DK1027332T3 - Hidtil ukendte lactametalloproteaseinhibitorer - Google Patents

Hidtil ukendte lactametalloproteaseinhibitorer

Info

Publication number: DK1027332T3
Authority: DK; Denmark
Prior art keywords: lactametalloprotease; inhibitors; new; new lactametalloprotease; lactametalloprotease inhibitors
Prior art date: 1997-10-03

Application number

DK98950954T

Other languages

English (en)

Inventor

Jinguw Duan

Zelda R Wasserman

Thomas P Maduskuie Jr

Carl P Decicco

Original Assignee

Bristol Myers Squibb Pharma Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-10-03

Filing date

1998-10-02

Publication date

2004-10-04

1998-10-02 Application filed by Bristol Myers Squibb Pharma Co filed Critical Bristol Myers Squibb Pharma Co

2004-10-04 Application granted granted Critical

2004-10-04 Publication of DK1027332T3 publication Critical patent/DK1027332T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/96—Spiro-condensed ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
- C07D233/78—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Ophthalmology & Optometry (AREA)
Immunology (AREA)
Virology (AREA)
Cardiology (AREA)
AIDS & HIV (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Hematology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Oncology (AREA)
Tropical Medicine & Parasitology (AREA)
Communicable Diseases (AREA)
Molecular Biology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Hydrogenated Pyridines (AREA)
Pyrrole Compounds (AREA)
Indole Compounds (AREA)

DK98950954T 1997-10-03 1998-10-02 Hidtil ukendte lactametalloproteaseinhibitorer DK1027332T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US6241897P	1997-10-03	1997-10-03

Publications (1)

Publication Number	Publication Date
DK1027332T3 true DK1027332T3 (da)	2004-10-04

Family

ID=22042365

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK98950954T DK1027332T3 (da)	1997-10-03	1998-10-02	Hidtil ukendte lactametalloproteaseinhibitorer

Country Status (25)

Country	Link
US (1)	US6057336A (da)
EP (1)	EP1027332B1 (da)
JP (1)	JP2001519331A (da)
KR (1)	KR20010015690A (da)
CN (1)	CN1272841A (da)
AR (1)	AR017291A1 (da)
AT (1)	ATE267805T1 (da)
AU (1)	AU747239B2 (da)
BR (1)	BR9815398A (da)
CA (1)	CA2305679A1 (da)
DE (1)	DE69824199T2 (da)
DK (1)	DK1027332T3 (da)
EE (1)	EE200000199A (da)
ES (1)	ES2217592T3 (da)
HR (1)	HRP980533A2 (da)
HU (1)	HUP0100186A3 (da)
IL (1)	IL135289A0 (da)
NO (1)	NO315648B1 (da)
NZ (1)	NZ504088A (da)
PL (1)	PL339738A1 (da)
PT (1)	PT1027332E (da)
SK (1)	SK4462000A3 (da)
TW (1)	TW541304B (da)
WO (1)	WO1999018074A1 (da)
ZA (1)	ZA988967B (da)

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CA2361848A1 (en)	1999-04-02	2000-10-12	Dupont Pharmaceuticals Company	Novel lactam inhibitors of matrix metalloproteinases, tnf-.alpha., and aggrecanase
AU4143300A (en) *	1999-04-28	2000-11-17	Takeda Chemical Industries Ltd.	Cyclic amide compounds, process for the preparation of the same and uses thereof
MXPA01012322A (es) *	1999-06-04	2002-07-22	Astrazeneca Ab	Inhibidores de metaloproteinasas.
US6656448B1 (en) *	2000-02-15	2003-12-02	Bristol-Myers Squibb Pharma Company	Matrix metalloproteinase inhibitors
US6989139B2 (en) *	2000-02-15	2006-01-24	Bristol-Myers Squibb Pharma Company	Matrix metalloproteinase inhibitors
US6620823B2 (en)	2000-07-11	2003-09-16	Bristol-Myers Squibb Pharme Company	Lactam metalloprotease inhibitors
GB0119474D0 (en) *	2001-08-09	2001-10-03	Astrazeneca Ab	Compounds
GB0127568D0 (en)	2001-11-16	2002-01-09	Glaxo Group Ltd	Chemical compounds
PE20030701A1 (es)	2001-12-20	2003-08-21	Schering Corp	Compuestos para el tratamiento de trastornos inflamatorios
WO2003082287A1 (en) *	2002-03-22	2003-10-09	Bristol-Myers Squibb Company	Dpc 333 formulation having unique biopharmaceutical characteristics
US20030225054A1 (en) *	2002-06-03	2003-12-04	Jingwu Duan	Combined use of tace inhibitors and COX2 inhibitors as anti-inflammatory agents
US6770763B2 (en) *	2002-06-11	2004-08-03	Bristol-Myers Squibb Company	Asymmetric synthesis of amino-pyrrolidinones
AU2003269801A1 (en) *	2002-06-28	2004-01-19	Bristol Myers Squibb Company	Asymmetric synthesis of amino-pyrrolidinones and a crystalline, free-base amino-pyrrolidinone
US7199155B2 (en)	2002-12-23	2007-04-03	Wyeth Holdings Corporation	Acetylenic aryl sulfonate hydroxamic acid TACE and matrix metalloproteinase inhibitors
SE0300445D0 (sv) *	2003-02-18	2003-02-18	Astrazeneca Ab	New combination
SE0300480D0 (sv)	2003-02-21	2003-02-21	Astrazeneca Ab	Novel compounds
EP1663201A4 (en) *	2003-07-15	2009-10-28	Korea Res Inst Of Bioscience	USE OF NEW 2-OXO-HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL PREPARATIONS CONTAINING THEREOF
JP4799408B2 (ja) *	2003-07-15	2011-10-26	コリアリサーチインスティテュートオブバイオサイエンスアンドバイオテクノロジー	新規な２−オキソ複素環化合物およびそれを含有する薬剤組成物の使用
WO2005077937A1 (en) *	2004-01-09	2005-08-25	Cadila Healthcare Limited	Substituted hydroxamic acid derivatives as tnf inhibitors
US20100226922A1 (en) *	2006-06-08	2010-09-09	Dorothea Maetzel	Specific protease inhibitors and their use in cancer therapy
US9096565B2 (en)	2007-04-09	2015-08-04	Methylgene Inc.	Inhibitors of histone deacetylase
WO2009094427A1 (en)	2008-01-23	2009-07-30	Bristol-Myers Squibb Company	4-pyridinone compounds and their use for cancer
DK2105164T3 (da)	2008-03-25	2011-03-21	Affectis Pharmaceuticals Ag	Nye P2X7R-antagonister og deres anvendelse
JP5650642B2 (ja) *	2008-08-01	2015-01-07	バイオキシネスファーマシューティカルズ，インコーポレイテッド	メチオニンアナログおよびそれらを使用する方法
RU2571662C2 (ru)	2009-03-25	2015-12-20	Эббви Инк.	Противовирусные соединения и их применения
WO2010118921A1 (en)	2009-04-14	2010-10-21	Affectis Pharmaceuticals Ag	Novel p2x7r antagonists and their use
KR20140000689A (ko) *	2010-10-08	2014-01-03	노파르티스 아게	술파미드 ｎｓ3 억제제의 염 및 다형체
WO2012077655A1 (ja) *	2010-12-07	2012-06-14	塩野義製薬株式会社	Ｇｐｒ１１９アゴニスト活性を有するスピロ誘導体
WO2012110190A1 (en)	2011-02-17	2012-08-23	Affectis Pharmaceuticals Ag	Novel p2x7r antagonists and their use
WO2012163792A1 (en)	2011-05-27	2012-12-06	Affectis Pharmaceuticals Ag	Novel p2x7r antagonists and their use
WO2012163456A1 (en)	2011-05-27	2012-12-06	Affectis Pharmaceuticals Ag	Novel p2x7r antagonists and their use
US20150023873A1 (en)	2011-11-11	2015-01-22	Lantheus Medical Imaging, Inc.	Evaluation of presence of and vulnerability to atrial fibrillation and other indications using matrix metalloproteinase-based imaging

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TW448172B (en) *	1996-03-08	2001-08-01	Pharmacia & Upjohn Co Llc	Novel hydroxamic acid derivatives useful for the treatment of diseases related to connective tissue degradation

1998
- 1998-10-01 ZA ZA9808967A patent/ZA988967B/xx unknown
- 1998-10-02 KR KR1020007003563A patent/KR20010015690A/ko not_active Application Discontinuation
- 1998-10-02 AT AT98950954T patent/ATE267805T1/de not_active IP Right Cessation
- 1998-10-02 CN CN98809703A patent/CN1272841A/zh active Pending
- 1998-10-02 HR HR60/062,418A patent/HRP980533A2/hr not_active Application Discontinuation
- 1998-10-02 NZ NZ504088A patent/NZ504088A/en unknown
- 1998-10-02 EP EP98950954A patent/EP1027332B1/en not_active Expired - Lifetime
- 1998-10-02 PT PT98950954T patent/PT1027332E/pt unknown
- 1998-10-02 BR BR9815398-6A patent/BR9815398A/pt not_active IP Right Cessation
- 1998-10-02 SK SK446-2000A patent/SK4462000A3/sk unknown
- 1998-10-02 US US09/165,747 patent/US6057336A/en not_active Expired - Lifetime
- 1998-10-02 IL IL13528998A patent/IL135289A0/xx unknown
- 1998-10-02 HU HU0100186A patent/HUP0100186A3/hu unknown
- 1998-10-02 PL PL98339738A patent/PL339738A1/xx unknown
- 1998-10-02 DE DE69824199T patent/DE69824199T2/de not_active Expired - Lifetime
- 1998-10-02 EE EEP200000199A patent/EE200000199A/xx unknown
- 1998-10-02 JP JP2000514886A patent/JP2001519331A/ja not_active Withdrawn
- 1998-10-02 WO PCT/US1998/021037 patent/WO1999018074A1/en not_active Application Discontinuation
- 1998-10-02 CA CA002305679A patent/CA2305679A1/en not_active Abandoned
- 1998-10-02 AR ARP980104945A patent/AR017291A1/es not_active Application Discontinuation
- 1998-10-02 AU AU96866/98A patent/AU747239B2/en not_active Ceased
- 1998-10-02 DK DK98950954T patent/DK1027332T3/da active
- 1998-10-02 ES ES98950954T patent/ES2217592T3/es not_active Expired - Lifetime
- 1998-10-21 TW TW087116499A patent/TW541304B/zh active
2000
- 2000-02-17 NO NO20000783A patent/NO315648B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP1027332A1 (en)	2000-08-16
EE200000199A (et)	2001-04-16
AR017291A1 (es)	2001-09-05
HRP980533A2 (en)	1999-10-31
EP1027332B1 (en)	2004-05-26
US6057336A (en)	2000-05-02
DE69824199D1 (de)	2004-07-01
AU9686698A (en)	1999-04-27
CN1272841A (zh)	2000-11-08
SK4462000A3 (en)	2002-06-04
JP2001519331A (ja)	2001-10-23
HUP0100186A2 (hu)	2001-05-28
ES2217592T3 (es)	2004-11-01
NO20000783D0 (no)	2000-02-17
ATE267805T1 (de)	2004-06-15
DE69824199T2 (de)	2005-01-27
PT1027332E (pt)	2004-08-31
NO20000783L (no)	2000-05-29
PL339738A1 (en)	2001-01-02
HUP0100186A3 (en)	2002-12-28
ZA988967B (en)	2000-04-03
BR9815398A (pt)	2000-10-31
IL135289A0 (en)	2001-05-20
NO315648B1 (no)	2003-10-06
WO1999018074A1 (en)	1999-04-15
NZ504088A (en)	2001-09-28
TW541304B (en)	2003-07-11
AU747239B2 (en)	2002-05-09
KR20010015690A (ko)	2001-02-26
CA2305679A1 (en)	1999-04-15

Publication	Publication Date	Title
DK1027332T3 (da)	2004-10-04	Hidtil ukendte lactametalloproteaseinhibitorer
DK0958287T3 (da)	2003-01-20	Sulfamidmetalloprotease-inhibitorer
DK1004669T3 (da)	2007-08-27	Hidtil ukendte differentieringsinhibitor
FI963597A0 (fi)	1996-09-12	Isoprenyylitransferaasi-inhibiittoreita
NO972930D0 (no)	1997-06-23	Fibronectin-adhesjonsinhibitorer
NO995433D0 (no)	1999-11-05	Protease-inhibitorer
NO20002121D0 (no)	2000-04-26	Benzotiazol-protein-tyrosin-kinaseinhibitorer
FI972160A (fi)	1997-05-22	Matriisimetalloproteaasi-inhibiittorit
DK1344524T3 (da)	2006-10-30	Refluksinhibitorer
NO996578D0 (no)	1999-12-30	Urokinase-inhibitorer
NO995434D0 (no)	1999-11-05	Proteaseinhibitorer
NO20003256L (no)	2000-06-22	ACE inhibitor-MMP inhibitor kombinasjoner
NO995435D0 (no)	1999-11-05	Protease-inhibitorer
NO995268D0 (no)	1999-10-28	Proteaseinhibitorer
PT1036083E (pt)	2004-10-29	Novos 9a-azalidos
ATE252547T1 (de)	2003-11-15	Matrixmetalloproteinaseinhibitoren
DK0983266T3 (da)	2002-03-11	Hidtil ukendte tetrahydrosioquinolinthiophencarboximidamider
DE69720957T2 (de)	2004-01-29	Ace-hemmer
ATA195097A (de)	2002-05-15	Korbartiger baustein
FI972138A0 (fi)	1997-05-20	Returtraog i bestrykningsanordning
CY2007006I2 (el)	2009-11-04	Αναστολεις συνθεσεις απολιποπρωτεϊνης-β
AR008310A1 (es)	1999-12-29	Metodos nuevos
MA26429A1 (fr)	2004-12-20	Inhibiteurs de protease
SE9703483D0 (sv)	1997-09-26	New use
FI971651A0 (fi)	1997-04-18	Spaormaskin i en elmaskin