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DK1517913T3 - A Mycobacterium tuberculosis coding sequence for expression of heterologous proteins - Google Patents

A Mycobacterium tuberculosis coding sequence for expression of heterologous proteins

Info

Publication number
DK1517913T3
DK1517913T3 DK00970619T DK00970619T DK1517913T3 DK 1517913 T3 DK1517913 T3 DK 1517913T3 DK 00970619 T DK00970619 T DK 00970619T DK 00970619 T DK00970619 T DK 00970619T DK 1517913 T3 DK1517913 T3 DK 1517913T3
Authority
DK
Denmark
Prior art keywords
expression
mycobacterium tuberculosis
coding sequence
polypeptide
heterologous proteins
Prior art date
Application number
DK00970619T
Other languages
Danish (da)
Inventor
Yasir Skeiky
Jeffrey Guderian
Original Assignee
Corixa Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Corixa Corp filed Critical Corixa Corp
Application granted granted Critical
Publication of DK1517913T3 publication Critical patent/DK1517913T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4721—Lipocortins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates generally to nucleic acid and amino acid sequences of a fusion polypeptide comprising a Mycobacterium tuberculosis polypeptide, and a heterologous polypeptide of interest, expression vectors and host cells comprising such nucleic acids, and methods for producing such fusion polypeptides. In particular, the invention relates to materials and methods of using such M. tuberculosis sequence as a fusion partner to facilitate the stable and high yield expression of recombinant heterologous polypeptides of both eukaryotic and prokaryotic origin.
DK00970619T 1999-10-07 2000-10-06 A Mycobacterium tuberculosis coding sequence for expression of heterologous proteins DK1517913T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15858599P 1999-10-07 1999-10-07
PCT/US2000/027652 WO2001025401A2 (en) 1999-10-07 2000-10-06 A mycobacterium tuberculosis coding sequence for expression of heterologous proteins

Publications (1)

Publication Number Publication Date
DK1517913T3 true DK1517913T3 (en) 2007-06-18

Family

ID=22568818

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00970619T DK1517913T3 (en) 1999-10-07 2000-10-06 A Mycobacterium tuberculosis coding sequence for expression of heterologous proteins

Country Status (12)

Country Link
US (1) US20060040356A1 (en)
EP (1) EP1517913B9 (en)
JP (1) JP2003527830A (en)
AT (1) ATE354663T1 (en)
AU (1) AU779846B2 (en)
CA (1) CA2386854A1 (en)
CY (1) CY1106593T1 (en)
DE (1) DE60033583T2 (en)
DK (1) DK1517913T3 (en)
ES (1) ES2282142T3 (en)
PT (1) PT1517913E (en)
WO (1) WO2001025401A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2374620T3 (en) * 2000-06-20 2012-02-20 Corixa Corporation ANTIGEN MTB32A OF MYCOBACTERIUM TUBERCULOSIS WITH THE ACTIVE ACTIVE SITE AND FUSION PROTEINS OF THEMSELVES.
SG159554A1 (en) 2004-11-16 2010-03-30 Crucell Holland Bv Multivalent vaccines comprising recombinant viral vectors
CN104292089B (en) * 2014-09-30 2016-01-13 大连九信生物化工科技有限公司 The synthesis technique of the chloro-1 '-chloracetyl cyclopropane of a kind of 1-

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6566072B1 (en) * 1995-05-31 2003-05-20 Washington University Mammaglobin, a secreted mammary-specific breast cancer protein
EP0850305B1 (en) * 1995-09-01 2006-04-26 Corixa Corporation Compounds and methods for diagnosis of tuberculosis
US6592877B1 (en) * 1995-09-01 2003-07-15 Corixa Corporation Compounds and methods for immunotherapy and diagnosis of tuberculosis
US6458366B1 (en) * 1995-09-01 2002-10-01 Corixa Corporation Compounds and methods for diagnosis of tuberculosis
US20020068285A1 (en) * 1996-01-11 2002-06-06 Frudakis Tony N. Compositions and methods for the therapy and diagnosis of breast cancer
EP0925364B1 (en) * 1996-09-06 2002-10-23 Bioteknologisk Institut A lactic acid bacterial regulatable expression system
AU4750597A (en) * 1996-10-11 1998-05-11 Corixa Corporation Compounds and methods for diagnosis of tuberculosis
US6627198B2 (en) * 1997-03-13 2003-09-30 Corixa Corporation Fusion proteins of Mycobacterium tuberculosis antigens and their uses
US6544522B1 (en) * 1998-12-30 2003-04-08 Corixa Corporation Fusion proteins of mycobacterium tuberculosis antigens and their uses
US6350456B1 (en) * 1997-03-13 2002-02-26 Corixa Corporation Compositions and methods for the prevention and treatment of M. tuberculosis infection
FR2767337B1 (en) * 1997-08-14 2002-07-05 Pasteur Institut NUCLEIC SEQUENCES OF POLYPEPTIDES EXPORTED FROM MYCOBACTERI ES, VECTORS COMPRISING THEM AND APPLICATIONS TO DIAGNOSIS AND THE PREVENTION OF TUBERCULOSIS
CA2302779C (en) * 1997-09-16 2010-02-02 Oregon Health Sciences University Recombinant mhc molecules useful for manipulation of antigen-specific t-cells
AU753995B2 (en) * 1998-04-07 2002-10-31 Corixa Corporation Fusion proteins of mycobacterium tuberculosis antigens and their uses
US6448234B1 (en) * 1998-12-08 2002-09-10 Corixa Corporation Compounds and methods for treatment and diagnosis of chlamydial infection
US6509448B2 (en) * 1999-06-30 2003-01-21 Corixa Corporation Compositions and methods for the therapy and diagnosis of lung cancer
US7311922B1 (en) * 1999-10-07 2007-12-25 Corixa Corporation Fusion proteins of mycobacterium tuberculosis
US7009042B1 (en) * 1999-10-07 2006-03-07 Corixa Corporation Methods of using a Mycobacterium tuberculosis coding sequence to facilitate stable and high yield expression of the heterologous proteins
WO2001034802A2 (en) * 1999-11-12 2001-05-17 Corixa Corporation Compositions and methods for the therapy and diagnosis of prostate cancer
KR20030016217A (en) * 2000-01-14 2003-02-26 코릭사 코포레이션 Compositions and methods for the therapy and diagnosis of prostate cancer
JP2004504808A (en) * 2000-03-27 2004-02-19 コリクサ　コーポレイション Compositions and methods for treatment and diagnosis of prostate cancer
ES2374620T3 (en) * 2000-06-20 2012-02-20 Corixa Corporation ANTIGEN MTB32A OF MYCOBACTERIUM TUBERCULOSIS WITH THE ACTIVE ACTIVE SITE AND FUSION PROTEINS OF THEMSELVES.

Also Published As

Publication number Publication date
WO2001025401A9 (en) 2002-09-26
WO2001025401A3 (en) 2005-02-03
EP1517913A2 (en) 2005-03-30
JP2003527830A (en) 2003-09-24
CA2386854A1 (en) 2001-04-12
AU7997200A (en) 2001-05-10
PT1517913E (en) 2007-05-31
DE60033583D1 (en) 2007-04-05
CY1106593T1 (en) 2012-01-25
WO2001025401A2 (en) 2001-04-12
EP1517913B1 (en) 2007-02-21
EP1517913B9 (en) 2007-08-29
DE60033583T2 (en) 2007-09-13
EP1517913A4 (en) 2005-09-14
ES2282142T3 (en) 2007-10-16
AU779846B2 (en) 2005-02-17
ATE354663T1 (en) 2007-03-15
US20060040356A1 (en) 2006-02-23

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