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DK2988728T3 - Reducering af partikelstørrelsen af en antimuscarin-forbindelse - Google Patents

Reducering af partikelstørrelsen af en antimuscarin-forbindelse Download PDF

Info

Publication number
DK2988728T3
DK2988728T3 DK14724332T DK14724332T DK2988728T3 DK 2988728 T3 DK2988728 T3 DK 2988728T3 DK 14724332 T DK14724332 T DK 14724332T DK 14724332 T DK14724332 T DK 14724332T DK 2988728 T3 DK2988728 T3 DK 2988728T3
Authority
DK
Denmark
Prior art keywords
antimuscarin
compound
reducing
particle size
particle
Prior art date
Application number
DK14724332T
Other languages
English (en)
Inventor
Irene Pasquali
Andrea Casazza
Mark Saunders
Elena Losi
Original Assignee
Chiesi Farm Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farm Spa filed Critical Chiesi Farm Spa
Application granted granted Critical
Publication of DK2988728T3 publication Critical patent/DK2988728T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK14724332T 2013-04-26 2014-04-24 Reducering af partikelstørrelsen af en antimuscarin-forbindelse DK2988728T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13165483 2013-04-26
PCT/EP2014/058295 WO2014173987A1 (en) 2013-04-26 2014-04-24 Particle size reduction of an antimuscarinic compound

Publications (1)

Publication Number Publication Date
DK2988728T3 true DK2988728T3 (da) 2019-11-04

Family

ID=48190260

Family Applications (2)

Application Number Title Priority Date Filing Date
DK19182996.9T DK3574895T3 (da) 2013-04-26 2014-04-24 Partikelstørrelsesreduktion af en antimuscarinforbindelse
DK14724332T DK2988728T3 (da) 2013-04-26 2014-04-24 Reducering af partikelstørrelsen af en antimuscarin-forbindelse

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK19182996.9T DK3574895T3 (da) 2013-04-26 2014-04-24 Partikelstørrelsesreduktion af en antimuscarinforbindelse

Country Status (28)

Country Link
US (2) US9393202B2 (da)
EP (2) EP2988728B1 (da)
JP (1) JP6449246B2 (da)
KR (1) KR102198354B1 (da)
CN (1) CN105120841B (da)
AR (1) AR096087A1 (da)
AU (1) AU2014259443B2 (da)
BR (1) BR112015024626B1 (da)
CA (1) CA2910314C (da)
DK (2) DK3574895T3 (da)
ES (2) ES2754255T3 (da)
FI (1) FI3574895T3 (da)
HK (1) HK1216302A1 (da)
HR (2) HRP20230337T1 (da)
HU (2) HUE046213T2 (da)
IL (1) IL242209A (da)
MX (1) MX365295B (da)
MY (1) MY169127A (da)
PH (1) PH12015502449B1 (da)
PL (2) PL3574895T3 (da)
PT (2) PT3574895T (da)
RU (1) RU2667636C2 (da)
SG (1) SG11201508760VA (da)
SI (2) SI3574895T1 (da)
TW (1) TWI630926B (da)
UA (1) UA120418C2 (da)
WO (1) WO2014173987A1 (da)
ZA (1) ZA201507916B (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9393202B2 (en) * 2013-04-26 2016-07-19 Chiesi Farmaceutici S.P.A Particle size reduction of an antimuscarinic compound
PE20212110A1 (es) 2013-07-11 2021-11-04 Chiesi Farm Spa Formulacion en polvo seco que comprende un anticolinergico, un corticosteroide y un beta-adrenergico para administrar por inhalacion
PE20170919A1 (es) 2014-10-16 2017-07-12 Teva Branded Pharmaceutical Products Randd Inc Formulacion inhalable
JP6500522B2 (ja) * 2015-03-16 2019-04-17 セイコーエプソン株式会社 回路装置、物理量検出装置、電子機器及び移動体
SG11201804050QA (en) 2015-11-16 2018-06-28 Chiesi Farm Spa A process for preparing a dry powder formulation comprising an anticholinergic, a corticosteroid and a beta-adrenergic
EP3689379B1 (en) 2015-11-16 2021-08-11 Chiesi Farmaceutici S.p.A. A process for preparing a dry powder formulation comprising an anticholinergic, a corticosteroid and a beta-adrenergic
US9925168B2 (en) * 2016-01-22 2018-03-27 Chiesi Farmaceutici S.P.A. Preparation of micronized particles of an antimuscarinic compound by hydrodynamic cavitation
JP6323846B2 (ja) * 2016-04-07 2018-05-16 塩野義製薬株式会社 オピオイドを含有する乱用防止製剤
PT109445B (pt) * 2016-06-08 2018-11-06 Hovione Farm Sa Co-cristais farmacêuticos cristalinos de brometo de glicopirrónio com lactose
PT3490533T (pt) * 2016-07-29 2020-07-21 Inke Sa Processo de estabilização do tamanho de partícula

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5399363A (en) * 1991-01-25 1995-03-21 Eastman Kodak Company Surface modified anticancer nanoparticles
DK0644755T3 (da) * 1992-06-10 1997-09-22 Nanosystems Llc Overflademodificerede NSAID-nanopartikler
GB0008660D0 (en) 2000-04-07 2000-05-31 Arakis Ltd The treatment of respiratory diseases
WO2004045585A1 (en) * 2002-11-18 2004-06-03 E.I. Du Pont De Nemours And Company Media milling using nonspherical grinding media
GB0321607D0 (en) * 2003-09-15 2003-10-15 Vectura Ltd Manufacture of pharmaceutical compositions
GB0409703D0 (en) * 2004-04-30 2004-06-02 Vectura Ltd Pharmaceutical compositions
GB0516549D0 (en) 2005-08-12 2005-09-21 Sulaiman Brian Milling system
GB0613161D0 (en) * 2006-06-30 2006-08-09 Novartis Ag Organic Compounds
KR20100099281A (ko) * 2007-12-13 2010-09-10 노파르티스 아게 유기 화합물
BRPI0820745A2 (pt) 2007-12-13 2015-06-16 Novartis Ag Compostos orgânicos
DE102008000482A1 (de) 2008-03-03 2009-09-10 Zf Friedrichshafen Ag Ölgekühltes Reibschaltelement
MX2011000405A (es) * 2008-07-18 2011-03-04 Prosonix Ltd Proceso para mejorar la cristalinidad.
BRPI1011220B1 (pt) * 2009-05-29 2020-03-10 Pearl Therapeutics, Inc. Composição farmacêutica administrável a partir de um inalador de dose medida compreendendo um meio de suspensão compreendendo um propelente, duas ou mais espécies diferentes de partículas de agente ativo e uma ou mais espécies de partículas respiráveis em suspensão
JP2014504260A (ja) * 2010-10-15 2014-02-20 グラクソ グループ リミテッド 集合ナノ粒子状薬物製剤、その製造及び使用
US9393202B2 (en) * 2013-04-26 2016-07-19 Chiesi Farmaceutici S.P.A Particle size reduction of an antimuscarinic compound

Also Published As

Publication number Publication date
ES2754255T3 (es) 2020-04-16
AU2014259443B2 (en) 2019-01-03
BR112015024626B1 (pt) 2022-11-01
TWI630926B (zh) 2018-08-01
UA120418C2 (uk) 2019-12-10
WO2014173987A1 (en) 2014-10-30
DK3574895T3 (da) 2023-05-01
ZA201507916B (en) 2017-05-31
SI3574895T1 (sl) 2023-05-31
FI3574895T3 (fi) 2023-05-25
SI2988728T1 (sl) 2019-11-29
RU2015145521A (ru) 2017-05-16
HK1216302A1 (zh) 2016-11-04
MY169127A (en) 2019-02-18
US9889094B2 (en) 2018-02-13
PT2988728T (pt) 2019-11-18
EP2988728B1 (en) 2019-08-21
JP6449246B2 (ja) 2019-01-09
TW201521790A (zh) 2015-06-16
EP3574895B1 (en) 2023-03-22
MX2015014904A (es) 2016-03-07
KR102198354B1 (ko) 2021-01-06
CN105120841B (zh) 2019-04-30
JP2016521274A (ja) 2016-07-21
HRP20191882T1 (hr) 2019-12-27
ES2943109T3 (es) 2023-06-09
IL242209A (en) 2017-12-31
US20140322142A1 (en) 2014-10-30
BR112015024626A2 (pt) 2017-07-18
PL2988728T3 (pl) 2020-02-28
MX365295B (es) 2019-05-29
PL3574895T3 (pl) 2023-06-19
PH12015502449A1 (en) 2016-02-22
US9393202B2 (en) 2016-07-19
KR20160002733A (ko) 2016-01-08
EP2988728A1 (en) 2016-03-02
CN105120841A (zh) 2015-12-02
PT3574895T (pt) 2023-04-28
AR096087A1 (es) 2015-12-02
PH12015502449B1 (en) 2016-02-22
EP3574895A1 (en) 2019-12-04
SG11201508760VA (en) 2015-11-27
AU2014259443A1 (en) 2015-11-12
HRP20230337T1 (hr) 2023-06-09
CA2910314A1 (en) 2014-10-30
CA2910314C (en) 2022-03-01
HUE062002T2 (hu) 2023-09-28
HUE046213T2 (hu) 2020-02-28
US20160279066A1 (en) 2016-09-29
RU2667636C2 (ru) 2018-09-21

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