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DK2920725T3 - Digital analyse af molekylære analytter ved hjælp af enkeltmolekyledetektering - Google Patents

Digital analyse af molekylære analytter ved hjælp af enkeltmolekyledetektering Download PDF

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Publication number
DK2920725T3
DK2920725T3 DK13855452.2T DK13855452T DK2920725T3 DK 2920725 T3 DK2920725 T3 DK 2920725T3 DK 13855452 T DK13855452 T DK 13855452T DK 2920725 T3 DK2920725 T3 DK 2920725T3
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Denmark
Prior art keywords
single molecule
molecule detection
digital analysis
molecular analytes
analytes
Prior art date
Application number
DK13855452.2T
Other languages
English (en)
Inventor
Bryan P Staker
Niandong Liu
Bart Lee Staker
Michael David Mclaughlin
Original Assignee
Apton Biosystems Inc
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Publication of DK2920725T3 publication Critical patent/DK2920725T3/da

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • H—ELECTRICITY
    • H03—ELECTRONIC CIRCUITRY
    • H03M—CODING; DECODING; CODE CONVERSION IN GENERAL
    • H03M13/00—Coding, decoding or code conversion, for error detection or error correction; Coding theory basic assumptions; Coding bounds; Error probability evaluation methods; Channel models; Simulation or testing of codes
    • H03M13/03—Error detection or forward error correction by redundancy in data representation, i.e. code words containing more digits than the source words
    • H03M13/05—Error detection or forward error correction by redundancy in data representation, i.e. code words containing more digits than the source words using block codes, i.e. a predetermined number of check bits joined to a predetermined number of information bits
    • H03M13/13—Linear codes
    • H03M13/15—Cyclic codes, i.e. cyclic shifts of codewords produce other codewords, e.g. codes defined by a generator polynomial, Bose-Chaudhuri-Hocquenghem [BCH] codes
    • H03M13/151—Cyclic codes, i.e. cyclic shifts of codewords produce other codewords, e.g. codes defined by a generator polynomial, Bose-Chaudhuri-Hocquenghem [BCH] codes using error location or error correction polynomials
    • H03M13/1515—Reed-Solomon codes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Medical Informatics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Theoretical Computer Science (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Evolutionary Biology (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Evolutionary Computation (AREA)
  • Artificial Intelligence (AREA)
  • Bioethics (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Data Mining & Analysis (AREA)
  • Databases & Information Systems (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
DK13855452.2T 2012-11-19 2013-11-19 Digital analyse af molekylære analytter ved hjælp af enkeltmolekyledetektering DK2920725T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261728067P 2012-11-19 2012-11-19
US201361869020P 2013-08-22 2013-08-22
PCT/US2013/070797 WO2014078855A1 (en) 2012-11-19 2013-11-19 Digital analysis of molecular analytes using single molecule detection

Publications (1)

Publication Number Publication Date
DK2920725T3 true DK2920725T3 (da) 2022-02-07

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DK13855452.2T DK2920725T3 (da) 2012-11-19 2013-11-19 Digital analyse af molekylære analytter ved hjælp af enkeltmolekyledetektering

Country Status (13)

Country Link
US (4) US20150330974A1 (da)
EP (2) EP2920725B1 (da)
JP (1) JP6395718B2 (da)
KR (1) KR102061257B1 (da)
CN (1) CN105264532B (da)
AU (1) AU2013344340B2 (da)
CA (1) CA2891939C (da)
DK (1) DK2920725T3 (da)
ES (1) ES2905265T3 (da)
HU (1) HUE058723T2 (da)
MX (2) MX2015006219A (da)
RU (1) RU2670133C2 (da)
WO (1) WO2014078855A1 (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10378053B2 (en) 2017-03-17 2019-08-13 Apton Biosystems, Inc. Sequencing and high resolution imaging
DK2920725T3 (da) 2012-11-19 2022-02-07 Apton Biosystems Inc Digital analyse af molekylære analytter ved hjælp af enkeltmolekyledetektering
US10829816B2 (en) 2012-11-19 2020-11-10 Apton Biosystems, Inc. Methods of analyte detection
EP3036358B8 (en) 2013-08-22 2023-11-22 Pacific Biosciences of California, Inc. Digital analysis of molecular analytes using electrical methods
WO2016011429A1 (en) 2014-07-17 2016-01-21 California Institute Of Technology Multiplex analysis of molecules in single cells by image correlation
US20170141793A1 (en) * 2015-11-13 2017-05-18 Microsoft Technology Licensing, Llc Error correction for nucleotide data stores
EP4365597A3 (en) 2016-12-01 2024-08-21 Nautilus Subsidiary, Inc. Methods of assaying proteins
WO2018175402A1 (en) * 2017-03-23 2018-09-27 Apton Biosystems, Inc. Polymorphism detection with increased accuracy
BR112019020255A2 (pt) 2017-03-31 2020-04-22 Univ Strathclyde lâmina de amostra para uso em um espectrômetro, dispositivo para uso com um espectrômetro, e, métodos para medir uma amostra e para preparar uma amostra para análise espectral ir.
EP3669018A4 (en) 2017-08-18 2021-05-26 Nautilus Biotechnology, Inc. Binding reagent selection methods
US11721412B2 (en) 2017-10-23 2023-08-08 Nautilus Subsidiary, Inc. Methods for identifying a protein in a sample of unknown proteins
EP4372383A3 (en) * 2017-10-23 2024-11-06 Nautilus Subsidiary, Inc. Methods and systems for protein identification
BR112020013252A2 (pt) 2017-12-29 2020-12-01 Nautilus Biotechnology, Inc. abordagens de decodificação para a identificação de proteína
WO2019148001A1 (en) * 2018-01-25 2019-08-01 Apton Biosystems, Inc. Methods and composition for high throughput single molecule protein detection systems
WO2019195633A1 (en) 2018-04-04 2019-10-10 Ignite Biosciences, Inc. Methods of generating nanoarrays and microarrays
WO2020061237A1 (en) 2018-09-19 2020-03-26 Apton Biosystems, Inc. Densely-packed analyte layers and detection methods
EP3884048A4 (en) 2018-11-20 2022-08-17 Nautilus Biotechnology, Inc. DESIGN AND SELECTION OF AFFINITY REAGENTS
GB2603051B (en) 2020-01-30 2023-04-26 Prognomiq Inc Lung biomarkers and methods of use thereof
WO2022103887A1 (en) 2020-11-11 2022-05-19 Nautilus Biotechnology, Inc. Affinity reagents having enhanced binding and detection characteristics
WO2023039579A1 (en) 2021-09-13 2023-03-16 PrognomIQ, Inc. Enhanced detection and quantitation of biomolecules
WO2023243922A1 (ko) * 2022-06-15 2023-12-21 주식회사 씨젠 기술 문서를 생성하는 방법 및 장치

Family Cites Families (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5302509A (en) 1989-08-14 1994-04-12 Beckman Instruments, Inc. Method for sequencing polynucleotides
US5494810A (en) 1990-05-03 1996-02-27 Cornell Research Foundation, Inc. Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease
US5828067A (en) 1993-10-20 1998-10-27 Cambridge Imaging Limited Imaging method and apparatus
US7569341B2 (en) 1994-01-31 2009-08-04 Trustees Of Boston University Nucleic acid directed immobilization arrays and methods of assembly
US5763594A (en) 1994-09-02 1998-06-09 Andrew C. Hiatt 3' protected nucleotides for enzyme catalyzed template-independent creation of phosphodiester bonds
US6214987B1 (en) 1994-09-02 2001-04-10 Andrew C. Hiatt Compositions for enzyme catalyzed template-independent formation of phosphodiester bonds using protected nucleotides
US6232465B1 (en) 1994-09-02 2001-05-15 Andrew C. Hiatt Compositions for enzyme catalyzed template-independent creation of phosphodiester bonds using protected nucleotides
US6654505B2 (en) 1994-10-13 2003-11-25 Lynx Therapeutics, Inc. System and apparatus for sequential processing of analytes
US6852487B1 (en) 1996-02-09 2005-02-08 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
US5853993A (en) * 1996-10-21 1998-12-29 Hewlett-Packard Company Signal enhancement method and kit
WO1999067641A2 (en) * 1998-06-24 1999-12-29 Illumina, Inc. Decoding of array sensors with microspheres
EP1110090B1 (en) * 1998-09-03 2009-03-25 Trellis Bioscience, Inc. Multihued labels
DE60045917D1 (de) 1999-02-23 2011-06-16 Caliper Life Sciences Inc Sequenzierung durch inkorporation
US20060275782A1 (en) 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
US6376191B1 (en) 2000-03-22 2002-04-23 Mergen, Ltd. Microarray-based analysis of polynucleotide sequence variations
US20030207300A1 (en) 2000-04-28 2003-11-06 Matray Tracy J. Multiplex analytical platform using molecular tags
KR100917731B1 (ko) 2001-05-11 2009-09-15 파나소닉 주식회사 생체분자 기판 및 그것을 이용한 검사 및 진단의 방법 및장치
US6636623B2 (en) * 2001-08-10 2003-10-21 Visiongate, Inc. Optical projection imaging system and method for automatically detecting cells with molecular marker compartmentalization associated with malignancy and disease
GB0129012D0 (en) 2001-12-04 2002-01-23 Solexa Ltd Labelled nucleotides
US7057026B2 (en) 2001-12-04 2006-06-06 Solexa Limited Labelled nucleotides
AU2003291249A1 (en) 2002-12-18 2004-07-29 Aclara Biosciences, Inc. Multiplexed immunohistochemical assays using molecular tags
AU2004232976B2 (en) 2003-04-18 2011-02-10 Becton, Dickinson And Company Immuno-amplification
US20050250094A1 (en) 2003-05-30 2005-11-10 Nanosphere, Inc. Method for detecting analytes based on evanescent illumination and scatter-based detection of nanoparticle probe complexes
CN1584592A (zh) * 2003-08-22 2005-02-23 中国科学院上海原子核研究所 免疫微阵列蛋白质芯片
US20050049796A1 (en) * 2003-09-03 2005-03-03 Webb Peter G. Methods for encoding non-biological information on microarrays
US20050153320A1 (en) 2003-11-06 2005-07-14 Herron James N. Single base extension
WO2006014392A1 (en) 2004-07-02 2006-02-09 The General Hospital Corporation Endoscopic imaging probe comprising dual clad fibre
US7170050B2 (en) 2004-09-17 2007-01-30 Pacific Biosciences Of California, Inc. Apparatus and methods for optical analysis of molecules
EP3257949A1 (en) 2005-06-15 2017-12-20 Complete Genomics Inc. Nucleic acid analysis by random mixtures of non-overlapping fragments
US20090081688A1 (en) 2005-06-20 2009-03-26 Advanced Cell Diagnostics Methods of detecting nucleic acids in individual cells and of identifying rare cells from large heterogeneous cell populations
EP2279691B1 (en) 2005-09-29 2023-07-19 The General Hospital Corporation Arrangements And Methods For Providing Multimodality Microscopic Imaging Of One Or More Biological Structures
US7960104B2 (en) 2005-10-07 2011-06-14 Callida Genomics, Inc. Self-assembled single molecule arrays and uses thereof
EP2407093A1 (en) 2006-02-22 2012-01-18 DexCom, Inc. Analyte sensor
WO2008033167A2 (en) 2006-03-28 2008-03-20 Inanovate, Inc. Nano-particle biochip substrates
US20090317810A1 (en) 2006-04-17 2009-12-24 Epigenomics Ag Methods and nucleic acids for the detection of colorectal cell proliferative disorders
US7839507B2 (en) 2006-06-28 2010-11-23 Applied Biosystems, Llc Minimizing effects of dye crosstalk
US7838302B2 (en) 2006-08-07 2010-11-23 President And Fellows Of Harvard College Sub-diffraction limit image resolution and other imaging techniques
US7948015B2 (en) 2006-12-14 2011-05-24 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
WO2008092155A2 (en) 2007-01-26 2008-07-31 Illumina, Inc. Image data efficient genetic sequencing method and system
EP2251435B1 (en) 2007-03-02 2013-10-16 DNA Electronics Ltd Sensing apparatus for monitoring nucleic acid amplification, using an ion-sensitive field effect transistor (ISFET) for pH sensing
US7769548B2 (en) 2007-05-10 2010-08-03 Illumina, Inc. Microarray analytical data stitching system and method
US9551026B2 (en) 2007-12-03 2017-01-24 Complete Genomincs, Inc. Method for nucleic acid detection using voltage enhancement
WO2009097626A2 (en) 2008-02-03 2009-08-06 Helicos Biosciences Corporation Paired-end reads in sequencing by synthesis
US20100301398A1 (en) 2009-05-29 2010-12-02 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US9524369B2 (en) 2009-06-15 2016-12-20 Complete Genomics, Inc. Processing and analysis of complex nucleic acid sequence data
US10072287B2 (en) 2009-09-10 2018-09-11 Centrillion Technology Holdings Corporation Methods of targeted sequencing
US8900850B2 (en) 2009-09-17 2014-12-02 Michael J. Lane Lateral flow based methods and assays for rapid and inexpensive diagnostic tests
US8914312B2 (en) 2009-09-24 2014-12-16 Commonwealth Scientific And Industrial Research Organisation Method of contaminant prediction
EP2488876B1 (en) 2009-10-13 2017-03-01 Nanostring Technologies, Inc Protein detection via nanoreporters
US8965076B2 (en) 2010-01-13 2015-02-24 Illumina, Inc. Data processing system and methods
US8774494B2 (en) 2010-04-30 2014-07-08 Complete Genomics, Inc. Method and system for accurate alignment and registration of array for DNA sequencing
CN101865843B (zh) * 2010-05-04 2012-05-23 中国科学院深圳先进技术研究院 多组分生物标识物的检测方法
US8465922B2 (en) 2010-08-26 2013-06-18 Pacific Biosciences Of California, Inc. Methods and systems for monitoring reactions
US9671344B2 (en) 2010-08-31 2017-06-06 Complete Genomics, Inc. High-density biochemical array chips with asynchronous tracks for alignment correction by moiré averaging
US8175452B1 (en) 2010-10-26 2012-05-08 Complete Genomics, Inc. Method and system for imaging high density biochemical arrays with sub-pixel alignment
JP2014516514A (ja) 2011-04-14 2014-07-17 コンプリート・ジェノミックス・インコーポレイテッド 複合核酸配列データの処理および解析
GB201108678D0 (en) 2011-05-24 2011-07-06 Olink Ab Multiplexed proximity ligation assay
US9001231B2 (en) 2011-06-03 2015-04-07 Rambus Inc. Image acquisition using oversampled one-bit poisson statistics
AU2012272161B2 (en) 2011-06-21 2015-12-24 Illumina Cambridge Limited Methods and systems for data analysis
US20130265459A1 (en) 2011-06-28 2013-10-10 Pelican Imaging Corporation Optical arrangements for use with an array camera
US10704164B2 (en) 2011-08-31 2020-07-07 Life Technologies Corporation Methods, systems, computer readable media, and kits for sample identification
WO2014015269A1 (en) 2012-07-19 2014-01-23 Ariosa Diagnostics, Inc. Multiplexed sequential ligation-based detection of genetic variants
DK2920725T3 (da) 2012-11-19 2022-02-07 Apton Biosystems Inc Digital analyse af molekylære analytter ved hjælp af enkeltmolekyledetektering
US10829816B2 (en) 2012-11-19 2020-11-10 Apton Biosystems, Inc. Methods of analyte detection
US10378053B2 (en) 2017-03-17 2019-08-13 Apton Biosystems, Inc. Sequencing and high resolution imaging
JP2014164004A (ja) 2013-02-22 2014-09-08 Hitachi High-Technologies Corp 蛍光顕微鏡
US9193998B2 (en) 2013-03-15 2015-11-24 Illumina, Inc. Super resolution imaging
EP3312295A1 (en) 2013-03-19 2018-04-25 Directed Genomics, LLC Enrichment of target sequences
US10510435B2 (en) 2013-04-30 2019-12-17 California Institute Of Technology Error correction of multiplex imaging analysis by sequential hybridization
KR102368591B1 (ko) 2013-04-30 2022-02-25 캘리포니아 인스티튜트 오브 테크놀로지 순차적 하이브리드화 바코딩에 의한 분자의 멀티플렉스 표지화
EP3036358B8 (en) 2013-08-22 2023-11-22 Pacific Biosciences of California, Inc. Digital analysis of molecular analytes using electrical methods
WO2016018960A1 (en) 2014-07-30 2016-02-04 President And Fellows Of Harvard College Systems and methods for determining nucleic acids
CN104372093B (zh) 2014-11-10 2016-09-21 博奥生物集团有限公司 一种基于高通量测序的snp检测方法
US11739371B2 (en) 2015-02-18 2023-08-29 Invitae Corporation Arrays for single molecule detection and use thereof
CN107532205B (zh) 2015-03-31 2021-06-08 伊卢米纳剑桥有限公司 模板的表面连环化
KR20180097536A (ko) 2015-11-04 2018-08-31 아트레카, 인크. 단일 세포와 연관된 핵산의 분석을 위한 핵산 바코드의 조합 세트
BR112018009086A8 (pt) 2015-11-04 2019-02-26 Procter & Gamble artigos absorventes delgados e flexíveis
CN108495938B (zh) 2016-01-12 2023-07-14 生物辐射实验室股份有限公司 利用相位移区块合成条码化序列及其用途
WO2017161251A1 (en) 2016-03-17 2017-09-21 President And Fellows Of Harvard College Methods for detecting and identifying genomic nucleic acids
US11512344B2 (en) 2016-05-10 2022-11-29 Arizona Board Of Regents On Behalf Of Arizona State University Consecutive hybridization for multiplexed analysis of biological samples
US20190284552A1 (en) 2016-05-26 2019-09-19 Singular Bio, Inc. Arrays for Single Molecule Detection and Uses Thereof
AU2017280025A1 (en) 2016-06-21 2018-11-01 Illumina Cambridge Limited Super-resolution microscopy
GB201701296D0 (en) 2017-01-26 2017-03-15 Univ College Cork - Nat Univ Of Ireland Smart coded access optical sensor
CA3055249A1 (en) 2017-03-03 2018-09-07 Apton Biosystems, Inc. High speed scanning system with acceleration tracking
WO2018175402A1 (en) 2017-03-23 2018-09-27 Apton Biosystems, Inc. Polymorphism detection with increased accuracy
WO2019055852A1 (en) 2017-09-15 2019-03-21 Apton Biosystems, Inc. PROFILING OF HETEROGENEOUS UNICELLULAR ORGANISMS USING MOLECULAR BARCODE CODING
MX2019014803A (es) 2018-03-09 2021-02-09 Illumina Cambridge Ltd Secuenciaciòn estocástica generalizada de super-resolución.

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Publication number Publication date
US20220214335A1 (en) 2022-07-07
US20210072233A1 (en) 2021-03-11
CA2891939A1 (en) 2014-05-22
US11650202B2 (en) 2023-05-16
EP2920725B1 (en) 2021-11-10
RU2015123570A (ru) 2017-01-10
EP2920725A4 (en) 2016-08-31
EP2920725A1 (en) 2015-09-23
US20150330974A1 (en) 2015-11-19
AU2013344340B2 (en) 2019-09-19
MX2015006219A (es) 2015-11-13
RU2670133C2 (ru) 2018-10-18
AU2013344340A1 (en) 2015-07-02
ES2905265T3 (es) 2022-04-07
KR20150095691A (ko) 2015-08-21
HUE058723T2 (hu) 2022-09-28
CN105264532A (zh) 2016-01-20
JP6395718B2 (ja) 2018-09-26
EP4012716A1 (en) 2022-06-15
US20240069012A1 (en) 2024-02-29
JP2016502079A (ja) 2016-01-21
MX2022002931A (es) 2022-04-06
WO2014078855A1 (en) 2014-05-22
CN105264532B (zh) 2019-02-26
KR102061257B1 (ko) 2019-12-31
CA2891939C (en) 2020-10-27

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