DK136579A - Thioetiansyrederivater - Google Patents

Thioetiansyrederivater

Info

Publication number: DK136579A
Authority: DK; Denmark
Prior art keywords: thioetianic; acid derivatives; derivatives; acid; thioetianic acid
Prior art date: 1978-04-05

Application number

DK136579A

Other languages

English (en)

Other versions

DK147735C (da

DK147735B (da

Inventor

J A Edwards

Original Assignee

Syntex Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-04-05

Filing date

1979-04-03

Publication date

1979-10-06

1979-04-03 Application filed by Syntex Inc filed Critical Syntex Inc

1979-10-06 Publication of DK136579A publication Critical patent/DK136579A/da

1984-11-26 Publication of DK147735B publication Critical patent/DK147735B/da

1985-08-19 Application granted granted Critical

1985-08-19 Publication of DK147735C publication Critical patent/DK147735C/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
- C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/0026—Oxygen-containing hetero ring cyclic ketals
- C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK136579A 1978-04-05 1979-04-03 Analogifremgangsmaade til fremstilling af 3-oxo-androst-4-en-17beta-thiocarboxylsyreestere DK147735C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US89338878		1978-04-05
US05/893,388 US4188385A (en)	1978-04-05	1978-04-05	Thioetianic acid derivatives

Publications (3)

Publication Number	Publication Date
DK136579A true DK136579A (da)	1979-10-06
DK147735B DK147735B (da)	1984-11-26
DK147735C DK147735C (da)	1985-08-19

Family

ID=25401484

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK136579A DK147735C (da)	1978-04-05	1979-04-03	Analogifremgangsmaade til fremstilling af 3-oxo-androst-4-en-17beta-thiocarboxylsyreestere

Country Status (28)

Country	Link
US (1)	US4188385A (da)
EP (1)	EP0004741B1 (da)
JP (2)	JPS54141758A (da)
AR (1)	AR226035A1 (da)
AT (1)	AT368168B (da)
AU (1)	AU526025B2 (da)
CA (1)	CA1134345A (da)
CS (1)	CS203956B2 (da)
DE (2)	DE2912331A1 (da)
DK (1)	DK147735C (da)
ES (1)	ES479271A1 (da)
FI (1)	FI66393C (da)
FR (1)	FR2421912A1 (da)
GB (1)	GB2018256B (da)
GR (1)	GR67275B (da)
HK (1)	HK41284A (da)
HU (1)	HU179314B (da)
IL (1)	IL56972A0 (da)
IT (1)	IT1120954B (da)
MY (1)	MY8500575A (da)
NO (1)	NO152935C (da)
NZ (1)	NZ190076A (da)
PL (1)	PL121469B1 (da)
PT (1)	PT69409A (da)
SG (1)	SG6786G (da)
SU (1)	SU1052161A3 (da)
YU (1)	YU40929B (da)
ZA (1)	ZA791635B (da)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4261984A (en) *	1978-04-05	1981-04-14	Syntex (U.S.A.) Inc.	17β-thiocarboxylic acid esters of 3-oxo-4-halo-16β-methylandrost-4-enes
US4263289A (en) *	1978-04-05	1981-04-21	Syntex (U.S.A.) Inc.	Thio etianic acid derivatives
US4310466A (en) *	1979-08-31	1982-01-12	Syntex (U.S.A.) Inc.	Thio etianic acid derivatives
GB2137206B (en) *	1980-02-15	1985-04-03	Glaxo Group Ltd	Androstane 17-carbothioc acid derivatives
NL191792C (nl) *	1980-02-15	1996-08-02	Glaxo Group Ltd	Esters van een androstaan-17beta-carbothiozuur, werkwijze ter bereiding van deze esters, en farmaceutische preparaten, die deze esters bevatten.
BE887518A (fr) *	1980-02-15	1981-08-13	Glaxo Group Ltd	Cartothioates d'androstanes
US4578221A (en) *	1980-04-23	1986-03-25	Glaxo Group Limited	Androstane carbothioic acids
SE449106B (sv) *	1980-07-10	1987-04-06	Otsuka Pharma Co Ltd	Steroid med anti-inflammatorisk verkan samt komposition innehallande denna
IL78144A0 (en) *	1985-04-04	1986-07-31	Draco Ab	Novel androstane-17beta-carboxylic acid esters
GB9225923D0 (en) *	1992-12-11	1993-02-03	Rhone Poulenc Rorer Ltd	New compositions of matter
DK0675897T3 (da) *	1992-12-24	1998-01-26	Rhone Poulenc Rorer Ltd	Nye steroider
CZ207498A3 (cs) *	1995-12-29	1998-11-11	Glaxo Group Limited	Laktonové deriváty androstanových sloučenin
US5981517A (en) *	1996-05-09	1999-11-09	Soft Drugs, Inc.	Androstene derivatives
US20020133032A1 (en) *	2000-02-25	2002-09-19	Jufang Barkalow	Method for the preparation of fluticasone and related 17beta-carbothioic esters using a novel carbothioic acid synthesis and novel purification methods
GB0017988D0 (en) *	2000-07-21	2000-09-13	Glaxo Group Ltd	Novel process
US6777399B2 (en) *	2000-08-05	2004-08-17	Smithkline Beecham Corporation	Anti-inflammatory androstane derivative compositions
US6858593B2 (en) *	2000-08-05	2005-02-22	Smithkline Beecham Corporation	Anti-inflammatory androstane derivative compositions
US6750210B2 (en) *	2000-08-05	2004-06-15	Smithkline Beecham Corporation	Formulation containing novel anti-inflammatory androstane derivative
GB0019172D0 (en) *	2000-08-05	2000-09-27	Glaxo Group Ltd	Novel compounds
ES2317922T3 (es) *	2000-08-05	2009-05-01	Glaxo Group Limited	Derivados de beta-carbotioato 17, alfa-acrilcarboniloxiloxi androstano como agentes antiinflamatorios.
US6759398B2 (en)	2000-08-05	2004-07-06	Smithkline Beecham Corporation	Anti-inflammatory androstane derivative
US6787532B2 (en) *	2000-08-05	2004-09-07	Smithkline Beecham Corporation	Formulation containing anti-inflammatory androstane derivatives
US6858596B2 (en) *	2000-08-05	2005-02-22	Smithkline Beecham Corporation	Formulation containing anti-inflammatory androstane derivative
US6777400B2 (en) *	2000-08-05	2004-08-17	Smithkline Beecham Corporation	Anti-inflammatory androstane derivative compositions
UA77656C2 (en) *	2001-04-07	2007-01-15	Glaxo Group Ltd	S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent
JP4446661B2 (ja) *	2001-04-30	2010-04-07	グラクソグループリミテッド	抗炎症性の、１７α位に環状エステル基を有するアンドロスタンの１７β−カルボチオ酸エステル誘導体
ATE399174T1 (de) *	2001-06-12	2008-07-15	Glaxo Group Ltd	Neue anti inflammatorische 17.alpha.- heterozyklische ester von 17.beta.-carbothioat androstan derivativen
US20050175545A1 (en) *	2002-02-04	2005-08-11	Keith Biggadike	Formulation for inhalation comprising a glucocorticoid and a beta 2-adrenoreceptor agonist
GB0202635D0 (en) *	2002-02-05	2002-03-20	Glaxo Wellcome Mfg Pte Ltd	Formulation containing novel anti-inflammatory androstane derivative
GB2389530B (en)	2002-06-14	2007-01-10	Cipla Ltd	Pharmaceutical compositions
IL150654A (en)	2002-07-09	2006-12-10	Ori Lerman	Method for acid isolation 6α, 9α - difluoro - ß, 17α11 - dihydroxy - 16α - methylfargana - 3 - oxo - 1, 4 - diene - 17ß - carboxylate
AU2004226318B2 (en) *	2003-04-04	2008-06-05	Xellia Pharmaceuticals Aps	Process for the preparation of steroidal carbothioic acid derivatives and intermediates
GB0507165D0 (en) *	2005-04-08	2005-05-18	Glaxo Group Ltd	Novel crystalline pharmaceutical product
AR059216A1 (es) *	2006-01-27	2008-03-19	Sun Pharmaceutical Ind Ltd	11b-hidroxiandrosta-4-eno-3-onas
GB0615108D0 (en) *	2006-07-28	2006-09-06	Glaxo Group Ltd	Novel formulations
PE20091525A1 (es) *	2007-12-21	2009-09-25	Schering Corp	Agonista del receptor glucocorticoide c-20-c21 sustituido
EP2443134A2 (en)	2009-06-16	2012-04-25	Schering Corporation	NOVEL [3,2-c]HETEROARYL STEROIDS AS GLUCOCORTICOID RECEPTOR AGONISTS, COMPOSITIONS AND USES THEREOF

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2509171A (en) *	1946-02-06	1950-05-23	Ciba Ltd	Primary alcohols from thiocarboxylic acids and esters
US3636010A (en) *	1968-12-23	1972-01-18	Ciba Geigy Corp	Esters of steroid-17-carboxylic acids
US3989686A (en) *	1972-06-15	1976-11-02	Glaxo Laboratories Limited	Anaesthetic steroids of the androstane series and process for preparing same
GB1438940A (en) *	1972-07-19	1976-06-09	Glaxo Lab Ltd	17beta-haloalkoxycarbonyl-17alpha-oxysteroids
CH628355A5 (de) *	1976-02-24	1982-02-26	Ciba Geigy Ag	Verfahren zur herstellung neuer androstadien-17beta-carbonsaeuren und ihrer ester und salze.

1978
- 1978-04-05 US US05/893,388 patent/US4188385A/en not_active Expired - Lifetime
1979
- 1979-03-28 DE DE19792912331 patent/DE2912331A1/de not_active Ceased
- 1979-03-28 IT IT67652/79A patent/IT1120954B/it active
- 1979-03-28 EP EP79300500A patent/EP0004741B1/en not_active Expired
- 1979-03-28 GB GB7910862A patent/GB2018256B/en not_active Expired
- 1979-03-28 DE DE7979300500T patent/DE2960096D1/de not_active Expired
- 1979-03-28 FR FR7907823A patent/FR2421912A1/fr active Granted
- 1979-03-29 AU AU45583/79A patent/AU526025B2/en not_active Ceased
- 1979-03-29 IL IL56972A patent/IL56972A0/xx not_active IP Right Cessation
- 1979-03-29 CS CS792107A patent/CS203956B2/cs unknown
- 1979-03-30 AR AR276014A patent/AR226035A1/es active
- 1979-03-30 CA CA000324557A patent/CA1134345A/en not_active Expired
- 1979-03-30 PT PT69409A patent/PT69409A/pt unknown
- 1979-03-31 GR GR58748A patent/GR67275B/el unknown
- 1979-04-02 FI FI791081A patent/FI66393C/fi not_active IP Right Cessation
- 1979-04-02 NZ NZ190076A patent/NZ190076A/en unknown
- 1979-04-03 HU HU79SI1682A patent/HU179314B/hu not_active IP Right Cessation
- 1979-04-03 DK DK136579A patent/DK147735C/da not_active IP Right Cessation
- 1979-04-04 AT AT0251979A patent/AT368168B/de not_active IP Right Cessation
- 1979-04-04 PL PL1979214676A patent/PL121469B1/pl unknown
- 1979-04-04 YU YU803/79A patent/YU40929B/xx unknown
- 1979-04-04 SU SU792787402A patent/SU1052161A3/ru active
- 1979-04-04 NO NO791140A patent/NO152935C/no unknown
- 1979-04-04 ES ES479271A patent/ES479271A1/es not_active Expired
- 1979-04-05 ZA ZA791635A patent/ZA791635B/xx unknown
- 1979-04-05 JP JP4041479A patent/JPS54141758A/ja active Granted
1984
- 1984-05-10 HK HK412/80A patent/HK41284A/xx unknown
- 1984-07-27 JP JP59155726A patent/JPS6069019A/ja active Granted
1985
- 1985-12-30 MY MY575/85A patent/MY8500575A/xx unknown
1986
- 1986-01-22 SG SG67/86A patent/SG6786G/en unknown

Also Published As

Publication number	Publication date
US4188385A (en)	1980-02-12
FI791081A (fi)	1979-10-06
ES479271A1 (es)	1980-01-16
CS203956B2 (en)	1981-03-31
DE2960096D1 (en)	1981-03-19
AU526025B2 (en)	1982-12-16
ATA251979A (de)	1982-01-15
NZ190076A (en)	1984-07-31
NO152935C (no)	1985-12-18
JPS54141758A (en)	1979-11-05
EP0004741A2 (en)	1979-10-17
YU80379A (en)	1983-04-30
AR226035A1 (es)	1982-05-31
NO152935B (no)	1985-09-09
ZA791635B (en)	1980-11-26
FI66393C (fi)	1984-10-10
DK147735C (da)	1985-08-19
HK41284A (en)	1984-05-18
AT368168B (de)	1982-09-27
AU4558379A (en)	1979-10-18
GB2018256A (en)	1979-10-17
SU1052161A3 (ru)	1983-10-30
EP0004741A3 (en)	1979-11-14
IT7967652A0 (it)	1979-03-28
PT69409A (en)	1979-04-01
HU179314B (en)	1982-09-28
GR67275B (da)	1981-06-26
JPS611038B2 (da)	1986-01-13
IT1120954B (it)	1986-03-26
IL56972A0 (en)	1979-05-31
GB2018256B (en)	1983-02-02
YU40929B (en)	1986-08-31
SG6786G (en)	1986-08-01
JPS6140648B2 (da)	1986-09-10
FR2421912A1 (fr)	1979-11-02
DE2912331A1 (de)	1979-10-18
FR2421912B1 (da)	1981-03-20
JPS6069019A (ja)	1985-04-19
PL121469B1 (en)	1982-05-31
MY8500575A (en)	1985-12-31
DK147735B (da)	1984-11-26
CA1134345A (en)	1982-10-26
PL214676A1 (da)	1980-01-02
FI66393B (fi)	1984-06-29
EP0004741B1 (en)	1981-01-28
NO791140L (no)	1979-10-08

Publication	Publication Date	Title
DK136579A (da)	1979-10-06	Thioetiansyrederivater
SE7907493L (sv)	1980-03-12	Anilinokinazolinderivat
SE7900380L (sv)	1979-07-21	Anisamidderivat
DK541878A (da)	1979-06-30	Phthalazin-4-yleddikesyrederivater
FI783115A (fi)	1979-09-15	Aoterfoerslutbar multipelfoerpackning foer i synnerhet vaotservetter
DK111179A (da)	1979-09-18	Carbaminsyrederivater
KR840004668A (ko)	1984-10-22	5-펜타노익산류
DK317178A (da)	1979-07-28	Phenyleddikesyrederivater
FI793692A (fi)	1980-05-25	Stoedarrangemang foer cylindriska behaollare i fartyg
SE8002708L (sv)	1980-10-12	Penem-3-karboxisyraderivat
FI791538A (fi)	1979-11-17	Foerbaettringar i tobaksroekfilter
FI791858A (fi)	1979-12-13	Foerbaettringar i postningsomslag
SE7903863L (sv)	1979-11-05	Syresensor
FI790281A (fi)	1979-08-01	Prostaglandin-derivat
FI65844B (fi)	1984-03-30	Virvelluftsrenar- och dimeliminatorenhet foer en gasturbinmotor i marint bruk
FI781935A (fi)	1979-12-17	Rengoeringsanordning foer skavarbladen i en pappersmaskin
FI794043A (fi)	1980-06-23	Hoernbett i lastningsskopa
FI791277A (fi)	1979-11-03	Slaglisthaollare foer rotorn i en slagkvarn
FI783516A (fi)	1979-09-23	Foerbaettringar i kapsyleringsanordningar
DK501880A (da)	1981-05-28	Cyclopropancarboxylsyreesterderivater
FI791442A (fi)	1979-11-12	Upphaengningskorrektor anvaendbar i laosta slingavstaemningssystem
FI790634A (fi)	1979-09-09	Tryckavlastningslucka saerskilt foer lastrum i gastransportfartyg
FI791189A (fi)	1979-10-13	Pyridinderivat
DK143979A (da)	1979-10-08	Chromanonderivater
FI65785B (fi)	1984-03-30	Foerfarande foer framstaellning av terapeutiskt anvaendbara sustituerade steroid-spiro-oxazolidinon-derivat

Legal Events

Date	Code	Title	Description
1994-12-27	PBP	Patent lapsed