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DK2364742T3 - Indretning til lægemiddelafgivelse - Google Patents

Indretning til lægemiddelafgivelse Download PDF

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Publication number
DK2364742T3
DK2364742T3 DK10184272.2T DK10184272T DK2364742T3 DK 2364742 T3 DK2364742 T3 DK 2364742T3 DK 10184272 T DK10184272 T DK 10184272T DK 2364742 T3 DK2364742 T3 DK 2364742T3
Authority
DK
Denmark
Prior art keywords
dose
piston rod
delivery
predetermined
drug
Prior art date
Application number
DK10184272.2T
Other languages
English (en)
Inventor
Lennart Brunnberg
Anders Karlsson
Victor Kronestedt
Stephan Olson
Tomas Deurell
Original Assignee
Shl Group Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42543328&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2364742(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US11/140,989 external-priority patent/US20060276753A1/en
Priority claimed from US11/282,593 external-priority patent/US9011386B2/en
Application filed by Shl Group Ab filed Critical Shl Group Ab
Application granted granted Critical
Publication of DK2364742T3 publication Critical patent/DK2364742T3/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0066—Inhalators with dosage or measuring devices with means for varying the dose size
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
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    • A61M2005/2013—Having specific accessories triggering of discharging means by contact of injector with patient body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61M2005/2488—Ampoule holder connected to rest of syringe via rotation, e.g. threads or bayonet
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
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    • A61M5/3159—Dose expelling manners
    • A61M5/31593—Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
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  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Vascular Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Claims (11)

1. Indretning (2; 100) til afgivelse af forudbestemte doser af flydende lægemiddel, hvilken indretning er indrettet til at være i en lægemiddelafgivelsesstilling og i en ikke-lægemiddelafgivelsesstilling, og indretningen er indrettet til at omfatte: - en kassette (10; 103), der er indrettet til at indeholde det flydende lægemiddel, og et stempel, der er anbragt tætnende og glidbart i kassetten; - et energiakkumulerende organ (26; 114) indrettet til akkumulering af energi i mindst ét forudbestemt trin, når indretningen er i den ikke-lægemiddelafgivende stilling; - en aflang, gevindforsynet stempelstang (16; 126) indrettet til anbringelse inden i indretningen; - et stempelstangsdrivorgan (40; 47; 128) i indgreb med den gevindforsynede stempelstang (16; 126) og indrettet til at være i en drivstilling, når indretningen er i lægemiddelafgivelsesstillingen, og indrettet til at være i en ikke-drivstilling, når indretningen er i den ikke-lægemiddelafgivende stilling, hvorved drejningen af stempelstangsdrivorganet (40; 47; 128) som følge af det energiakkumulerende organs (26; 114) udgangsmoment driver den gevindforsynede stempelstang (16; 126) og tillader stangen, som er i kontakt med stemplet, at blive drevet mod den proksimale ende af kassetten med en forudbestemt afstand og udstøder en forudbestemt dosis af det flydende lægemiddel fra kassetten; kendetegnet ved, at det energiakkumulerende organ (26; 114) er en flad spiralfjeder.
2. Indretning ifølge krav 1, kendetegnet ved, at et kassettehus (8; 101) er koblet til det ydre hylster (48), og hvor den indvendige del af kassettehuset (8; 101), som er i indgreb med stempelstangen, er forsynet med dele (52) i indgreb med langstrakte dele (53) på stempelstangen, og hvor den indvendige del af stempelstangsdrivorganet (40; 128), som er i indgreb med stempelstangen, er forsynet med et gevind, der passer til gevindet på stempelstangen, således at drejningen af stempelstangsdrivorganet (40; 128) vil drive stempelstangen mod den proksimale ende af kassetten den forudbestemte afstand uden drejning.
3. Indretning ifølge krav 1, kendetegnet ved, at den indvendige del af stempelstangsdrivorganet (47), som står i indgreb med stempelstangen, er forsynet med dele (52), der griber ind i langsgående dele (53) på stempelstangen, og at stempelstangsdrivorganet (47) er indrettet til at rumme et ikke-roterende leje (41), hvor den indvendige del (43) af det ikke-roterende leje (41) er forsynet med et gevind, der passer til gevindet på stempelstangen, således at stempelstangen bevæger sig mod den proksimale ende af kassetten den forudbestemte afstand under drejning.
4. Indretning ifølge ethvert af de foregående krav, kendetegnet ved, at et dosisindstillingsorgan (4; 104) er indrettet til at blive drejet mindst ét forudbestemt trin, når indretningen står i den ikke-lægemiddelafgivende stilling, for at øge den akkumulerede energi i det energiakkumulerende organ med mindst ét trin, og også er indrettet til at blive trukket mod den distale ende af afgivelsesindretningen for at frigive den akkumulerede energi i det energiakkumulerende organ til lukning af en dosis.
5. Indretning ifølge ethvert af de foregående krav, kendetegnet ved, at den udvendige del af stempelstangsdrivorganet (40; 47; 128) er udformet således, at det i sin proksimale ende er forsynet med udad ragende flanger (42; 302; 130), der er i indgreb med indad ragende stoporganer (51; 306; 111), der er tilvejebragt på den indvendige del af en aktiveringsbøsning (50; 109), når indretningen står i den ikke-lægemiddelafgivende stilling.
6. Indretning ifølge ethvert af de foregående krav, kendetegnet ved, at de udad ragende flanger (302) kan være udformet med et antal dosistrinfremspring (302a, 302b), der er jævnt fordelt langs omkredsen af den proksimale del af stempelstangsdrivorganet (47), således at hvert dosistrin afgiver samme forudbestemte mængde lægemiddel.
7. Indretning ifølge ethvert af de foregående krav, kendetegnet ved, at indretningen under lægemiddelafgivelse er indrettet til at blive sat i den ikke-lægemiddelafgivende stilling, før hele den indstillede dosis er afgivet, hvorpå stempelstangen stopper sin bevægelse mod den proksimale ende af kassetten, og at indretningen derefter er beregnet til at sættes i den lægemiddelafgivende stilling, hvorefter stempelstangen fortsætter at bevæge sig den forudbestemte afstand mod den proksimale ende af indretningen.
8. Indretning ifølge ethvert af de foregående krav, kendetegnet ved, at indretningen er indrettet til at blive forbundet til et lægemiddeladministreringsorgan i form af et mund- eller næsestykke, som patienten anbringer i munden eller næsen, hvorved den forudbestemte dosis lægemiddel inhaleres af patienten, når afgivelsesindretningen er i lægemiddelafgivelsesstillingen.
9. Indretning ifølge ethvert af de foregående krav, kendetegnet ved, at indretningen er beregnet til at blive forbundet til et lægemiddelafgivelsesorgan i form af en dyse, hvorved den forudbestemte dosis lægemiddel sprøjtes i øjet eller på huden af patienten, når afgivelsesindretningen er i lægemiddelafgivelsesstillingen.
10. Indretning ifølge ethvert af de foregående krav, kendetegnet ved, at indretningen er beregnet til at blive forbundet til et lægemiddeladministreringsorgan i form af et organ, der afgiver den forudbestemte dosis lægemiddel i form af mindst én dråbe, når afgivelsesindretningen er i lægemiddelafgivelsesstillingen.
11. Indretning ifølge ethvert af de foregående krav, kendetegnet ved, at indretningen er beregnet til at blive forbundet til et lægemiddeladministreringsorgan i form af en kanyle til injektion af den forudbestemte dosis lægemiddel ind i patientens krop, når afgivelsesindretningen er i lægemiddelafgivelsesstillingen.
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US11/140,989 US20060276753A1 (en) 2005-06-01 2005-06-01 Device for delivering medicament
EP05104734.8A EP1728529B2 (en) 2005-06-01 2005-06-01 Device for delivering medicament
US11/282,593 US9011386B2 (en) 2005-06-01 2005-11-21 Device for delivering medicament
EP06733519.0A EP1885415B1 (en) 2005-06-01 2006-05-22 Device for delivering medicament
PCT/SE2006/050150 WO2006130100A1 (en) 2005-06-01 2006-05-22 Device for delivering medicament

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JP5026412B2 (ja) 2012-09-12
EP2484395B1 (en) 2023-11-08
EP1885415A1 (en) 2008-02-13
EP1885415B1 (en) 2013-05-15
EP2484395A2 (en) 2012-08-08
EP1885415A4 (en) 2012-02-22
ES2423199T3 (es) 2013-09-18
EP2364742A2 (en) 2011-09-14
EP2484395A3 (en) 2013-04-17
EP2364742A3 (en) 2012-11-07
EP2364742B1 (en) 2018-11-14
WO2006130100A1 (en) 2006-12-07
JP2008541932A (ja) 2008-11-27

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