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DK1446478T3 - Dimeriseret vækstfaktor samt materialer og fremgangmåder til fremstilling heraf - Google Patents

Dimeriseret vækstfaktor samt materialer og fremgangmåder til fremstilling heraf

Info

Publication number
DK1446478T3
DK1446478T3 DK02773824T DK02773824T DK1446478T3 DK 1446478 T3 DK1446478 T3 DK 1446478T3 DK 02773824 T DK02773824 T DK 02773824T DK 02773824 T DK02773824 T DK 02773824T DK 1446478 T3 DK1446478 T3 DK 1446478T3
Authority
DK
Denmark
Prior art keywords
sub
polypeptide chains
amino acid
making
materials
Prior art date
Application number
DK02773824T
Other languages
English (en)
Inventor
Margaret D Moore
Brian A Fox
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Application granted granted Critical
Publication of DK1446478T3 publication Critical patent/DK1446478T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/49—Platelet-derived growth factor [PDGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Glass Compositions (AREA)
DK02773824T 2001-10-19 2002-10-18 Dimeriseret vækstfaktor samt materialer og fremgangmåder til fremstilling heraf DK1446478T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34611701P 2001-10-19 2001-10-19
PCT/US2002/033563 WO2003033677A2 (en) 2001-10-19 2002-10-18 Dimerized growth factor and materials and methods for producing it

Publications (1)

Publication Number Publication Date
DK1446478T3 true DK1446478T3 (da) 2008-06-02

Family

ID=23358033

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02773824T DK1446478T3 (da) 2001-10-19 2002-10-18 Dimeriseret vækstfaktor samt materialer og fremgangmåder til fremstilling heraf

Country Status (10)

Country Link
US (1) US7122351B2 (da)
EP (1) EP1446478B1 (da)
JP (1) JP2005506073A (da)
AT (1) ATE384783T1 (da)
AU (1) AU2002337920A1 (da)
CA (1) CA2463003A1 (da)
DE (1) DE60224822T2 (da)
DK (1) DK1446478T3 (da)
ES (1) ES2302845T3 (da)
WO (1) WO2003033677A2 (da)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6287850B1 (en) * 1995-06-07 2001-09-11 Affymetrix, Inc. Bioarray chip reaction apparatus and its manufacture
EP3225632B1 (en) 1999-11-30 2020-05-06 Mayo Foundation for Medical Education and Research Antibodies binding to b7-h1, a novel immunoregulatory molecule
US7030219B2 (en) 2000-04-28 2006-04-18 Johns Hopkins University B7-DC, Dendritic cell co-stimulatory molecules
AU2003210996A1 (en) * 2002-02-11 2003-09-04 Zymogenetics, Inc. Materials and methods for preparing dimeric growth factors
US7432351B1 (en) 2002-10-04 2008-10-07 Mayo Foundation For Medical Education And Research B7-H1 variants
AR046594A1 (es) * 2003-10-16 2005-12-14 Applied Research Systems Usos terapeuticos de variantes de quemoquina
US7381794B2 (en) 2004-03-08 2008-06-03 Zymogenetics, Inc. Dimeric fusion proteins and materials and methods for producing them
DK1810026T3 (da) 2004-10-06 2018-07-16 Mayo Found Medical Education & Res B7-h1 og pd-1 til behandling af renalcellekarcinom
US7473678B2 (en) * 2004-10-14 2009-01-06 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods of use thereof
CA2630077C (en) 2005-11-17 2014-07-15 Biomimetic Therapeutics, Inc. Maxillofacial bone augmentation using rhpdgf-bb and a biocompatible matrix
EP1801121A1 (en) * 2005-12-23 2007-06-27 CONARIS research institute AG Soluble gp130 molecule variants useful as a medicament
EP1991282B1 (en) * 2006-02-09 2013-06-19 BioMimetic Therapeutics, LLC Compositions and methods for treating bone
US9161967B2 (en) * 2006-06-30 2015-10-20 Biomimetic Therapeutics, Llc Compositions and methods for treating the vertebral column
CA2656278C (en) * 2006-06-30 2016-02-09 Biomimetic Therapeutics, Inc. Compositions and methods for treating rotator cuff injuries
EP2462895B1 (en) 2006-11-03 2016-11-02 BioMimetic Therapeutics, LLC Compositions and methods for arthrodetic procedures
AU2008293885A1 (en) 2007-07-13 2009-03-05 The John Hopkins University B7-DC variants
EP2268301B1 (en) * 2008-01-24 2020-02-26 Remedor Biomed Ltd. Erythropoietin and fibronectin compositions for bone regeneration
AU2009212151C1 (en) * 2008-02-07 2015-09-17 Biomimetic Therapeutics, Llc Compositions and methods for distraction osteogenesis
SI2350129T1 (sl) 2008-08-25 2015-11-30 Amplimmune, Inc. Sestavki PD-1 antagonistov in postopek njihove uporabe
US8870954B2 (en) 2008-09-09 2014-10-28 Biomimetic Therapeutics, Llc Platelet-derived growth factor compositions and methods for the treatment of tendon and ligament injuries
US20100247651A1 (en) * 2009-03-05 2010-09-30 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods for the treatment of osteochondral defects
CA2790403C (en) 2010-02-22 2019-08-27 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods for the treatment of tendinopathies
US9133486B2 (en) * 2012-03-12 2015-09-15 The Board Of Trustees Of The Leland Stanford Junior University Hydrogenase fusion protein for improved hydrogen production
CN107266574A (zh) 2012-03-30 2017-10-20 拜尔健康护理有限责任公司 蛋白酶调节的抗体
US9302005B2 (en) 2013-03-14 2016-04-05 Mayo Foundation For Medical Education And Research Methods and materials for treating cancer
EP3470081A1 (en) 2013-10-01 2019-04-17 Mayo Foundation for Medical Education and Research Methods for treating cancer in patients with elevated levels of bim
US10302653B2 (en) 2014-05-22 2019-05-28 Mayo Foundation For Medical Education And Research Distinguishing antagonistic and agonistic anti B7-H1 antibodies
EP3171896A4 (en) 2014-07-23 2018-03-21 Mayo Foundation for Medical Education and Research Targeting dna-pkcs and b7-h1 to treat cancer
WO2017075045A2 (en) 2015-10-30 2017-05-04 Mayo Foundation For Medical Education And Research Antibodies to b7-h1

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5013653A (en) * 1987-03-20 1991-05-07 Creative Biomolecules, Inc. Product and process for introduction of a hinge region into a fusion protein to facilitate cleavage
US5336603A (en) * 1987-10-02 1994-08-09 Genentech, Inc. CD4 adheson variants
US6018026A (en) * 1988-01-22 2000-01-25 Zymogenetics, Inc. Biologically active dimerized and multimerized polypeptide fusions
EP1762623A1 (en) * 1988-01-22 2007-03-14 ZymoGenetics, Inc. Methods for producing biologically active peptide dimers
ES2176174T3 (es) 1988-12-22 2002-12-01 Genentech Inc Procedimiento de preparacion de polipeptidos solubles en agua.
US5116964A (en) * 1989-02-23 1992-05-26 Genentech, Inc. Hybrid immunoglobulins
JPH09509054A (ja) * 1994-02-01 1997-09-16 アメリカ合衆国 抗体部分および非抗体部分を含む融合タンパク質
US5731168A (en) * 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US20020137890A1 (en) * 1997-03-31 2002-09-26 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
GB9720054D0 (en) * 1997-09-19 1997-11-19 Celltech Therapeutics Ltd Biological products
EP1129110B1 (en) * 1998-11-10 2009-12-09 Ludwig Institute For Cancer Research Platelet-derived growth factor d, dna coding therefor, and uses thereof
US6468543B1 (en) * 1999-05-03 2002-10-22 Zymogenetics, Inc. Methods for promoting growth of bone using ZVEGF4
EP2228446A1 (en) 1999-12-01 2010-09-15 Genentech, Inc. Secreted and transmembrane polypeptieds and nucleic acids encoding the same
AU2001237957A1 (en) 2000-01-31 2001-08-07 Human Genome Sciences, Inc. 17 human secreted proteins
CA2410551A1 (en) 2000-06-30 2002-01-10 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw (Vib) Heterodimeric fusion proteins
CA2440596C (en) 2001-03-09 2011-05-24 Zymogenetics, Inc. Soluble heterodimeric cytokine receptor

Also Published As

Publication number Publication date
EP1446478A2 (en) 2004-08-18
DE60224822D1 (de) 2008-03-13
CA2463003A1 (en) 2003-04-24
WO2003033677A3 (en) 2003-07-10
ATE384783T1 (de) 2008-02-15
ES2302845T3 (es) 2008-08-01
US20030109000A1 (en) 2003-06-12
WO2003033677A2 (en) 2003-04-24
EP1446478A4 (en) 2005-03-16
US7122351B2 (en) 2006-10-17
EP1446478B1 (en) 2008-01-23
AU2002337920A1 (en) 2003-04-28
DE60224822T2 (de) 2009-01-22
JP2005506073A (ja) 2005-03-03

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