[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

DK143588A - Substituerede 9-amino-tetrahydroacridiner, deres fremstilling og anvendelse som laegemidler - Google Patents

Substituerede 9-amino-tetrahydroacridiner, deres fremstilling og anvendelse som laegemidler

Info

Publication number
DK143588A
DK143588A DK143588A DK143588A DK143588A DK 143588 A DK143588 A DK 143588A DK 143588 A DK143588 A DK 143588A DK 143588 A DK143588 A DK 143588A DK 143588 A DK143588 A DK 143588A
Authority
DK
Denmark
Prior art keywords
tetrahydroacridines
amino
substituted
preparation
medicinal products
Prior art date
Application number
DK143588A
Other languages
English (en)
Other versions
DK172864B1 (da
DK143588D0 (da
Inventor
Gregory Michael Shutske
Grover Cleveland Helsley
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of DK143588D0 publication Critical patent/DK143588D0/da
Publication of DK143588A publication Critical patent/DK143588A/da
Application granted granted Critical
Publication of DK172864B1 publication Critical patent/DK172864B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08—Nitrogen atoms
    • C07D219/10—Nitrogen atoms attached in position 9
    • C07D219/12—Amino-alkylamino radicals attached in position 9
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08—Nitrogen atoms
    • C07D219/10—Nitrogen atoms attached in position 9
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/06—Oxygen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DK198801435A 1987-03-17 1988-03-16 4-Amino-2,3-alkylen-quinolinderivater, farmaceutisk præparat indeholdende disse, anvendelse af derivaterne til fremstilling DK172864B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2673087A 1987-03-17 1987-03-17
US2673087 1987-03-17

Publications (3)

Publication Number Publication Date
DK143588D0 DK143588D0 (da) 1988-03-16
DK143588A true DK143588A (da) 1988-09-18
DK172864B1 DK172864B1 (da) 1999-08-23

Family

ID=21833471

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198801435A DK172864B1 (da) 1987-03-17 1988-03-16 4-Amino-2,3-alkylen-quinolinderivater, farmaceutisk præparat indeholdende disse, anvendelse af derivaterne til fremstilling

Country Status (15)

Country Link
US (1) US5391553A (da)
EP (1) EP0282959A3 (da)
JP (1) JP2888485B2 (da)
KR (1) KR960015001B1 (da)
AU (2) AU635370B2 (da)
CA (1) CA1318675C (da)
DK (1) DK172864B1 (da)
FI (1) FI91401C (da)
HU (1) HU201018B (da)
IL (1) IL85741A (da)
NO (1) NO173498C (da)
NZ (1) NZ223875A (da)
PH (1) PH25124A (da)
PT (1) PT86986B (da)
ZA (1) ZA881865B (da)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5202440A (en) * 1987-10-05 1993-04-13 Pfizer Inc. Certain 9-amino-2-(or 4)-oxa 1,2,3,4-tetrahydro- or 1,2,3,4,5,6,7,8-octahydro-acridines
IL87861A0 (en) * 1987-10-05 1989-03-31 Pfizer 4-aminopyridine derivatives
US5008853A (en) 1987-12-02 1991-04-16 Xerox Corporation Representation of collaborative multi-user activities relative to shared structured data objects in a networked workstation environment
US4985430A (en) 1987-12-03 1991-01-15 Mitsubishi Kasei Corporation 9-acylamino-tetrahydroacridine derivatives and memory enhancing agent containing said derivative as active ingredient
US4868177A (en) * 1988-11-09 1989-09-19 Hoechst-Roussel Pharmaceuticals, Inc. 1,2,3,4-tetrahydro-1,9-acridinediamines, pharmaceutical compositions and use
IL92307A0 (en) * 1988-11-16 1990-07-26 Hoechst Roussel Pharma Hydroxy-1,2,3,4-tetrahydroamino-acridines,a process for their preparation and pharmaceutical compositions containing them
JP2720517B2 (ja) * 1989-05-31 1998-03-04 三菱化学株式会社 ９―アシルアミノーテトラヒドロアクリジン誘導体および該誘導体を有効成分とする記憶障害改善剤
US5112829A (en) * 1989-11-28 1992-05-12 Hoechst-Roussel Pharmaceuticals Inc. Hexahydro-1H-quino[4,3,2-ef][1,4]benzoxazepines and related compounds
US4994452A (en) * 1989-11-28 1991-02-19 Hoechst-Roussel Pharmaceuticals Inc. Hexahydro-1H-quino[4,3,2-ef][1,4]benzoxazepines and related compounds
RU2024509C1 (ru) * 1991-05-07 1994-12-15 Всероссийский научный центр по безопасности биологически активных веществ Производные 9-аминоакридина или их соли с органическими или неорганическими кислотами, проявляющие психотропную, антиамнестическую и липидрегулирующую активность
GB9524346D0 (en) * 1995-11-29 1996-01-31 Univ Strathclyde Polycyclic compounds
US5783584A (en) * 1995-12-11 1998-07-21 Mayo Foundation For Medical Education And Research THA analogs useful as cholinesterase inhibitors
US5929093A (en) * 1996-06-13 1999-07-27 Mayo Foundation For Medical Education And Research Bifunctional acetylcholinesterase reactivators
TW521072B (en) * 1997-06-02 2003-02-21 Meiji Seika Kaisha 4-quinolinol derivatives and fungicides containing the same as an active ingredient used for agriculture and horticulture
JP4685742B2 (ja) * 1997-06-02 2011-05-18 明治製菓株式会社 ４−キノリノール誘導体及びこれを有効成分として含有する農園芸用殺菌剤
ES2144353B1 (es) * 1997-12-26 2001-01-01 Consejo Superior Investigacion Nuevos analogos de tacrina: potenciales agentes neuroprotectores para las enfermedades de alzheimer y parkinson. su procedimiento de obtencion.
US6218383B1 (en) 1998-08-07 2001-04-17 Targacept, Inc. Pharmaceutical compositions for the prevention and treatment of central nervous system disorders
ES2168926B1 (es) * 1999-12-14 2003-10-16 Prous Science S A Derivados de ciclopenta- ciclohexa- y ciclohepta (b)quinoleina, procedimiento para su fabricacion, utilizacion y composicion farmaceutica correspondiente.
CA2456594A1 (en) * 2001-08-06 2003-02-20 Mitsubishi Pharma Corporation Preventives/remedies for cholinergic neuropathy
JP4598674B2 (ja) * 2003-01-08 2010-12-15 田辺三菱製薬株式会社 統合失調症治療剤
EP2533645B1 (en) 2010-02-09 2016-07-27 The Johns Hopkins University Methods and compositions for improving cognitive function
CN102219740B (zh) * 2010-09-10 2013-02-13 长春华洋高科技有限公司 1，2，3，4，5，6，7，8-八氢-9-苯乙酰胺基吖啶及制备方法和药用用途
EP3610890A1 (en) 2012-11-14 2020-02-19 The Johns Hopkins University Methods and compositions for treating schizophrenia
WO2014144663A1 (en) 2013-03-15 2014-09-18 The Johns Hopkins University Methods and compositions for improving cognitive function
ES2881081T3 (es) 2013-03-15 2021-11-26 Agenebio Inc Procedimientos y composiciones para mejorar la función cognitiva
RU2567388C1 (ru) * 2014-12-10 2015-11-10 Открытое акционерное общество "Нижегородский химико-фармацевтический завод" Способ получения 9-бутиламино-3,3-диметил-3,4-дигидроакридин-1(2н)-она гидрохлорида
US10159648B2 (en) 2015-05-22 2018-12-25 Agenebio, Inc. Extended release pharmaceutical compositions of levetiracetam
SG10201911831RA (en) * 2015-08-03 2020-02-27 Bristol Myers Squibb Co Heterocyclic compounds useful as modulators of tnf alpha
KR101953366B1 (ko) 2018-12-26 2019-02-28 정종문 침향을 포함하는 기억력 및 인지능력을 향상시키는 기능성 건강식품 및 이의 제조방법
CN111704576A (zh) * 2020-06-17 2020-09-25 菏泽学院 一种轴手性9-芳基四氢吖啶的合成方法及应用

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3232945A (en) * 1962-08-13 1966-02-01 S E Massengill Company 7,8,9,10-tetrahalo-6h-cyclohepta-(b)-quinolines
US3318896A (en) * 1963-12-05 1967-05-09 Squibb & Sons Inc Production of 12-substituted-6, 7, 8, 9, 10, 11-hexahydrocycloocta[b]quinolines
US3318895A (en) * 1963-12-05 1967-05-09 Squibb & Sons Inc Production of 12-substituted-6, 7, 8, 9, 10, 11-hexahydrocycloocta[b]quinolines
BE658695A (da) * 1964-02-03 1965-07-22
US3580915A (en) * 1968-09-16 1971-05-25 American Home Prod 1,2,3,4-tetrahydrobenzol(b)(1,6)naphthyridine derivatives
US3541066A (en) * 1968-09-16 1970-11-17 American Home Prod 2,3-dihydro-1,4-ethanobenzo(b)(1,5)naphthyridine derivatives
US3647800A (en) * 1970-04-30 1972-03-07 American Home Prod 10-substituted - 1 2 3 4 - tetrahydrobenzo(b)(1 6)naphthyridines useful as cns depressants
US3637706A (en) * 1970-04-30 1972-01-25 American Home Prod 10-(4 - (lower)alkylpiperazino) - 1 2 3 4-tetrahydrobenzo(b)(1 6) naphthyridine derivatives useful as cns depressants
US3657233A (en) * 1970-04-30 1972-04-18 American Home Prod 10-morpholino-1 2 3 4-tetrahydrobenzo(b)(1 6)naphthyridine derivatives
US3674790A (en) * 1970-05-01 1972-07-04 American Home Prod 2,10-disubstituted-1,2,3,4-tetrahydrobenzo(bhq (1,6)naphthyridines useful as cns depressants
ES431307A1 (es) * 1973-11-16 1976-09-01 Thomae Gmbh Dr K Procedimiento para la preparacion de nuevos derivados de quinoleina.
US4108998A (en) * 1976-11-08 1978-08-22 American Home Products Corp. Furo[3,4-b]quinoline derivatives and pharmaceutical compositions and methods employing them
JPS6147466A (ja) * 1984-08-10 1986-03-07 Dainippon Pharmaceut Co Ltd アミン誘導体
ATE63903T1 (de) * 1984-10-25 1991-06-15 Hoechst Roussel Pharma 9-amino-1,2,3,4-tetrahydroacridin-1-ol und verwandte verbindungen, verfahren zu ihrer herstellung und verwendung als arzneimittel.
US4695573A (en) * 1984-10-25 1987-09-22 Hoechst-Roussel Pharmaceuticals Inc. 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds
US4631286A (en) * 1984-10-25 1986-12-23 Hoechst-Roussel Pharmaceuticals Inc. 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds
US4816456A (en) * 1986-10-01 1989-03-28 Summers William K Administration of monoamine acridines in cholinergic neuronal deficit states
EP0268871A1 (en) * 1986-10-31 1988-06-01 Sumitomo Pharmaceuticals Company, Limited Quinoline derivatives
AU634004B2 (en) * 1987-03-17 1993-02-11 Hoechst Marion Roussel, Inc. Intermediates for substituted 9-amino-tetrahydro-acridines, a process for their preparation and their use as medicaments
US4762841A (en) * 1987-03-30 1988-08-09 Hoechst-Roussel Pharmaceuticals Inc. Substituted 9-amino-spiro(cycloalkyl(b)quinoline-2,1'cycloalkanes)
US4851536A (en) * 1987-05-07 1989-07-25 American Home Products Corporation Cyclohexylquinolines as inhibitors of interleukin 1
US4985430A (en) * 1987-12-03 1991-01-15 Mitsubishi Kasei Corporation 9-acylamino-tetrahydroacridine derivatives and memory enhancing agent containing said derivative as active ingredient
US4868177A (en) * 1988-11-09 1989-09-19 Hoechst-Roussel Pharmaceuticals, Inc. 1,2,3,4-tetrahydro-1,9-acridinediamines, pharmaceutical compositions and use
US4999430A (en) * 1989-07-31 1991-03-12 Warner-Lambert Company Derivatives of 1,2,3,4-tetrahydro-9-acrisinamine
GB8917568D0 (en) * 1989-08-01 1989-09-13 Morton Oswald Compounds

Also Published As

Publication number Publication date
PT86986B (pt) 1992-06-30
HUT46672A (en) 1988-11-28
NO173498C (no) 1993-12-22
NO173498B (no) 1993-09-13
FI881223A0 (fi) 1988-03-15
PH25124A (en) 1991-02-19
KR960015001B1 (ko) 1996-10-23
AU1314188A (en) 1988-09-15
AU608300B2 (en) 1991-03-28
DK172864B1 (da) 1999-08-23
ZA881865B (en) 1988-11-30
AU633668B2 (en) 1993-02-04
IL85741A0 (en) 1988-08-31
US5391553A (en) 1995-02-21
CA1318675C (en) 1993-06-01
NO881164L (no) 1988-09-19
AU635370B2 (en) 1993-03-18
HU201018B (en) 1990-09-28
FI881223A (fi) 1988-09-18
NZ223875A (en) 1991-01-29
JP2888485B2 (ja) 1999-05-10
AU6824190A (en) 1991-03-14
PT86986A (pt) 1988-04-01
KR880011111A (ko) 1988-10-26
FI91401B (fi) 1994-03-15
JPS63238063A (ja) 1988-10-04
AU6824090A (en) 1991-05-02
FI91401C (fi) 1994-06-27
EP0282959A2 (en) 1988-09-21
EP0282959A3 (en) 1989-05-31
NO881164D0 (no) 1988-03-16
DK143588D0 (da) 1988-03-16
IL85741A (en) 1996-05-14

Similar Documents

Publication Publication Date Title
DK143588D0 (da) Substituerede 9-amino-tetrahydroacridiner, deres fremstilling og anvendelse som laegemidler
DK658688A (da) 1-aryl-3-quinolin- og 1-aryl-3-isoquinolin-carboxamider, deres fremstilling og anvendelse som laegemidler
DK267489D0 (da) 1-deoxy-nojirimycin-derivater, deres fremstilling og anvendelse som laegemidler
DK139287D0 (da) Tertiaere hydroxyalkylxanthiner, deres fremstilling og anvendelse som laegemidler
DK209188D0 (da) Bifunktionelle proteiner, deres fremstilling og anvendelse som laegemiddel
DK55088A (da) 3,4-dihydro-2h-benzo(b)pyraner, deres fremstilling og anvendelse som laegemidler
DK166590A (da) Substituerede allylaminderivater, deres fremstilling og anvendelse som laegemidler
DK219685D0 (da) Heterocycliske forbindelser, deres fremstilling og anvendelse som laegemidler
DK366888A (da) Castanosperminestre og -glykosider, deres fremstilling og anvendelse som laegemidler
DK581586D0 (da) N-(pyrrol-l-yl)-pyridinaminer, deres fremstilling og anvendelse som laegemidler
DK103987A (da) Substituerede 1,3,4,9-tetrahydropyranooe3,4-baaindol-l-eddikesyrer, deres fremstilling og anvendelse som laegemidler
DK284688A (da) Beta-lactam-forbindelser, deres fremstilling og anvendelse som laegemidler
DK144885A (da) Substituerede 4-hydroxybenzopyraner eller farmaceutisk acceptable additionssalte deraf, deres fremstilling og anvendelse som laegemidler
DK614186A (da) Substituerede piperazin-1,4-naphtalendioner, deres fremstilling og anvendelse som laegemidler
DK648389D0 (da) Anthracylin-derivater, deres fremstilling og anvendelse som laegemidler
DK501888A (da) 6-mercaptopurin-derivater, deres fremstilling og anvendelse som laegemidler
DK42888A (da) Arylthiadiazolylsulfonamider og derivater deraf, deres fremstilling og anvendelse som laegemiddel
DK602184D0 (da) Imidazoquinoliner, deres fremstilling og anvendelse som laegemidler
DK568289D0 (da) 1-aminoalkyl-3-oxy-substituerede-4-aryl-1,3,4,5-tetrahydro-2h-1,3-benzodiazepin-2-oner, deres fremstilling og anvendelse som laegemidler
DK37787A (da) 2,3-dioxabicyclooe3,3,0aaoctan-derivater og deres anvendelse som laegemidler
DK278290A (da) Substituerede 6h-pyridooe4,3-baacarbazoler og deres anvendelse som laegemidler
DK111887D0 (da) Aromatiske omega-alkylimino-tetrahydro-6h-1,3-thiazin-6-on-derivater, deres fremstilling og anvendelse som laegemidler
DK116787A (da) Diarylsulfidderivater, deres fremstilling og anvendelse som laegemidler
DK14885A (da) 1,4-dihydropyrazin, deres fremstilling og anvendelse som laegemidler
DK288989A (da) Cholestadienderivater, deres fremstilling og anvendelse som laegemidler

Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed

Country of ref document: DK