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DK1525215T3 - Modulators for the progesterone receptor with elevated anti-gonadotropic activity for women's fertility control and hormone replacement therapy - Google Patents

Modulators for the progesterone receptor with elevated anti-gonadotropic activity for women's fertility control and hormone replacement therapy

Info

Publication number
DK1525215T3
DK1525215T3 DK03784154T DK03784154T DK1525215T3 DK 1525215 T3 DK1525215 T3 DK 1525215T3 DK 03784154 T DK03784154 T DK 03784154T DK 03784154 T DK03784154 T DK 03784154T DK 1525215 T3 DK1525215 T3 DK 1525215T3
Authority
DK
Denmark
Prior art keywords
replacement therapy
modulators
women
hormone replacement
progesterone receptor
Prior art date
Application number
DK03784154T
Other languages
Danish (da)
Inventor
Walter Elger
Alexander Hillisch
Gerd Schubert
Birgitt Schneider
Gudrun Reddersen
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10236405A external-priority patent/DE10236405A1/en
Application filed by Schering Ag filed Critical Schering Ag
Application granted granted Critical
Publication of DK1525215T3 publication Critical patent/DK1525215T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention relates to novel compounds of general formula (I), to the production thereof and to pharmaceutical preparations containing these compounds. The inventive compounds are preferably used in female fertility testing and hormone replacement therapy.
DK03784154T 2002-08-02 2003-08-01 Modulators for the progesterone receptor with elevated anti-gonadotropic activity for women's fertility control and hormone replacement therapy DK1525215T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40006502P 2002-08-02 2002-08-02
DE10236405A DE10236405A1 (en) 2002-08-02 2002-08-02 New 4-(3-oxo-estra-4,9-dien-11 beta-yl)-benzaldehyde oximes, are progesterone receptor modulators useful in female contraception, hormone replacement therapy and treatment of gynecological disorders

Publications (1)

Publication Number Publication Date
DK1525215T3 true DK1525215T3 (en) 2007-01-15

Family

ID=31716602

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03784154T DK1525215T3 (en) 2002-08-02 2003-08-01 Modulators for the progesterone receptor with elevated anti-gonadotropic activity for women's fertility control and hormone replacement therapy

Country Status (8)

Country Link
EP (1) EP1525215B1 (en)
JP (1) JP2005539016A (en)
AT (1) ATE338763T1 (en)
AU (1) AU2003255355A1 (en)
DE (1) DE50304970D1 (en)
DK (1) DK1525215T3 (en)
ES (1) ES2273061T3 (en)
WO (1) WO2004014935A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20011762A1 (en) 2001-08-10 2003-02-10 Cosmo Spa 17ALPHA ESTERS, 21-DIHYDROXYPREGNENE, THEIR USE AS ANTI-ANDROGENETIC AGENTS AND PROCEDURES FOR THEIR PREPARATION
DE102006018869A1 (en) * 2006-04-13 2007-10-18 Bayer Schering Pharma Ag 17alpha-substituted 4- (3-oxoestra-4,9-diene-11beta-yl) -benzoic acid, its derivatives and processes for their preparation
BRPI0702900A2 (en) * 2006-06-28 2011-03-15 Teva Pharma crystalline forms of atorvastatin
US7981927B2 (en) 2007-03-07 2011-07-19 Janssen Pharmaceutica N.V. Steroids derivatives as selective progesterone receptor modulators
ITMI20071616A1 (en) 2007-08-03 2009-02-04 Cosmo Spa ENZYMATIC PROCESS FOR THE OBTAINING OF 17-ALFA MONOESTERS OF CORTEXOLONE AND / OR ITS 9,11-DEIDRODERIVATI.
WO2010010201A1 (en) 2008-07-22 2010-01-28 Equipo Ivi Investigacion Sl Gene expression profile as a marker of endometrial receptivity
DE102009034368A1 (en) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluoroethyl-estra-4,9 (10) -diene-11-acyloxyalkylenephenyl derivatives, process for their preparation and their use for the treatment of diseases
DE102009034367A1 (en) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluoroethyl-estra-4,9 (10) -diene-11-benzylidene derivatives, process for their preparation and their use for the treatment of diseases
DE102009034366A1 (en) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluoroethyl-estra-4,9 (10) -diene-11-methyleneoxyalkylene aryl derivatives, process for their preparation and their use for the treatment of diseases
DE102009034526A1 (en) 2009-07-21 2011-02-10 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluoroethyl-estra-4,9 (10) -diene-11-ethynylphenyl derivatives, process for their preparation and their use for the treatment of diseases
EP2348318A1 (en) * 2010-01-21 2011-07-27 Equipo Ivi Investigación, S.L. Diagnostic method for endometrial receptivity
DE102010007719A1 (en) 2010-02-10 2011-08-11 Bayer Schering Pharma Aktiengesellschaft, 13353 Progesterone receptor antagonist
RS65719B1 (en) 2014-06-17 2024-08-30 Asherman Therapy S L Stem cell therapy in endometrial pathologies
EP3108879A1 (en) 2015-06-25 2016-12-28 Cassiopea S.p.A. High concentration formulation

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3504421A1 (en) * 1985-02-07 1986-08-07 Schering AG, 1000 Berlin und 4709 Bergkamen 11 beta -Phenylgonanes, the preparation thereof and pharmaceutical products containing these
DE4332283A1 (en) * 1993-09-20 1995-04-13 Jenapharm Gmbh Novel 11-benzaldoximestradiene derivatives, processes for their preparation and medicaments containing these compounds
DE4332284C2 (en) * 1993-09-20 1997-05-28 Jenapharm Gmbh 11-Benzaldoxime-17beta-methoxy-17alpha-methoxymethyl-estradiene derivatives, process for their preparation and medicaments containing these compounds
DE19745085A1 (en) * 1997-10-11 1999-04-15 Jenapharm Gmbh 11β-Benzaldoxim-9alpha, 10alpha-epoxy-estr-4-ene derivatives, processes for their preparation and pharmaceutical preparations containing these compounds
DE19809845A1 (en) * 1998-03-03 1999-09-09 Jenapharm Gmbh S-substituted 11beta-benzaldoxime-estra-4,9-diene-carbonic acid thiol esters, processes for their preparation and pharmaceutical preparations containing these compounds
UA77150C2 (en) * 1999-08-31 2006-11-15 Schering Ag Use of mesoprogestins j867, j912, or j1042 for female contraception, pharmaceutical composition and kit (variants)
IL148417A0 (en) * 1999-08-31 2002-09-12 Jenapharm Gmbh Mesoprogestins (progesterone receptor modulators) as a component of compositions for hormone replacement therapy (hrt)
EE05172B1 (en) * 1999-08-31 2009-06-15 Jenapharm Gmbh & Co. Kg Mesoprogestins (progesterone receptor modulators) for the treatment and prevention of benign hormone dependent gynecological diseases
DE19961219A1 (en) * 1999-12-15 2001-07-19 Jenapharm Gmbh 11beta-phenyltratriene derivatives with fluoroalkyl groups in the aromatic side chain, their preparation and pharmaceutical compositions containing these compounds

Also Published As

Publication number Publication date
EP1525215A1 (en) 2005-04-27
WO2004014935A1 (en) 2004-02-19
DE50304970D1 (en) 2006-10-19
JP2005539016A (en) 2005-12-22
EP1525215B1 (en) 2006-09-06
AU2003255355A1 (en) 2004-02-25
ATE338763T1 (en) 2006-09-15
ES2273061T3 (en) 2007-05-01

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