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DK1928872T3 - Hidtil ukendte sulfonylpyrroler som inhibitorer af hdac - Google Patents

Hidtil ukendte sulfonylpyrroler som inhibitorer af hdac

Info

Publication number
DK1928872T3
DK1928872T3 DK06793379.6T DK06793379T DK1928872T3 DK 1928872 T3 DK1928872 T3 DK 1928872T3 DK 06793379 T DK06793379 T DK 06793379T DK 1928872 T3 DK1928872 T3 DK 1928872T3
Authority
DK
Denmark
Prior art keywords
pyroles
hdac
sulphonyl
inhibitors
hitherto unknown
Prior art date
Application number
DK06793379.6T
Other languages
English (en)
Inventor
Thomas Maier
Thomas Beckers
Rolf-Peter Hummel
Martin Feth
Matthias Mueller
Thomas Baer
Juergen Volz
Original Assignee
4Sc Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 4Sc Ag filed Critical 4Sc Ag
Application granted granted Critical
Publication of DK1928872T3 publication Critical patent/DK1928872T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/48Sulfur atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/38Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK06793379.6T 2005-09-21 2006-09-08 Hidtil ukendte sulfonylpyrroler som inhibitorer af hdac DK1928872T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05108728 2005-09-21
PCT/EP2006/066197 WO2007039404A1 (en) 2005-09-21 2006-09-08 Novel sulphonylpyrroles as inhibitors of hdac s novel sulphonylpyrroles

Publications (1)

Publication Number Publication Date
DK1928872T3 true DK1928872T3 (da) 2012-05-07

Family

ID=37035343

Family Applications (1)

Application Number Title Priority Date Filing Date
DK06793379.6T DK1928872T3 (da) 2005-09-21 2006-09-08 Hidtil ukendte sulfonylpyrroler som inhibitorer af hdac

Country Status (25)

Country Link
US (1) US8232297B2 (da)
EP (1) EP1928872B1 (da)
JP (1) JP5305910B2 (da)
KR (1) KR101256846B1 (da)
CN (1) CN101268070B (da)
AR (1) AR057824A1 (da)
AT (1) ATE549333T1 (da)
AU (1) AU2006298882B2 (da)
BR (1) BRPI0617167B8 (da)
CA (1) CA2622673C (da)
CY (1) CY1112780T1 (da)
DK (1) DK1928872T3 (da)
EA (1) EA016345B1 (da)
ES (1) ES2381962T3 (da)
HR (1) HRP20120399T1 (da)
IL (1) IL189782A (da)
NO (1) NO341744B1 (da)
NZ (1) NZ566074A (da)
PL (1) PL1928872T3 (da)
PT (1) PT1928872E (da)
RS (1) RS52383B (da)
SI (1) SI1928872T1 (da)
TW (1) TWI406846B (da)
WO (1) WO2007039404A1 (da)
ZA (1) ZA200801394B (da)

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US7838541B2 (en) 2002-02-11 2010-11-23 Bayer Healthcare, Llc Aryl ureas with angiogenesis inhibiting activity
ES2288694T3 (es) 2003-05-20 2008-01-16 Bayer Pharmaceuticals Corporation Diaril ureas para enfermedades mediadas por el receptor del factor de crecimiento derivado de plaquetas.
ME00294B (me) 2003-07-23 2011-05-10 Bayer Pharmaceuticals Corp Fluoro supstituisana omega-karaboksiaril difenil urea za liječenje i prevenciju bolesti i stanja bolesti
EA012451B1 (ru) 2004-03-11 2009-10-30 4Сц Аг Новые амидозамещённые гидрокси-6-фенилфенантридины
PL1861365T3 (pl) 2005-03-15 2009-11-30 4Sc Ag N-sulfonylopirole i ich zastosowanie jako inhibitorów deacetylazy histonów
US8232297B2 (en) 2005-09-21 2012-07-31 4Sc Ag Sulphonylpyrroles as inhibitors of HDACs novel sulphonylpyrroles
CN101287706A (zh) 2005-09-21 2008-10-15 尼科梅德有限责任公司 作为组蛋白脱乙酰基酶抑制剂的磺酰基吡咯盐酸盐
EP2100878A1 (en) * 2008-03-12 2009-09-16 4Sc Ag Novel method for the production of sulphonylpyrroles as HDAC inhibitors
EP2100882A1 (en) * 2008-03-12 2009-09-16 4Sc Ag (E) -N -(2-Amino-phenyl) -3-{1-[4-(1-methyl-1H-pyrazol-4-yl)- benzenesulfonyl]-1H-pyrrol-3-yl} -acrylamide salts
AU2009289649B2 (en) 2008-09-03 2016-05-05 Biomarin Pharmaceutical Inc. Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors
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EP2802568A1 (en) 2012-01-13 2014-11-19 Acea Biosciences, Inc. Heterocyclic compounds and uses as anticancer agents.
RU2645672C2 (ru) * 2012-08-06 2018-02-27 Ацея Байосайенсиз Инк. Новые соединения пирролопиримидина в качестве ингибиторов протеинкиназ
KR20150132345A (ko) 2013-03-15 2015-11-25 바이오마린 파머수티컬 인크. Hdac 저해제
ES2761572T3 (es) 2013-07-11 2020-05-20 Acea Therapeutics Inc Derivados de pirimidina como inhibidores de quinasa
RU2018115334A (ru) 2015-10-09 2019-11-11 Ацея Терапьютикс, Инк. Фармацевтические соли, физические формы и композиции пирролопиримидиновых ингибиторов киназ, и способы их получения
CN105622680B (zh) * 2015-12-22 2018-01-19 杭州卢普生物科技有限公司 一种舒尼替尼衍生物及其制备方法和应用
JP2019511544A (ja) 2016-04-14 2019-04-25 4エスツェー アクチェンゲゼルシャフト アジア人患者におけるレスミノスタットの医薬用途
EP3606925A1 (en) 2017-04-07 2020-02-12 ACEA Therapeutics, Inc. Pharmaceutical salts, physical forms, and compositions of pyrrolopyrimidine kinase inhibitors, and methods of making same
TW201912183A (zh) 2017-08-31 2019-04-01 德商4Sc製藥公司 Hdac抑制劑與抗代謝藥劑組合用於癌症治療
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CN101287706A (zh) * 2005-09-21 2008-10-15 尼科梅德有限责任公司 作为组蛋白脱乙酰基酶抑制剂的磺酰基吡咯盐酸盐
US8232297B2 (en) 2005-09-21 2012-07-31 4Sc Ag Sulphonylpyrroles as inhibitors of HDACs novel sulphonylpyrroles

Also Published As

Publication number Publication date
KR101256846B1 (ko) 2013-04-24
KR20080047607A (ko) 2008-05-29
AR057824A1 (es) 2007-12-19
HRP20120399T1 (hr) 2012-06-30
JP5305910B2 (ja) 2013-10-02
IL189782A0 (en) 2008-08-07
AU2006298882A1 (en) 2007-04-12
RS52383B (en) 2012-12-31
CA2622673A1 (en) 2007-04-12
NO20081797L (no) 2008-04-17
AU2006298882B2 (en) 2011-10-27
CA2622673C (en) 2017-06-27
CY1112780T1 (el) 2016-02-10
TWI406846B (zh) 2013-09-01
ES2381962T3 (es) 2012-06-04
NO341744B1 (no) 2018-01-15
PT1928872E (pt) 2012-05-25
WO2007039404A1 (en) 2007-04-12
EP1928872B1 (en) 2012-03-14
JP2009508826A (ja) 2009-03-05
HK1124320A1 (en) 2009-07-10
CN101268070A (zh) 2008-09-17
CN101268070B (zh) 2012-09-05
BRPI0617167B1 (pt) 2021-02-09
SI1928872T1 (sl) 2012-06-29
IL189782A (en) 2013-06-27
ATE549333T1 (de) 2012-03-15
US20090263353A1 (en) 2009-10-22
NZ566074A (en) 2011-08-26
EP1928872A1 (en) 2008-06-11
BRPI0617167B8 (pt) 2021-05-25
EA016345B1 (ru) 2012-04-30
US8232297B2 (en) 2012-07-31
ZA200801394B (en) 2009-12-30
PL1928872T3 (pl) 2012-08-31
EA200800700A1 (ru) 2009-04-28
TW200745028A (en) 2007-12-16
BRPI0617167A2 (pt) 2011-07-12

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