DK1021712T3 - Phosphorescerende dendritiske makromolekylære forbindelser til billeddannelse af oxygen i væv - Google Patents
Phosphorescerende dendritiske makromolekylære forbindelser til billeddannelse af oxygen i vævInfo
- Publication number
- DK1021712T3 DK1021712T3 DK97950994T DK97950994T DK1021712T3 DK 1021712 T3 DK1021712 T3 DK 1021712T3 DK 97950994 T DK97950994 T DK 97950994T DK 97950994 T DK97950994 T DK 97950994T DK 1021712 T3 DK1021712 T3 DK 1021712T3
- Authority
- DK
- Denmark
- Prior art keywords
- tissues
- phosphorescent
- macromolecular compounds
- dendritic macromolecular
- imaging oxygen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
- A61B5/14556—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases by fluorescence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/1459—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/683—Means for maintaining contact with the body
- A61B5/6832—Means for maintaining contact with the body using adhesives
- A61B5/6833—Adhesive patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
- A61B5/6848—Needles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
- G01N21/6458—Fluorescence microscopy
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N31/00—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
- G01N31/22—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators
- G01N31/223—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators for investigating presence of specific gases or aerosols
- G01N31/225—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators for investigating presence of specific gases or aerosols for oxygen, e.g. including dissolved oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/14—Coupling media or elements to improve sensor contact with skin or tissue
- A61B2562/146—Coupling media or elements to improve sensor contact with skin or tissue for optical coupling
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- General Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Optics & Photonics (AREA)
- Emergency Medicine (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Luminescent Compositions (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Materials For Medical Uses (AREA)
- Porous Artificial Stone Or Porous Ceramic Products (AREA)
- Compositions Of Oxide Ceramics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/767,158 US5837865A (en) | 1993-10-15 | 1996-12-16 | Phosphorescent dendritic macromolecular compounds for imaging tissue oxygen |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1021712T3 true DK1021712T3 (da) | 2006-03-27 |
Family
ID=25078652
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK97950994T DK1021712T3 (da) | 1996-12-16 | 1997-12-12 | Phosphorescerende dendritiske makromolekylære forbindelser til billeddannelse af oxygen i væv |
Country Status (9)
Country | Link |
---|---|
US (1) | US5837865A (da) |
EP (1) | EP1021712B1 (da) |
JP (1) | JP2002501479A (da) |
AT (1) | ATE310243T1 (da) |
AU (1) | AU722502B2 (da) |
CA (1) | CA2275191C (da) |
DE (1) | DE69734683T2 (da) |
DK (1) | DK1021712T3 (da) |
WO (1) | WO1998026708A1 (da) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0915883B1 (en) * | 1996-07-22 | 2002-04-03 | Novartis AG | Process for the preparation of platinum or palladium benzoporphyrins and platinum or palladium cyclohexenoporphyrins, intermediates, and an oxygen sensor comprising platinum or palladium cyclohexenoporphyrin |
US6274086B1 (en) * | 1996-12-16 | 2001-08-14 | The Trustees Of The University Of Pennsylvania | Apparatus for non-invasive imaging oxygen distribution in multi-dimensions |
US7011943B2 (en) * | 2000-09-06 | 2006-03-14 | Transnetyx, Inc. | Method for detecting a designated genetic sequence in murine genomic DNA |
AU3926902A (en) * | 2000-11-17 | 2002-06-03 | Biomoda Inc | Compositions and methods for detecting pre-cancerous conditions in cell and tissue samples using 5, 10, 15, 20-tetrakis (carboxyphenyl) porphine |
JP2006522329A (ja) * | 2003-03-07 | 2006-09-28 | ラクセル・バイオサイエンシズ・リミテッド | 酸素感受性プローブ |
KR20060133974A (ko) * | 2003-10-16 | 2006-12-27 | 더 유니버시티 오브 아크론 | 탄소 나노섬유 기판 상의 탄소 나노튜브 |
WO2006026396A2 (en) * | 2004-08-26 | 2006-03-09 | Oxygen Enterprises, Ltd. | Imaging of oxygen by phosphorescence quenching |
CN1302049C (zh) * | 2005-05-26 | 2007-02-28 | 复旦大学 | 一种超支化高分子电致发光材料 |
DE102005036410A1 (de) * | 2005-07-29 | 2007-02-01 | Biocam Gmbh | Verfahren zur Ermittlung der Sauerstoffpartialdruckverteilung in zumindest einem Gewebeflächenabschnitt, insbesondere Hautgewebeflächenabschnitt |
JP2007064999A (ja) * | 2005-08-29 | 2007-03-15 | Mitsubishi Electric Corp | 液晶表示装置 |
US7575890B2 (en) | 2006-01-18 | 2009-08-18 | Oxygen Enterprises, Ltd. | Method for rapid detection and evaluation of cultured cell growth |
US20080051646A1 (en) * | 2006-07-24 | 2008-02-28 | Papkovsky Dmitri B | Probe for cellular oxygen |
WO2009108947A2 (en) * | 2008-02-28 | 2009-09-03 | The Trustees Of The University Of Pennsylvania | Imaging dendrimer nanoprobes and uses thereof |
US8623239B2 (en) | 2008-10-17 | 2014-01-07 | National University Corporation Gunma University | Compound and functional luminescent probe comprising the same |
WO2010053888A1 (en) * | 2008-11-07 | 2010-05-14 | Mocon, Inc | Calibration card for oxygen optical sensors |
US8241911B2 (en) * | 2008-11-07 | 2012-08-14 | Mocon, Inc. | Calibration card for photoluminescent oxygen sensors with zero point maintained with a metal-air battery |
US8323978B2 (en) * | 2008-11-07 | 2012-12-04 | Mocon, Inc. | Calibration system and technique for photoluminescent oxygen sensors with zero point maintained with a metal-air battery |
WO2010066273A1 (en) | 2008-12-11 | 2010-06-17 | Luxcel Biosciences Limited | Optochemical sensor active element, method of its preparation and use |
US8332007B2 (en) * | 2009-01-12 | 2012-12-11 | The Board Of Trustees Of The University Of Illinois | Quantitative three-dimensional mapping of oxygen tension |
US20110136247A1 (en) * | 2009-12-07 | 2011-06-09 | Dmitri Boris Papkovsky | Photoluminescent oxygen probe with reduced cross-sensitivity to humidity |
WO2012052068A1 (en) | 2010-10-22 | 2012-04-26 | University College Cork, National University Of Ireland, Cork | Method and probe for monitoring oxygen status in live mammalian cells |
US9274060B1 (en) | 2011-01-13 | 2016-03-01 | Mocon, Inc. | Methods for transmembrane measurement of oxygen concentration and monitoring changes in oxygen concentration within a space enclosed by a membrane employing a photoluminescent transmembrane oxygen probe |
US10493168B2 (en) * | 2012-02-27 | 2019-12-03 | Oxygen Enterprises, Ltd | Phosphorescent meso-unsubstituted metallo-porphyrin probe molecules for measuring oxygen and imaging methods |
EA201491551A1 (ru) * | 2012-02-27 | 2015-02-27 | Сергей Виноградов | Улучшенные фосфоресцентные молекулы для измерения содержания кислорода и способы визуализации |
US9057687B2 (en) | 2012-04-20 | 2015-06-16 | Mocon, Inc. | Calibration vial and technique for calibrating a fiber optic oxygen sensing needle |
JP6321004B2 (ja) | 2012-07-10 | 2018-05-09 | ザ ジェネラル ホスピタル コーポレイション | 対象のモニタリングと表面処理のためのシステムおよび方法 |
WO2015006015A1 (en) * | 2013-07-10 | 2015-01-15 | The General Hospital Corporation | Compounds, systems, and methods for monitoring and treating a surface of a subject |
US8658429B1 (en) | 2012-08-06 | 2014-02-25 | Mocon, Inc. | Photoluminescent oxygen probe tack |
CN113274007B (zh) | 2013-03-14 | 2024-10-18 | 普罗菲尤萨股份有限公司 | 用于校正光学信号的方法和装置 |
CN105263936B (zh) * | 2013-03-14 | 2018-06-05 | 普罗菲尤萨股份有限公司 | 氧传感器 |
EP4079242A1 (en) | 2013-03-19 | 2022-10-26 | Surgisense Corporation | Apparatus, systems and methods for determining tissue oxygenation |
US9789206B2 (en) | 2013-07-10 | 2017-10-17 | The General Hospital Corporation | Compounds, systems, and methods for monitoring and treating a surface of a subject |
CN110352036B (zh) | 2016-12-21 | 2022-11-15 | 普罗菲尤萨股份有限公司 | 可聚合的近红外染料 |
WO2019194875A2 (en) | 2017-12-28 | 2019-10-10 | Profusa, Inc. | Oxidase-based sensors and methods of using |
CN111117600A (zh) * | 2019-12-27 | 2020-05-08 | 复旦大学 | 一种氧气纳米探针及其制备方法与应用 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4289872A (en) * | 1979-04-06 | 1981-09-15 | Allied Corporation | Macromolecular highly branched homogeneous compound based on lysine units |
US4568737A (en) * | 1983-01-07 | 1986-02-04 | The Dow Chemical Company | Dense star polymers and dendrimers |
US4631337A (en) * | 1983-01-07 | 1986-12-23 | The Dow Chemical Company | Hydrolytically-stable dense star polyamine |
US4507466A (en) * | 1983-01-07 | 1985-03-26 | The Dow Chemical Corporation | Dense star polymers having core, core branches, terminal groups |
US4558120A (en) * | 1983-01-07 | 1985-12-10 | The Dow Chemical Company | Dense star polymer |
US4587329A (en) * | 1984-08-17 | 1986-05-06 | The Dow Chemical Company | Dense star polymers having two dimensional molecular diameter |
US4947850A (en) * | 1988-03-11 | 1990-08-14 | Trustees Of The University Of Pennsylvania | Method and apparatus for imaging an internal body portion of a host animal |
US5041516A (en) * | 1989-06-21 | 1991-08-20 | Cornell Research Foundation, Inc. | Dendritic molecules and method of production |
US5098475A (en) * | 1991-01-28 | 1992-03-24 | Xerox Corporation | Inks with dendrimer colorants |
US6362175B1 (en) * | 1991-09-20 | 2002-03-26 | The Trustees Of The University Of Pennsylvania | Porphyrin compounds for imaging tissue oxygen |
SE9200564L (sv) * | 1992-02-26 | 1993-03-15 | Perstorp Ab | Dendritisk makromolekyl av polyestertyp, foerfarande foer framstaellning daerav samt anvaendning daerav |
US5256193A (en) * | 1992-06-25 | 1993-10-26 | Xerox Corporation | Porphyrin chromophore and dendrimer ink composition |
US5387617A (en) * | 1993-01-22 | 1995-02-07 | The Dow Chemical Company | Small cell foams and blends and a process for their preparation |
-
1996
- 1996-12-16 US US08/767,158 patent/US5837865A/en not_active Expired - Lifetime
-
1997
- 1997-12-12 WO PCT/US1997/023599 patent/WO1998026708A1/en active IP Right Grant
- 1997-12-12 DK DK97950994T patent/DK1021712T3/da active
- 1997-12-12 AU AU53857/98A patent/AU722502B2/en not_active Ceased
- 1997-12-12 DE DE69734683T patent/DE69734683T2/de not_active Expired - Lifetime
- 1997-12-12 EP EP97950994A patent/EP1021712B1/en not_active Expired - Lifetime
- 1997-12-12 JP JP52800798A patent/JP2002501479A/ja active Pending
- 1997-12-12 CA CA002275191A patent/CA2275191C/en not_active Expired - Fee Related
- 1997-12-12 AT AT97950994T patent/ATE310243T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE69734683T2 (de) | 2006-08-17 |
CA2275191A1 (en) | 1998-06-25 |
EP1021712B1 (en) | 2005-11-16 |
ATE310243T1 (de) | 2005-12-15 |
EP1021712A1 (en) | 2000-07-26 |
JP2002501479A (ja) | 2002-01-15 |
AU5385798A (en) | 1998-07-15 |
AU722502B2 (en) | 2000-08-03 |
US5837865A (en) | 1998-11-17 |
DE69734683D1 (de) | 2005-12-22 |
EP1021712A4 (en) | 2000-07-26 |
WO1998026708A1 (en) | 1998-06-25 |
CA2275191C (en) | 2007-02-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK1021712T3 (da) | Phosphorescerende dendritiske makromolekylære forbindelser til billeddannelse af oxygen i væv | |
ATE254129T1 (de) | Fluoreszierende chelate als gewebespezifische bildgebende mittel | |
BR9803596A (pt) | Derivados do resorcinol. | |
DE69534388D1 (de) | Vorrichtung zur Bilderzeugung von erkranktem Gewebe unter verwendung der integrierten Autofluoreszenz | |
ATE380793T1 (de) | N-phenyl-alkylsulfonamid-derivate, deren herstellung und deren verwendung als alpha1a/1l- adrenoceptor agonisten | |
DE69718351D1 (de) | Diaminobenzoesäure derivate als farbstoffvorläufer | |
AR010062A1 (es) | Nuevos benzamidaldehidos y su utilizacion | |
DE69833223D1 (de) | 4-aminothiazol derivate, deren herstellung und deren verwendung als inhibitoren cyclin-abhängiger kinasen | |
ATE245649T1 (de) | 2,3-diaryl-pyrazolo(1,5-b)pyridazin derivate, deren herstellung und deren verwendung als cyclooxygenase 2 (cox-2) inhibitoren | |
PT941067E (pt) | Formulacoes em po estaveis no estado vitreo | |
ES2195189T3 (es) | Benzonaftiridinas como agentes terapeuticos bronquiales. | |
UA91321C2 (uk) | Застосування модифікованого еритропоетину, що не є еритропоетичним, для захисту, відновлення і підсилення еритропоетинреактивних клітин, тканин і органів | |
ES2189235T3 (es) | 6-fenilfenantridinas sustituidas. | |
DE69940256D1 (de) | Zusammensetzung zur hautbleichung | |
DE69832315D1 (de) | Medizinische Laserbestrahlungsvorrichtung | |
BR0114059A (pt) | Derivados de resorcinol | |
ES2165710T3 (es) | Composicion de teñido por oxidacion de las fibras queratinicas que contienen una lacasa y procedimiento de teñido que utiliza esta composicion. | |
DE60039365D1 (de) | Zubereitung zur färbung von keratinfasern | |
BR0009771A (pt) | Utilização de derivados de bisindóis indigóides capazes de penetrarem na membrana de células | |
PT942896E (pt) | Fenois e tiofenois substituidos uteis como agentes antioxidantes | |
HN1999000196A (es) | Derivados de indol | |
ES2161850T3 (es) | Colorantes reactivos, su obtencion y uso. | |
AR016930A1 (es) | Composicion de tenido por oxidacion de las fibras queratinicas y procedimiento de tenido que utiliza esta composicion | |
DK0877631T3 (da) | Konjugat af albumin og et xanthen-farvestof til differentiering mellem sygdomsramt og sundt væv | |
BR0009194A (pt) | Composição do resorcinol |