DK2335370T3 - Organ-på-en-chip-anordning - Google Patents
Organ-på-en-chip-anordningInfo
- Publication number
- DK2335370T3 DK2335370T3 DK09757294.5T DK09757294T DK2335370T3 DK 2335370 T3 DK2335370 T3 DK 2335370T3 DK 09757294 T DK09757294 T DK 09757294T DK 2335370 T3 DK2335370 T3 DK 2335370T3
- Authority
- DK
- Denmark
- Prior art keywords
- organ
- chip device
- chip
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/16—Microfluidic devices; Capillary tubes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/10—Perfusion
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0663—Whole sensors
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Sustainable Development (AREA)
- Analytical Chemistry (AREA)
- Hematology (AREA)
- Dispersion Chemistry (AREA)
- Clinical Laboratory Science (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Fluid Mechanics (AREA)
- Pathology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Food Science & Technology (AREA)
- Toxicology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Microscoopes, Condenser (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5876608P | 2008-06-04 | 2008-06-04 | |
PCT/EP2009/004008 WO2009146911A2 (en) | 2008-06-04 | 2009-06-04 | Organ-on-a-chip-device |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2335370T3 true DK2335370T3 (da) | 2014-05-26 |
Family
ID=41398604
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK09757294.5T DK2335370T3 (da) | 2008-06-04 | 2009-06-04 | Organ-på-en-chip-anordning |
Country Status (11)
Country | Link |
---|---|
US (2) | US20110086382A1 (da) |
EP (3) | EP2335370B1 (da) |
JP (1) | JP5774477B2 (da) |
CN (1) | CN102257124B (da) |
AU (1) | AU2009254177B2 (da) |
CA (1) | CA2727003C (da) |
DK (1) | DK2335370T3 (da) |
HK (1) | HK1159157A1 (da) |
RU (1) | RU2517046C2 (da) |
SG (1) | SG193829A1 (da) |
WO (1) | WO2009146911A2 (da) |
Families Citing this family (65)
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EP2313487B1 (en) | 2008-07-16 | 2018-04-04 | Children's Medical Center Corporation | Organ mimic device with microchannels and methods of use |
US9719068B2 (en) | 2010-05-06 | 2017-08-01 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
US9447447B2 (en) * | 2010-09-30 | 2016-09-20 | National University Corporation Tokyo Medical And Dental University | Method and apparatus for testing cardiotoxicity and evaluating cardiomyocytes |
WO2014081840A1 (en) * | 2012-11-21 | 2014-05-30 | Vanderbilt University | Organ on chip integration and applications of the same |
WO2012048261A2 (en) | 2010-10-07 | 2012-04-12 | Vanderbilt University | Peristaltic micropump and related systems and methods |
US10023832B2 (en) | 2013-07-16 | 2018-07-17 | Vanderbilt University | Interconnections of multiple perfused engineered tissue constructs and microbioreactors, multi-microformulators and applications of the same |
EP3498818A1 (en) | 2011-02-28 | 2019-06-19 | President and Fellows of Harvard College | Cell culture system |
WO2012166903A1 (en) * | 2011-06-02 | 2012-12-06 | President And Fellows Of Harvard College | Methods and uses for ex vivo tissue culture systems |
WO2013086486A1 (en) | 2011-12-09 | 2013-06-13 | President And Fellows Of Harvard College | Integrated human organ-on-chip microphysiological systems |
EP2633870B1 (en) * | 2012-02-29 | 2018-08-01 | Technische Universität Berlin | Method of preparing an artificial tooth primordium in vitro and artificial tooth primordium derived therefrom |
EP2634251A1 (en) | 2012-02-29 | 2013-09-04 | Technische Universität Berlin | 3D in vitro bi-phasic cartilage-bone construct |
ES2663903T3 (es) * | 2012-04-26 | 2018-04-17 | Tissuse Gmbh | Métodos para determinar y/o vigilar estados de un sistema de cultivo celular tridimensional y dispositivo de sensor óptico para llevar a cabo dichos métodos |
DK2712918T3 (da) * | 2012-09-28 | 2015-02-16 | Tissuse Gmbh | Multiorganchip med forbedret levetid og homøostase |
US9267938B2 (en) * | 2013-03-14 | 2016-02-23 | The Trustees Of The Stevens Institute Of Technology | Ex vivo human multiple myeloma cancer niche and its use as a model for personalized treatment of multiple myeloma |
EP3024582A4 (en) | 2013-07-22 | 2017-03-08 | President and Fellows of Harvard College | Microfluidic cartridge assembly |
EP3083940A4 (en) | 2013-12-20 | 2017-08-23 | President and Fellows of Harvard College | Low shear microfluidic devices and methods of use and manufacturing thereof |
GB2583047B (en) | 2013-12-20 | 2021-03-24 | Harvard College | Organomimetic devices and methods of use and manufacturing thereof |
CN103981096B (zh) * | 2014-05-27 | 2015-11-18 | 东南大学 | 一种两层细胞培养体系器官芯片及其制备方法 |
SG10201801654RA (en) | 2014-05-28 | 2018-04-27 | Childrens Hospital Med Ct | Methods and systems for converting precursor cells into gastric tissues through directed differentiation |
WO2016010861A1 (en) | 2014-07-14 | 2016-01-21 | President And Fellows Of Harvard College | Systems and methods for improved performance of fluidic and microfluidic systems |
AU2015311618B2 (en) * | 2014-09-03 | 2021-03-04 | Davies, Graham James PROF | Microfluidic devices and fabrication |
US11060067B2 (en) * | 2014-09-30 | 2021-07-13 | D. Lansing Taylor | Human liver microphysiology platform and self assembly liver acinus model and methods of their use |
EP3207123A1 (en) | 2014-10-17 | 2017-08-23 | Children's Hospital Center D/b/a Cincinnati Children's Hospital Medical Center | In vivo model of human small intestine using pluripotent stem cells and methods of making and using same |
RU2584598C1 (ru) * | 2015-03-27 | 2016-05-20 | Общество с ограниченной ответственностью Научно-технический центр "БиоКлиникум" | Микрофлюидный чип для создания клеточных моделей органов млекопитающих |
JP6423082B2 (ja) | 2015-04-03 | 2018-11-14 | 国立研究開発法人産業技術総合研究所 | 細胞培養装置および細胞培養方法 |
NL2014840B1 (en) * | 2015-05-21 | 2017-01-31 | Intecrypt B V | Microfluidic device for in vitro 3D cell culture experimentation. |
RU2592687C1 (ru) * | 2015-06-30 | 2016-07-27 | Евгений Александрович Тоневицкий | Устройство пневматического управления клапанами микрофлюидной системы |
US10202569B2 (en) | 2015-07-24 | 2019-02-12 | President And Fellows Of Harvard College | Radial microfluidic devices and methods of use |
CN105170205B (zh) * | 2015-09-19 | 2017-01-25 | 大连理工大学 | 一种基于微流控芯片技术构建的仿生芯片 |
EP3190172A3 (en) * | 2016-01-07 | 2017-08-30 | Vanderbilt University | Interconnections of multiple perfused engineered tissue constructs and microbioreactors, multi-microformulators and applications of the same |
RU171690U1 (ru) * | 2016-03-24 | 2017-06-09 | Общество с ограниченной ответственностью Научно-технический центр "БиоКлиникум" | Микрофлюидный чип для создания клеточных моделей органов млекопитающих |
US11065618B2 (en) * | 2016-04-06 | 2021-07-20 | Fluidic Analytics Limited | Flow balancing |
RU2612904C1 (ru) * | 2016-04-15 | 2017-03-13 | Евгений Александрович Тоневицкий | Способ и микрофлюидный чип для культивирования клеток или клеточной модели |
CN116790476A (zh) | 2016-05-05 | 2023-09-22 | 儿童医院医疗中心 | 用于体外制造胃底组织的方法和与其相关的组合物 |
AU2017286096B2 (en) | 2016-06-15 | 2022-01-20 | Mimetas B.V. | Cell culture device and methods |
CA3036378A1 (en) | 2016-09-13 | 2018-03-22 | President And Fellows Of Harvard College | Methods relating to intestinal organ-on-a-chip |
KR102026329B1 (ko) | 2016-11-10 | 2019-09-27 | 울산대학교 산학협력단 | 마이크로유체칩 |
US11390836B2 (en) * | 2016-11-17 | 2022-07-19 | Cleveland State University | Chip platforms for microarray 3D bioprinting |
CN110062764B (zh) | 2016-12-05 | 2024-07-02 | 儿童医院医学中心 | 结肠类器官及其制备和使用方法 |
RU2671476C2 (ru) * | 2016-12-28 | 2018-10-31 | Федеральное государственное бюджетное учреждение "Государственный научный центр Российской Федерации - Федеральный Медицинский биофизический центр имени А.И. Бурназяна Федерального Медико-биологического агентства" (ФГБУ ГНЦ ФМБЦ им. А.И. Бурназяна ФМБА России) | Устройство для двухсторонней децеллюляризации сосудистых графтов различного диаметра и способ оптимизации его работы (варианты) |
WO2018208332A2 (en) | 2017-02-17 | 2018-11-15 | Koniku, Inc. | Systems for detection |
US11826757B2 (en) * | 2017-08-02 | 2023-11-28 | Wake Forest University Health Sciences | Niches-on-a-chip |
US11499128B2 (en) | 2017-09-22 | 2022-11-15 | The Regents Of The University Of Colorado | Organ-on-chip microphysiological system |
DE102017222261B4 (de) | 2017-12-08 | 2019-08-29 | Technische Universität Braunschweig | Herstellungsverfahren für Organ-on-a-Chip Systeme |
CN108004144B (zh) * | 2017-12-18 | 2021-04-06 | 清华大学深圳研究生院 | 一种含管道网络的器官芯片单元 |
AU2019215096A1 (en) | 2018-02-02 | 2020-08-06 | Wake Forest University Health Sciences | Organoids related to immunotherapy and methods of preparing and using the same |
WO2019157464A1 (en) | 2018-02-09 | 2019-08-15 | The Regents Of The University Of Colorado, A Body Corporate | Bioprinter and methods of manufacturing an organomimetic device |
CN110305787A (zh) * | 2018-03-27 | 2019-10-08 | 华东理工大学 | 一种体内力学环境模拟装置 |
US11480560B2 (en) | 2018-06-11 | 2022-10-25 | The Regents Of The University Of Colorado, A Body Corporate | Delivery of aerosolized respiratory pathogens |
CN109576155B (zh) * | 2018-12-18 | 2021-12-07 | 大连理工大学 | 通用神经系统芯片 |
US12024696B2 (en) * | 2019-05-08 | 2024-07-02 | Molecular Devices (Austria) GmbH | System and method for organoid culture |
CN110283724B (zh) * | 2019-07-09 | 2022-07-29 | 汇芯(北京)科技有限公司 | 一种高通量类器官表型筛查系统和方法 |
KR20210092408A (ko) | 2020-01-16 | 2021-07-26 | 삼성전자주식회사 | 세포 클러스터를 이용한 생체 전자약 장치 |
CN111657861B (zh) * | 2020-06-04 | 2022-02-25 | 浙江大学 | 基于双光子显微镜技术的溶栓药效评价方法 |
KR20230061566A (ko) * | 2020-09-24 | 2023-05-08 | 큐리스 테크놀로지스 리미티드 | Ai-칩-온-칩, 임상 예측 엔진 |
US20240110137A1 (en) | 2021-02-26 | 2024-04-04 | Universidade Do Minho | Multiorgan-on-a-chip device with integrated microbiosensors, methods and uses thereof |
EP4071234A1 (en) | 2021-04-06 | 2022-10-12 | Julius-Maximilians-Universität Würzburg | Decive for fabricating a perfusable three-dimensional tissue construct |
CN113186162B (zh) * | 2021-04-19 | 2023-08-15 | 西安交通大学 | 一种结构仿生的三维活性类脑组织生物芯片 |
WO2022260653A1 (en) * | 2021-06-08 | 2022-12-15 | Hewlett-Packard Development Company, L.P. | Interface device for digital microfluidics |
TWI769861B (zh) * | 2021-06-15 | 2022-07-01 | 國立清華大學 | 三維細胞培養與藥物測試篩選的陣列平台 |
CN114369532B (zh) * | 2021-12-31 | 2023-10-03 | 中国科学院苏州纳米技术与纳米仿生研究所 | 一种模拟滤过泡的微流控细胞培养装置及其应用 |
KR20250002306A (ko) | 2022-03-30 | 2025-01-07 | 인피니트 디.오.오. | 독성 발현 및/또는 질병의 유발 및 억제를 평가하기 위한 에이전트의 예측 테스트 방법 |
EP4289929A1 (en) * | 2022-06-06 | 2023-12-13 | Finnadvance Oy | Membrane structure for stimulating and sensing biological materials, and cell culture plate and microfluidic device both using the same |
CN115322904B (zh) * | 2022-10-12 | 2023-01-31 | 成都诺医德医学检验实验室有限公司 | 一种模拟膀胱结构的类器官培养装置及其应用 |
CN115671397B (zh) * | 2022-11-10 | 2023-10-13 | 上海大学 | 一种多肽和双生长因子梯度分布的含细胞骨软骨支架及其制备方法和应用 |
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-
2009
- 2009-06-04 DK DK09757294.5T patent/DK2335370T3/da active
- 2009-06-04 AU AU2009254177A patent/AU2009254177B2/en active Active
- 2009-06-04 CA CA2727003A patent/CA2727003C/en active Active
- 2009-06-04 EP EP09757294.5A patent/EP2335370B1/en active Active
- 2009-06-04 US US12/996,015 patent/US20110086382A1/en not_active Abandoned
- 2009-06-04 JP JP2011512022A patent/JP5774477B2/ja active Active
- 2009-06-04 RU RU2010154493/14A patent/RU2517046C2/ru active
- 2009-06-04 SG SG2013064787A patent/SG193829A1/en unknown
- 2009-06-04 CN CN200980120885.6A patent/CN102257124B/zh active Active
- 2009-06-04 EP EP14152941.2A patent/EP2730645A3/en not_active Withdrawn
- 2009-06-04 WO PCT/EP2009/004008 patent/WO2009146911A2/en active Application Filing
- 2009-06-04 EP EP14152939.6A patent/EP2730644A3/en not_active Withdrawn
-
2011
- 2011-12-20 HK HK11113717.2A patent/HK1159157A1/xx unknown
-
2014
- 2014-06-20 US US14/309,905 patent/US20140302549A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
SG193829A1 (en) | 2013-10-30 |
EP2335370A2 (en) | 2011-06-22 |
JP5774477B2 (ja) | 2015-09-09 |
WO2009146911A3 (en) | 2011-09-15 |
AU2009254177B2 (en) | 2014-09-11 |
CA2727003C (en) | 2018-09-18 |
JP2011528653A (ja) | 2011-11-24 |
CA2727003A1 (en) | 2009-12-10 |
RU2517046C2 (ru) | 2014-05-27 |
US20110086382A1 (en) | 2011-04-14 |
EP2730645A3 (en) | 2014-10-22 |
US20140302549A1 (en) | 2014-10-09 |
AU2009254177A1 (en) | 2009-12-10 |
RU2010154493A (ru) | 2012-07-20 |
CN102257124A (zh) | 2011-11-23 |
EP2730644A3 (en) | 2014-10-22 |
HK1159157A1 (en) | 2012-07-27 |
EP2335370B1 (en) | 2014-03-19 |
EP2730645A2 (en) | 2014-05-14 |
CN102257124B (zh) | 2014-12-03 |
EP2730644A2 (en) | 2014-05-14 |
WO2009146911A2 (en) | 2009-12-10 |
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