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DK1157998T3 - Heterocykliske forbindelser, mellemprodukter derfor og elastaseinhibitorer - Google Patents

Heterocykliske forbindelser, mellemprodukter derfor og elastaseinhibitorer

Info

Publication number
DK1157998T3
DK1157998T3 DK00905282T DK00905282T DK1157998T3 DK 1157998 T3 DK1157998 T3 DK 1157998T3 DK 00905282 T DK00905282 T DK 00905282T DK 00905282 T DK00905282 T DK 00905282T DK 1157998 T3 DK1157998 T3 DK 1157998T3
Authority
DK
Denmark
Prior art keywords
group
different
same
intermediates
heterocyclic compounds
Prior art date
Application number
DK00905282T
Other languages
English (en)
Inventor
Fuminori Sato
Yasunao Inoue
Tomoki Omodani
Ryotaro Shiratake
Seiji Honda
Masanobu Komiya
Tadashi Takemura
Original Assignee
Dainippon Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Pharmaceutical Co filed Critical Dainippon Pharmaceutical Co
Application granted granted Critical
Publication of DK1157998T3 publication Critical patent/DK1157998T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0802Tripeptides with the first amino acid being neutral
    • C07K5/0804Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0821Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10Tetrapeptides
    • C07K5/1002Tetrapeptides with the first amino acid being neutral
    • C07K5/1005Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
DK00905282T 1999-03-03 2000-02-23 Heterocykliske forbindelser, mellemprodukter derfor og elastaseinhibitorer DK1157998T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP11056052A JP2000256396A (ja) 1999-03-03 1999-03-03 複素環式化合物およびその中間体ならびにエラスターゼ阻害剤
PCT/JP2000/001022 WO2000052032A1 (fr) 1999-03-03 2000-02-23 Composes heterocycliques, leurs intermediaires, et inhibiteurs d'elastase

Publications (1)

Publication Number Publication Date
DK1157998T3 true DK1157998T3 (da) 2004-06-14

Family

ID=13016323

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00905282T DK1157998T3 (da) 1999-03-03 2000-02-23 Heterocykliske forbindelser, mellemprodukter derfor og elastaseinhibitorer

Country Status (23)

Country Link
US (1) US6835714B1 (da)
EP (1) EP1157998B1 (da)
JP (1) JP2000256396A (da)
KR (1) KR100622709B1 (da)
CN (1) CN1183156C (da)
AT (1) ATE259376T1 (da)
AU (1) AU758739B2 (da)
CA (1) CA2362911A1 (da)
DE (1) DE60008218T2 (da)
DK (1) DK1157998T3 (da)
ES (1) ES2215608T3 (da)
HK (1) HK1044955B (da)
HU (1) HUP0200608A3 (da)
IL (2) IL144813A0 (da)
MX (1) MXPA01008836A (da)
NZ (1) NZ513594A (da)
PL (1) PL199136B1 (da)
PT (1) PT1157998E (da)
RU (1) RU2222539C2 (da)
TR (1) TR200102540T2 (da)
TW (1) TW534905B (da)
WO (1) WO2000052032A1 (da)
ZA (1) ZA200106514B (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2414960C (en) 2000-06-30 2012-04-10 Seikagaku Corporation Epoxycarboxamide compound, azide compound, and amino alcohol compound, and process for preparing .alpha.keto amide compound using them
AR029851A1 (es) 2000-07-21 2003-07-16 Dendreon Corp Nuevos peptidos como inhibidores de ns3-serina proteasa del virus de hepatitis c
KR100939155B1 (ko) * 2000-07-21 2010-01-28 쉐링 코포레이션 C형 간염 바이러스의 ns3-세린 프로테아제 억제제로서의신규한 펩티드
US7244721B2 (en) 2000-07-21 2007-07-17 Schering Corporation Peptides as NS3-serine protease inhibitors of hepatitis C virus
SK742003A3 (en) 2000-07-21 2003-06-03 Schering Corp Novel peptides as NS3-serine protease inhibitors of hepatitis C virus
GB0021315D0 (en) * 2000-08-30 2000-10-18 Dainippon Pharmaceutical Co Heterocyclic compounds and intermediates thereof
WO2002026229A1 (fr) * 2000-09-29 2002-04-04 Ono Pharmaceutical Co., Ltd. Inhibiteurs de secretions de muqueuses des voies aeriennes
US7067491B2 (en) * 2002-02-05 2006-06-27 Dainippon Pharmaceutical Co., Ltd. Heterocyclic compounds having elastase-inhibiting activity and intermediates thereof
DE602005015834D1 (de) 2004-02-27 2009-09-17 Schering Corp 3,4-(cyclopentyl)kondensierte prolinverbindungen als inhibitoren der ns3-serinprotease des hepatitis-c-virus
AU2007253819B2 (en) 2006-05-23 2011-02-17 Irm Llc Compounds and compositions as channel activating protease inhibitors
PL2019837T3 (pl) * 2006-05-23 2011-09-30 Irm Llc Związki i kompozycje jako inhibitory proteazy aktywującej kanały
US8142818B2 (en) * 2006-09-12 2012-03-27 Himalaya Global Holdings Limited Herbal composition for the prevention of wrinkles and skin disorders, methods of preparing the same and uses thereof
WO2008097673A1 (en) * 2007-02-09 2008-08-14 Irm Llc Compounds and compositions as channel activating protease inhibitors
KR20090108131A (ko) * 2007-02-09 2009-10-14 아이알엠 엘엘씨 채널 활성화 프로테아제 억제제로서의 화합물 및 조성물
ES2587856T3 (es) 2011-03-18 2016-10-27 Ono Pharmaceutical Co., Ltd. Derivado de tetrahidrocarbolina
CN104031014B (zh) * 2013-03-08 2016-05-11 华中师范大学 香豆素衍生物及其制备方法以及弹性蛋白酶活性检测方法和检测试剂盒
CN104165869B (zh) * 2013-05-17 2016-12-28 华中师范大学 一种检测蛋白水解酶活性的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS231228B1 (en) 1982-10-01 1984-10-15 Evzen Kasafirek Biologically effective tri and tetrapeptide alkylamide derivatives and their processing method
GB8600263D0 (en) 1985-01-22 1986-02-12 Ici America Inc Peptide derivatives
GB8809316D0 (en) 1987-05-11 1988-05-25 Ici America Inc Heterocyclic ketones
CA1340191C (en) 1988-06-13 1998-12-15 Katsuhiro Imaki Derivatives of p-substituted phenyl ester of pivalic acid
US5565568A (en) * 1995-04-06 1996-10-15 Eli Lilly And Company 2-acylaminopropanamides as tachykinin receptor antagonists

Also Published As

Publication number Publication date
EP1157998B1 (en) 2004-02-11
HUP0200608A2 (en) 2002-08-28
CN1183156C (zh) 2005-01-05
JP2000256396A (ja) 2000-09-19
NZ513594A (en) 2003-04-29
KR20020002396A (ko) 2002-01-09
ZA200106514B (en) 2002-05-10
IL144813A (en) 2006-12-10
DE60008218T2 (de) 2004-12-09
PL199136B1 (pl) 2008-08-29
AU758739B2 (en) 2003-03-27
DE60008218D1 (de) 2004-03-18
IL144813A0 (en) 2002-06-30
CA2362911A1 (en) 2000-09-08
HK1044955B (zh) 2005-07-08
EP1157998A1 (en) 2001-11-28
EP1157998A4 (en) 2003-01-29
TW534905B (en) 2003-06-01
WO2000052032A1 (fr) 2000-09-08
TR200102540T2 (tr) 2002-01-21
ATE259376T1 (de) 2004-02-15
HK1044955A1 (en) 2002-11-08
US6835714B1 (en) 2004-12-28
CN1349542A (zh) 2002-05-15
KR100622709B1 (ko) 2006-09-13
MXPA01008836A (es) 2002-05-14
RU2222539C2 (ru) 2004-01-27
HUP0200608A3 (en) 2002-09-30
ES2215608T3 (es) 2004-10-16
PT1157998E (pt) 2004-06-30
AU2690200A (en) 2000-09-21

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