DK277488A - Phosporholdige hmg-coa-reduktaseinhibitorer, deres anvendelse og fremstilling samt mellemprodukter ved fremstillingen - Google Patents

Phosporholdige hmg-coa-reduktaseinhibitorer, deres anvendelse og fremstilling samt mellemprodukter ved fremstillingen

Info

Publication number: DK277488A
Authority: DK; Denmark
Prior art keywords: hmg; phosphorus; preparation; manufacturing; coa reductase
Prior art date: 1987-05-22

Application number

DK277488A

Other languages

English (en)

Other versions

DK277488D0 (da

Inventor

Donald Steven Karanewsky

Scott Adams Biller

Eric Michael Gordon

Original Assignee

Squibb & Sons Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-05-22

Filing date

1988-05-20

Publication date

1988-11-23

1988-05-20 Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc

1988-05-20 Publication of DK277488D0 publication Critical patent/DK277488D0/da

1988-11-23 Publication of DK277488A publication Critical patent/DK277488A/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/301—Acyclic saturated acids which can have further substituents on alkyl
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/32—Esters thereof
- C07F9/3205—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/3211—Esters of acyclic saturated acids which can have further substituents on alkyl
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/36—Amides thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/44—Amides thereof
- C07F9/4403—Amides thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4407—Amides of acyclic saturated acids which can have further substituents on alkyl

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrane Compounds (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK277488A 1987-05-22 1988-05-20 Phosporholdige hmg-coa-reduktaseinhibitorer, deres anvendelse og fremstilling samt mellemprodukter ved fremstillingen DK277488A (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US5328187A	1987-05-22	1987-05-22
US10968087A	1987-10-19	1987-10-19

Publications (2)

Publication Number	Publication Date
DK277488D0 DK277488D0 (da)	1988-05-20
DK277488A true DK277488A (da)	1988-11-23

Family

ID=26731667

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK277488A DK277488A (da)	1987-05-22	1988-05-20	Phosporholdige hmg-coa-reduktaseinhibitorer, deres anvendelse og fremstilling samt mellemprodukter ved fremstillingen

Country Status (24)

Country	Link
JP (1)	JP2680347B2 (da)
KR (1)	KR880013958A (da)
CN (1)	CN88103091A (da)
AU (1)	AU610591B2 (da)
BE (1)	BE1004193A3 (da)
CH (1)	CH676984A5 (da)
DE (1)	DE3817375C2 (da)
DK (1)	DK277488A (da)
ES (1)	ES2009918A6 (da)
FI (1)	FI89493C (da)
FR (1)	FR2615508B1 (da)
GB (1)	GB2205837B (da)
GR (1)	GR1000959B (da)
HU (1)	HU205125B (da)
IE (2)	IE63760B1 (da)
IL (1)	IL86464A (da)
IT (1)	IT1217685B (da)
NL (1)	NL8801330A (da)
NO (1)	NO882218L (da)
NZ (1)	NZ224733A (da)
PH (1)	PH25350A (da)
PL (1)	PL154877B1 (da)
PT (1)	PT87539B (da)
SE (1)	SE503210C2 (da)

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NZ224734A (en) *	1987-05-22	1991-04-26	Squibb & Sons Inc	Organophosphorus hmg-coa reductase inhibitors, and pharmaceutical compositions
CA2007643A1 (en) *	1989-02-01	1990-08-01	Donald S. Karanewsky	Combination of an hmg coa reductase inhibitor and a squalene synthetase inhibitor and method for lowering serum cholesterol using such combination
CA2042526A1 (en) *	1990-06-11	1991-12-12	Adeoye Y. Olukotun	Method for preventing a second heart attack employing an hmg coa reductase inhibitor
US5202327A (en) *	1991-07-10	1993-04-13	E. R. Squibb & Sons, Inc.	Phosphorus-containing hmg-coa reductase inhibitors
GB9126144D0 (en) *	1991-12-10	1992-02-12	British Bio Technology	Compounds
US20010006644A1 (en)	1997-07-31	2001-07-05	David J. Bova	Combinations of hmg-coa reductase inhibitors and nicotinic acid and methods for treating hyperlipidemia once a day at night
BR9913831A (pt)	1998-09-17	2001-05-29	Bristol Myers Squibb Co	Processo para tratamento de arteriosclerose empregando um inibidor de ap2 e combinação
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US7459474B2 (en)	2003-06-11	2008-12-02	Bristol-Myers Squibb Company	Modulators of the glucocorticoid receptor and method
US6995183B2 (en)	2003-08-01	2006-02-07	Bristol Myers Squibb Company	Adamantylglycine-based inhibitors of dipeptidyl peptidase IV and methods
US8158362B2 (en)	2005-03-30	2012-04-17	Decode Genetics Ehf.	Methods of diagnosing susceptibility to myocardial infarction and screening for an LTA4H haplotype
CA2558766A1 (en)	2004-03-05	2005-09-22	The Trustees Of The University Of Pennsylvania	The use of mtp inhibitors for treating disorders or diseases associated with hyperlipidemia and hypercholesterolemia while minimizing side effects
US7534763B2 (en)	2004-07-02	2009-05-19	Bristol-Myers Squibb Company	Sustained release GLP-1 receptor modulators
US7145040B2 (en)	2004-07-02	2006-12-05	Bristol-Myers Squibb Co.	Process for the preparation of amino acids useful in the preparation of peptide receptor modulators
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FR2596393B1 (fr) *	1986-04-01	1988-06-03	Sanofi Sa	Derives de l'acide hydroxy-3 dihydroxyoxophosphorio-4 butanoique, leur procede de preparation, leur application comme medicament et les compositions les renfermant
NZ224734A (en) *	1987-05-22	1991-04-26	Squibb & Sons Inc	Organophosphorus hmg-coa reductase inhibitors, and pharmaceutical compositions

1988
- 1988-05-20 PT PT87539A patent/PT87539B/pt not_active IP Right Cessation
- 1988-05-20 ES ES8801610A patent/ES2009918A6/es not_active Expired
- 1988-05-20 DK DK277488A patent/DK277488A/da not_active Application Discontinuation
- 1988-05-20 HU HU882614A patent/HU205125B/hu not_active IP Right Cessation
- 1988-05-20 FI FI882384A patent/FI89493C/fi not_active IP Right Cessation
- 1988-05-20 GR GR880100331A patent/GR1000959B/el unknown
- 1988-05-20 GB GB8811929A patent/GB2205837B/en not_active Expired - Fee Related
- 1988-05-20 IE IE154388A patent/IE63760B1/en not_active IP Right Cessation
- 1988-05-20 IL IL86464A patent/IL86464A/xx not_active IP Right Cessation
- 1988-05-20 PH PH36956A patent/PH25350A/en unknown
- 1988-05-20 IE IE930324A patent/IE930324L/xx unknown
- 1988-05-20 NO NO882218A patent/NO882218L/no unknown
- 1988-05-20 NZ NZ224733A patent/NZ224733A/en unknown
- 1988-05-20 SE SE8801903A patent/SE503210C2/sv not_active IP Right Cessation
- 1988-05-20 IT IT20682/88A patent/IT1217685B/it active
- 1988-05-20 DE DE3817375A patent/DE3817375C2/de not_active Expired - Fee Related
- 1988-05-20 AU AU16508/88A patent/AU610591B2/en not_active Ceased
- 1988-05-21 JP JP63124809A patent/JP2680347B2/ja not_active Expired - Lifetime
- 1988-05-21 KR KR1019880006020A patent/KR880013958A/ko not_active Ceased
- 1988-05-21 CN CN198888103091A patent/CN88103091A/zh active Pending
- 1988-05-21 PL PL1988272597A patent/PL154877B1/pl unknown
- 1988-05-24 FR FR8806885A patent/FR2615508B1/fr not_active Expired - Fee Related
- 1988-05-24 CH CH1967/88A patent/CH676984A5/fr not_active IP Right Cessation
- 1988-05-24 BE BE8800566A patent/BE1004193A3/fr not_active IP Right Cessation
- 1988-05-24 NL NL8801330A patent/NL8801330A/nl not_active Application Discontinuation

Also Published As

Publication number	Publication date
JP2680347B2 (ja)	1997-11-19
PL272597A1 (en)	1989-03-06
FI882384A0 (fi)	1988-05-20
IE930324L (en)	1988-11-22
IL86464A0 (en)	1988-11-15
BE1004193A3 (fr)	1992-10-13
IL86464A (en)	1993-06-10
AU1650888A (en)	1988-11-24
IT8820682A0 (it)	1988-05-20
IE63760B1 (en)	1995-06-14
HU205125B (en)	1992-03-30
NO882218L (no)	1988-11-23
PT87539A (pt)	1989-05-31
FI89493C (fi)	1993-10-11
JPS6456689A (en)	1989-03-03
SE503210C2 (sv)	1996-04-22
PT87539B (pt)	1992-09-30
PH25350A (en)	1991-05-13
GR880100331A (en)	1989-02-23
SE8801903L (sv)	1988-11-23
NZ224733A (en)	1990-12-21
DK277488D0 (da)	1988-05-20
ES2009918A6 (es)	1989-10-16
FI89493B (fi)	1993-06-30
FI882384A7 (fi)	1988-11-23
FR2615508B1 (fr)	1994-11-25
GR1000959B (el)	1993-03-16
HUT49358A (en)	1989-09-28
CN88103091A (zh)	1988-12-21
NO882218D0 (no)	1988-05-20
GB2205837A (en)	1988-12-21
IE881543L (en)	1988-11-22
AU610591B2 (en)	1991-05-23
GB8811929D0 (en)	1988-06-22
DE3817375C2 (de)	1997-04-30
PL154877B1 (en)	1991-09-30
KR880013958A (ko)	1988-12-22
CH676984A5 (da)	1991-03-28
DE3817375A1 (de)	1988-12-08
FR2615508A1 (fr)	1988-11-25
NL8801330A (nl)	1988-12-16
GB2205837B (en)	1991-11-20
SE8801903D0 (sv)	1988-05-20
IT1217685B (it)	1990-03-30

Publication	Publication Date	Title
DK277488A (da)	1988-11-23	Phosporholdige hmg-coa-reduktaseinhibitorer, deres anvendelse og fremstilling samt mellemprodukter ved fremstillingen
NO177212C (no)	1995-08-09	Fremgangsmåte ved fremstilling av deig og bröd, samt enzympreparat for anvendelse ved fremgangsmåten
NO902272D0 (no)	1990-05-23	Metall-karbidgjenstander og fremgangsmaate ved deres fremstilling.
DK328585D0 (da)	1985-07-18	Modificerede succinimider, fremgangsmaade til deres fremstilling samt deres anvendelse
DE3681991D1 (de)	1991-11-21	Hmg-coa-reduktase-hemmungskoerper.
FI921790A7 (fi)	1992-04-22	Säiliö ja menetelmä sen valmistamiseksi
NO884309D0 (no)	1988-09-29	Lagringsstabile yogurtprodukter og fremgangsmaate for deres fremstilling.
DK198387D0 (da)	1987-04-15	1-hydroxy-2-pyridoner, deres fremstilling og anvendelse samt ved fremgangsmaaden anvendelige mellemprodukter og disses fremstilling
DK148590A (da)	1990-06-18	Homogene, isaer flerfarvede strukturerede kunststofbaner eller -plader samt fremgangsmaade til deres fremstilling
DK698088A (da)	1989-06-18	Piperidinylforbindelser, deres anvendelse samt mellemprodukter til brug ved fremstillingen af disse
DK277388A (da)	1988-11-23	Phosphorholdige hmg-coa-reduktase-inhibitorer, mellemprodukter og fremgangsmaade
FI893004A7 (fi)	1989-12-30	5-oksygenoituja HMG-CoA-reduktaasi-inhibiittoreita
DK361288A (da)	1989-01-02	Hydroxyethylazolylderivater, deres fremstilling og anvendelse samt mellemprodukter til fremstilling og disses fremstilling
IT8820130A0 (it)	1988-04-08	Smalto o vernice per unghie avente caratteristiche fotocromatiche erelativo procedimento di preparazione.
DK326085A (da)	1986-01-19	4-amino-2-phenylquinoliner, deres fremstilling og anvendelse samt ved fremstillingen anvendelige mellemprodukter
NO903801D0 (no)	1990-08-30	Alkalipullunase, mikroorganisme og fremgangsmaate ved fremstilling derav.
DK332287A (da)	1987-12-31	Antibiotika ll-e19020-alfa og ll-e19020-beta, deres fremstilling og anvendelse samt mikroorganisme til fremstillingen
DK39486D0 (da)	1986-01-27	4,4-diakyl-2-azetidinoner, fremstilling og anvendelse deraf, samt vedfremstillingen anvendelige mellemprodukter og deres fremstilling
DK610388A (da)	1989-05-04	(6-(hetero) aryloxy-naphthalin-2-yl-oxy)-alkancarboxylsyrederivater, deres fremstilling og anvendelse samt ved fremgangsmaaden anvendelige mellemprodukter og disses fremstilling
DK192989D0 (da)	1989-04-20	3,4-dihydroxypyrrolidin-2-on-derivater, deres fremstilling og anvendelse samt ved fremgangsmaaden anvendelige mellemprodukter
NO880628L (no)	1988-08-15	Annelerte azepinon- og azocinon-derivater, fremgangsmaate til deres fremstilling, midler som inneholder dem og deresanvendelse, samt mellomprodukter ved deres fremstilling.
DK490985D0 (da)	1985-10-25	Benzoylurinstoffer, deres fremstilling og anvendelse, samt ved fremstillingen anvendelige mellemprodukter og fremstilling deraf
EP0306263A3 (en)	1989-08-23	Novel hmg-coa reductase inhibitors
NO901934D0 (no)	1990-04-30	Fraktureringsmateriale, samt anvendelse av det ved produksjon av hydrokarboner.
DK548487A (da)	1988-04-22	Substituerede aminoketaler, deres fremstilling og anvendelse samt ved fremgangsmaaden anvendelige dioxalaner og disses fremstilling

Legal Events

Date	Code	Title	Description
2000-01-17	AHB	Application shelved due to non-payment