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DK137786D0 - 5-(6-imidazo/1,2-a/pyridyl)pyridinderivat, farmaceutisk praeparat indeholdende et saadant derivat og fremgangsmaade til fremstilling af derivatet - Google Patents

5-(6-imidazo/1,2-a/pyridyl)pyridinderivat, farmaceutisk praeparat indeholdende et saadant derivat og fremgangsmaade til fremstilling af derivatet

Info

Publication number
DK137786D0
DK137786D0 DK137786A DK137786A DK137786D0 DK 137786 D0 DK137786 D0 DK 137786D0 DK 137786 A DK137786 A DK 137786A DK 137786 A DK137786 A DK 137786A DK 137786 D0 DK137786 D0 DK 137786D0
Authority
DK
Denmark
Prior art keywords
sup
derivative
group
hydrogen atom
represents hydrogen
Prior art date
Application number
DK137786A
Other languages
English (en)
Other versions
DK137786A (da
DK164788B (da
DK164788C (da
Inventor
Motosuke Yamanaka
Kazutoshi Miyake
Shinji Suda
Hideto Ohhara
Toshiaki Ogawa
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of DK137786D0 publication Critical patent/DK137786D0/da
Publication of DK137786A publication Critical patent/DK137786A/da
Publication of DK164788B publication Critical patent/DK164788B/da
Application granted granted Critical
Publication of DK164788C publication Critical patent/DK164788C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK137786A 1985-03-26 1986-03-25 5-(6-imidazooe1,2-aaapyridyl)pyridin-derivater, tautomere heraf, farmaceutiske praeparater indeholdende disse og fremgangsmaade til fremstilling af derivaterne DK164788C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP5945085 1985-03-26
JP60059450A JPS61218589A (ja) 1985-03-26 1985-03-26 ５―（６―イミダゾ〔１，２―ａ〕ピリジニル）ピリジン誘導体

Publications (4)

Publication Number Publication Date
DK137786D0 true DK137786D0 (da) 1986-03-25
DK137786A DK137786A (da) 1986-09-27
DK164788B DK164788B (da) 1992-08-17
DK164788C DK164788C (da) 1992-12-28

Family

ID=13113637

Family Applications (1)

Application Number Title Priority Date Filing Date
DK137786A DK164788C (da) 1985-03-26 1986-03-25 5-(6-imidazooe1,2-aaapyridyl)pyridin-derivater, tautomere heraf, farmaceutiske praeparater indeholdende disse og fremgangsmaade til fremstilling af derivaterne

Country Status (23)

Country Link
US (4) US4751227A (da)
EP (1) EP0199127B1 (da)
JP (1) JPS61218589A (da)
KR (1) KR930005005B1 (da)
CN (1) CN1020608C (da)
AT (1) ATE48603T1 (da)
AU (1) AU589410B2 (da)
CA (1) CA1309718C (da)
DD (2) DD283390A5 (da)
DE (1) DE3667466D1 (da)
DK (1) DK164788C (da)
ES (5) ES8706146A1 (da)
FI (1) FI86722C (da)
GR (1) GR860720B (da)
HU (1) HU198045B (da)
IE (1) IE59294B1 (da)
IL (1) IL78248A (da)
MX (1) MX163696B (da)
NO (1) NO163490C (da)
PH (1) PH22999A (da)
PT (1) PT82270B (da)
SU (1) SU1468420A3 (da)
ZA (1) ZA862259B (da)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5002941A (en) * 1985-12-12 1991-03-26 Smithkline Beecham Corporation Pyrrolo(1,2-a)imidazole and imidazo(1,2-a)pyridine derivatives and their use as 5-lipoxygenase pathway inhibitors
KR920702621A (ko) * 1989-06-13 1992-10-06 스튜어트 알. 슈터 단핵세포 및/또는 마크로파지에 의한 인터루킨-1 또는 종양회사인자 생성의 억제
GB9008818D0 (en) * 1990-04-19 1990-06-13 Ici Plc Amine derivatives
US5958926A (en) * 1996-11-01 1999-09-28 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
SE9903611D0 (sv) * 1999-10-06 1999-10-06 Astra Ab Novel compounds III
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
JP5546451B2 (ja) 2007-06-04 2014-07-09 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸の障害、炎症、癌および他の障害の処置に有用なグアニル酸シクラーゼのアゴニスト
EP2810951B1 (en) 2008-06-04 2017-03-15 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP3241839B1 (en) 2008-07-16 2019-09-04 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
KR101692126B1 (ko) * 2009-12-18 2017-01-02 미쓰비시 타나베 파마 코퍼레이션 신규 항혈소판약
CN101830900B (zh) * 2010-05-27 2012-06-06 齐鲁制药(海南)有限公司 盐酸奥普力农晶型及其制备方法
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
DK2681236T3 (da) 2011-03-01 2018-04-16 Synergy Pharmaceuticals Inc Fremgangsmåde til fremstilling af guanylat-cyclase-c-agonister
CN102702197B (zh) * 2012-06-27 2014-12-03 武汉武药科技有限公司 盐酸奥普力农衍生物及其制备方法
CN102718747B (zh) * 2012-06-27 2014-06-11 武汉武药科技有限公司 盐酸奥普力农衍生物及其合成方法
JP6499591B2 (ja) 2013-02-25 2019-04-10 シナジー ファーマシューティカルズ インコーポレイテッド 結腸洗浄において用いるためのグアニル酸シクラーゼ受容体アゴニスト
JP2016514671A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼのアゴニストおよびその使用
EP2968439A2 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
EP4424697A2 (en) 2013-06-05 2024-09-04 Bausch Health Ireland Limited Ultra-pure agonists of guanylate cyclase c, method of making and using same
EP3884935B1 (en) 2013-08-09 2023-06-14 Ardelyx, Inc. Compounds and methods for inhibiting phosphate transport
CN106349246B (zh) * 2016-08-29 2018-10-26 山东百诺医药股份有限公司 奥普力农及9-氮杂吲哚-5-硼酸的制备方法
CN108840866A (zh) * 2018-05-24 2018-11-20 河北宇辰医药科技有限公司 一种奥普力农类似物ⅰ的制备方法与用途
CN109575017A (zh) * 2018-11-01 2019-04-05 山东蒲济医药科技有限公司 一种盐酸奥普力农化合物的制备方法
CN114340631A (zh) 2019-05-21 2022-04-12 阿德利克斯股份有限公司 用于降低患者的血清磷酸盐的组合
CN111499631B (zh) * 2020-06-02 2021-07-30 济南康桥医药科技有限公司 一种盐酸奥普力农关键中间体1-咪唑并[1,2-a]吡啶-6-基-2-丙酮的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4105767A (en) * 1977-03-28 1978-08-08 Merck & Co., Inc. Imidazo [1,2-a] pyridines substituted with a thienyl, thiazolyl, or thiadiazolyl group
ZA81219B (en) * 1980-01-23 1982-01-27 Schering Corp Imidazo (1,2-a) pyridines ,process for their preparation and pharmaceutical compositions containing them
DE3269604D1 (en) * 1981-06-26 1986-04-10 Schering Corp Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them
DE3406329A1 (de) * 1984-02-22 1985-08-22 Merck Patent Gmbh, 6100 Darmstadt Pyridone

Also Published As

Publication number Publication date
ATE48603T1 (de) 1989-12-15
CN1020608C (zh) 1993-05-12
ES8801654A1 (es) 1988-02-16
SU1468420A3 (ru) 1989-03-23
ZA862259B (en) 1986-11-26
ES557588A0 (es) 1988-02-16
DD283390A5 (de) 1990-10-10
DK137786A (da) 1986-09-27
DD263057A5 (de) 1988-12-21
DK164788B (da) 1992-08-17
IL78248A0 (en) 1986-07-31
JPH0558437B2 (da) 1993-08-26
PH22999A (en) 1989-02-24
ES8801655A1 (es) 1988-02-16
IE860775L (en) 1986-09-26
FI861262A (fi) 1986-09-27
IE59294B1 (en) 1994-02-09
CA1309718C (en) 1992-11-03
JPS61218589A (ja) 1986-09-29
DK164788C (da) 1992-12-28
US4803276A (en) 1989-02-07
AU589410B2 (en) 1989-10-12
CN86102812A (zh) 1986-11-26
KR860007257A (ko) 1986-10-10
ES557235A0 (es) 1987-10-01
MX163696B (es) 1992-06-15
NO163490C (no) 1990-06-06
ES553370A0 (es) 1987-05-16
ES8706146A1 (es) 1987-05-16
US4791203A (en) 1988-12-13
KR930005005B1 (ko) 1993-06-11
US4791202A (en) 1988-12-13
GR860720B (en) 1986-03-25
HUT41026A (en) 1987-03-30
ES557587A0 (es) 1988-02-16
DE3667466D1 (de) 1990-01-18
NO861190L (no) 1986-09-29
PT82270A (en) 1986-04-01
AU5507286A (en) 1986-10-02
ES557236A0 (es) 1987-10-01
PT82270B (pt) 1988-02-17
HU198045B (en) 1989-07-28
FI86722B (fi) 1992-06-30
FI86722C (fi) 1992-10-12
US4751227A (en) 1988-06-14
NO163490B (no) 1990-02-26
ES8708230A1 (es) 1987-10-01
EP0199127A1 (en) 1986-10-29
IL78248A (en) 1989-09-10
EP0199127B1 (en) 1989-12-13
ES8708231A1 (es) 1987-10-01
FI861262A0 (fi) 1986-03-25

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