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DK1638539T3 - Farmaceutiske sammensætninger omfattende pH-sensitive blokcopolymerer og et hydrofobisk medikament - Google Patents

Farmaceutiske sammensætninger omfattende pH-sensitive blokcopolymerer og et hydrofobisk medikament

Info

Publication number
DK1638539T3
DK1638539T3 DK04727195T DK04727195T DK1638539T3 DK 1638539 T3 DK1638539 T3 DK 1638539T3 DK 04727195 T DK04727195 T DK 04727195T DK 04727195 T DK04727195 T DK 04727195T DK 1638539 T3 DK1638539 T3 DK 1638539T3
Authority
DK
Denmark
Prior art keywords
pharmaceutical compositions
block copolymers
poly
alkyl
hydrophobic drug
Prior art date
Application number
DK04727195T
Other languages
Danish (da)
English (en)
Inventor
Vinayak Sant
Jean-Christophe Leroux
Original Assignee
Univ Montreal
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Montreal filed Critical Univ Montreal
Application granted granted Critical
Publication of DK1638539T3 publication Critical patent/DK1638539T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C08L71/02—Polyalkylene oxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Polymers & Plastics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cephalosporin Compounds (AREA)
DK04727195T 2003-06-25 2004-04-14 Farmaceutiske sammensætninger omfattende pH-sensitive blokcopolymerer og et hydrofobisk medikament DK1638539T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/607,446 US7094810B2 (en) 2001-06-08 2003-06-25 pH-sensitive block copolymers for pharmaceutical compositions
PCT/CA2004/000561 WO2004112757A1 (en) 2003-06-25 2004-04-14 Pharmaceutical compositions comprising ph-sensitive block copolymers and a hydrophobic drug

Publications (1)

Publication Number Publication Date
DK1638539T3 true DK1638539T3 (da) 2009-05-04

Family

ID=33540273

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04727195T DK1638539T3 (da) 2003-06-25 2004-04-14 Farmaceutiske sammensætninger omfattende pH-sensitive blokcopolymerer og et hydrofobisk medikament

Country Status (16)

Country Link
US (1) US7094810B2 (pt)
EP (1) EP1638539B1 (pt)
JP (1) JP4619357B2 (pt)
AT (1) ATE418970T1 (pt)
AU (1) AU2004248863B2 (pt)
BR (1) BRPI0411872A (pt)
CA (1) CA2530736C (pt)
CY (1) CY1110264T1 (pt)
DE (1) DE602004018772D1 (pt)
DK (1) DK1638539T3 (pt)
ES (1) ES2323701T3 (pt)
MX (1) MXPA05014017A (pt)
PL (1) PL1638539T3 (pt)
PT (1) PT1638539E (pt)
SI (1) SI1638539T1 (pt)
WO (1) WO2004112757A1 (pt)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003523544A (ja) * 2000-02-17 2003-08-05 レックスマーク・インターナショナル・インコーポレーテツド 導電性駆動ハブを備えたトナーカートリッジ
US6939564B2 (en) * 2001-06-08 2005-09-06 Labopharm, Inc. Water-soluble stabilized self-assembled polyelectrolytes
WO2005079856A1 (en) * 2004-02-23 2005-09-01 The University Of British Columbia Drug delivery compositions comprising hydrophobic polymers and amphipathic molecules
US20060198891A1 (en) * 2004-11-29 2006-09-07 Francois Ravenelle Solid formulations of liquid biologically active agents
EP2037888A2 (en) * 2006-06-26 2009-03-25 Mutual Pharmaceutical Company, Inc. Active agent formulations, methods of making, and methods of use
US20090074872A1 (en) * 2006-06-26 2009-03-19 Mutual Pharmaceutical Company, Inc. Active Agent Formulations, Methods of Making, and Methods of Use
BRPI0716890A2 (pt) * 2006-09-22 2013-10-22 Labopharm Inc Composição, e, método de produção de uma composição, de administração de um agente farmaceuticamente ativo insolúvel em água a um mamífero, e de tratamento de câncer em um mamífero
JP5340956B2 (ja) * 2006-12-20 2013-11-13 アーケマ・インコーポレイテッド ポリマーの封入および／または結合
AU2008241367A1 (en) * 2007-04-20 2008-10-30 University Of South Australia Nanoparticle-coated capsule formulation for dermal drug delivery
US8003621B2 (en) * 2007-09-14 2011-08-23 Nitto Denko Corporation Drug carriers
FR2922452B1 (fr) * 2007-10-19 2010-01-22 Coatex Sas Formulations de composes organoplatiniques en presence de polymeres associatifs, produits obtenus et leurs utilisations
TWI388591B (zh) * 2008-03-28 2013-03-11 Ind Tech Res Inst 溫度敏感性材料
US8778400B2 (en) * 2008-04-21 2014-07-15 University Of South Australia Nanoparticle-stabilized capsule formulation for treatment of inflammation
KR101764427B1 (ko) 2008-05-13 2017-08-02 유니버시티 오브 워싱톤 미셀성 어셈블리
WO2009140427A2 (en) * 2008-05-13 2009-11-19 University Of Washington Diblock copolymers and polynucleotide complexes thereof for delivery into cells
CA2724455A1 (en) * 2008-05-13 2009-11-19 University Of Washington Polymeric carrier
JP2011520901A (ja) * 2008-05-13 2011-07-21 ユニヴァーシティ オブ ワシントン 治療剤の細胞内送達のためのミセル
WO2009140423A2 (en) * 2008-05-13 2009-11-19 University Of Washington Targeted polymer bioconjugates
NZ589287A (en) * 2008-05-16 2012-06-29 Univ Sydney Administrable compositions
CA2635187A1 (en) * 2008-06-05 2009-12-05 The Royal Institution For The Advancement Of Learning/Mcgill University Oligonucleotide duplexes and uses thereof
ES2425772T3 (es) * 2008-06-24 2013-10-17 Nanocarrier Co., Ltd. Composición líquida que comprende un compuesto de coordinación de cisplatino
EP2331069A4 (en) 2008-08-22 2011-10-26 Univ Washington HETEROGENEOUS POLYMER MICELLES FOR INTRACELLULAR DELIVERY
CA2742955A1 (en) 2008-11-06 2010-05-14 University Of Washington Bispecific intracellular delivery vehicles
JP5766611B2 (ja) 2008-11-06 2015-08-19 ユニヴァーシティ オブ ワシントン マルチブロック共重合体
US9593169B2 (en) 2008-12-08 2017-03-14 University Of Washington Omega-functionalized polymers, junction-functionalized block copolymers, polymer bioconjugates, and radical chain extension polymerization
US20100159010A1 (en) * 2008-12-24 2010-06-24 Mutual Pharmaceutical Company, Inc. Active Agent Formulations, Methods of Making, and Methods of Use
TWI374903B (en) * 2008-12-31 2012-10-21 Ind Tech Res Inst Biodegradable copolymer hydrogel materials
WO2011062965A2 (en) 2009-11-18 2011-05-26 University Of Washington Through Its Center For Commercialization Targeting monomers and polymers having targeting blocks
WO2015017519A1 (en) 2013-07-30 2015-02-05 Phaserx, Inc. Block copolymers and their conjugates or complexes with oligonucleotides
EP3247328A1 (en) 2015-01-21 2017-11-29 PhaseRx, Inc. Methods, compositions, and systems for delivering therapeutic and diagnostic agents into cells
WO2017156183A1 (en) 2016-03-08 2017-09-14 Los Gatos Pharmaceuticals, Inc. Camptothecin derivatives and uses thereof
WO2017156191A1 (en) 2016-03-08 2017-09-14 Los Gatos Pharmaceuticals, Inc. Composite nanoparticles and uses thereof
CN106432647B (zh) * 2016-09-26 2018-10-30 华南理工大学 基于叔氨基的pH响应嵌段聚合物及其混合胶束与应用
WO2018126084A1 (en) 2016-12-30 2018-07-05 Phaserx, Inc. Branched peg molecules and related compositions and methods
WO2019032975A1 (en) * 2017-08-10 2019-02-14 Mec Device Pharma International Llc ANTI-ABUSE MEDICINAL FORMULATIONS
CN114377144B (zh) * 2022-01-28 2024-10-29 南通大学 pH/活性氧双重响应性超分子聚肽前药纳米粒子

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1411843A (en) * 1973-02-28 1975-10-29 Univ Strathclyde Method of modifying the properties of a polymer
JPS5767860A (en) * 1980-10-15 1982-04-24 Fuji Photo Film Co Ltd Material for multilayer analysis
JP2517760B2 (ja) * 1989-05-11 1996-07-24 新技術事業団 水溶性高分子化医薬製剤
KR940003548U (ko) * 1992-08-14 1994-02-21 김형술 세탁물 건조기
US5840319A (en) * 1992-10-08 1998-11-24 Alakhov; Valery Yu Biological agent compositions
EP0639592A1 (en) * 1993-08-18 1995-02-22 Nippon Shokubai Co., Ltd. Water-soluble graft polymers and production process thereof
WO1995025764A1 (fr) * 1994-03-23 1995-09-28 Meiji Seika Kabushiki Kaisha Derive bicatenaire de lipide contenant un polyoxyethylene
US5620850A (en) * 1994-09-26 1997-04-15 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
US5997861A (en) 1994-10-31 1999-12-07 Burstein Laboratories, Inc. Antiviral supramolecules containing target-binding molecules and therapeutic molecules bound to spectrin
US5656611A (en) * 1994-11-18 1997-08-12 Supratek Pharma Inc. Polynucleotide compositions
US6221959B1 (en) * 1994-11-18 2001-04-24 Supratek Pharma, Inc. Polynucleotide compositions
AU4690596A (en) 1994-12-30 1996-07-24 Chiron Viagene, Inc. Nucleic acid condensing agents with reduced immunogenicity
US5492996A (en) * 1995-02-21 1996-02-20 The United States Of America As Represented By The Secretary Of The Air Force Alcohol soluble benzazole polymers
ATE226603T1 (de) * 1995-04-19 2002-11-15 Kazunori Kataoka Heterotelechelische blockcopolymere und verfahren zu deren herstellung
US5908777A (en) * 1995-06-23 1999-06-01 University Of Pittsburgh Lipidic vector for nucleic acid delivery
JP3711288B2 (ja) * 1995-08-10 2005-11-02 一則 片岡 両末端に官能基を有するブロックポリマー
US5770627A (en) * 1995-08-16 1998-06-23 University Of Washington Hydrophobically-modified bioadhesive polyelectrolytes and methods relating thereto
US5702717A (en) * 1995-10-25 1997-12-30 Macromed, Inc. Thermosensitive biodegradable polymers based on poly(ether-ester)block copolymers
ATE207798T1 (de) 1996-03-15 2001-11-15 Harvard College Verfahren zum formen von gegenständen und zum mikrostrukturieren von oberflächen durch giessformen mit kapillarwirkung
US5955509A (en) * 1996-05-01 1999-09-21 Board Of Regents, The University Of Texas System pH dependent polymer micelles
JP2001508762A (ja) * 1996-06-27 2001-07-03 ジー．ディー．サール アンド カンパニー 架橋した外殻領域および内部芯領域を有する両親媒性コポリマーからなり、医薬およびその他の用途に有用な粒子
GB9623051D0 (en) 1996-11-06 1997-01-08 Schacht Etienne H Delivery of DNA to target cells in biological systems
WO1998037902A1 (en) 1997-02-28 1998-09-03 The Regents Of The University Of California Inhibition of cell-cell binding by lipid assemblies
EP0963758A3 (en) 1998-05-07 2000-03-22 Universiteit Gent Synthetic polyaminoacid complexes for delivery of nucleic acids to target cells
US5939453A (en) * 1998-06-04 1999-08-17 Advanced Polymer Systems, Inc. PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers
JP2002520435A (ja) * 1998-07-13 2002-07-09 エクスプレション・ジェネティックス・インコーポレーテッド 可溶性、生物分解性な遺伝子輸送キャリアーとしてのポリ−ｌ−リジンのポリエステル類似体
DE19919785A1 (de) * 1999-04-30 2000-12-07 Wella Ag Haarbehandlungsmittel mit Polymeren aus ungesättigten Sacchariden, ungesättigten Saccharidsäuren oder deren Derivaten
DE10008895A1 (de) * 2000-02-25 2001-08-30 Beiersdorf Ag Stabilisierung oxidations- und/oder UV-empfindlicher Wirkstoffe
WO2001087227A2 (en) 2000-05-17 2001-11-22 Labopharm, Inc. Drug containing polymeric micelles
US6780428B2 (en) * 2001-06-08 2004-08-24 Labopharm, Inc. Unimolecular polymeric micelles with an ionizable inner core
US6939564B2 (en) * 2001-06-08 2005-09-06 Labopharm, Inc. Water-soluble stabilized self-assembled polyelectrolytes
GB0131112D0 (en) * 2001-12-31 2002-02-13 Univ London Pharmacy Block copolymers
ES2301846T3 (es) 2002-10-21 2008-07-01 L'oreal Proceso para disolver compuestos lipofilos en fase acuosa con copolimeros de bloque anfifilico; y composiciones cosmeticas.

Also Published As

Publication number Publication date
EP1638539B1 (en) 2008-12-31
CY1110264T1 (el) 2015-01-14
US7094810B2 (en) 2006-08-22
PL1638539T3 (pl) 2009-10-30
JP2007505029A (ja) 2007-03-08
SI1638539T1 (sl) 2009-10-31
DE602004018772D1 (de) 2009-02-12
JP4619357B2 (ja) 2011-01-26
ES2323701T3 (es) 2009-07-23
BRPI0411872A (pt) 2006-08-08
AU2004248863A1 (en) 2004-12-29
AU2004248863B2 (en) 2009-03-12
CA2530736C (en) 2013-07-02
EP1638539A1 (en) 2006-03-29
WO2004112757A1 (en) 2004-12-29
CA2530736A1 (en) 2004-12-29
MXPA05014017A (es) 2007-01-31
ATE418970T1 (de) 2009-01-15
US20040072784A1 (en) 2004-04-15
PT1638539E (pt) 2009-04-09

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