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DK169478A - PROCEDURE FOR THE PREPARATION OF THYMOSIN ALFA1 AND AN ANALOG - Google Patents

PROCEDURE FOR THE PREPARATION OF THYMOSIN ALFA1 AND AN ANALOG

Info

Publication number
DK169478A
DK169478A DK169478A DK169478A DK169478A DK 169478 A DK169478 A DK 169478A DK 169478 A DK169478 A DK 169478A DK 169478 A DK169478 A DK 169478A DK 169478 A DK169478 A DK 169478A
Authority
DK
Denmark
Prior art keywords
alfa1
thymosin
analog
procedure
preparation
Prior art date
Application number
DK169478A
Other languages
Danish (da)
Other versions
DK147918C (en
DK147918B (en
Inventor
S S Wang
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/871,563 external-priority patent/US4116951A/en
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of DK169478A publication Critical patent/DK169478A/en
Publication of DK147918B publication Critical patent/DK147918B/en
Application granted granted Critical
Publication of DK147918C publication Critical patent/DK147918C/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06086Dipeptides with the first amino acid being basic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/57581Thymosin; Related peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06017Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06043Leu-amino acid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10Tetrapeptides
    • C07K5/1002Tetrapeptides with the first amino acid being neutral
    • C07K5/1005Tetrapeptides with the first amino acid being neutral and aliphatic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DK169478A 1977-04-22 1978-04-18 METHOD OF ANALOGUE FOR THE PREPARATION OF THYMOSINE ALFA1 (18 - 28) OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF DK147918C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US78989877A 1977-04-22 1977-04-22
US78989877 1977-04-22
US87156378 1978-01-23
US05/871,563 US4116951A (en) 1977-04-22 1978-01-23 [Asn2 ]-thymosin α1 and analogs thereof

Publications (3)

Publication Number Publication Date
DK169478A true DK169478A (en) 1978-10-23
DK147918B DK147918B (en) 1985-01-07
DK147918C DK147918C (en) 1985-08-19

Family

ID=27120967

Family Applications (1)

Application Number Title Priority Date Filing Date
DK169478A DK147918C (en) 1977-04-22 1978-04-18 METHOD OF ANALOGUE FOR THE PREPARATION OF THYMOSINE ALFA1 (18 - 28) OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF

Country Status (18)

Country Link
JP (1) JPS53137914A (en)
AT (1) AT364470B (en)
CA (1) CA1113088A (en)
CH (3) CH641152A5 (en)
DE (1) DE2817082A1 (en)
DK (1) DK147918C (en)
ES (1) ES469016A1 (en)
FI (1) FI781241A (en)
FR (2) FR2401134A1 (en)
GB (1) GB1590668A (en)
GR (1) GR71886B (en)
HU (1) HU180783B (en)
IT (1) IT1113134B (en)
LU (1) LU79488A1 (en)
NL (1) NL7804364A (en)
NO (2) NO781404L (en)
PT (1) PT67937B (en)
SE (1) SE447262B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4116951A (en) * 1977-04-22 1978-09-26 Hoffmann-La Roche Inc. [Asn2 ]-thymosin α1 and analogs thereof
DE2919592A1 (en) * 1979-05-15 1981-01-15 Max Planck Gesellschaft METHOD FOR PRODUCING THYMOSINE ALPHA 1 AND DERIVATIVES THEREOF
EP0033384B1 (en) * 1980-01-18 1984-02-15 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Medicaments containing fragments of thymosin-alpha-1 with immunostimulating activity, and thymosin-alpha-1 fragments
US4339427A (en) * 1980-04-14 1982-07-13 Hoffmann-La Roche Inc. Radioimmunoassay of thymosinα
EP0056594B1 (en) * 1981-01-14 1984-09-12 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Thymosin-alpha-1 fragments and pharmaceutical compositions with immunoregulating action containing them
CN1058500C (en) * 1993-02-03 2000-11-15 施塞克龙药品公司 Thymosin alpha-1 derivatives
US6262230B1 (en) * 1994-01-28 2001-07-17 Sciclone Pharmaceuticals Inc. Analogs of thymosin α1

Also Published As

Publication number Publication date
SE7804612L (en) 1978-12-20
CH641152A5 (en) 1984-02-15
IT7822629A0 (en) 1978-04-21
DK147918C (en) 1985-08-19
ES469016A1 (en) 1980-01-01
GB1590668A (en) 1981-06-03
NO781404L (en) 1978-10-24
PT67937A (en) 1978-05-01
NO148924B (en) 1983-10-03
NO148924C (en) 1984-01-11
JPS53137914A (en) 1978-12-01
IT1113134B (en) 1986-01-20
HU180783B (en) 1983-04-29
AT364470B (en) 1981-10-27
FR2405926B1 (en) 1983-09-09
FR2401134B1 (en) 1983-09-30
NO821608L (en) 1978-10-24
GR71886B (en) 1983-08-04
CH640218A5 (en) 1983-12-30
DK147918B (en) 1985-01-07
LU79488A1 (en) 1979-05-25
FI781241A (en) 1978-10-23
PT67937B (en) 1980-04-07
SE447262B (en) 1986-11-03
FR2401134A1 (en) 1979-03-23
CH641153A5 (en) 1984-02-15
CA1113088A (en) 1981-11-24
ATA286178A (en) 1981-03-15
FR2405926A1 (en) 1979-05-11
DE2817082A1 (en) 1978-11-02
NL7804364A (en) 1978-10-24

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Legal Events

Date Code Title Description
PBP Patent lapsed
B1 Patent granted (law 1993)
PBP Patent lapsed