DK2435568T3 - Samling af syntetiske antistoffer til behandling af sygdom - Google Patents
Samling af syntetiske antistoffer til behandling af sygdomInfo
- Publication number
- DK2435568T3 DK2435568T3 DK10722101.2T DK10722101T DK2435568T3 DK 2435568 T3 DK2435568 T3 DK 2435568T3 DK 10722101 T DK10722101 T DK 10722101T DK 2435568 T3 DK2435568 T3 DK 2435568T3
- Authority
- DK
- Denmark
- Prior art keywords
- collection
- treat disease
- synthetic antibodies
- antibodies
- synthetic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
- C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/06—Biochemical methods, e.g. using enzymes or whole viable microorganisms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B30/00—Methods of screening libraries
- C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Virology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18235009P | 2009-05-29 | 2009-05-29 | |
| EP09162724 | 2009-06-15 | ||
| US29940110P | 2010-01-29 | 2010-01-29 | |
| PCT/EP2010/057507 WO2010136598A1 (en) | 2009-05-29 | 2010-05-29 | A collection and methods for its use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2435568T3 true DK2435568T3 (da) | 2014-09-08 |
Family
ID=41210731
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK10722101.2T DK2435568T3 (da) | 2009-05-29 | 2010-05-29 | Samling af syntetiske antistoffer til behandling af sygdom |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US8685896B2 (da) |
| EP (1) | EP2435568B1 (da) |
| JP (1) | JP5804521B2 (da) |
| KR (1) | KR101805202B1 (da) |
| CN (1) | CN102449149B (da) |
| AU (1) | AU2010252939B2 (da) |
| CA (1) | CA2758356C (da) |
| DK (1) | DK2435568T3 (da) |
| ES (1) | ES2511051T3 (da) |
| HK (1) | HK1168635A1 (da) |
| IL (1) | IL216536B (da) |
| MX (1) | MX2011012696A (da) |
| NZ (1) | NZ596603A (da) |
| PT (1) | PT2435568E (da) |
| RU (1) | RU2569187C2 (da) |
| SG (1) | SG175407A1 (da) |
| WO (1) | WO2010136598A1 (da) |
| ZA (1) | ZA201107652B (da) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100069614A1 (en) | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
| DK2435568T3 (da) | 2009-05-29 | 2014-09-08 | Morphosys Ag | Samling af syntetiske antistoffer til behandling af sygdom |
| US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| US20120021409A1 (en) * | 2010-02-08 | 2012-01-26 | Regeneron Pharmaceuticals, Inc. | Common Light Chain Mouse |
| BR112012019887B1 (pt) | 2010-02-08 | 2021-06-08 | Regeneron Pharmaceuticals, Inc | método para fabricação de anticorpo e método para selecionar uma sequência de ácido nucleico da região variável da cadeia pesada humana para produzir um anticorpo |
| US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
| PL2640742T3 (pl) * | 2010-11-19 | 2019-01-31 | Morphosys Ag | Kolekcja sekwencji przeciwciał i jej zastosowanie |
| AU2012233313C1 (en) | 2011-03-30 | 2017-08-03 | Chugai Seiyaku Kabushiki Kaisha | Method for altering plasma retention and immunogenicity of antigen-binding molecule |
| BR112013027540A2 (pt) * | 2011-04-28 | 2016-09-20 | Us Dept Veterans Affairs | banco de composição de polinucleotídeo, método para produzir um ou mais polinucletídeos de interesse e método para analisar e utilizar dados de sequenciamento |
| PT2710033T (pt) | 2011-05-17 | 2021-03-11 | Univ Rockefeller | Anticorpos neutralizantes do vírus da imunodeficiência humana e métodos de utilização destes |
| LT3572517T (lt) | 2011-08-05 | 2021-04-26 | Regeneron Pharmaceuticals, Inc. | Humanizuotos universalios lengvosios grandinės pelės |
| JP6244301B2 (ja) * | 2011-08-18 | 2017-12-06 | アフィニティ バイオサイエンス ピーティーワイ リミテッド | 可溶性ポリペプチド |
| CA2791109C (en) * | 2011-09-26 | 2021-02-16 | Merus B.V. | Generation of binding molecules |
| EP2762493B1 (en) | 2011-09-30 | 2021-06-09 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule promoting disappearance of antigens having plurality of biological activities |
| CN107287660A (zh) | 2011-09-30 | 2017-10-24 | 中外制药株式会社 | 离子浓度依赖性结合分子文库 |
| US10556949B2 (en) | 2011-09-30 | 2020-02-11 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule inducing immune response to target antigen |
| AU2012356894B2 (en) * | 2011-12-23 | 2018-01-18 | Araris Biotech Ltd. | Enzymatic conjugation of polypeptides |
| RU2664473C2 (ru) | 2012-03-16 | 2018-08-17 | Регенерон Фармасьютикалз, Инк. | ОТЛИЧНЫЕ ОТ ЧЕЛОВЕКА ЖИВОТНЫЕ, ЭКСПРЕССИРУЮЩИЕ ЧУВСТВИТЕЛЬНЫЕ К pН ПОСЛЕДОВАТЕЛЬНОСТИ ИММУНОГЛОБУЛИНОВ |
| RU2017135754A (ru) | 2012-03-16 | 2019-02-08 | Регенерон Фармасьютикалз, Инк. | Антитела со встроенным в легкие цепи гистидином и генетически модифицированные отличные от человека животные для их получения |
| WO2014009426A2 (en) | 2012-07-13 | 2014-01-16 | Innate Pharma | Screening of conjugated antibodies |
| EP3564259A3 (en) | 2012-11-09 | 2020-02-12 | Innate Pharma | Recognition tags for tgase-mediated conjugation |
| WO2014128628A1 (en) * | 2013-02-20 | 2014-08-28 | Affinity Biosciences Pty Ltd | Cytoplasmic expression of fab proteins |
| US10611824B2 (en) | 2013-03-15 | 2020-04-07 | Innate Pharma | Solid phase TGase-mediated conjugation of antibodies |
| EP3010547B1 (en) | 2013-06-20 | 2021-04-21 | Innate Pharma | Enzymatic conjugation of polypeptides |
| WO2014202775A1 (en) | 2013-06-21 | 2014-12-24 | Innate Pharma | Enzymatic conjugation of polypeptides |
| MX2015017959A (es) * | 2013-06-24 | 2018-03-01 | Neximmune Inc | Composiciones y metodos para inmunoterapia. |
| US20150011405A1 (en) * | 2013-07-03 | 2015-01-08 | Atreca, Inc. | Use of Nanoexpression to Interrogate Antigen Repertoires |
| AU2015230938C1 (en) | 2014-03-21 | 2021-10-14 | Regeneron Pharmaceuticals, Inc. | Non-human animals that make single domain binding proteins |
| EP3271403A1 (en) | 2015-03-19 | 2018-01-24 | Regeneron Pharmaceuticals, Inc. | Non-human animals that select for light chain variable regions that bind antigen |
| CA2998548A1 (en) * | 2015-09-10 | 2017-03-16 | Affigen, Inc. | Sequencing-directed selection of tumor theranostics |
| KR102709778B1 (ko) | 2017-07-12 | 2024-09-26 | 노우스콤 아게 | 미세부수체 불안정성(msi) 암의 예방 및 치료를 위한 공유된 종양 신생항원을 기반으로 한 범용 백신 |
| US20210130440A1 (en) * | 2019-10-03 | 2021-05-06 | Janssen Biotech, Inc. | Methods for producing biotherapeutics with increased stability by sequence optimization |
| MX2022012004A (es) * | 2020-03-27 | 2022-10-21 | Ddbio Co Ltd Shang Hai | Metodo de construccion y aplicacion del vector de visualizacion genica del polipeptido de union especifica de antigeno. |
Family Cites Families (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5618920A (en) | 1985-11-01 | 1997-04-08 | Xoma Corporation | Modular assembly of antibody genes, antibodies prepared thereby and use |
| NZ224615A (en) | 1987-05-14 | 1990-04-26 | Commw Scient Ind Res Org | Process for the production of whey protein fractions |
| AU612370B2 (en) | 1987-05-21 | 1991-07-11 | Micromet Ag | Targeted multifunctional proteins |
| US5258498A (en) | 1987-05-21 | 1993-11-02 | Creative Biomolecules, Inc. | Polypeptide linkers for production of biosynthetic proteins |
| US5091513A (en) | 1987-05-21 | 1992-02-25 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
| EP0768377A1 (en) | 1988-09-02 | 1997-04-16 | Protein Engineering Corporation | Generation and selection of recombinant varied binding proteins |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| KR0184860B1 (ko) | 1988-11-11 | 1999-04-01 | 메디칼 리써어치 카운실 | 단일영역 리간드와 이를 포함하는 수용체 및 이들의 제조방법과 이용(법) |
| US6291159B1 (en) | 1989-05-16 | 2001-09-18 | Scripps Research Institute | Method for producing polymers having a preselected activity |
| CA2016841C (en) | 1989-05-16 | 1999-09-21 | William D. Huse | A method for producing polymers having a preselected activity |
| US6291158B1 (en) | 1989-05-16 | 2001-09-18 | Scripps Research Institute | Method for tapping the immunological repertoire |
| CA2016842A1 (en) | 1989-05-16 | 1990-11-16 | Richard A. Lerner | Method for tapping the immunological repertoire |
| US6291161B1 (en) | 1989-05-16 | 2001-09-18 | Scripps Research Institute | Method for tapping the immunological repertiore |
| CA2057923A1 (en) | 1989-05-16 | 1990-11-17 | William D. Huse | Co-expression of heteromeric receptors |
| US6291160B1 (en) | 1989-05-16 | 2001-09-18 | Scripps Research Institute | Method for producing polymers having a preselected activity |
| US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| US5780225A (en) | 1990-01-12 | 1998-07-14 | Stratagene | Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules |
| WO1991010737A1 (en) | 1990-01-11 | 1991-07-25 | Molecular Affinities Corporation | Production of antibodies using gene libraries |
| DE4002897A1 (de) | 1990-02-01 | 1991-08-08 | Behringwerke Ag | Herstellung und verwendung von genbanken synthetischer menschlicher antikoerper ("synthetische human-antikoerper-bibliotheken") |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| WO1992020791A1 (en) | 1990-07-10 | 1992-11-26 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| AU1457992A (en) | 1991-03-01 | 1992-10-06 | Stratagene | Pcr generated dicistronic dna molecules for producing antibodies |
| DK1820858T3 (da) | 1991-03-01 | 2009-11-02 | Dyax Corp | Kimært protein omfatende mikroprotein med to eller flere disulfidbindinger og udförelsesformer deraf |
| DE69228247T2 (de) | 1991-08-10 | 1999-07-08 | Medical Research Council, London | Behandlung von Zellpopulationen |
| EP0605522B1 (en) | 1991-09-23 | 1999-06-23 | Medical Research Council | Methods for the production of humanized antibodies |
| US5565332A (en) | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
| ES2227512T3 (es) | 1991-12-02 | 2005-04-01 | Medical Research Council | Produccion de anticuerpos contra auto-antigenos a partir de repertorios de segmentos de anticuerpos fijados en un fago. |
| US5667988A (en) | 1992-01-27 | 1997-09-16 | The Scripps Research Institute | Methods for producing antibody libraries using universal or randomized immunoglobulin light chains |
| US5395750A (en) | 1992-02-28 | 1995-03-07 | Hoffmann-La Roche Inc. | Methods for producing proteins which bind to predetermined antigens |
| WO1993019172A1 (en) | 1992-03-24 | 1993-09-30 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| US5855885A (en) | 1993-01-22 | 1999-01-05 | Smith; Rodger | Isolation and production of catalytic antibodies using phage technology |
| EP0725838A4 (en) | 1993-10-26 | 1997-02-26 | United Biomedical Inc | STRUCTURED SYNTHETIC ANTIGAN BANKS AS DIAGNOSTICS, VACCINE AND THERAPEUTIC AGENTS |
| US20010049107A1 (en) | 1994-01-31 | 2001-12-06 | Boston University | Polyclonal antibody libraries |
| US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
| EP0873363B1 (en) | 1995-06-14 | 2010-10-06 | The Regents of The University of California | High affinity human antibodies to tumor antigens |
| WO1997008320A1 (en) | 1995-08-18 | 1997-03-06 | Morphosys Gesellschaft Für Proteinoptimierung Mbh | Protein/(poly)peptide libraries |
| US7264963B1 (en) | 1995-08-18 | 2007-09-04 | Morphosys Ag | Protein(poly)peptide libraries |
| GB9603507D0 (en) | 1996-02-20 | 1996-04-17 | Isis Innovation | Antibody variants |
| CA2297070A1 (en) | 1997-08-01 | 1999-02-11 | Morphosys Ag | Novel method and phage for the identification of nucleic acid sequences encoding members of a multimeric (poly)peptide complex |
| GB9722131D0 (en) | 1997-10-20 | 1997-12-17 | Medical Res Council | Method |
| IL144559A0 (en) | 1999-03-01 | 2002-05-23 | Genentech Inc | Antibodies for cancer therapy and diagnosis |
| IL142025A0 (en) | 1999-07-20 | 2002-03-10 | Morphosys Ag | Novel methods for displaying (poly) peptides/proteins on bacteriophage particles via disulfide bonds |
| IL136459A0 (en) | 2000-05-30 | 2001-06-14 | Galim Galil Immunology Ltd | Antibody library |
| US7117096B2 (en) | 2001-04-17 | 2006-10-03 | Abmaxis, Inc. | Structure-based selection and affinity maturation of antibody library |
| US20030186374A1 (en) | 2001-10-01 | 2003-10-02 | Hufton Simon E. | Multi-chain eukaryotic display vectors and uses thereof |
| GB0130267D0 (en) | 2001-12-19 | 2002-02-06 | Neutec Pharma Plc | Focussed antibody technology |
| WO2003054016A2 (en) | 2001-12-21 | 2003-07-03 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | Method for cloning of variable domain sequences |
| US7244592B2 (en) | 2002-03-07 | 2007-07-17 | Dyax Corp. | Ligand screening and discovery |
| AU2003253193B2 (en) | 2002-07-30 | 2009-07-02 | Morphosys Ag | Novel tricistronic vectors and uses therefor |
| US8557743B2 (en) | 2002-09-05 | 2013-10-15 | Dyax Corp. | Display library process |
| GB0309126D0 (en) | 2003-04-17 | 2003-05-28 | Neutec Pharma Plc | Clostridium difficile focussed antibodies |
| EP2824190A1 (en) | 2003-09-09 | 2015-01-14 | Integrigen, Inc. | Methods and compositions for generation of germline human antibody genes |
| TWI333977B (en) | 2003-09-18 | 2010-12-01 | Symphogen As | Method for linking sequences of interest |
| AU2004317819A1 (en) | 2003-11-12 | 2005-10-13 | Patrys, Limited | Methods of identifying neoplasm-specific antibodies and uses thereof |
| US20080003566A1 (en) | 2004-01-26 | 2008-01-03 | David Vaux | Molecular Analysis |
| ATE505727T1 (de) | 2004-05-26 | 2011-04-15 | Fraunhofer Ges Forschung | Isolation allergen-spezifischer immunoglobulin- gene aus humanen b-zellen von atopikern |
| ES2563491T3 (es) | 2004-07-06 | 2016-03-15 | Bioren, LLC | Bibliotecas universales de anticuerpos |
| WO2006028987A2 (en) | 2004-09-02 | 2006-03-16 | Bioarray Solutions Ltd. | Nucleic acid amplification with integrated multiplex detection |
| US20060078898A1 (en) | 2004-10-12 | 2006-04-13 | Curry Bo U | Methods and compositions for reducing label variation in array-based comparative genome hybridization assays II |
| JP4829609B2 (ja) * | 2004-12-22 | 2011-12-07 | 独立行政法人科学技術振興機構 | ヒト抗体酵素およびその生産方法 |
| EP1848672A4 (en) | 2005-02-01 | 2009-11-04 | Morphosys Ag | BANKS AND METHODS FOR ISOLATING ANTIBODIES |
| WO2007056441A2 (en) | 2005-11-07 | 2007-05-18 | Genentech, Inc. | Binding polypeptides with diversified and consensus vh/vl hypervariable sequences |
| DK1979378T3 (da) | 2005-12-20 | 2012-10-29 | Morphosys Ag | Ny samling af HCDR3 områder og anvendelser derfor |
| EP2021795A4 (en) | 2006-05-04 | 2009-05-13 | Abmaxis Inc | CROSS SPECIES AND MULTI-SPECIAL PRESENTATION SYSTEMS |
| DK2190987T3 (da) | 2007-08-21 | 2013-02-18 | Morphosys Ag | Fremgangsmåder til dannelse af disulfidbindinger |
| DK3124497T3 (da) | 2007-09-14 | 2020-05-11 | Adimab Llc | Rationelt designede syntetiske antistofbiblioteker og anvendelser deraf |
| AU2008343589A1 (en) | 2007-12-19 | 2009-07-09 | Centocor Ortho Biotech Inc. | Design and generation of human de novo pIX phage display libraries via fusion to pIX or pVII, vectors, antibodies and methods |
| EP2088432A1 (en) | 2008-02-11 | 2009-08-12 | MorphoSys AG | Methods for identification of an antibody or a target |
| EP2100970B1 (en) | 2008-03-13 | 2017-05-10 | National Institute of Immunology | Ig genes specific oligonucleotides and uses thereof |
| US9873957B2 (en) | 2008-03-13 | 2018-01-23 | Dyax Corp. | Libraries of genetic packages comprising novel HC CDR3 designs |
| CA2736277C (en) | 2008-09-10 | 2016-06-21 | Philochem Ag | Display library for antibody selection |
| US9221902B2 (en) | 2008-11-07 | 2015-12-29 | Fabrus, Inc. | Combinatorial antibody libraries and uses thereof |
| WO2010130824A2 (en) | 2009-05-15 | 2010-11-18 | Morphosys Ag | Collections and uses thereof |
| DK2435568T3 (da) | 2009-05-29 | 2014-09-08 | Morphosys Ag | Samling af syntetiske antistoffer til behandling af sygdom |
| DK2528944T3 (da) | 2010-01-29 | 2015-09-14 | Morphosys Ag | Kombinatoriske gnaver-antistofbiblioteker |
-
2010
- 2010-05-29 DK DK10722101.2T patent/DK2435568T3/da active
- 2010-05-29 RU RU2011147741/10A patent/RU2569187C2/ru active
- 2010-05-29 CN CN201080022793.7A patent/CN102449149B/zh active Active
- 2010-05-29 MX MX2011012696A patent/MX2011012696A/es active IP Right Grant
- 2010-05-29 AU AU2010252939A patent/AU2010252939B2/en active Active
- 2010-05-29 US US13/321,564 patent/US8685896B2/en active Active
- 2010-05-29 CA CA2758356A patent/CA2758356C/en active Active
- 2010-05-29 JP JP2012512407A patent/JP5804521B2/ja active Active
- 2010-05-29 ES ES10722101.2T patent/ES2511051T3/es active Active
- 2010-05-29 KR KR1020117031164A patent/KR101805202B1/ko active IP Right Grant
- 2010-05-29 WO PCT/EP2010/057507 patent/WO2010136598A1/en active Application Filing
- 2010-05-29 SG SG2011079761A patent/SG175407A1/en unknown
- 2010-05-29 NZ NZ596603A patent/NZ596603A/xx not_active IP Right Cessation
- 2010-05-29 PT PT107221012T patent/PT2435568E/pt unknown
- 2010-05-29 EP EP10722101.2A patent/EP2435568B1/en active Active
-
2011
- 2011-10-19 ZA ZA2011/07652A patent/ZA201107652B/en unknown
- 2011-11-22 IL IL216536A patent/IL216536B/en active IP Right Grant
-
2012
- 2012-09-25 HK HK12109457.3A patent/HK1168635A1/xx unknown
-
2014
- 2014-01-31 US US14/169,162 patent/US9624293B2/en active Active
-
2017
- 2017-03-03 US US15/449,561 patent/US10647757B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| SG175407A1 (en) | 2011-11-28 |
| US9624293B2 (en) | 2017-04-18 |
| ZA201107652B (en) | 2012-06-27 |
| PT2435568E (pt) | 2014-10-08 |
| EP2435568B1 (en) | 2014-07-02 |
| KR20120087809A (ko) | 2012-08-07 |
| CN102449149B (zh) | 2014-04-23 |
| US8685896B2 (en) | 2014-04-01 |
| US20120077713A1 (en) | 2012-03-29 |
| CA2758356A1 (en) | 2010-12-02 |
| US10647757B2 (en) | 2020-05-12 |
| IL216536A0 (en) | 2012-02-29 |
| MX2011012696A (es) | 2012-03-29 |
| NZ596603A (en) | 2013-07-26 |
| JP2012527881A (ja) | 2012-11-12 |
| RU2011147741A (ru) | 2013-07-10 |
| CN102449149A (zh) | 2012-05-09 |
| US20170218048A1 (en) | 2017-08-03 |
| EP2435568A1 (en) | 2012-04-04 |
| WO2010136598A1 (en) | 2010-12-02 |
| KR101805202B1 (ko) | 2017-12-07 |
| JP5804521B2 (ja) | 2015-11-04 |
| CA2758356C (en) | 2016-07-26 |
| AU2010252939A1 (en) | 2011-10-13 |
| US20140163208A1 (en) | 2014-06-12 |
| RU2569187C2 (ru) | 2015-11-20 |
| HK1168635A1 (en) | 2013-01-04 |
| ES2511051T3 (es) | 2014-10-22 |
| IL216536B (en) | 2018-06-28 |
| AU2010252939B2 (en) | 2014-06-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK2435568T3 (da) | Samling af syntetiske antistoffer til behandling af sygdom | |
| CY2017025I2 (el) | Αντιδοτα αντιπηκτικων | |
| BR112013012782A2 (pt) | anticorpos humanos para o receptor de glucagon | |
| BRPI0916973A2 (pt) | anticorpos para ccr2 | |
| BRPI1011005A2 (pt) | anticorpos anti-epcam | |
| ZA201200732B (en) | Fully human antibodies to btla | |
| DK2975051T3 (da) | Let-at-isolere bispecifikke antistoffer med nativt immunoglobulinformat | |
| SMT201700083B (it) | Anticorpi monoclonali | |
| CR20130228A (es) | Anticuerpos neutralizadores anti-ccl20 | |
| DK2627345T3 (da) | Formuleringer til behandling af sygdomme i de øvre luftveje | |
| CO6791565A2 (es) | Anticuerpos anti-notch1 | |
| BRPI1014262A2 (pt) | anticorpos específicos para caderina-17 | |
| DK2453858T3 (da) | Fremgangsmåde | |
| BR112013025721A8 (pt) | métodos de fabricação de elementos absorventes volumosos | |
| DK2755613T3 (da) | Opsamlingspose til humant affald | |
| ES1069567Y (es) | Recogedor de excrementos de animales | |
| DK2566505T3 (da) | Fremføring af kolesterylester til steroidogene væv | |
| ES1071594Y (es) | Recogedor de micciones procedentes de animales | |
| ES1073603Y (es) | Conjunto de elementos para la recogida de excrementos caninos | |
| BR112013007817A2 (pt) | síntese aperfeiçoada de peretinoin | |
| BR112013007818A2 (pt) | síntese aperfeiçoada de peretinoin | |
| DK2426116T3 (da) | Fremgangsmåde til fremstilling af (S)-3-N-methylamino-1-(2-thienyl)-1-propanol | |
| ES1075144Y (es) | Recogedor de excrementos de animales de compania | |
| ES1072065Y (es) | Elemento de mobiliario urbano ceramico | |
| ES1075419Y (es) | Elemento de mobiliario urbano ceramico |