| EP4341276A1 (en) | 2021-05-17 | 2024-03-27 | DSM IP Assets B.V. | Novel technology to enable sucrose utilization in strains for biosyntetic production |
| EP4355464A1 (en) | 2021-06-15 | 2024-04-24 | DSM IP Assets B.V. | Separation of human milk oligosaccharides from a fermentation broth |
| WO2022263424A1 (en) | 2021-06-15 | 2022-12-22 | Dsm Ip Assets B.V. | Separation of human milk oligosaccharides from a fermentation broth |
| WO2022263425A1 (en) | 2021-06-15 | 2022-12-22 | Dsm Ip Assets B.V. | Separation of human milk oligosaccharides from a fermentation broth |
| BE1029437B1 (nl) | 2021-06-15 | 2023-07-31 | Dsm Ip Assets Bv | Scheiding van moedermelkoligosachariden uit een fermentatiebouillon |
| DK202170552A1 (en) | 2021-11-11 | 2023-09-01 | Dsm Ip Assets Bv | Combined fermentation process for producing one or more human milk oligosaccharide(s) (hmo(s)) |
| WO2023099680A1 (en) | 2021-12-01 | 2023-06-08 | Dsm Ip Assets B.V. | Cells with tri-, tetra- or pentasaccharide importers useful in oligosaccharide production |
| DK202200561A1 (en) | 2022-06-13 | 2024-02-14 | Dsm Ip Assets Bv | Sigma factor modifications for biosynthetic production |
| DK202200689A1 (en) | 2022-07-15 | 2024-02-27 | Dsm Ip Assets Bv | New fucosyltransferases for in vivo synthesis of lnfp-iii |
| WO2024013348A1 (en) | 2022-07-15 | 2024-01-18 | Dsm Ip Assets B.V. | New fucosyltransferases for in vivo synthesis of complex fucosylated human milk oligosaccharides |
| WO2024042235A1 (en) | 2022-08-25 | 2024-02-29 | Dsm Ip Assets B.V. | Hybrid method for producing complex hmos |
| WO2024110667A1 (en) | 2022-11-25 | 2024-05-30 | Dsm Ip Assets B.V. | Two-strain system for producing oligosaccharides |
| DK202201117A1 (en) | 2022-12-09 | 2024-08-08 | Dsm Ip Assets Bv | Genetically modified udp-n-acetylgalactosamine producing cells |
| DK202201204A1 (en) | 2022-12-22 | 2024-08-22 | Dsm Ip Assets Bv | New fucosyltransferases for production of 3fl |
| DK202201202A1 (en) | 2022-12-22 | 2024-08-21 | Dsm Ip Assets Bv | New fucosyltransferases for in vivo synthesis of complex fucosylated human milk oligosaccharides mixtures comprising lndfh-iii |
| WO2024175777A1 (en) | 2023-02-24 | 2024-08-29 | Dsm Ip Assets B.V. | Product specific transporter for in vivo synthesis of human milk oligosaccharides |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2796082B1 (fr) | 1999-07-07 | 2003-06-27 | Centre Nat Rech Scient | Procede de production d'oligosaccharides |
| IT1392456B1 (it) | 2008-12-18 | 2012-03-09 | Inalco Spa | Processo per la sintesi di di- o oligosaccaridi l-fucosilati e loro nuovi intermedi 2,3,4-tribenzil-fucosil-derivati. |
| BRPI0923433B1 (pt) | 2008-12-19 | 2021-06-01 | Jennewein Biotechnologie Gmbh | Método para produzir uma célula geneticamente modificada tendo a capacidade de produzir compostos fucosilados e método para fazer um composto fucosilado |
| CA2798675A1 (en) | 2010-06-01 | 2011-12-08 | Glycom A/S | Polymorphs of 2'-o-fucosyllactose and producing thereof |
| SG10201504733XA (en) | 2010-07-12 | 2015-07-30 | Univ Gent | Metabolically engineered organisms for the production of added value bio-products |
| EP2479263B1 (en) | 2011-01-20 | 2013-11-27 | Jennewein Biotechnologie GmbH | Novel Fucosyltransferases and their applications |
| WO2012112777A2 (en) | 2011-02-16 | 2012-08-23 | Glycosyn LLC | Biosynthesis of human milk oligosaccharides in engineered bacteria |
| ITFI20120143A1 (it) | 2012-07-12 | 2014-01-13 | Inalco S A S Di Giovanni Cipollett I & C | Polimorfi idrati e anidri del 2'-o-fucosillattosio e loro metodi di produzione. |
| WO2014069625A1 (ja) * | 2012-11-01 | 2014-05-08 | 協和発酵バイオ株式会社 | オリゴ糖の結晶およびその製造方法 |
| WO2014086373A1 (en) * | 2012-12-07 | 2014-06-12 | Glycom A/S | Crystallisation of human milk oligosaccharides (hmo) |
-
2015
- 2015-06-11 ES ES15806229T patent/ES2968677T3/es active Active
- 2015-06-11 DE DE202015009782.0U patent/DE202015009782U1/de active Active
- 2015-06-11 WO PCT/DK2015/050158 patent/WO2015188834A1/en active Application Filing
- 2015-06-11 DK DK15806229.9T patent/DK3154995T3/da active
- 2015-06-11 EP EP15806229.9A patent/EP3154995B1/en active Active
-
2019
- 2019-12-19 DK DKBA201900111U patent/DK201900111U1/da not_active Application Discontinuation
-
2020
- 2020-09-11 DK DKBA202000086U patent/DK202000086Y4/da active IP Right Grant
-
2021
- 2021-12-17 DK DKBA202100114U patent/DK202100114Y4/da active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| DK202100114Y4 (da) | 2022-06-02 |
| EP3154995A4 (en) | 2017-12-13 |
| WO2015188834A1 (en) | 2015-12-17 |
| DK202000086Y4 (da) | 2023-02-02 |
| EP3154995A1 (en) | 2017-04-19 |
| ES2968677T3 (es) | 2024-05-13 |
| DK201900111U1 (da) | 2020-01-06 |
| DE202015009782U1 (de) | 2020-02-10 |
| EP3154995B1 (en) | 2023-11-01 |
| DK202100114U1 (en) | 2021-12-21 |
| DK202000086U1 (en) | 2020-12-07 |
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