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DK1234025T3 - Human enzymes from the metalloprotease family - Google Patents

Human enzymes from the metalloprotease family

Info

Publication number
DK1234025T3
DK1234025T3 DK00981279T DK00981279T DK1234025T3 DK 1234025 T3 DK1234025 T3 DK 1234025T3 DK 00981279 T DK00981279 T DK 00981279T DK 00981279 T DK00981279 T DK 00981279T DK 1234025 T3 DK1234025 T3 DK 1234025T3
Authority
DK
Denmark
Prior art keywords
polypeptides
human enzymes
metalloprotease family
therapy
polynucleotides
Prior art date
Application number
DK00981279T
Other languages
Danish (da)
Inventor
Willy Deleersnijder
Rico Wiegers
Michael Weske
Original Assignee
Solvay Pharm Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharm Bv filed Critical Solvay Pharm Bv
Application granted granted Critical
Publication of DK1234025T3 publication Critical patent/DK1234025T3/en

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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
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    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • C12N9/6497—Endothelin-converting enzyme (3.4.24.71)
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Abstract

This invention relates to newly identified polypeptides which have zinc metalloprotease activities and are referred to as IGS5, and polynucleotides encoding such polypeptides, to their use in therapy and in identifying compounds which may be stimulators and/or inhibitors which are useful in therapy, to antibodies specific to such peptides, and to production of such polypeptides and polynucleotides.
DK00981279T 1999-11-19 2000-11-17 Human enzymes from the metalloprotease family DK1234025T3 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP99203862 1999-11-19
NL1013616 1999-11-19
NL1015356 2000-05-31
EP00201937 2000-05-31
PCT/EP2000/011532 WO2001036610A1 (en) 1999-11-19 2000-11-17 Human enzymes of the metalloprotease family

Publications (1)

Publication Number Publication Date
DK1234025T3 true DK1234025T3 (en) 2008-11-17

Family

ID=27440008

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00981279T DK1234025T3 (en) 1999-11-19 2000-11-17 Human enzymes from the metalloprotease family

Country Status (13)

Country Link
US (5) US6855532B2 (en)
EP (1) EP1234025B1 (en)
JP (1) JP2003514525A (en)
CN (1) CN1250717C (en)
AT (1) ATE406438T1 (en)
AU (1) AU784327B2 (en)
CA (1) CA2392076A1 (en)
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Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020086405A1 (en) * 2000-09-25 2002-07-04 Inmaculada Silos-Santiago 56638, a novel human neprilysin protease and uses thereof
ATE406438T1 (en) 1999-11-19 2008-09-15 Solvay Pharm Bv HUMAN HOMOLOGUE FROM THE FAMILY OF METALLOPROTEASES
US6991916B2 (en) * 2000-07-14 2006-01-31 Pfizer Inc. Compounds for the treatment of sexual dysfunction
AU2003273540A1 (en) * 2002-05-31 2003-12-19 Cognosci, Inc. Assays for measuring matrix metalloproteinase activities
US20040014131A1 (en) * 2002-07-09 2004-01-22 Pfizer Inc. Assay methods
US7262184B2 (en) 2003-09-26 2007-08-28 Solvay Pharmaceuticals Gmbh Amidomethyl-substituted 1-(carboxyalkyl) cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them
US7452875B2 (en) 2003-09-26 2008-11-18 Solvay Pharmaceuticals Gmbh Amidomethyl-substituted 1-(carboxyalkyl) cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them
US7427611B2 (en) 2003-09-26 2008-09-23 Solvay Pharmaceuticals Gmbh Amidomethyl-substituted 1-(carboxyalkyl)-cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them
US8883144B2 (en) * 2010-09-02 2014-11-11 The Regents Of The University Of Colorado, A Body Corporate Treatment of pulmonary vascular remodeling with neprilysin
WO2012083102A1 (en) 2010-12-16 2012-06-21 Scion Neurostim, Llc Apparatus and methods for titrating caloric vestibular stimulation
US11898187B2 (en) 2017-08-15 2024-02-13 Northwestern University Protein glycosylation sites by rapid expression and characterization of N-glycosyltransferases
US11725224B2 (en) 2018-04-16 2023-08-15 Northwestern University Methods for co-activating in vitro non-standard amino acid (nsAA) incorporation and glycosylation in crude cell lysates

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4960700A (en) * 1986-12-24 1990-10-02 Genentech, Inc. Compositions and methods for the synthesis and assay of a mammalian enkephalinase
IL88535A0 (en) * 1987-12-04 1989-06-30 Dana Farber Cancer Inst Inc Common acute lymphoblastic leukemia antigen
JP4236698B2 (en) 1990-11-26 2009-03-11 ジェネティックス インスティチュート，リミテッド ライアビリティ カンパニー Expression of PACE in host cells and uses thereof
CA2100355A1 (en) * 1991-02-04 1992-08-05 Lynne H. Parker Botehlo Endothelin converting enzyme
DE19681565D2 (en) * 1996-07-22 1999-11-11 Goehrig Anja Bolt cutters
DE19638020A1 (en) * 1996-09-18 1998-03-19 Solvay Pharm Gmbh Gastrointestinal blood flow promoting drugs
FR2777291B1 (en) 1998-04-08 2000-07-07 Inst Nat Sante Rech Med NOVEL MEMBRANE METALLOPROTEASE NEP II AND ITS USE FOR THE SCREENING OF INHIBITORS USEFUL IN THERAPY
US20020086405A1 (en) 2000-09-25 2002-07-04 Inmaculada Silos-Santiago 56638, a novel human neprilysin protease and uses thereof
CA2260376A1 (en) 1999-02-11 2000-08-11 Universite De Montreal New metalloproteases of the neprilysin family
DE19906310A1 (en) * 1999-02-16 2000-08-17 Solvay Pharm Gmbh Use of 3-(1-(2-aralkyl-2-carboxyethyl)-1-cyclopentanecarboxamido)-2,3,4,5-tetrahydro-2-oxo-1H-benz(b)azepine-1-acetic acid derivatives for treating hypertension
AUPP948299A0 (en) * 1999-03-29 1999-04-22 Taylor, Stephen Dennis Adjustable mounting literature display system
EP1069188A1 (en) * 1999-07-15 2001-01-17 Sanofi-Synthelabo Three neprilysin-like membrane metallopeptidases
ATE406438T1 (en) 1999-11-19 2008-09-15 Solvay Pharm Bv HUMAN HOMOLOGUE FROM THE FAMILY OF METALLOPROTEASES
JP2001275687A (en) 2000-04-04 2001-10-09 Masafumi Matsuo Membrane-bound metalloprotease and soluble secretor thereof
JP2004504812A (en) 2000-05-04 2004-02-19 スージェン・インコーポレーテッド New protease
GB0017387D0 (en) * 2000-07-14 2000-08-30 Pfizer Ltd Novel enzyme
US6991916B2 (en) 2000-07-14 2006-01-31 Pfizer Inc. Compounds for the treatment of sexual dysfunction
EP1315800A2 (en) 2000-07-21 2003-06-04 Incyte Genomics, Inc. Human proteases
US20030119714A1 (en) 2000-12-15 2003-06-26 Naylor Alasdair Mark Treatment of male sexual dysfunction
HUP0400528A2 (en) 2000-12-15 2004-06-28 Pfizer Inc. Use of neuropeptidaz inhibitor for preparation of pharmaceutical conposition suitable for treatment of male sexual dysfunction
AR039352A1 (en) 2001-05-18 2005-02-16 Solvay Pharm Gmbh USE OF A COMPOUND THAT HAS COMBINED INHIBITORY ACTIVITY AND CONCURRENT WITH NEUTRAL ENDOPEPTIDASE AND IGS5 METALOPROTEASE.
EP1308459A3 (en) 2001-11-05 2003-07-09 Research Association for Biotechnology Full-length cDNA sequences
WO2003040393A2 (en) 2001-11-06 2003-05-15 Decode Genetics Ehf. Nucleic acids encoding proteases
GB0130219D0 (en) 2001-12-18 2002-02-06 Pfizer Ltd Compounds for the treatment of sexual dysfunction
US7427611B2 (en) * 2003-09-26 2008-09-23 Solvay Pharmaceuticals Gmbh Amidomethyl-substituted 1-(carboxyalkyl)-cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them
US7262184B2 (en) * 2003-09-26 2007-08-28 Solvay Pharmaceuticals Gmbh Amidomethyl-substituted 1-(carboxyalkyl) cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them
MXPA06005547A (en) * 2003-11-18 2006-08-17 Solvay Pharm Gmbh Pharmaceutical compositions for the treatment of renal dysfunction, disease or disorder, in particular in diabetic patients.

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CN1250717C (en) 2006-04-12
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US7189525B2 (en) 2007-03-13
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