DK2167470T3 - Triazolo-[1,5A]-chinoliner som adenosin-A3-receptor ligander - Google Patents

Triazolo-[1,5A]-chinoliner som adenosin-A3-receptor ligander

Info

Publication number: DK2167470T3
Authority: DK; Denmark
Prior art keywords: quinolines; triazolo; adenosine; receptor ligands; ligands
Prior art date: 2007-06-07

Application number

DK08762666.9T

Other languages

English (en)

Inventor

Edit Susan

Kinga Boer

Sandor Batori

Zoltan Szlavik

Endre Mikus

Szeredi Judit Vargane

Michel Finet

Szabo Katalin Urban

Tibor Szabo

Zoltan Kapui

Geza Timari

Original Assignee

Sanofi Aventis

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-06-07

Filing date

2008-06-02

Publication date

2011-06-27

2008-06-02 Application filed by Sanofi Aventis filed Critical Sanofi Aventis

2011-06-27 Application granted granted Critical

2011-06-27 Publication of DK2167470T3 publication Critical patent/DK2167470T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pulmonology (AREA)
Biomedical Technology (AREA)
Immunology (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Urology & Nephrology (AREA)
Dermatology (AREA)
Psychiatry (AREA)
Ophthalmology & Optometry (AREA)
Rheumatology (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Hematology (AREA)
Obesity (AREA)
Psychology (AREA)
Transplantation (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Vascular Medicine (AREA)

DK08762666.9T 2007-06-07 2008-06-02 Triazolo-[1,5A]-chinoliner som adenosin-A3-receptor ligander DK2167470T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
HU0700395A HUP0700395A2 (en)	2007-06-07	2007-06-07	Substituted [1,2,4] triazolo [1,5-a] quinolines, process for their preparation, pharmaceutical compositions thereof, and intermediates
PCT/HU2008/000063 WO2008149168A1 (en)	2007-06-07	2008-06-02	Triazolo [1, 5-a] quinolines as adenosine a3 receptor ligands

Publications (1)

Publication Number	Publication Date
DK2167470T3 true DK2167470T3 (da)	2011-06-27

Family

ID=89987565

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK08762666.9T DK2167470T3 (da)	2007-06-07	2008-06-02	Triazolo-[1,5A]-chinoliner som adenosin-A3-receptor ligander

Country Status (45)

Country	Link
US (1)	US8338411B2 (da)
EP (1)	EP2167470B1 (da)
JP (1)	JP5487100B2 (da)
KR (1)	KR20100031610A (da)
CN (1)	CN101679272B (da)
AR (1)	AR066873A1 (da)
AT (1)	ATE502016T1 (da)
AU (1)	AU2008259534B2 (da)
BR (1)	BRPI0812257A2 (da)
CA (1)	CA2689612A1 (da)
CL (1)	CL2008001648A1 (da)
CO (1)	CO6270233A2 (da)
CR (1)	CR11171A (da)
CY (1)	CY1111644T1 (da)
DE (1)	DE602008005589D1 (da)
DK (1)	DK2167470T3 (da)
DO (1)	DOP2009000276A (da)
EC (1)	ECSP099783A (da)
ES (1)	ES2363672T3 (da)
GT (1)	GT200900301A (da)
HK (1)	HK1138581A1 (da)
HN (1)	HN2009003357A (da)
HR (1)	HRP20110332T1 (da)
HU (1)	HUP0700395A2 (da)
IL (1)	IL202471A0 (da)
JO (1)	JO2689B1 (da)
MA (1)	MA31738B1 (da)
ME (1)	ME00958B (da)
MX (1)	MX2009013209A (da)
MY (1)	MY148654A (da)
NI (1)	NI200900210A (da)
NZ (1)	NZ581186A (da)
PA (1)	PA8782901A1 (da)
PE (1)	PE20090325A1 (da)
PL (1)	PL2167470T3 (da)
PT (1)	PT2167470E (da)
RU (1)	RU2489432C2 (da)
SI (1)	SI2167470T1 (da)
SV (1)	SV2009003420A (da)
TN (1)	TN2009000482A1 (da)
TW (1)	TWI424998B (da)
UA (1)	UA99463C2 (da)
UY (1)	UY31130A1 (da)
WO (1)	WO2008149168A1 (da)
ZA (1)	ZA200908280B (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2540232T3 (es)	2009-07-08	2015-07-09	Dermira (Canada), Inc.	Análogos de TOFA útiles en el tratamiento de trastornos o afecciones dermatológicas
FR3053968A1 (fr)	2016-07-13	2018-01-19	Biomerieux	Reactifs pour la protection reversible de molecules biologiques
MA45202B1 (fr)	2016-09-24	2022-04-29	Kbp Biosciences Co Ltd	Composition pharmaceutique comprenant un antagoniste du récepteur minéralocorticoïde et son utilisation
MA52422A (fr)	2018-02-27	2021-01-06	Incyte Corp	Imidazopyrimidines et triazolopyrimidines en tant qu'inhibiteurs a2a/a2b
EP3810610A1 (en)	2018-05-18	2021-04-28	Incyte Corporation	Fused pyrimidine derivatives as a2a / a2b inhibitors
TWI851441B (zh)	2018-07-05	2024-08-01	美商英塞特公司	作為a2a/a2b抑制劑之稠合吡嗪衍生物
PE20211768A1 (es)	2018-11-30	2021-09-07	Merck Sharp & Dohme	Derivados de amino triazolo quinazolina 9-sustituidos como antagonistas del receptor de adenosina, composiciones farmaceuticas y su uso
MX2021007426A (es)	2018-12-20	2021-09-08	Incyte Corp	Compuestos de imidazopiridazina e imidazopiridina como inhibidores de cinasa-2 de tipo receptor de activina.
TWI829857B (zh)	2019-01-29	2024-01-21	美商英塞特公司	作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1479759A (en) *	1974-11-23	1977-07-13	Lepetit Spa	Heterocyclic fused derivatives of indole and quinoline
GR76063B (da) *	1981-04-03	1984-08-03	Roussel Uclaf
ZA836701B (en) *	1982-10-01	1984-10-31	Roussel Uclaf	Imidazo(1,2-a)quinolines
GB0108475D0 (en)	2001-04-04	2001-05-23	Merck Sharp & Dohme	New compounds
IL158854A0 (en) *	2001-05-31	2004-05-12	Sanofi Synthelabo	Aminoquinoline and aminopyridine derivatives and their use as adenosine a3 ligands
US6514989B1 (en)	2001-07-20	2003-02-04	Hoffmann-La Roche Inc.	Aromatic and heteroaromatic substituted 1,2,4-triazolo pyridine derivatives
HUP0105407A3 (en) *	2001-12-21	2004-04-28	Sanofi Aventis	Triazolo[1,5-a]quinolin derivatives, process for their preparation, pharmaceutical compositions thereof and intermediates
HUP0105406A3 (en) *	2001-12-21	2003-12-29	Sanofi Aventis	Imidazo[1,2-a]quinolin derivatives, process for their preparation, pharmaceutical compositions thereof and intermediates
NZ533682A (en)	2001-12-21	2007-06-29	Jsw Res Forschungslabor Gmbh	Pyrazolyl-substituted triazoloquinoxalines
HUP0203976A3 (en) *	2002-11-15	2004-08-30	Sanofi Aventis	Adenozine a3 receptors, process for their preparation and pharmaceutical compositions containing them
PT1663982E (pt) *	2003-07-31	2008-01-31	Sanofi Aventis	Derivados de aminoquinolina e sua utilização como ligandos de adenosina a3

2007
- 2007-06-07 HU HU0700395A patent/HUP0700395A2/hu unknown
2008
- 2008-02-06 UA UAA200913976A patent/UA99463C2/ru unknown
- 2008-06-02 EP EP08762666A patent/EP2167470B1/en active Active
- 2008-06-02 KR KR1020107000342A patent/KR20100031610A/ko not_active Application Discontinuation
- 2008-06-02 SI SI200830255T patent/SI2167470T1/sl unknown
- 2008-06-02 DK DK08762666.9T patent/DK2167470T3/da active
- 2008-06-02 AU AU2008259534A patent/AU2008259534B2/en not_active Ceased
- 2008-06-02 WO PCT/HU2008/000063 patent/WO2008149168A1/en active Application Filing
- 2008-06-02 ME MEP-2009-340A patent/ME00958B/me unknown
- 2008-06-02 MX MX2009013209A patent/MX2009013209A/es active IP Right Grant
- 2008-06-02 NZ NZ581186A patent/NZ581186A/en not_active IP Right Cessation
- 2008-06-02 CN CN2008800191923A patent/CN101679272B/zh not_active Expired - Fee Related
- 2008-06-02 DE DE602008005589T patent/DE602008005589D1/de active Active
- 2008-06-02 ES ES08762666T patent/ES2363672T3/es active Active
- 2008-06-02 JP JP2010510891A patent/JP5487100B2/ja not_active Expired - Fee Related
- 2008-06-02 MY MYPI20095180A patent/MY148654A/en unknown
- 2008-06-02 BR BRPI0812257-1A2A patent/BRPI0812257A2/pt not_active IP Right Cessation
- 2008-06-02 PL PL08762666T patent/PL2167470T3/pl unknown
- 2008-06-02 PT PT08762666T patent/PT2167470E/pt unknown
- 2008-06-02 RU RU2009149518/04A patent/RU2489432C2/ru not_active IP Right Cessation
- 2008-06-02 AT AT08762666T patent/ATE502016T1/de active
- 2008-06-02 CA CA002689612A patent/CA2689612A1/en not_active Abandoned
- 2008-06-05 AR ARP080102391A patent/AR066873A1/es not_active Application Discontinuation
- 2008-06-05 JO JO2008263A patent/JO2689B1/en active
- 2008-06-05 CL CL200801648A patent/CL2008001648A1/es unknown
- 2008-06-05 PA PA20088782901A patent/PA8782901A1/es unknown
- 2008-06-05 PE PE2008000960A patent/PE20090325A1/es not_active Application Discontinuation
- 2008-06-06 TW TW097121025A patent/TWI424998B/zh not_active IP Right Cessation
- 2008-06-06 UY UY31130A patent/UY31130A1/es not_active Application Discontinuation
2009
- 2009-11-13 TN TNP2009000482A patent/TN2009000482A1/fr unknown
- 2009-11-20 GT GT200900301A patent/GT200900301A/es unknown
- 2009-11-23 ZA ZA2009/08280A patent/ZA200908280B/en unknown
- 2009-11-24 SV SV2009003420A patent/SV2009003420A/es unknown
- 2009-12-02 IL IL202471A patent/IL202471A0/en unknown
- 2009-12-03 NI NI200900210A patent/NI200900210A/es unknown
- 2009-12-04 EC EC2009009783A patent/ECSP099783A/es unknown
- 2009-12-04 HN HN2009003357A patent/HN2009003357A/es unknown
- 2009-12-04 DO DO2009000276A patent/DOP2009000276A/es unknown
- 2009-12-04 US US12/631,139 patent/US8338411B2/en active Active
- 2009-12-16 CR CR11171A patent/CR11171A/es unknown
2010
- 2010-01-06 CO CO10001036A patent/CO6270233A2/es active IP Right Grant
- 2010-01-07 MA MA32498A patent/MA31738B1/fr unknown
- 2010-04-29 HK HK10104249.9A patent/HK1138581A1/xx not_active IP Right Cessation
2011
- 2011-05-06 HR HR20110332T patent/HRP20110332T1/hr unknown
- 2011-05-30 CY CY20111100519T patent/CY1111644T1/el unknown

Also Published As

Publication number	Publication date
MA31738B1 (fr)	2010-10-01
PT2167470E (pt)	2011-05-16
BRPI0812257A2 (pt)	2014-12-23
CO6270233A2 (es)	2011-04-20
JP5487100B2 (ja)	2014-05-07
WO2008149168A1 (en)	2008-12-11
CY1111644T1 (el)	2015-10-07
RU2009149518A (ru)	2011-07-20
AR066873A1 (es)	2009-09-16
CR11171A (es)	2010-04-21
KR20100031610A (ko)	2010-03-23
HK1138581A1 (en)	2010-08-27
HU0700395D0 (en)	2007-07-30
NI200900210A (es)	2010-07-15
GT200900301A (es)	2010-04-22
NZ581186A (en)	2012-03-30
ES2363672T3 (es)	2011-08-11
ZA200908280B (en)	2010-07-28
US8338411B2 (en)	2012-12-25
HN2009003357A (es)	2013-08-12
EP2167470A1 (en)	2010-03-31
WO2008149168A8 (en)	2010-01-07
TW200914451A (en)	2009-04-01
EP2167470B1 (en)	2011-03-16
IL202471A0 (en)	2010-06-30
PA8782901A1 (es)	2009-01-23
CN101679272A (zh)	2010-03-24
DOP2009000276A (es)	2010-01-31
UY31130A1 (es)	2009-01-30
CN101679272B (zh)	2013-02-06
MX2009013209A (es)	2010-04-09
RU2489432C2 (ru)	2013-08-10
ATE502016T1 (de)	2011-04-15
DE602008005589D1 (de)	2011-04-28
HRP20110332T1 (hr)	2011-06-30
TN2009000482A1 (en)	2011-03-31
PE20090325A1 (es)	2009-04-17
US20100216786A1 (en)	2010-08-26
JP2010529100A (ja)	2010-08-26
PL2167470T3 (pl)	2011-08-31
AU2008259534B2 (en)	2012-07-05
HUP0700395A2 (en)	2009-03-02
SV2009003420A (es)	2010-04-26
CA2689612A1 (en)	2008-12-11
UA99463C2 (en)	2012-08-27
CL2008001648A1 (es)	2008-10-10
ECSP099783A (es)	2010-01-29
SI2167470T1 (sl)	2011-06-30
TWI424998B (zh)	2014-02-01
ME00958B (me)	2012-06-20
MY148654A (en)	2013-05-15
JO2689B1 (en)	2013-03-03
AU2008259534A1 (en)	2008-12-11

Publication	Publication Date	Title
DK2384326T3 (da)	2014-05-05	Pyrrolo[2,3-d]pyrimidinforbindelser
BRPI0822237A2 (pt)	2015-06-30	Compostos de imidazo [1,2-a] piridina
DK2201012T3 (da)	2014-09-08	Pyrrolo[2,3-d]pyrimidinderivater som proteinkinase b-hæmmere
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