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DK2173749T3 - 2-oxo-2-(2-phenyl-5,6,7,8-tetrahydro-indolizin-3-yl)-acetamidderivater og beslægtede forbindelser som antisvampemidler - Google Patents

2-oxo-2-(2-phenyl-5,6,7,8-tetrahydro-indolizin-3-yl)-acetamidderivater og beslægtede forbindelser som antisvampemidler

Info

Publication number
DK2173749T3
DK2173749T3 DK08750663.0T DK08750663T DK2173749T3 DK 2173749 T3 DK2173749 T3 DK 2173749T3 DK 08750663 T DK08750663 T DK 08750663T DK 2173749 T3 DK2173749 T3 DK 2173749T3
Authority
DK
Denmark
Prior art keywords
indolizin
tetrahydro
oxo
phenyl
antifungal agents
Prior art date
Application number
DK08750663.0T
Other languages
English (en)
Inventor
Lloyd James Payne
Robert Downham
Graham Edward Morris Sibley
Philip Edwards
Gareth Morse Davies
Original Assignee
F2G Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F2G Ltd filed Critical F2G Ltd
Application granted granted Critical
Publication of DK2173749T3 publication Critical patent/DK2173749T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Environmental Sciences (AREA)
  • Epidemiology (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Communicable Diseases (AREA)
  • Wood Science & Technology (AREA)
  • Oncology (AREA)
  • Zoology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK08750663.0T 2007-05-25 2008-05-21 2-oxo-2-(2-phenyl-5,6,7,8-tetrahydro-indolizin-3-yl)-acetamidderivater og beslægtede forbindelser som antisvampemidler DK2173749T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0710121.5A GB0710121D0 (en) 2007-05-25 2007-05-25 Antifungal agents
PCT/GB2008/001738 WO2008145963A1 (en) 2007-05-25 2008-05-21 2-oxo-2- (2-phenyl-5,6,7,8-tetrahydro-indolizin-3-yl) -acetamide derivatives and related compounds as antifungal agents

Publications (1)

Publication Number Publication Date
DK2173749T3 true DK2173749T3 (da) 2011-05-02

Family

ID=38265404

Family Applications (1)

Application Number Title Priority Date Filing Date
DK08750663.0T DK2173749T3 (da) 2007-05-25 2008-05-21 2-oxo-2-(2-phenyl-5,6,7,8-tetrahydro-indolizin-3-yl)-acetamidderivater og beslægtede forbindelser som antisvampemidler

Country Status (14)

Country Link
US (1) US8524705B2 (da)
EP (1) EP2173749B1 (da)
JP (1) JP5409610B2 (da)
KR (1) KR101595579B1 (da)
CN (1) CN101743246B (da)
AT (1) ATE495174T1 (da)
AU (1) AU2008257196B2 (da)
CA (1) CA2687790C (da)
DE (1) DE602008004540D1 (da)
DK (1) DK2173749T3 (da)
ES (1) ES2359187T3 (da)
GB (1) GB0710121D0 (da)
NZ (1) NZ581143A (da)
WO (1) WO2008145963A1 (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ589010A (en) * 2008-04-24 2012-11-30 F2G Ltd Pyrrole antifungal agents
GB0809773D0 (en) * 2008-05-29 2008-07-09 F2G Ltd Antifungal combination therapy
RU2012107429A (ru) * 2009-08-31 2013-10-10 Ихара Кемикал Индастри Ко., Лтд. Способ получения пиримидинилацетонитрильных производных и промежуточных производных для их синтеза
WO2015154191A1 (en) * 2014-04-10 2015-10-15 Dalhousie University Treatment of parkinson's disease through arfgap1 inhibition using substituted piperazine derivatives
BR112017010439B1 (pt) * 2014-11-21 2023-03-07 F2G Limited Composto, composição farmacêutica, combinação farmacêutica, kit, métodos para controle de uma doença fúngica em uma planta, e, uso de um composto, de uma composição ou de uma combinação
CN104910116B (zh) * 2015-05-19 2017-03-22 中节能万润股份有限公司 一种制备4,4‑吡喃二甲酸二乙酯衍生物的方法
CN106412680B (zh) * 2015-07-31 2021-01-22 中兴通讯股份有限公司 多屏控制方法及装置
GB201609222D0 (en) 2016-05-25 2016-07-06 F2G Ltd Pharmaceutical formulation
WO2019223791A1 (zh) * 2018-05-25 2019-11-28 正大天晴药业集团股份有限公司 2,3-二氢-1h-吡咯嗪-7-甲酰胺类衍生物及其应用
CN113365999B (zh) * 2019-01-31 2023-04-14 正大天晴药业集团股份有限公司 含有吡咯并杂环的衣壳蛋白装配抑制剂
US11819503B2 (en) 2019-04-23 2023-11-21 F2G Ltd Method of treating coccidioides infection
CN112898316A (zh) * 2019-12-03 2021-06-04 微境生物医药科技(上海)有限公司 新型吡咯化合物
CN114644634B (zh) * 2020-12-21 2023-06-20 深圳市祥根生物医药有限公司 一种吡咯衍生物及其制备方法和用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601368B1 (fr) 1986-07-08 1989-04-07 Synthelabo Derives de nitrofuranne, leur preparation et leur application en therapeutique.
JPH09249669A (ja) 1996-03-13 1997-09-22 Ono Pharmaceut Co Ltd 縮合ピロール誘導体、およびそれらを有効成分として含有する薬剤
ATE335739T1 (de) 2001-06-06 2006-09-15 Vertex Pharma Cak inhibitoren und deren verwendungen
ATE420639T1 (de) * 2005-05-18 2009-01-15 F2G Ltd Antimykotische mittel
GB0623209D0 (en) 2006-11-21 2007-01-03 F2G Ltd Antifungal agents

Also Published As

Publication number Publication date
WO2008145963A1 (en) 2008-12-04
JP5409610B2 (ja) 2014-02-05
ES2359187T3 (es) 2011-05-19
CA2687790C (en) 2014-11-18
US8524705B2 (en) 2013-09-03
AU2008257196A1 (en) 2008-12-04
NZ581143A (en) 2011-07-29
KR101595579B1 (ko) 2016-02-18
EP2173749A1 (en) 2010-04-14
KR20100033383A (ko) 2010-03-29
CN101743246B (zh) 2013-07-17
CA2687790A1 (en) 2008-12-04
ATE495174T1 (de) 2011-01-15
CN101743246A (zh) 2010-06-16
EP2173749B1 (en) 2011-01-12
JP2010527979A (ja) 2010-08-19
US20110009390A1 (en) 2011-01-13
GB0710121D0 (en) 2007-07-04
AU2008257196B2 (en) 2013-06-20
DE602008004540D1 (de) 2011-02-24

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