DK1888582T3 - Imidazo- og triazolopyridiner som hæmmere af 11-beta-hydroxysteroid dehydrigenase - Google Patents

Imidazo- og triazolopyridiner som hæmmere af 11-beta-hydroxysteroid dehydrigenase

Info

Publication number: DK1888582T3
Authority: DK; Denmark
Prior art keywords: dehydrigenase; triazolopyridines; hydroxysteroid; imidazo; inhibitors
Prior art date: 2005-06-09

Application number

DK06784721.0T

Other languages

English (en)

Inventor

James J Li

Lawrence G Hamann

Haixia Wang

Zheming Ruan

Christopher B Cooper

Jun Li

Jeffrey A Robl

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-06-09

Filing date

2006-06-08

Publication date

2011-02-28

2006-06-08 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

2011-02-28 Application granted granted Critical

2011-02-28 Publication of DK1888582T3 publication Critical patent/DK1888582T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Ophthalmology & Optometry (AREA)
Rheumatology (AREA)
Immunology (AREA)
Biomedical Technology (AREA)
Hospice & Palliative Care (AREA)
Endocrinology (AREA)
Heart & Thoracic Surgery (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Child & Adolescent Psychology (AREA)
Emergency Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Pyridine Compounds (AREA)

DK06784721.0T 2005-06-09 2006-06-08 Imidazo- og triazolopyridiner som hæmmere af 11-beta-hydroxysteroid dehydrigenase DK1888582T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US68899305P	2005-06-09	2005-06-09
US11/448,947 US7579360B2 (en)	2005-06-09	2006-06-07	Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors
PCT/US2006/022576 WO2006135795A1 (en)	2005-06-09	2006-06-08	Imidazo- and triazolopyridines as inhibitors of 11-beta hydroxysteroid dehydrogenase type i

Publications (1)

Publication Number	Publication Date
DK1888582T3 true DK1888582T3 (da)	2011-02-28

Family

ID=37574243

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK06784721.0T DK1888582T3 (da)	2005-06-09	2006-06-08	Imidazo- og triazolopyridiner som hæmmere af 11-beta-hydroxysteroid dehydrigenase

Country Status (27)

Country	Link
US (2)	US7579360B2 (da)
EP (1)	EP1888582B1 (da)
JP (1)	JP4994368B2 (da)
KR (1)	KR20080019276A (da)
CN (1)	CN102558176A (da)
AR (1)	AR054385A1 (da)
AT (1)	ATE487717T1 (da)
AU (1)	AU2006257924B2 (da)
BR (1)	BRPI0611773A2 (da)
CA (1)	CA2611529C (da)
CY (1)	CY1111148T1 (da)
DE (1)	DE602006018135D1 (da)
DK (1)	DK1888582T3 (da)
EA (1)	EA013017B1 (da)
GE (1)	GEP20105073B (da)
HK (1)	HK1112463A1 (da)
HR (1)	HRP20110073T1 (da)
IL (1)	IL187812A (da)
MX (1)	MX2007015285A (da)
NO (1)	NO20076055L (da)
NZ (1)	NZ563457A (da)
PE (1)	PE20070164A1 (da)
PL (1)	PL1888582T3 (da)
PT (1)	PT1888582E (da)
SI (1)	SI1888582T1 (da)
TW (1)	TW200716111A (da)
WO (1)	WO2006135795A1 (da)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0420722D0 (en) *	2004-09-17	2004-10-20	Addex Pharmaceuticals Sa	Novel allosteric modulators
TWI417095B (zh)	2006-03-15	2013-12-01	Janssen Pharmaceuticals Inc	１，４-二取代之３-氰基-吡啶酮衍生物及其作為ｍＧｌｕＲ２-受體之正向異位性調節劑之用途
PE20110235A1 (es)	2006-05-04	2011-04-14	Boehringer Ingelheim Int	Combinaciones farmaceuticas que comprenden linagliptina y metmorfina
AU2007283113A1 (en)	2006-08-08	2008-02-14	Sanofi-Aventis	Arylaminoaryl-alkyl-substituted imidazolidine-2,4-diones, processes for preparing them, medicaments comprising these compounds, and their use
TW200900065A (en)	2007-03-07	2009-01-01	Janssen Pharmaceutica Nv	3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
TW200845978A (en)	2007-03-07	2008-12-01	Janssen Pharmaceutica Nv	3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
EP2025674A1 (de)	2007-08-15	2009-02-18	sanofi-aventis	Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
ES2356032T3 (es)	2007-09-14	2011-04-04	Ortho-Mcneil-Janssen Pharmaceuticals, Inc.	4-fenil-3,4,5,6-tetrahidro-2h,1'h-[1,4']bipiridinil-2'-onas 1,3'-disustituidas.
AU2008297877C1 (en)	2007-09-14	2013-11-07	Addex Pharma S.A.	1,3-disubstituted-4-phenyl-1 H-pyridin-2-ones
NZ584152A (en)	2007-09-14	2011-11-25	Ortho Mcneil Janssen Pharm	1,3-disubstituted 4-(aryl-x-phenyl)-1h-pyridin-2-ones
US8119658B2 (en) *	2007-10-01	2012-02-21	Bristol-Myers Squibb Company	Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors
CA2704436C (en)	2007-11-14	2016-01-05	Ortho-Mcneil-Janssen Pharmaceuticals, Inc.	Imidazo[1,2-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
WO2010003624A2 (en)	2008-07-09	2010-01-14	Sanofi-Aventis	Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof
JP5547194B2 (ja)	2008-09-02	2014-07-09	ジャンセンファーマシューティカルズ，インコーポレイテッド．	代謝型グルタミン酸受容体の調節因子としての３−アザビシクロ［３．１．０］ヘキシル誘導体
RU2517181C2 (ru)	2008-10-16	2014-05-27	Орто-Макнейл-Янссен Фармасьютикалз, Инк.	Производные индола и бензоморфолина в качестве модулятора метаботропных глутаматных рецепторов
CN102232074B (zh)	2008-11-28	2014-12-03	奥梅-杨森制药有限公司	作为代谢性谷氨酸盐受体调节剂的吲哚和苯并噁嗪衍生物
WO2010068601A1 (en)	2008-12-08	2010-06-17	Sanofi-Aventis	A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
EP2417135A1 (en)	2009-04-07	2012-02-15	Schering Corporation	Substituted triazolopyridines and analogs thereof
BRPI1010831A2 (pt)	2009-05-12	2016-04-05	Addex Pharmaceuticals Sa	derivados de 1,2,4-triazolo[4,3-a]piridina e seu como moduladores alostéricos positivos de receptores de mglur2
MY153913A (en)	2009-05-12	2015-04-15	Janssen Pharmaceuticals Inc	7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
MY161325A (en)	2009-05-12	2017-04-14	Janssen Pharmaceuticals Inc	1, 2, 4-triazolo[4,3-a]pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders
ES2350077B1 (es)	2009-06-04	2011-11-04	Laboratorios Salvat, S.A.	Compuestos inhibidores de 11beta-hidroxiesteroide deshidrogenasa de tipo 1.
KR20120060207A (ko)	2009-08-26	2012-06-11	사노피	신규한 결정성 헤테로방향족 플루오로글리코시드 수화물, 이들 화합물을 포함하는 약제 및 이들의 용도
WO2011107494A1 (de)	2010-03-03	2011-09-09	Sanofi	Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2582709B1 (de)	2010-06-18	2018-01-24	Sanofi	Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
US8530413B2 (en)	2010-06-21	2013-09-10	Sanofi	Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215387A (en)	2010-07-05	2012-04-16	Sanofi Aventis	Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201221505A (en)	2010-07-05	2012-06-01	Sanofi Sa	Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215388A (en)	2010-07-05	2012-04-16	Sanofi Sa	(2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
WO2012062751A1 (en)	2010-11-08	2012-05-18	Janssen Pharmaceuticals, Inc.	1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
ES2552455T3 (es)	2010-11-08	2015-11-30	Janssen Pharmaceuticals, Inc.	Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2
ES2552879T3 (es)	2010-11-08	2015-12-02	Janssen Pharmaceuticals, Inc.	Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2
WO2012120056A1 (de)	2011-03-08	2012-09-13	Sanofi	Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8828994B2 (en)	2011-03-08	2014-09-09	Sanofi	Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
EP2766349B1 (de)	2011-03-08	2016-06-01	Sanofi	Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2683699B1 (de)	2011-03-08	2015-06-24	Sanofi	Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8828995B2 (en)	2011-03-08	2014-09-09	Sanofi	Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
WO2013037390A1 (en)	2011-09-12	2013-03-21	Sanofi	6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en)	2011-09-27	2013-04-04	Sanofi	6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
JO3368B1 (ar)	2013-06-04	2019-03-13	Janssen Pharmaceutica Nv	مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar)	2013-09-06	2019-03-13	Janssen Pharmaceutica Nv	مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
WO2015061272A1 (en)	2013-10-22	2015-04-30	Bristol-Myers Squibb Company	Isotopically labeled triazolopyridine 11-beta hydroxysteroid dehydrogenase type i inhibitors
GB201321742D0 (en)	2013-12-09	2014-01-22	Ucb Pharma Sa	Therapeutic agents
US9969687B2 (en)	2013-12-23	2018-05-15	Norgine B.V.	Compounds useful as CCR9 modulators
KR20200126026A (ko)	2014-01-21	2020-11-05	얀센 파마슈티카 엔.브이.	대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도
EP3431106B1 (en)	2014-01-21	2020-12-30	Janssen Pharmaceutica NV	Combinations comprising positive allosteric modulators of metabotropic glutamatergic receptor subtype 2 and their use
US9493442B2 (en)	2014-02-13	2016-11-15	Incyte Corporation	Cyclopropylamines as LSD1 inhibitors
ME03580B (me)	2014-02-13	2020-07-20	Incyte Corp	Ciklopropilamini kao lsd1 inhibitori
US9527835B2 (en)	2014-02-13	2016-12-27	Incyte Corporation	Cyclopropylamines as LSD1 inhibitors
AU2015217073B2 (en)	2014-02-13	2019-08-22	Incyte Holdings Corporation	Cyclopropylamines as LSD1 inhibitors
WO2016007727A1 (en)	2014-07-10	2016-01-14	Incyte Corporation	Triazolopyridines and triazolopyrazines as lsd1 inhibitors
TWI687419B (zh)	2014-07-10	2020-03-11	美商英塞特公司	作為ｌｓｄ１抑制劑之咪唑并吡啶及咪唑并吡嗪
WO2016007736A1 (en)	2014-07-10	2016-01-14	Incyte Corporation	Imidazopyrazines as lsd1 inhibitors
US9695167B2 (en)	2014-07-10	2017-07-04	Incyte Corporation	Substituted triazolo[1,5-a]pyridines and triazolo[1,5-a]pyrazines as LSD1 inhibitors
US9580420B2 (en)	2014-08-06	2017-02-28	Bristol-Meyers Squibb Company	Process for the preparation of 4-(8-(2-chlorophenoxy)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)bicyclo[2.2.1]heptan-1-ol and novel intermediates therefor
EP3277689B1 (en)	2015-04-03	2019-09-04	Incyte Corporation	Heterocyclic compounds as lsd1 inhibitors
PE20181175A1 (es)	2015-08-12	2018-07-20	Incyte Corp	Sales de un inhibidor de lsd1
AU2017252328B2 (en)	2016-04-22	2023-02-23	Incyte Corporation	Formulations of an LSD1 inhibitor
EP3472161B1 (en) *	2016-06-20	2020-03-25	Novartis AG	Triazolopyridine compounds and uses thereof
US10968200B2 (en)	2018-08-31	2021-04-06	Incyte Corporation	Salts of an LSD1 inhibitor and processes for preparing the same

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3597423A (en) *	1966-08-31	1971-08-03	Boehringer Mannheim Gmbh	5-nitrofuryl-2-s-triazolo-(4,3-a)-pyridine derivatives
US4358453A (en) *	1982-01-08	1982-11-09	Schering Corporation	1,2,4-Triazolo[4,3-a]pyridines
US5236917A (en) *	1989-05-04	1993-08-17	Sterling Winthrop Inc.	Saccharin derivatives useful as proteolytic enzyme inhibitors and compositions and method of use thereof
IL96432A0 (en)	1989-11-30	1991-08-16	Schering Ag	Pesticidal compositions containing pyridine derivatives and novel pyridine derivatives
JP3531169B2 (ja)	1996-06-11	2004-05-24	三菱ウェルファーマ株式会社	縮合ヘテロ環化合物およびその医薬用途
BR0010139A (pt)	1999-04-28	2004-03-02	Reddy Research Foundation	Heterociclos bicìclicos substituìdos, processo para seu preparo e seu uso como agentes anti-obesidade e hipocolesterolêmico
JP2000319277A (ja)	1999-05-11	2000-11-21	Ono Pharmaceut Co Ltd	縮合ピラジン化合物およびその化合物を有効成分とする薬剤
JP4747396B2 (ja)	2000-05-17	2011-08-17	日立化成工業株式会社	接着剤組成物、それを用いた回路端子の接続方法及び回路端子の接続構造
CN1496366A (zh) *	2001-03-09	2004-05-12	�Ʒ�	作为抗炎剂的三唑并吡啶
US20050113283A1 (en) *	2002-01-18	2005-05-26	David Solow-Cordero	Methods of treating conditions associated with an EDG-4 receptor
AU2003207717B9 (en)	2002-02-01	2009-05-07	Merck & Co., Inc.	11-beta-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia
AR040241A1 (es)	2002-06-10	2005-03-23	Merck & Co Inc	Inhibidores de la 11-beta-hidroxiesteroide deshidrogrenasa 1 para el tratamiento de la diabetes obesidad y dislipidemia
JP2006508914A (ja) *	2002-08-30	2006-03-16	ファイザー・プロダクツ・インク	トリアゾロ−ピリジン製造のための新規な方法および中間体
MY139563A (en) *	2002-09-04	2009-10-30	Bristol Myers Squibb Co	Heterocyclic aromatic compounds useful as growth hormone secretagogues
JO2397B1 (en)	2002-12-20	2007-06-17	ميرك شارب اند دوم كوربوريشن	Terazol derivatives as beta-hydroxy steroid dihydrogenase-1 inhibitors
WO2004056744A1 (en) *	2002-12-23	2004-07-08	Janssen Pharmaceutica N.V.	Adamantyl acetamides as hydroxysteroid dehydrogenase inhibitors
TW200503994A (en)	2003-01-24	2005-02-01	Novartis Ag	Organic compounds
EP1601672B1 (en) *	2003-02-14	2006-07-26	Pfizer Products Inc.	Triazolo-pyridines as anti-inflammatory compounds
WO2004089380A2 (en)	2003-04-11	2004-10-21	Novo Nordisk A/S	Pharmaceutical use of fused 1,2,4-triazoles
CA2524376A1 (en) *	2003-05-05	2004-12-16	Neurogen Corporation	Substituted imidazolopyrazine and triazolopyrazyne derivatives: gabaa receptor ligands
CA2526712A1 (en)	2003-05-29	2004-12-09	Merck & Co., Inc.	Triazole derivatives as inhibitors of 11-beta hydroxysteroid dehydrogenase-1
US20050049276A1 (en) *	2003-07-23	2005-03-03	Warner-Lambert Company, Llc	Imidazopyridines and triazolopyridines
US7538120B2 (en) *	2003-09-03	2009-05-26	Array Biopharma Inc.	Method of treating inflammatory diseases
US7144907B2 (en) *	2003-09-03	2006-12-05	Array Biopharma Inc.	Heterocyclic inhibitors of MEK and methods of use thereof
GB0325745D0 (en)	2003-11-05	2003-12-10	Astrazeneca Ab	Chemical compounds
GB0326029D0 (en)	2003-11-07	2003-12-10	Astrazeneca Ab	Chemical compounds
IN2012DN03023A (da)	2004-01-26	2015-07-31	Merck Sharp & Dohme
US7306631B2 (en)	2004-03-30	2007-12-11	The Procter & Gamble Company	Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof
WO2006015737A1 (de)	2004-08-02	2006-02-16	Schwarz Pharma Ag	Carboxamide des indolizins und seiner aza- und diazaderivate
DE602005010714D1 (de) *	2004-08-12	2008-12-11	Pfizer	Der p38-map-kinase
JP2008509987A (ja)	2004-08-18	2008-04-03	ファルマシアアンドアップジョンカンパニーリミテッドライアビリティカンパニー	トリアゾロピリジン化合物
EP1781655A2 (en)	2004-08-18	2007-05-09	Pharmacia & Upjohn Company LLC	Triazolopyridine compounds useful for the treatment of inflammation
EP1786813A2 (en)	2004-09-03	2007-05-23	Plexxikon, Inc.	Bicyclic heteroaryl pde4b inhibitors
EP1790641A4 (en)	2004-09-16	2009-08-26	Astellas Pharma Inc	DERIVATIVE OF TRIAZOLE OR SALT OF SAID DERIVATIVE
US20080171740A1 (en)	2004-09-24	2008-07-17	Smithkline Beecham Corporation	Chemical Compounds
CN101039942A (zh)	2004-09-27	2007-09-19	伊利舍医药品公司	磺酰胺类及其用途
JP4682207B2 (ja)	2004-09-29	2011-05-11	エフ．ホフマン−ラロシュアーゲー	１１ｂ−ｈｓｄ１阻害剤としてのインドゾロン誘導体
WO2006038116A2 (en)	2004-10-07	2006-04-13	Warner-Lambert Company Llc	Triazolopyridine derivatives as antibacterial agents
US20080021069A1 (en)	2004-10-08	2008-01-24	Takeda Pharmaceutical Company Limited	Receptor Function Regulating Agent
CA2584179C (en)	2004-10-13	2013-01-29	Wolfgang Staehle	N,n'-diphenylurea derivatives which are suitable as kinase inhibitors
WO2006042599A1 (de)	2004-10-13	2006-04-27	Merck Patent Gmbh	Phenylharnstoffderivate als hemmstoffe von tyrosinkinasen zur behandlung von tumorerkrankungen
WO2006044687A2 (en)	2004-10-15	2006-04-27	Takeda San Diego, Inc.	Kinase inhibitors
GB0519957D0 (en)	2005-09-30	2005-11-09	Sb Pharmco Inc	Chemical compound
US7652035B2 (en)	2004-10-19	2010-01-26	Neurocrine Bioscience, Inc.	CRF receptor antagonists and methods relating thereto
US7151176B2 (en)	2004-10-21	2006-12-19	Bristol-Myers Squibb Company	Pyrrolotriazine compounds
CA2588350A1 (en)	2004-10-25	2006-05-04	University Of Medicine And Dentistry Of New Jersey	Anti-mitotic anti-proliferative compounds
DK1807072T3 (da)	2004-10-29	2009-03-16	Lilly Co Eli	Cycloalkyllactamderivater som inhibitorer af 11-beta-hydroxysteroid-dehydrogenase 1
EP1655283A1 (en)	2004-11-08	2006-05-10	Evotec OAI AG	11beta-HSD1 Inhibitors
EP1666467A1 (en)	2004-11-08	2006-06-07	Evotec AG	11Beta-HSD1 Inhibitors
AU2005311451A1 (en)	2004-12-01	2006-06-08	Merck Serono Sa	[1,2,4]triazolo[4,3-a]pyridine derivatives for the treatment of hyperproliferative diseases
JPWO2006080533A1 (ja)	2005-01-31	2008-06-19	持田製薬株式会社	３−アミノ−１，２，４−トリアゾール誘導体
JPWO2007007688A1 (ja)	2005-07-08	2009-01-29	持田製薬株式会社	３，５−ジアミノ−１，２，４−トリアゾール誘導体
KR20080104351A (ko)	2006-03-31	2008-12-02	노파르티스 아게	유기 화합물

2006
- 2006-06-07 US US11/448,947 patent/US7579360B2/en active Active
- 2006-06-08 DE DE602006018135T patent/DE602006018135D1/de active Active
- 2006-06-08 PT PT06784721T patent/PT1888582E/pt unknown
- 2006-06-08 AR ARP060102406A patent/AR054385A1/es unknown
- 2006-06-08 EA EA200800006A patent/EA013017B1/ru not_active IP Right Cessation
- 2006-06-08 KR KR1020087000469A patent/KR20080019276A/ko not_active Application Discontinuation
- 2006-06-08 DK DK06784721.0T patent/DK1888582T3/da active
- 2006-06-08 BR BRPI0611773-2A patent/BRPI0611773A2/pt not_active IP Right Cessation
- 2006-06-08 WO PCT/US2006/022576 patent/WO2006135795A1/en active Application Filing
- 2006-06-08 AU AU2006257924A patent/AU2006257924B2/en not_active Ceased
- 2006-06-08 PE PE2006000636A patent/PE20070164A1/es not_active Application Discontinuation
- 2006-06-08 SI SI200630920T patent/SI1888582T1/sl unknown
- 2006-06-08 EP EP06784721A patent/EP1888582B1/en active Active
- 2006-06-08 PL PL06784721T patent/PL1888582T3/pl unknown
- 2006-06-08 CN CN2011104026933A patent/CN102558176A/zh active Pending
- 2006-06-08 NZ NZ563457A patent/NZ563457A/en not_active IP Right Cessation
- 2006-06-08 CA CA2611529A patent/CA2611529C/en not_active Expired - Fee Related
- 2006-06-08 JP JP2008515986A patent/JP4994368B2/ja not_active Expired - Fee Related
- 2006-06-08 MX MX2007015285A patent/MX2007015285A/es active IP Right Grant
- 2006-06-08 GE GEAP200610470A patent/GEP20105073B/en unknown
- 2006-06-08 AT AT06784721T patent/ATE487717T1/de active
- 2006-06-08 TW TW095120401A patent/TW200716111A/zh unknown
2007
- 2007-11-26 NO NO20076055A patent/NO20076055L/no not_active Application Discontinuation
- 2007-12-02 IL IL187812A patent/IL187812A/en not_active IP Right Cessation
2008
- 2008-06-04 HK HK08106205.0A patent/HK1112463A1/xx not_active IP Right Cessation
2009
- 2009-04-16 US US12/424,674 patent/US8148396B2/en active Active
2011
- 2011-01-31 HR HR20110073T patent/HRP20110073T1/hr unknown
- 2011-01-31 CY CY20111100103T patent/CY1111148T1/el unknown

Also Published As

Publication number	Publication date
AU2006257924A1 (en)	2006-12-21
JP4994368B2 (ja)	2012-08-08
PT1888582E (pt)	2011-01-14
CA2611529C (en)	2013-12-03
KR20080019276A (ko)	2008-03-03
AU2006257924B2 (en)	2012-03-08
US8148396B2 (en)	2012-04-03
EP1888582A1 (en)	2008-02-20
CA2611529A1 (en)	2006-12-21
GEP20105073B (en)	2010-09-10
CY1111148T1 (el)	2015-06-11
WO2006135795A1 (en)	2006-12-21
US7579360B2 (en)	2009-08-25
US20090203668A1 (en)	2009-08-13
AR054385A1 (es)	2007-06-20
MX2007015285A (es)	2008-02-22
SI1888582T1 (sl)	2011-03-31
EA013017B1 (ru)	2010-02-26
HRP20110073T1 (hr)	2011-02-28
ATE487717T1 (de)	2010-11-15
NO20076055L (no)	2008-03-05
TW200716111A (en)	2007-05-01
CN102558176A (zh)	2012-07-11
NZ563457A (en)	2010-06-25
JP2008543776A (ja)	2008-12-04
EA200800006A1 (ru)	2008-06-30
US20060287357A1 (en)	2006-12-21
BRPI0611773A2 (pt)	2010-09-28
PL1888582T3 (pl)	2011-05-31
HK1112463A1 (en)	2008-09-05
DE602006018135D1 (de)	2010-12-23
IL187812A (en)	2012-02-29
IL187812A0 (en)	2008-08-07
EP1888582B1 (en)	2010-11-10
PE20070164A1 (es)	2007-03-11

Publication	Publication Date	Title
DK1888582T3 (da)	2011-02-28	Imidazo- og triazolopyridiner som hæmmere af 11-beta-hydroxysteroid dehydrigenase
DK1962830T3 (da)	2013-06-24	Azaindolhæmmere af aurorakinaser.
DK1898903T3 (da)	2013-07-01	Inhibitorer af Akt-aktivitet
DK1940839T3 (da)	2013-10-14	Pyridopyrimidione Inhibitors of P13Ka
DK1730146T3 (da)	2011-08-15	Azaindoler anvendelige som inhibitorer af JAK og andre proteinkinaser
DK1802579T3 (da)	2014-01-20	Derivater af 3-arylaminopyridin
DK3395338T3 (da)	2019-07-22	Hurtigt opløsende formulering af cinacalcet-hcl
CY2014011I1 (el)	2015-12-09	Χορηγηση αναστολεων διπεπτιδυλοπεπτιδασης
CY2013042I1 (el)	2015-12-09	Αναστολεις πυριδυλιου της σηματοδοτησης hedgehog
DK1789041T3 (da)	2008-09-08	Aryl-pyridinderivater som 11-beta-HSD1-inhibitorer
DK1720866T3 (da)	2011-11-21	Fremgangsmåde
DK1981875T3 (da)	2014-07-14	Substituerede indolylalkylaminoderivater som inhibitorer af histondeacetylase
DK1948643T3 (da)	2013-09-08	3-Alkyl-5-(4-alkyl-5-oxo-tetrahydrofuran-2-yl)pyrrolidin-2-on-derivater som mellemprodukter i syntese af renininhibitorer
DK1797042T3 (da)	2009-03-02	Indozolonderivater som 11B-HSD1-inhibitorer
DE602006007982D1 (de)	2009-09-03	Modular-indikations-sicherungshalter
DE502006007287D1 (de)	2010-08-05	N von werkstücken
FR2877833B1 (fr)	2007-10-12	Correcteur de lordoses
NO20053517L (no)	2007-01-19	Anvendelse av lipidsenkende midler
DE112005002726A5 (de)	2008-02-07	Zentriervorrichtung
FI20050571A0 (fi)	2005-05-30	Käyttömenetelmä
ITMO20040025A1 (it)	2004-05-06	Mezzi di collegamento
ITVR20040028A1 (it)	2004-06-02	Struttura di longherone
UA12593S (uk)	2006-08-15	Стела-цінник світива
ITPS20050012A1 (it)	2006-10-22	Struttura di fitodepuratore
ITVI20050244A1 (it)	2007-03-24	Struttura di colonnina