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DK2961378T3 - Fremgangsmåder til behandlingen af mitochondrisk sygdom - Google Patents

Fremgangsmåder til behandlingen af mitochondrisk sygdom Download PDF

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Publication number
DK2961378T3
DK2961378T3 DK14757000T DK14757000T DK2961378T3 DK 2961378 T3 DK2961378 T3 DK 2961378T3 DK 14757000 T DK14757000 T DK 14757000T DK 14757000 T DK14757000 T DK 14757000T DK 2961378 T3 DK2961378 T3 DK 2961378T3
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Prior art keywords
mitochondric
disease
treating
methods
treating mitochondric
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DK14757000T
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English (en)
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D Travis Wilson
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Stealth Biotherapeutics Corp
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DK14757000T 2013-03-01 2014-02-28 Fremgangsmåder til behandlingen af mitochondrisk sygdom DK2961378T3 (da)

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Application Number Priority Date Filing Date Title
US201361771642P 2013-03-01 2013-03-01
US201361771534P 2013-03-01 2013-03-01
PCT/US2014/019645 WO2014134562A1 (en) 2013-03-01 2014-02-28 Methods for the treatment of mitochondrial disease

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DK2961378T3 true DK2961378T3 (da) 2019-11-25

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US (3) US10793597B2 (da)
EP (2) EP2961378B1 (da)
JP (2) JP6839490B2 (da)
CN (5) CN117752766A (da)
CA (1) CA2916884C (da)
DK (1) DK2961378T3 (da)
ES (1) ES2755134T3 (da)
HK (1) HK1219653A1 (da)
HU (1) HUE046596T2 (da)
WO (1) WO2014134562A1 (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107312066A (zh) * 2011-12-09 2017-11-03 康德生物医疗技术公司 芳香族阳离子肽及其用途
EP2961420B1 (en) 2013-03-01 2019-09-11 Stealth Biotherapeutics Corp Methods and compositions for the prevention or treatment of barth syndrome
US10047395B2 (en) 2013-06-26 2018-08-14 Stealth Biotherapeutics Corp Methods and compositions for detecting and diagnosing diseases and conditions
EP3501532A3 (en) * 2014-05-28 2019-07-17 Stealth BioTherapeutics Corp Therapeutic compositions including frataxin, lactoferrin, and mitochondrial energy generating enzymes, and uses thereof
JP2019523260A (ja) 2016-04-11 2019-08-22 カーノット, エルエルシー キラルペプチド
CN117205298A (zh) * 2016-05-19 2023-12-12 康德生物医疗有限公司 用于预防和治疗线粒体肌病的组合物和方法
WO2018187400A1 (en) 2017-04-05 2018-10-11 Stealth Biotherapeutics Corp. Crystalline salt forms of boc-d-arg-dmt-lys-(boc)-phe-nh2
US10676506B2 (en) 2018-01-26 2020-06-09 Stealth Biotherapeutics Corp. Crystalline bis- and tris-hydrochloride salt of elamipretide
EP3864417A1 (en) * 2018-10-10 2021-08-18 Helsingin Yliopisto Biomarkers for mitochondrial diseases and related methods
WO2020214518A1 (en) * 2019-04-18 2020-10-22 Arcuate Therapeutics, Inc. Methods of treating renal conditions using peptides that improve mitochondrial function
US12116382B2 (en) 2022-11-28 2024-10-15 Hongene Biotech Corporation Functionalized N-acetylgalactosamine analogs

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US5858784A (en) 1991-12-17 1999-01-12 The Regents Of The University Of California Expression of cloned genes in the lung by aerosol- and liposome-based delivery
US5716644A (en) 1992-06-11 1998-02-10 Alkermes, Inc. Composition for sustained release of non-aggregated erythropoietin
US5674534A (en) 1992-06-11 1997-10-07 Alkermes, Inc. Composition for sustained release of non-aggregated erythropoietin
US5989463A (en) 1997-09-24 1999-11-23 Alkermes Controlled Therapeutics, Inc. Methods for fabricating polymer-based controlled release devices
US6245740B1 (en) 1998-12-23 2001-06-12 Amgen Inc. Polyol:oil suspensions for the sustained release of proteins
CA2457391A1 (en) 2001-08-06 2003-02-20 Vanderbilt University Device and methods for detecting the response of a plurality of cells to at least one analyte of interest
BRPI0105509B8 (pt) 2001-11-05 2021-05-25 Univ Minas Gerais formulações do peptídeo angiotensina-(1-7) usando as ciclodextrinas, lipossomas e o polímero plga
DK2656854T3 (da) * 2003-02-04 2015-07-06 Cornell Res Foundation Inc Anvendelser af et aromatisk-kationisk peptid
CN101440124B (zh) * 2003-02-04 2012-07-18 科内尔研究基金会 用于防止线粒体通透性改变的方法
CA2514071A1 (en) 2003-02-10 2004-08-19 Autogen Research Pty Ltd Therapeutic molecules
US20070026090A1 (en) * 2003-09-05 2007-02-01 Oren Tirosh Treatment and prevention of inflammatory disease and mitochondrial dysfunction with high dose selenium
CA2851972C (en) * 2004-01-23 2015-06-23 Cornell Research Foundation, Inc. Methods for reducing oxidative damage
US8500720B2 (en) 2005-05-09 2013-08-06 Medtronic, Inc Method and apparatus for treatment of cardiac disorders
US20070265216A1 (en) 2005-10-05 2007-11-15 Gross Richard W Enhanced medical treatment in diabetic cardiomyopathy
US20090298848A1 (en) 2006-04-18 2009-12-03 Cortendo Invest Ab, Methods and Compositions for Treating Barth Syndrome, Cardiomyopathy, Mitochondrial Diseases and Other Conditions
EP2150117A4 (en) * 2007-05-02 2011-10-05 Mclean Hospital Corp METHOD AND COMPOSITIONS FOR MITOCHONDRIAL SPARE THERAPY
US20080318909A1 (en) 2007-06-14 2008-12-25 Sparagna Genevieve C Use Of Linoleic Compounds Against Heart Failure
WO2008156654A2 (en) * 2007-06-15 2008-12-24 Massachusetts Institute Of Technology Cytoskeleton modulators for treating metabolic disorders
DK2262520T3 (da) * 2008-02-26 2017-08-07 Univ Cornell Sammensætninger til forebyggelse og behandling af nyreskader
WO2009149307A2 (en) 2008-06-04 2009-12-10 San Diego State University Research Foundation Compositions and methods for restoring mitochondrial electron transfer function
US8999940B2 (en) 2008-08-07 2015-04-07 Ipsen Pharma S.A.S. Analogues of glucose-dependent insulinotropic polypeptide (GIP) modified at N-terminal
EP3563862B1 (en) * 2009-03-20 2021-05-05 The General Hospital Corporation d/b/a Massachusetts General Hospital D-arg-2'6'-dimethyltyrosine-lys-phe-nh2 for use in the prevention of secondary complications of burn injuries
US20120122957A1 (en) * 2009-04-17 2012-05-17 The Salk Institute For Biological Studies Regulation of aging by modulation of mitochondrial function
US20120046363A1 (en) 2009-05-11 2012-02-23 University Of Maryland, Baltimore Docosahexaenoic acid for the treatment of heart failure
CN102647994A (zh) 2009-08-12 2012-08-22 康奈尔大学 预防或治疗代谢综合症的方法
CA2772094C (en) * 2009-08-24 2018-04-03 Stealth Peptides International, Inc. Methods and compositions for preventing or treating ophthalmic conditions
EP2944317A1 (en) * 2009-10-05 2015-11-18 Cornell University Methods for the prevention or treatment of heart failure
WO2011082324A1 (en) 2009-12-31 2011-07-07 Stealth Peptides International, Inc. Methods for the prevention or treatment of vessel occlusion injury
EP2519232A1 (en) * 2009-12-31 2012-11-07 Edison Pharmaceuticals, Inc. Treatment of leigh syndrome and leigh-like syndrome with tocotrienol quinones
US8719939B2 (en) 2009-12-31 2014-05-06 Mcafee, Inc. Malware detection via reputation system
JP4643749B1 (ja) 2010-02-03 2011-03-02 昭和電工株式会社 表面被覆サーメット部材の耐酸化膜形成用の処理液
EP3332795A1 (en) 2010-02-26 2018-06-13 Cornell University Cornell Center For Technology, Enterprise & Commercialization ("CCTEC") Mitochondrial-targeted antioxidants protect against mechanical ventilation-induced diaphragm dysfunction and skeletal muscle atrophy
EP3560508A1 (en) 2010-03-15 2019-10-30 Stealth Peptides International, Inc. Combination therapies using cyclosporine and aromatic cationic peptides
EP2942354A1 (en) 2010-05-03 2015-11-11 Stealth Peptides International, Inc. Aromatic-Cationic Peptides and Uses of Same
WO2012009171A2 (en) * 2010-07-15 2012-01-19 The Schepens Eye Research Institute, Inc. Compositions and methods of treatment of corneal endothelium disorders
AU2011285619B2 (en) * 2010-08-06 2016-12-01 Ptc Therapeutics, Inc. Treatment of mitochondrial diseases with naphthoquinones
WO2012019032A1 (en) * 2010-08-06 2012-02-09 Ampere Life Sciences, Inc. Treatment of mitochondrial diseases with vitamin k
US9241933B2 (en) * 2011-03-01 2016-01-26 Pharnext Compositions for treating amyotrophic lateral sclerosis
WO2012129427A2 (en) * 2011-03-24 2012-09-27 Cornell University Aromatic-cationic peptides and uses of same
JP6157481B2 (ja) 2011-09-29 2017-07-05 メイヨ ファンデーション フォア メディカル エディケイション アンド リサーチ 芳香族陽イオン性ペプチドおよびその使用方法
CA2852454A1 (en) * 2011-10-17 2013-04-25 Cornell University Aromatic-cationic peptides and uses of same
KR20190077124A (ko) 2011-10-21 2019-07-02 스템제닉스 인코포레이티드 생물학적 활성 분자의 세포내 전달을 위한 작용화 나노입자
JP2015509500A (ja) * 2012-02-22 2015-03-30 ステルス ペプチドズ インターナショナル インコーポレイテッド 眼疾患を予防または治療するための方法および組成物
CN104203262A (zh) * 2012-02-23 2014-12-10 康奈尔大学 芳香族阳离子肽及其用途
US20150266946A1 (en) * 2012-10-09 2015-09-24 President And Fellows Of Harvard College Treatment of age-related and mitochondrial diseases by inhibition of hif-1 alpha function
BR112015009072A2 (pt) 2012-10-22 2017-07-04 Henry Ford Health Systems métodos para redução dos riscos associados à insuficiência cardíaca e fatores associados à mesma
EP2961420B1 (en) 2013-03-01 2019-09-11 Stealth Biotherapeutics Corp Methods and compositions for the prevention or treatment of barth syndrome
US10047395B2 (en) 2013-06-26 2018-08-14 Stealth Biotherapeutics Corp Methods and compositions for detecting and diagnosing diseases and conditions

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CN105517533A (zh) 2016-04-20
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